Egyptian Medicine Research Articles

Effect of some wild egyptian medicinal plants on HAV

Background: Folk Egyptian medicine considered from the most important source of the use of wild plants in medication. Wild plants are considered a perfect source of natural compounds that have been used as antimicrobial andante virus activities. Aims and Objective: The aim of the current study was to investigate the effect of the commonly used wild plants in the treatment of jaundice and they effect on HAV. This article provides much-needed insight into the effect of wild plants on the hepatitis A virus to shed more light on the important subject, which is unfortunately poorly investigated. Materials and Methods: In this investigation, the aqueous plant extracts of twenty-five wild Egyptian species, 16 perennials, and 9 annuals; three concentrations, 1%, 3% & 5%; were tested for HAV replication by using PA and PCR techniques. Questionnaires and interviews with Bedouins have been carried to know the most used species in the treatment of jaundice, and the usage values were calculated. Those species were collected from their habitats, rare ones purchased and reviewed their identifications and used in this work. Fecal and blood samples were taken from 9-10Y old patients, 35 girls and 25 boys. Results: The PA test revealed that 16 species out of twenty-five gave positive results, while the rest of the species gave negative results on Vero cells. Twelve of the sixteen species were perennial species, and the rest are annuals. The Plaque assay results showed that the most effective aqueous extract species, with the three concentrations, on HAV activity were those of Salvia verbennaca, Mentha microphylla, Ocimum basilicum, Cassia senna, Solenostemma argel, and Thymus capitatus, respectively. PCR test has been carried for the first three species and gave very faint nucleic acid tapes, which means that the plant extract of these species, the three concentrations, minimize the virus activity by a way or another. Samples from the patients tested for the antibodies for IgM and IgG using the ELISA test. Within both the females (58%) and males (42%), 6% have positive antibodies for IgM, while 36% in females and 34% in males’ have positive antibodies for IgG and 8% females and 10% males have both antibodies (IgM & IgG). Conclusion: Wild plants, especially those with essential oils can tolerate the Hepatitis A virus (HAV) activity and reduce its symptoms.

Development and Validation of Novel Gas Chromatography (GC) and Thin Layer Chromatography (TLC) Densitometry Methods for the Quantification of Stigmasterol 3-O-β-D-Glucopyranoside (S3G) in Balanites Aegyptiaca Extract: Application to Newly Formulated Balanites Capsules

Balanites aegyptiaca is a commonly used antihyperglycemic in Egyptian folk medicine. The objective of the present study is to develop two chromatographic methods for standardizing the Balanites extract by quantification of its main component, stigmasterol 3-O-β-D-glucopyranoside (S3G). The first method is gas chromatography (GC) where nitrogen was adopted as the carrier gas. The second method was thin layer chromatography (TLC) densitometry where chromatographic separation was established on aluminum plates using chloroform; methanol was used as the mobile phase followed by a densitometric measurement at 254 nm. Validation of the proposed methods was applied per International Council for Harmonization (ICH) guidelines. Both methods were adopted for quantification of S3G in Balanites capsules. The standard calibration curve was established for S3G in the concentration range of 10–130 μg/mL and 0.5–7.5 μg/mL for the GC and TLC methods, respectively. A good linearity with a correlation coefficient of 0.999 was obtained for both methods. Furthermore, the mean percentage recovery was found to be 99.46% for GC and 100.67% for TLC. Good precision was achieved, with relative standard deviation values <1%, and finally, the limits of detection and quantification were 2.51 and 7.59 μg/mL for GC and 0.13 and 0.40 μg/mL for TLC, respectively.

Traditional ancient Egyptian medicine: A review.

