Medication Compliance Research Articles

From data extraction to analysis: a comparative study of ELISE capabilities in scientific literature

The exponential growth of scientific literature presents challenges for pharmaceutical, biotechnological, and Medtech industries, particularly in regulatory documentation, clinical research, and systematic reviews. Ensuring accurate data extraction, literature synthesis, and compliance with industry standards require AI tools that not only streamline workflows but also uphold scientific rigor. This study evaluates the performance of AI tools designed for bibliographic review, data extraction, and scientific synthesis, assessing their impact on decision-making, regulatory compliance, and research productivity. The AI tools assessed include general-purpose models like ChatGPT and specialized solutions such as ELISE (Elevated LIfe SciencEs), SciSpace/Typeset, Humata, and Epsilon. The evaluation is based on three main criteria: Extraction, Comprehension, and Analysis with Compliance and Traceability (ECACT) as additional dimensions. Human experts established reference benchmarks, while AI Evaluator models ensure objective performance measurement. The study introduces the ECACT score, a structured metric assessing AI reliability in scientific literature analysis, regulatory reporting and clinical documentation. Results demonstrate that ELISE consistently outperforms other AI tools, excelling in precise data extraction, deep contextual comprehension, and advanced content analysis. ELISE’s ability to generate traceable, well-reasoned insights makes it particularly well-suited for high-stakes applications such as regulatory affairs, clinical trials, and medical documentation, where accuracy, transparency, and compliance are paramount. Unlike other AI tools, ELISE provides expert-level reasoning and explainability, ensuring AI-generated insights align with industry best practices. ChatGPT is efficient in data retrieval but lacks precision in complex analysis, limiting its use in high-stakes decision-making. Epsilon, Humata, and SciSpace/Typeset exhibit moderate performance, with variability affecting their reliability in critical applications. In conclusion, while AI tools such as ELISE enhance literature review, regulatory writing, and clinical data interpretation, human oversight remains essential to validate AI outputs and ensure compliance with scientific and regulatory standards. For pharmaceutical, biotechnological, and Medtech industries, AI integration must strike a balance between automation and expert supervision to maintain data integrity, transparency, and regulatory adherence.

Building Compliance-Driven AI Systems: Navigating IEC 62304 and PCI-DSS Constraints

Due to the ever-increasing adoption of AI systems in the financial space, it is necessary to assess these regulatory frameworks, such as IEC 62304 and PCI DSS. As AI technologies within the finance sector process huge quantities of data that are sensitive, like transaction and personal information, these must be handled securely so that these are not breached or involve fraud—meeting the strict data security standards, privacy, and operation standards for a medical device software compliance with IEC 62304 and PCI DSS for payment card data security results. This article investigates how these compliance frameworks create the responsibility for designing, structuring, and building AI systems in financial institutions. It describes the technical problems in implementing real-time financial data processing and the issues addressed with cloud-native platforms, encryption, and data management applications. It discusses how, with technological advancements like large language models, Apache Kafka, and Apache Spark, the resulting financial AI systems can be compliance-driven and perform well. The article also delves into the ethical options of AI in finance and, in particular, data privacy, bias, and transparency. The conclusions include insights into the future of AI compliance with new technologies such as quantum computing and blockchain that will change the face of science. This study offers an actionable roadmap for companies to address the difficulties of regulatory compliance in the vein of AI’s potential fulfillment.

Strategies for Coronary Artery Disease Prevention at Ayub Teaching Hospital: Challenges, Opportunities, and Future Directions

CAD is still a pressing global health issue and a leading cause of mortality and morbidity; its incidence is increasingly observed in developing countries, including Pakistan. The paper aims to explore the CAD prevention plan within ATH, analyzing its successes and failures, barriers, and positives, and future planning to reduce this disease. A cross-sectional survey design was adopted to collect data from CAD patients, high-risk individuals, and healthcare providers regarding awareness, preventive practices, medication compliance, and perceived barriers to CAD prevention. The findings show that there is low awareness of CAD, particularly among high-risk groups, failure to follow necessary lifestyle changes, and issues around medication use. Lack of financial resources, low levels of health literacy, and the overall shortage of primary healthcare facilities were identified as the primary challenges affecting prevention. Lack of patient compliance, shortage of resources, and a heavy workload were attributed by most healthcare providers as some of their major challenges in CAD management. However, increased interest was prevalent in community-based prevention programs, telemedicine, and low-cost healthcare services, which point to potential obstacles. Thus, the development of an effective system to fight CAD requires a multi-faceted approach based on the organization of special targeted public health programs, increasing accessibility in healthcare, and utilizing information technologies. Improving primary health care, employing preventive cardiology, and reforming policies will reduce CAD rates in Pakistan in significant ways. The findings of this research are valuable to guide future activities to improve CAD prevention at ATH and to establish national-level policies for cardiovascular disease prevention.

