461 Background: Regionalization of major surgery such as cystectomy has spurred interest in the association of high-volume centers (HVC) & improved postoperative outcomes. However, concerns have been raised regarding access to care, with increasing travel distance playing a role in treatment selection. Our objective was to evaluate the effect of distance to closest HVC on treatment selection for muscle-invasive bladder cancer (MIBC). Methods: Using a linked data resource combining NC Cancer Registry with administrative claims data from Medicare, Medicaid, and private insurance plans, we included adult patients diagnosed with Stage 2 bladder cancer from 2003-2008. We created 2 mutually exclusive treatment groups (standard: cystectomy or chemo-radiation; non-standard: other or no treatment). HVCs were identified as those performing > 15 cystectomies during the study period. Nearest distance was calculated by using straight-line distance between zip code of the patient and closest HVC. Bivariable analyses and multivariable logistic regression were used to evaluate the effect of nearest distance to a HVC on receipt of non-standard treatment for MIBC. Results: 274 patients with confirmed MIBC were identified, with n = 123 undergoing standard and n = 151 non-standard treatment. Mean age of patients in the standard group was 73.1 vs. 77.7 in the non-standard group (p < 0.001). Groups also differed by race and insurance type (minority patients and those with Medicaid or Medicare were more likely to receive non-standard treatment). However, no significant difference was noted for comorbidity, gender, or education. Patients who underwent non-standard therapy had shorter distances to a HVC (73% have a distance of < 30 miles) vs. those who received standard therapy (56%, < 30 miles) (p < 0.004). On multivariable analysis, distance > 30 miles to a HVC was associated with lower likelihood to undergo non-standard therapy (p = 0.005), even when controlling for age, gender, race, comorbidity, insurance and other factors. Conclusions: Distance to HVC is not associated with increased likelihood of receipt of standard therapy for MIBC. Regionalization of care may not significantly impact access to care as previously hypothesized.
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