The ancient Egyptians practiced medicine with highly professional methods. They had advanced knowledge of anatomy and surgery. Also, they treated a lot of diseases including dental, gynecological, gastrointestinal, and urinary disorders. They could diagnose diabetes and cancer. The used therapeutics extended from different plants to include several animal products and minerals. Some of these plants are still used in the present day. Fortunately, they documented their life details by carving on stone, clay, or papyri. Although a lot of these records have been lost or destroyed, the surviving documents represent a huge source of knowledge in different scientific aspects including medicine. This review article is an attempt to understand some information about traditional medicine in ancient Egypt, we will look closely at some basics, sources of information of Egyptian medicine in addition to common treated diseases and therapeutics in this great civilization.

Approaching the history of an Egyptian biomedicine

AbstractThis piece explores the history of medicine in Egypt, the roots of an Egyptian practice of biomedicine in particular, through its historiography. In the period after World War II, the term “biomedicine” came to describe a practice of medicine defined by the close relations among clinicians, biological laboratory research, and the pharmaceutical industry in Europe and the United States. The history of medicine in Egypt and other parts of the Middle East and North Africa has long possessed close links to that in regions of Europe. In Egypt too, biomedicine has deep historical roots shaped by the influence of the nineteenth‐century Ottoman‐Egyptian state, the experience of colonialism, and the anti‐colonial objectives of the post‐colonial Egyptian state in the second half of the twentieth century. These influences were particularly important in relation to the treatment of schistosomiasis, one of Egypt's top‐ranking health problems of the twentieth century. The history of schistosomiasis demonstrates the gaps in the historiography of medicine in modern Egypt as well as how we might begin to consider the emergence of biomedical knowledge and theory at sites in Global South.

Neurosurgery in Egypt from ancient Egyptians to Modern Neurosurgery, African Perspective

Neurosurgery has been practiced for more than 12,000 years worldwide. Cranial and transnasal approaches to the brain have beenpracticed for variable religious, mystical, or therapeutic purposes in ancient civilizations of Africa and specifically in Egypt (1). AncientEgyptian medicine is documented in the paintings on the walls of temples and numerous papyri (figure 1) (2-4).Ancient Egyptian medicine dates to 3500 BC when Athotis (Hor-Aha), the second king of the first dynasty, was found to have in his tombthe first “Book of the Dead” that was later quoted with modifications till it reached “Practical Medicine and Anatomic Book” in Ani’spapyrus (5, 6).

A behavioural & social sciences core curriculum for Egyptian undergraduate medical education at the Armed Forces College of Medicine.

Introduction: Medical practice is a highly emotionally and behaviorally demanding occupation. Thus, the design of teaching and learning programs in medical colleges need to be modified to adapt such need. Behavioral and social sciences must be implemented to develop competent medical health care workers. Educational programs in Egyptian medical schools are undergoing a gradual shift toward integration, student-centeredness, and early clinical exposure. The Psychiatry Department & Medical Education Department at the Armed Forces College of Medicine in Egypt in collaboration with the Medical Education Department at Michigan state university; developed behavioral & Social science curriculum by adopting ADDIE’s basic five-step model, which includes Analysis, Design, Development, Implementation, and Evaluation processes. The identified curriculum has been split into three divisions: social topics related to behavioral medicine, basic psychology, and clinical medicine related to behavioral science. Twenty-six topics were included in these three divisions and were distributed in the seven selected core competencies. The working team expects to include more sociocultural and anthropology topics in the curriculum in the future. Additionally, it is hoped that more time will be allocated for this module, so it would be more possible to include other teaching & assessment methods for developing global understanding of disorders, and practical skills for behavior modification, as well as, encourage students to consider actual treatment strategies in clinical case scenarios. It is also hoped that students could get the chance for early exposure to hospital-based cases. This will motivate the students by allowing them to come into contact with various real-life settings. Context: Medical practice is a highly emotionally and behaviorally demanding occupation. Thus, the design of teaching and learning programs in medical colleges need to be modified to adapt such need. Behavioral and social sciences must be implemented to develop competent medical health care workers. Educational programs in Egyptian medical schools are undergoing a gradual shift toward integration, student-centeredness, and early clinical exposure