Analysis of Treatment Compliance Factors in Type 2 Diabetes Mellitus Patients

Non-compliance with taking medication in DM patients can reduce a person's quality of life and become the main cause of a number of microvascular problems. Therefore, complex problems related to diabetes are one of the global health problems that must be addressed immediately. The purpose of this study was to determine the factors related to medication compliance in type 2 DM patients. This study used a mixed method study approach or a combination of two types of research, namely quantitative research and qualitative research. The type of mixed method research design used is explanatory sequential design. The sampling method in this study was by proportional sampling. Furthermore, to determine the target sample, a simple random block sampling technique was used, namely 347 DM patients. The results of the analysis showed no significant relationship between gender p-value = 1,000 (> 0.05), education p-value = 0.232 (>, 0.05), knowledge p-value = 0.076 (> 0.05), dxuration of suffering p-value = 0.162 (> 0.05), belief p-value = 0.680 (> 0.05), access to health services p-value = 0.602 (> 0.05), and there was a significant relationship between family support and DM treatment compliance with p-value = 0.020 (<0.05). The conclusion of this study is that more than half of DM patients have low treatment compliance, are female, have low education, have a duration of <5 years, have access to health that takes a long time, and lack of family support. More than half of DM patients have high knowledge and positive beliefs.

Effects of the October 2023 war on diabetes treatment and medication adherence in Gaza

Background: Diabetes management requires lifelong medical and medication supervision. The war in Gaza has worsened essential care for diabetes patients, disrupting access to treatment and medications and causing non-adherence. Aim: To evaluate the effects of the October 2023 war on diabetes treatment and medication compliance in Gaza. Methods: Between February and May 2024, this cross-sectional study collected data from 278 diabetes patients residing in Rafah, Gaza Strip. It analysed the impact of the war on access to care and medications and medication adherence. Results: Access to health care facility had decreased from 90% before the October 2023 war to 22% at the time of the study, and medication adherence had decreased from 85% to 45%. Financial constraints severely impacted medication affordability (55% significantly, 37% moderately, 7% lightly, and only 1% not at all) and medication adherence (65% due to mild constraint, 40% due to moderate constraint and 15% due to high constraint). Conclusion: Findings from this study indicate the need for accelerated assistance to rehabilitate health infrastructure and services in Gaza to guarantee continuous care for diabetic patients and patients suffering from other chronic diseases.

Yi Shen Tiao Gan decoction alleviates aromatase inhibitor-related bone loss by promoting H-type vessel formation.

Yi Shen Tiao Gan decoction alleviates aromatase inhibitor-related bone loss by promoting H-type vessel formation.

Relationship Between Depression and Medication Adherence in Older Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis.

Depression and cardiovascular disease (CVD) by the end of 2030 will be among the major causes of disability worldwide. Meanwhile, medication adherence is an important factor in predicting clinical outcomes in patients with CVD. Further, lack of medication compliance is affected by depression. Thus, this study aimed to explore the relationship between depression and medication adherence among older patients with CVD. The search was done across eight databases of PubMed/MEDLINE, Google Scholar, Embase, Scopus, APA Psycinfo, CINAHL/ebsco, ProQuest, and Web of Science. For the selection of included studies, there were no constraints regarding publication language. All studies available in each of the databases were searched up to December 9, 2021. Risk of bias assessment was done based on the Joanna Briggs Institute scale. The final result was estimated using a random effects model. The data were analyzed by CMA 2 software. Seven studies and 10,153 elderly suffering from CVD were identified. Most included studies had reported an inverse association between depression and medication adherence. There was a small effect between depression and medication adherence among these older patients (combined odds ratio 0.603, 95% confidence interval 0.252-1.442). Thus, having depression would reduce medication adherence by 40%. Depression has a considerable effect on medication adherence among older patients with CVD. Thus, it is suggested that considering the importance of depression and lack of medication adherence in increasing the negative outcomes of this disease in these patients, primary studies be conducted in this regard to achieve conclusive results in subsequent systematic reviews and meta-analyses.