The Effect of Using an Exercise-Nutrition Program on Some Physiological Variables on Diabetes Patients

The tremendous and astonishing technological progress in the modern era in all different fields has ledto a lack of human mobility and thus a lack of physical and physiological competence, which made himvulnerable to many diseases called hypokinetic diseases such as cardiovascular disease, obesity, lower backpain, diabetes, and high blood pressure. The Study Problem: Diabetes is one of the most common andwidespread diseases today, and failure to control this disease will lead to many complications, includingcardiovascular disease, high-fat content, in addition to limb muscle atrophy, high blood pressure andperipheral nerve inflammation, which sometimes leads to leg amputation. The cause of death and this is thesource of the problem. The Study Objectives: Knowing the blood sugar level of non-athletic patients aged40-55 years before the program. Designing an athletic program for diabetics aged 40-55 years who are nonathletes for the research group. To know the effect of the program on blood sugar, HDL cholesterol, and PCVblood viscosity for the research group. Identify the effect of the program on the nerve signals received fromthe upper and lower extremities of the research group. The study community the human field: people withdiabetes who are 40-55 years old who are not athletes. from 1/3/2020 to 1/7/2020. Hospitals and specializedcenters for treating this disease and the Physiotherapy Center for Sports Medicine in Egypt. Results: thevalues of the blood sugar test indicate the significance of the differences between the pre-and post-tests andin favor of the post-test, considering that the drop in blood sugar level is a positive case. blood HDL ratiotest indicates the significance of the differences between the pre-and post-tests and in favor of the post-test,considering that the drop in blood sugar level is a positive case. blood HDL ratio test considering the highlevel of HDL cholesterol is a positive case. Conclusions: 1-The diet and exercise program has a positiveeffect on low blood sugar levels. 2-The sports and nutritional program have a positive effect on the levelof high-density lipoprotein (HDL) cholesterol in the blood. 3-The sports and nutritional program have apositive effect on blood viscosity (PCV). 4-The sports and nutritional program have a positive effect on thenerve signals coming from the upper and lower extremities.

House Officers' Choice of Family Medicine Specialty amid the Implementation of the New Universal Health Insurance Law.

BackgroundThe new Egyptian Universal Health Insurance Law is introduced through family-oriented primary health care. Increasing the number of recent graduates who specialized in family medicine is considered a national need to overcome family physicians’ shortage.AimTo explore the factors affecting the house officers’ choice of Family Medicine as a future career amid the implementation of the new Universal Health Insurance Law in Egypt.MethodsThis is a cross-sectional study conducted on house officers during their training in Cairo university hospitals from the first of March 2020 to February 2021. The researchers offered an anonymous self-administered questionnaire to all house officers at the beginning of their 2-week family medicine training (1170 house officers).ResultsA total of 1052 completed the questionnaire (response rate 90%). Family medicine as a specialty was considered by 53.6% (n = 564) of participants, while only 23.4% (n = 246) of participants had an obvious intention to choose family medicine. Multivariate (adjusted) logistic regression model revealed that factors significantly associated with intention to choose family medicine were marital status, knowledge about governmental advantages for family medicine offered to the specialized recent graduates, and previously encountered with family practice as customers.ConclusionsThe choice of family medicine specialty is increasing among house officers. This could be attributed to the growing interest in family medicine in Egypt, especially after implementing the new insurance law’s first phase in several Egyptian governorates.

Biological activity and investigation of some active constituents with molecular docking from two Cleome species

Objective Cleome genus belonging to Cleomeaceae family is used as an antidiabetic agent in Egyptian folk medicine. The current study aimed to isolated and identify the active constitutes of two species, Cleome africana and Cleome droserifolia, and to study the biological activities, such as antidiabetic, anti-inflammatory, and hepatoprotective.Materials and methods The lipid constituents of two plant species, C. africana and C. droserifolia, were extracted with petroleum ether and fractionated to acetone-insoluble fraction and acetone-soluble fraction. Molecular docking studies were carried out in isolated compounds. Antidiabetic, anti-inflammatory, and hepatoprotective activities of the promising compounds were investigated.Results and conclusion The fatty alcohols and hydrocarbons were identified from the acetone-insoluble fraction. C. africana comprises four fatty alcohols, in which tetratetracontanol is the main one, whereas C. droserifolia consists of two fatty alcohols, in which dotriacontanol is the main one. The hydrocarbons include seven compounds, with tritriacontane as the main one in both species. The acetone-soluble fraction was saponified to afford the unsaponifiable fraction, which contains in C. africana a series of n-alkanes from n-C14 to n-C31, representing 93.66%, with n-C22 as the main one, in addition to a sterol fraction, forming 5.13%, in which β-sitosterol is the main compound, and the fraction of C. droserifolia was found to contain a series of n-alkanes from n-C18 to n-C30, representing 60.46%, in which n-C30 is the main compound, besides sterols, representing about 39.54%, with campesterol as a major compound (12.46%), and finally, a triterpene fraction consisting of α-amyrin and β-amyrin. In addition, fatty acids as a mixture of eight acids (saturated and unsaturated) were found in both species; the major two acids are linoleic acid (38.99%) and palmitic acid (33.05%). Extraction of the glucosinolate (GL) constituents from the methanolic extract of C. africana led to isolation and identification of one compound (G), identified as 3-ethylsulfonyl-2,3-dimethoxypropyl GLs. Enzymatic hydrolysis of the total GLs allowed us to identify eight isothiocyanate and two thione compounds. Molecular docking of compound G with glucosidase enzyme using C-DOCKER protocol resulted in having higher docking scores relative to the lead molecule and the ligand (Glimepiride). Accordingly, molecular docking studies proved that the molecule of G compound has a promising active hits and can be used as antidiabetic through glucosidase inhibitor and also different extracts exhibited an anti-inflammatory and hepatoprotective activity.

Cervical spine surgery in the ancient and medieval worlds.

The early historical literature on cervical spine surgery lacks printed material for review, and we can rely only on pathological material from the prehistoric period that has survived as a result of anthropological investigations. After the introduction of Egyptian and early Hellenic medicine, some written material became available. This paper reviews these materials, from both books and manuscripts, in an effort to understand the development of cervical spine surgery from the perspectives of the personalities involved and the early surgical practices used. The review thus considers the following five eras of medicine: 1) prehistoric; 2) Egyptian and Babylonian; 3) Greek and early Byzantine; 4) Middle Eastern; and 5) medieval.

Exploring ATR Fourier transform IR spectroscopy with chemometric analysis and laser scanning microscopy in the investigation of forensic documents fraud

Forensic examiners are overwhelmed every day by many cases of official and other business documental forgery. Many cases of which involve the addition or deletion of one or more similar writing/copying paper(s) to the original document. Another challenge that faces the examiners is the determination of the intersected signature lines chronological sequence. This suggests a forgery case in that instance if such modifications are made without the consent of all parties. The importance of the documents under question mandates the usage of non-destructive discriminative analytical methods. The main tool used by the forensic examiners in the Egyptian medicine forensic authority is the Video spectral comparator (VSC). However, in many times the latter doesn’t give conclusive suggestions to the examiner who becomes hesitant to give a fair judgement on the case. The current study investigated the use of a molecular spectroscopic technique like Fourier transform infrared spectroscopy (FTIR) in the discrimination between writing/copying papers and the sequence of the used writing inks by Atomic force microscopy (AFM) as non-destructive techniques. The apparently similar used papers were from the commonly used documents under question in the Egyptian market. We investigated 12 different main types of office/copying paper and the toner inks of two different laser printers versus three brands of blue ballpoint pens in the Egyptian market. FTIR spectroscopy and AFM were found to be potential tools that can be combined with VSC in the discrimination between different papers and determining the chronological sequence of writing inks. Principal component analysis (PCA) as a multivariate analysis tool achieved a satisfactory discrimination capacity between the 12 papers in the FTIR region 830–1185 cm−1.