Application of Full Disease Course Management via Internet Platform in Rehabilitation Management of Patients with Depression

Objective: To observe the application effect of full disease course management via an internet platform in the rehabilitation management of patients with depression. Methods: Eighty patients with depression meeting the inclusion criteria were selected as the study subjects and randomly divided into an experimental group and a control group, with 40 patients in each group. The control group was followed up every 4 weeks for 12 weeks after discharge. The experimental group underwent full disease course management via an internet platform for 12 weeks after discharge. The quality-of-life scores, depression scores, medication compliance, insight and treatment attitude questionnaire scores, and self-efficacy scores were compared between the two groups. Results: After 12 weeks of follow-up, the experimental group had higher quality-of-life scores, lower depression scores, higher medication compliance, higher insight and treatment attitude scores, and higher self-efficacy scores than the control group (P < 0.05). Conclusion: Full disease course management via an internet platform has a positive impact on the quality of life, medication compliance, self-efficacy, and disease stability of discharged patients with depression.

Profil Kadar HbA1c dan Karakteristik Klinis Pasien Diabetes Melitus Tipe 2 di Poli Penyakit dalam RSUD Cut Meutia Aceh Utara

Chronic disease caused by increased blood sugar levels and potentially causing many complications especially when uncontrolled conditions are known as diabetes mellitus. Glycosylated hemoglobin examination is a reliable method in evaluating long-term glycemic control because it is not affected by daily fluctuations and reflects glucose levels for 120 days. The province with the 10th highest number of diabetes mellitus cases in 2018 was Aceh. One of the districts in Aceh, namely North Aceh, is the area with the highest incidence of cases. This study aims to describe HbA1c levels and characteristics of type 2 diabetes mellitus patients at Cut Meutia Regional Hospital, North Aceh in 2023. Using a descriptive cross-sectional design, 77 patients were selected through purposive sampling. Data were collected from laboratory results and MMAS-8 and MIAS-8 questionnaires. The results showed that most patients had uncontrolled HbA1c levels (90.9%), uncontrolled HbA1c men (91.7%), 56–65 years old (40.3%), had pre-hypertension blood pressure (83.1%), and medication compliance in the moderate category (54.5%). This can be concluded that cases of diabetes with uncontrolled glycosylated hemoglobin levels are men.

Auditory Hallucination and Bipolar Disorder in a Mental Rehabilitation Patient: Case Study

Mental health is a condition in which individuals can develop physically, mentally, spiritually, and socially so that they are able to realise their potential, overcome stress, work productively, and contribute to society. This research was conducted at the Nur Ilahie Assanie Mental Rehabilitation Clinic Samarang, Garut Regency. The purpose of this study was to gain more real experience in carrying out the process of mental nursing care with hallucinatory sensory perception disorders focusing on improving the client's perceptual power and the client can relate to reality which includes assessment, diagnosis formulation, planning, implementation and evaluation. This case shows a holistic approach (biopsychosocial-spiritual) is effective in dealing with cases of hallucinations in bipolar disorder. Structured and sustainable nursing interventions are proven to reduce hallucination symptoms. In addition, the role of family has a significant influence in the long-term rehabilitation process. On the other hand, medication compliance is also a key factor in controlling symptoms and preventing relapse. Thus, a combination of medical therapy, family support, and a comprehensive approach from healthcare professionals is essential in the management of bipolar disorders with hallucinatory symptoms.

Faktor yang Memengaruhi Kepatuhan Minum Obat pada Lansia Penderita Hipertensi di Wilayah Kerja Puskesmas Pelawan Sarolangun