Perception of Medical Students and Staff towards Community Medicine Educational Process in Traditional and Integrated Medical Schools

ABSTRACT Background: Community medicine teaching has a vital role in graduation of community oriented primary health care physicians, who can identify and solve health problems in their community.However, the majority of undergraduate medical students perceived it as irrelevant to their role as physicians and not prefer it as a future career. Integration in medical curricula makes the learning and teaching to occur in a holistic way that reflects the real world, so it may be perceived better by students and staff members. Objectives: To investigate the perception of undergraduate medical students towards community medicine teaching process and their future career preference, to identify the perception of teaching staff about the community medicine educational process in traditional and integrated medical schools. Participants and Methods: a cross sectional study, conducted on 600 randomly chosen undergraduate students (300 from each system), and 110 community medicine teaching staff members at some faculties of medicine in Egypt (68 from traditional system and 42 from integrated system). Data were collected by self-administered pre-tested questionnaires using Likert-scale. Results: The mean age of participant students was 21.8 year±0.8, while the mean age of participant staff members was >40 years, and the majorities of both were females. The median of total scores was low in both groups, while it was significantly higher among the participants from integrated versus traditional schools (students score was 58.5 versus 51) and (staff score was 79.5 versus 74) respectively. Only 12% among studied students preferred community medicine as a future career, 53.5% among them were highly satisfied by community medicine course. Conclusions: Perceptions regarding the community medicine educational process was better among the integrated system participants than traditional ones. The majorities of students in both systems did not prefer community medicine as a future career.

TIRYAQ E ARBA: A classical Unani Formulation to boost immunity

Unani System of medicine is one among the oldest systems of medicine that prevails till date with its efficient drugs derived from animal, plant and mineral resources. Over 2400 years ago the father of medicine, Hippocrates practiced it, however His medicine included a great deal of ancient Egyptian Medicine as well as important components of the ancient Mesopotamian traditions. This system of medicine has a detailed description of drugs that are utilized in many infectious diseases like influenza, pneumonia and other respiratory disorders. Unani scholars have prescribed several single drugs as well as compound formulations for the prevention and treatment of infectious diseases in general. Tiryaq e Arba is one such formulation, which is known to improve host immunity anytime or during the outbreak of epidemics, endemics and pandemics. Through this paper, an attempt has been made to present Unani concept of infectious and epidemic diseases and details of Tiryaq e Arba with a possible approach to manage Covid-19.
 Keywords: Tiryaq e Arba, ingredients, epidemics, Unani Medicine.

Emergency Medicine in Egypt.

Egyptplays a pivotal role in North Africa and the Middle East, and has the largest population of any Arab country and serves as a regional cultural hub. Emergency medicine as a field of study was first initiated at Alexandria University in 1978, but it was only formally recognized as a medical specialty in 2002. Since then, the prehospital system and practice of emergency medicine has evolved and grown. This article will outline the development of emergency medicine in Egypt, including infrastructure, education, specialty certification, and future challenges, including those which are common to other specialties in development, and also those which are unique to Egypt. Opportunities remain with respect to the development of emergency medicine in Egypt, most notably in a continuing 'brain drain' of physicians who leave the country after receiving training, supervision, and oversight of residency programs, and general public and professional awareness of this new specialty. Egypt has made great strides with respect to the delivery of emergency services, physician education and certification within the specialty of emergency medicine. Learning about these developments in Egypt will provide the reader with a compelling example of how an emergency system is developed in an advancing national setting.

Medicine and Humankind since Ancient Times: Historical and Legal Aspects of Joint Development

This article highlights the historical and legal foundations of the development of medicine and humankind. Based on the analysis of the results of archaeological, anthropological studies and historical sources, we legally proved that starting with the very early stages of human development, medicine existed alongside the primitive man.While investigating the state of medicine in ancient Egypt, we came to the conclusion that treatment not only helped people, but sometimes, on the contrary, greatly damaged the health of patients. For example, many recipes included the obligatory use of manure, which contains products of fermentation and mold, which is very dangerous to the body and health. However, despite these negative results, we can argue that medical practice in ancient Egypt was well developed. The The studies of this period made it possible to conclude that medicine develops in an inextricable connection with human development, and the obtained medical knowledge is used by society for its well-being.The study of the development of medicine and humanity in Ancient India gives grounds for arguing that due to advanced medical education. Society has come to the conclusion that medicine is an integral part of human life and a guarantee of its development and continuation. It was during this period that humankind switched to a new stage of healthcare when the state control of medicine emerges. It was in India where state institutions began to consider the medical sector as one of the main tools for guaranteeing the well-being of citizens. And in ancient China, medicine gained state support and became the foundation of the society’s development at the one level with religion.The results obtained in the course of our study are based on historical facts, they prove that medicine arose with the appearance of human and subsequently existed and developed along with human development.

Assessment of Family Function of Academic Physicians

Background: A balance between Work and family is required to maintain a stable professional and personal life. It is necessary for well-being, job satisfaction, and productivity; Academic physicians' family function usually affected by multiple responsibilities at work. Aim: To assess the family function of the academic staff and to identify the risk factors of family dysfunction. Subjects and Methods: A Cross-sectional descriptive study on 277 academic physicians from different specialties working at the faculty of medicine, Suez Canal University, Ismailia, Egypt, participated in an online anonymous questionnaire assessing sociodemographic characteristics, work duties, and family function using APGAR score. Results: Mean age of participants was 38.38 years; Females represented 60.6%. Seventy-two percent of the medical staff had severe family dysfunction, 21% had moderate family dysfunction and only 7% of them were highly functional. There was a statistically significant relation between family dysfunction and age, gender, marital status, having children, job title, and the number of working hours per week. Conclusion: This study showed that most of the academic physicians were suffering from severe family dysfunction. Further studies about work stress in faculties of medicine in Egypt and its impact on family function are needed for further assessment and improvement.

Coptic Medicine And Monastic Health Care System In The Early Centuries Of Coptic Christianity

Ancient Egyptians had influenced Greeks, Romans and Copts in medical and surgical skills. When the land of Egypt embraced Christian faith, early Copts had been affected by ancient Egyptian medicine with its remedies and prescriptions. Thus, Coptic medicine was considered as a continuation of medicine and healthcare of ancient Egyptians. This study discusses some Coptic medical sources such as parchments, papyri, ostraca, and graffiti which came to us and preserved now in different museums of the world. This part of Coptic literature shows different medical practices, remedies and prescriptions from the 5th to the 11th century such as Cairo medical papyrus which shows eye, ear, teeth and some women diseases in Coptic period. This papyrus shows how Coptic medical practices were a continuation of ancient Egyptian medicine. The research also focuses on some Coptic saints as healers in Coptic era. These saints were physicians treated their patients without a reward following by this the word of the god such as, saint Cosmas and Damian who were represented in a 7th Century wall painting holding some medical tools. From the early 4th century, the monastic healthcare system was clearly represented and defined in early Coptic monasteries. In Coenobitic monasticism, healthcare was delivered through two main types; inpatient and outpatient health care systems. These two main monastic healthcare systems and the monastic medical personnel in early monasteries are also discussed in the present study. Additionally, the study explores the using of magic as a protective method, and to heal some difficult diseases which were hard to be cured by rational medicine. The Descriptive analytic method has been used in this study, which was useful in discussing different aspects related to Coptic medicine and its deep roots in Ancient Egyptian civilization.