The World Health Organization (WHO) in 2023 estimates that currently the global prevalence of hypertension is 43% of the total world population. Meanwhile, the hypertension report at the Pelawan Health Center in 2021 was 301 cases, in 2022 there were 324 cases, in 2023 there were 397 cases. The purpose of the study was to analyze the factors that influence medication compliance in elderly people with hypertension in the Pelawan Sarolangun Health Center Working Area. The research design used Analytical Survey method with Cross Sectional approach. The population in this study were all elderly hypertensive patients in the Pelawan Sarolangun Health Center Working Area, namely 73 patients who were all made into research samples with total population techniques. Data analysis using univariate analysis, bivariate with chi-square test. The results showed that there was an effect of motivation p = 0.006, family support p = 0.004 and health worker support p = 0.031. The conclusion of this study is that there is an influence of motivation, family support, health worker support. The dominant factor, namely family support, influences compliance with taking medication in elderly people with hypertension in the Pelawan Sarolangun Health Center Working Area. It is suggested that the Pelawan Sarolangun Community Health Center is expected to be taken into consideration and input for the health center to be active in field counseling activities and use social media as a promotional medium to increase the acceleration of healing of hypertension in the elderly, so as to improve health status in the elderly.

The effects of high fat diet consumption on morphine-induced constipation.

Opioids, prescribed for pain relief or as maintenance therapies for opioid use disorder, induce constipation, which can lead to medication compliance issues. However, it is not known how dietary manipulation might impact opioid-induced constipation. To test the hypothesis that eating a high fat diet exacerbates opioid-induced constipation, male and female Sprague-Dawley rats (n = 8/diet/sex) were fed either a low fat (standard) diet, a high fat/high carbohydrate diet, or a ketogenic diet. Rats were injected with either saline or morphine (1-10 mg/kg) and constipation was measured by counting fecal boli hourly for 6 h. Morphine-induced comparable constipation in all groups; however, rats eating a high fat/high carbohydrate or ketogenic diet produced significantly less feces following injections of saline or morphine as compared to rats eating a standard diet (P < 0.05). Dietary considerations might be important for patients prescribed opioid medications.

Effectiveness of inbuilt cell phone reminders in chronic medication compliance.

Adherence to chronic medication is crucial for managing chronic diseases and preventing complications. However, maintaining consistent adherence remains challenging, particularly in low- and middle-income countries where forgetfulness is a common barrier. The widespread use of mobile phones, even in resource-limited settings, offers a practical opportunity to leverage inbuilt reminder features to support medication adherence. This study evaluates the effectiveness of inbuilt cell phone reminders in enhancing chronic medication compliance among patients in the eThekwini health district of KwaZulu-Natal, South Africa. In this prospective, cross-sectional study, 400 patients on chronic medications were systematically selected from five healthcare centres. Participants were divided into two groups: those using mobile phone reminders (Group 1) and those who did not (Group 2). Medication adherence was assessed using a standardised questionnaire, and statistical analyses, including Chi-square tests and logistic regression, were conducted to identify differences in adherence rates. Group 1 exhibited significantly higher adherence rates (87%) compared to Group 2 (67%,p 0.001). The use of cell phone reminders was associated with a 2.5-fold increase in the odds of adherence (odds ratio [OR] = 2.5, 95% confidence interval [CI]: 1.7-3.6,p 0.001). Inbuilt cell phone reminders are a cost-effective intervention that significantly enhances medication adherence, especially in resource-limited settings. Integrating mobile technologies into public health strategies could improve chronic disease management.Contribution:This study highlights the potential of mobile phone reminders as a practical tool for improving medication adherence, with significant implications for public health strategies in low-resource settings.

Determination of 59 Psychotropic Drugs, Including Antipsychotics, Antidepressants, Antiepileptics, Anti-Alcohol Abuse Drugs, Anti-ADHD Drugs, and Their Metabolites in Urine Using LC-MS/MS for Medication Compliance Monitoring.

Increasing social concern regarding individuals with mental health disorders in the criminal justice system has underscored the need for effective strategies to reduce recidivism. Medication compliance monitoring is a critical approach that ensures adherence to prescribed treatments, facilitating the reintegration of these individuals into society. This study focuses on the development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for detecting 59 psychotropic drugs and their metabolites in urine, addressing a significant gap in existing monitoring techniques. Utilizing a dilute-and-shoot approach for urine sample preparation, we established a robust analytical method that demonstrated high sensitivity and precision, with limits of detection ranging from 0.07 to 1.5 ng/mL and correlation coefficients consistently above 0.997. The method was validated through various parameters, including selectivity, stability, and accuracy, ensuring reliable performance in forensic applications. Analysis of urine samples from 248 individuals on probation with mental health conditions confirmed the practicality of the method, identifying 53 psychotropic substances. The LC-MS/MS method was successfully applied for medication compliance monitoring of mentally disordered probationers. Therefore, this analytical method could provide clear evidence for preventing the recurrence of mentally disordered crimes.