Ancient Egyptian Medicine - Investigation Paper

Ancient Egyptian Medicine - Investigation Paper

Cytogenetic analyses of the anti-mutagenic effect of Tamarix nilotica in mice bone marrow

The usages of medicinal plants as therapeutic agents have been practiced in a large scale of applications that make studies of their mutagenicity and/or anti-mutagenic /anti-carcinogenic effects very essential. The current investigation is focused on the anti-mutagenic effects of the Tamarix nilotica (Ehrenb) crude extract using chromosomal aberrations analysis in mice bone marrow. In fact, a single plant may have diversity of phytochemicals ranging from bitter compounds that stimulate digestive system, phenolic compounds for antioxidants and many other pharmacological properties, antibacterial, and antifungal, tannins that work as natural antibiotics, diuretic substances and alkaloids, etc. Tamarix is represented in Egypt with two indigenous species which are Tamarix aphylla (L.) (H.Karst) and T. nilotica (Ehrenb.) Bunge (T. nilotica (Ehrenb.). In addition, it was used in Egyptian traditional medicine as an antiseptic agent. Extracts of Tamarix species have been widely used in traditional medicine in Asia and Africa mainly for their antiseptic, astringent, diaphoretic and diuretic properties. The current investigation is focused on the anti-mutagenic effects of the Tamarix nilotica crude extract using chromosomal aberrations analysis in mice bone marrow. Mitomycin C (MMC) was administered to mice as a positive control alone before and after treatment with 5 or 0.5 mg/ kg b.wt Tamarix crude extract as acute (24 and 48 h) and sub-acute (15 consecutive days) doses respectively. Results indicated that the Mitomycin C (MMC) exposure induced statistically significant increase in chromosomal aberrations compared to the control, however T. nilotica revealed slight insignificant effect on aberrant mitosis rate. Chromosomal aberration domain structural and numerical aberrations. The frequency of chromosomal aberrations (CA) and mitotic index (MI) decreased with increasing the dose and time of T. nilotica treatment, especially pre-treatment (plant + MMC). This effect was found to be dose-dependent. In conclusion, the results showed that T. nilotica could be considered as a good anti-mutagenic agent.

Phytochemical Analysis and Antifungal bioactivity of Pulicaria undulata (L.) Methanolic Extract and Essential Oil

PULICARIA UNDULATA is one of the aromatic annual herbs used in folk medicine in Egypt. The aerial parts of P. undulata plants were collected from the Red sea coastal desert during the flowering stage and used for phytochemical analysis. It was revealed that P. undulata aerial portions contain phenols, flavonoids terpenoids, saponins, alkaloids, glucosinolates and cardiac glycosides highlighting its participation in drug development and using as an alternative strategy to the harmful synthetic fungicides. The greater accumulation of the bioactive compounds in the methanolic extract was comparable with its higher antioxidant capacity and IC50 value as compared with those of the petroleum ether extract. The GC-MS analysis revealed the occurrence of ten bioactive phytocomponents including cyclotrisiloxane, hexamethyl-, cyclotetrasiloxane, octamethyl-, cyclopentasiloxane, decamethyl, dodecanoic acid, methyl ester, tetrafluorophthalonitrile, gamma-Sitosterol, nonacosane, 4,4,6a,6b,8a,11,11,14b-Octamethyl ,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-octadecahydro-2H-picen-3-one, thiazolo[4,5-f]quinoline and 7-methyl-. In addition, the methanolic extract exhibited antifungal activity against the investigated six pathogenic fungal strains: Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Microsporum canis, Microsporum boulardii and Trichophyton mentagrophytes. Based on the values of the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC), the methanolic extract has demonstrated a fungicidal effect on M. boulardii IFM 56403, T. mentagrophytes AUMC 11661, M. canis AUMC 11663, and C. albicans AUMC 9142. The cytotoxicity evaluation of the methanolic extract showed safe levels in case of these four fungal strains. The petroleum ether extract, inhibited the tested fungi but with lower efficiency. Our results suggest the promising antifungal activity of P. undulata on medically important fungi.