A Bibliometric Study of 3D Printing In Pharmaceutical Technology For Tablet Dosage Form

Three-dimensional printing (3DP) is the process of producing 3D items layer by layer using computer-generated designs. 3DP has been utilized to manufacture numerous drug dosage forms. The goal of 3D printing products is to create personalized medicine so it can enhance medication compliance and obtain better treatment outcomes. There are a lot of publications about fabricated tablets using 3DP. However, the results of analyses based on previous research in this field are lower. We conducted a bibliometric study using RStudio and VOSviewer software to summarize tabletting using 3DP research from 2014-2024. This study was based on the Scopus Database, and 405 suitable publications were evaluated. The most productive authors are Basit, A.W, Goyanes, A., and Gaisford, S., from the Department of Pharmaceutics, UCL School of Pharmacy, University College London, United Kingdom. Its affiliations and its country are also ranked the highest in producing articles in this field. In the future, 3DP will be an attractive alternative for tablet printing. Pharmacists in hospitals and drugstores can produce personalized tablets to improve treatment outcomes.

RISK FACTORS FOR RECURRENT HOSPITALIZATION INPATIENTS WITH HEART FAILURE WITH REDUCEDEJECTION FRACTION

Background: Heart failure with reduced ejection fraction (HFrEF) is a progressive condition contributing to substantial healthcare burden due to frequent hospital readmissions. Timely identification of associated risk factors is essential for reducing recurrence, improving quality of life, and optimizing hospital resource utilization, especially in low-resource settings. Preventable causes of decompensation continue to challenge post-discharge management strategies in heart failure care. Objective: To determine the frequency and impact of various risk factors associated with hospital readmissions among patients with HFrEF admitted to Lady Reading Hospital, Peshawar. Methods: This cross-sectional study was conducted over six months in the Department of Cardiology, Lady Reading Hospital. A total of 122 patients aged 20–80 years with documented HFrEF (EF &lt; 50%) and a history of prior hospitalization for heart failure were enrolled using non-probability consecutive sampling. Data were gathered through structured interviews, clinical examination, and review of medical records. Risk factors assessed included poor drug compliance, NSAID and steroid use, uncontrolled blood pressure, infections, arrhythmias, myocardial infarction, thyroid dysfunction, anemia, hyperglycemia, and electrolyte abnormalities. Statistical analysis was performed using SPSS version 25, with chi-square and Fisher’s exact tests applied. A p-value &lt; 0.05 was considered statistically significant. Results: Out of 122 patients, 49 (40.2%) experienced unplanned readmission. Among them, 61.2% had poor medication compliance, 53.1% had uncontrolled blood pressure, 40.8% presented with infections, and 36.7% had arrhythmias. Electrolyte disturbances (44.9%), anemia (38.8%), and hyperglycemia (32.7%) were also significantly associated (p &lt; 0.05). Readmitted patients had a mean ejection fraction of 28.7% ± 5.4%, significantly lower than 35.1% ± 7.6% in non-readmitted patients (p &lt; 0.001). Low socioeconomic status was significantly linked with readmissions (p = 0.036). Conclusion: Recurrent hospitalizations in HFrEF are largely driven by modifiable clinical and behavioral factors. Targeted interventions, including medication adherence reinforcement, blood pressure control, infection management, and socioeconomic support, are critical to improving outcomes and minimizing preventable readmissions.

Hubungan Kepatuhan Minum Obat dengan Kejadian Cacat kusta di Puskesmas Batumarmar Pamekasan

Morbus Hansen, or leprosy, is a chronic infectious disease caused by the bacterium Mycobacterium leprae. There are two types of leprosy, namely MB (Multi Bacillary) and PB (Pauci Bacillary). According to the WHO, the level of disability due to leprosy is divided into three levels: Level 0, Level 1, and Level 3. This study is an analytic observational study using a cross-sectional research design, involving 45 respondents selected through total sampling technique. Data collection was carried out by filling out a questionnaire consisting of questions regarding leprosy medication compliance. Data analysis used the chi-square test and prevalence rate. The results showed no association between medication compliance (p=0.092, PR=2.0) and the incidence of leprosy disability at the Batumarmar Health Center, Pamekasan Regency. The conclusion of this study indicates that although theoretically adherence to medication can lead to disability in leprosy patients, the results of this study show something different. The difference between the results of this study and the theory may be due to other factors affecting disability. The suggestion is that the health center is expected to improve the monitoring system to evaluate patient compliance with treatment. Support from medical personnel and families is also needed to encourage patients to be more consistent in undergoing therapy.

Hyperphosphatemia Control: A Quality Improvement Initiative for Adult End-Stage Renal Disease Patients on Hemodialysis.

Background: Hyperphosphatemia is a modifiable risk factor for cardiovascular morbidity and mortality in patients on hemodialysis. However, despite efforts to control hyperphosphatemia, it remains a prevalent issue among adult patients on maintenance hemodialysis worldwide. Objectives: An intensive multidisciplinary educational program focusing on diet control and medication compliance was developed to lower the incidence rate of hyperphosphatemia and serum phosphorus levels among adult patients on hemodialysis and to improve their understanding of hyperphosphatemia control. The objectives were to decrease the incidence rate of hyperphosphatemia and the mean phosphorus level among participants by 10% and to improve their knowledge assessment scores by 30% within 3 months. Methods: The education program was implemented at a hemodialysis clinic serving adult end-stage renal disease patients. Education was delivered via videos, pamphlets, and bimonthly one-on-one follow-up sessions. The incidence rate of hyperphosphatemia, mean serum phosphorus levels, and knowledge assessment scores were measured before and after the intervention. Descriptive and comparison statistics were used in data analysis. Results: Following the intervention, the incidence rate of hyperphosphatemia decreased by 45% within the intervention group and by 18% across the entire dialysis clinic. The mean serum phosphorus level within the intervention group decreased by 16% after intervention (p = .007). Additionally, the intervention group showed a statistically significant improvement in knowledge assessment test scores (p = .018). Conclusion: The intensive multidisciplinary education program effectively educated patients with hyperphosphatemia about phosphorus control, reduced the incidence rate of hyperphosphatemia, and helped lower serum phosphorus levels to within a normal range. Implications for Nursing Practice: Advanced practice registered nurses can play an important role in improving patient outcomes and management of hyperphosphatemia.

CASE REPORT: PARANOID SCHIZOPHRENIA

Schizophrenia is a mental disorder characterized by distortion of reality, disorganization, and psychomotor poverty. Schizophrenia is characterized by positive symptoms such as hallucinations, delusions, bizarre behavior and thought disorders and negative symptoms such as flat or blunted affect, alogia, anhedonia and deficits in social interaction. Schizophrenia disorders persist for at least six months and there must be at least one month of symptoms. Schizophrenia affects approximately 1% of the world's population. Although schizophrenia treatment can improve symptoms, it cannot restore normal function in most patients. Treatments that can be given to schizophrenia sufferers such as oral antipsychotics, especially second-generation such as risperidone, olanzapine, aripiprazole are recommended for initial treatment of acute psychosis. Case illustration is a 27-year-old male patient with complaints of hearing voices that cannot be heard by others and making it difficult for the patient to sleep. Management of this patient was given quetiapine 2x400 mg and lorazepam 1x1 mg. The result of this patient's management is an improvement in clinical symptoms. The conclusion of this case report is that paranoid schizophrenia is a case that is easy to relapse and can even become chronic, so it is necessary to do the importance of medication compliance, appropriate social support in order to improve social function in patients.

Removing Student Access Barriers: An Intervention to Reduce Medical Exclusion for Students Without Physical Examinations.

High school freshman students without documentation of physical examinations and/or vaccination are excluded from school by state-mandated health requirements. With social determinants impacting student medical compliance, school nurses lack evidence-based interventions to reduce medical exclusion. This quality improvement project aims to reduce medical exclusion at the project site by 25% from the previous year by focusing on meeting the freshman physical examination requirement. A three-pronged PDSA cycle evaluates each program intervention [resource guides, phone calls, temporary health clinic] in reducing medical exclusion. After the distribution of two resource guides, 93 personalized phone calls were made to families with missing health documentation. On the first day of school, 28 freshmen remained out of medical compliance. The temporary on-site health clinic provided physical examinations to 13 of the 28 students. Through a systematic approach operationalizing community partnerships, school nurses can reduce barriers to achieving medical compliance and support student agencies in accessing healthcare.