Mechanism Of Penetration Research Articles

Psychoneurological disorders in the stage of post-COVID syndrome

Аim. Generalization and systematization of ideas about the pathophysiological mechanisms of asthenic syndrome development against the background of COVID-19.Materials and methods. The work analyzed scientific articles and monographs devoted to the etiopathogenesis of post-COVID asthenic syndrome (PCAS). The search was carried out by the keywords «COVID-19», «post-COVID syndrome», «psychoneurological disorders», «asthenic syndrome» using the PubMed, Medline, eLibrary.ru databases.Results and discussion. The ideas about the clinical structure of PCAS are systematized, the mechanisms of penetration of the SARS-CoV-2 virus into the nervous system are presented, modern views on the molecular mechanisms of the development of neurological symptoms in COVID-19 convalescents are highlighted. The key pathogenetic links of PCAS are described, including immune deviations associated with cytokine imbalance, oxidative and nitrosative stress reactions with subsequent activation of anaerobic metabolic pathways in brain and muscle tissues; neurometabolic changes accompanied by dysfunction of the serotonergic, dopaminergic, noradrenergic and GABAergic systems.Conclusion. Analysis of world literature data, as well as our own clinical experience, allows us to conclude that psychoneurological disorders associated with COVID-19 infection are multifaceted and complex and are accompanied by highly variable symptoms. At the same time, the existing fragmentary knowledge regarding the pathomechanisms of psychoneurological disorders against the background of COVID-19 dictates an urgent need to continue further research in this area.

Take Two: Second Systolic Blood Pressure Provides Prognostic Information in Trauma

Abstract Introduction: An initial systolic blood pressure (SBP1) of <110 mmHg has been shown to predict mortality. However, SBP1 may not reflect hemodynamic changes during initial resuscitation. We aimed to determine if the second recorded blood pressure (SBP2) could provide additional prognostic value. Methods: An 8-year retrospective chart review was performed including patients who underwent trauma activations at a single institution. The initial systolic blood pressure (SBP 1) and second systolic blood pressure (SBP 2) were analyzed. Difference between the first and second systolic blood pressure (ΔSBP) was defined as SBP2 − SBP1. The primary outcome was inhospital mortality, and the secondary outcome was receipt of ≥2 units of blood in the first 4 h of admission. Univariable analysis and logistic regression analysis were performed to assess the relationship of SBP2 and ΔSBP with the study outcomes. Regression model fit was assessed by the likelihood ratio test and Akaike information criterion. Results: Eight thousand seven hundred and ninety-eight patients were included with 12% and 13% presenting with SBP1 <110 mmHg and SBP2 <110 mmHg, respectively. Four hundred and six (5%) died and 327 (4%) received ≥2 units of blood in the first 4 h. The addition of ΔSBP to regression models improved model fit in explaining the primary and secondary outcomes. Subgroup analysis found that the addition of ΔSBP improved model fit for those with penetrating mechanism of injury and those with Injury Severity Score of ≥9, but not for those with blunt moderate or severe traumatic brain injury. Conclusion: SBP2 offers additional prognostic value in predicting trauma outcomes. Incorporating subsequent hemodynamic data during resuscitation beyond the initial SBP in trauma databases should be considered.

Design and characterization of defined alpha-helix mini-proteins with intrinsic cell permeability

Proteins with intrinsic cell permeability that can access intracellular targets represent a promising strategy for novel drug development; however, a general design principle is still lacking. Here, we established a library of 46,678 de novo-designed mini-proteins and performed cell permeability screening via phage display. Analyses revealed a characteristic neighboring distribution of positive charges across helices among enriched mini-proteins of CPP7, CPP11, CPP55, CPP109 and CPP112. Compared with the state-of-the-art cell-penetrating mini-protein ZF5.3, the optimized mini-protein CPP11D36R exhibited a sevenfold increase in cell permeability. Endocytosis uptake and early endosome release are the key penetrating mechanisms. A machine learning model with high-throughput data achieved an F1 score of 0.41, significantly outperforming the previously reported CPP prediction models, including MLACP, CPPpred and CellPPD, by 41 %. Overall, our findings validate the effectiveness of a helical structure with a cationic distribution as a design principle on a large scale and present a robust approach for the development of cell-permeable mini-protein drugs.

Anti-ballistic properties of hybrid UHMWPE fiber-reinforced composite armour

The ballistic performance of three hybrid composite plates, including ultra-high molecular weight polyethylene (UHMWPE), UHMWPE/Aramid, and UHMWPE/CFRP with similar surface density, was studied in the paper. These plates were tested under the impact of 7.62×25 mm full metal jacket (FMJ) bullets, with the dynamic back deformation (BFD) captured using Digital Image Correlation (DIC) technology. The effects of material combinations and striking faces on the dynamic response were discussed. The deformation and penetration mechanisms were analyzed using optical microscopy and micro-CT tomography. The results indicated that the UHMWPE/CFRP plate exhibited the lowest BFD, followed by UHMWPE and the UHMWPE/Aramid plate. When UHMWPE severed as the striking face, the fibers underwent through-thickness compression, which transitioned to in-plane tension and led to an elongated fracture of yarns. Similarly, Aramid fibers also experienced tensile fractures under similar conditions. In contrast, carbon fibers had brittle shear fractures when CFRP was the striking face. Additionally, the “V-shaped” cone traveling hinge velocity was calculated using DIC results, and the effects of the plate bending stiffness and wave impedance on protective performance were discussed. The findings emphasize the importance of an optimal material configuration to mitigate the propagation of compressive waves in the thickness direction and enhance bending stiffness, which is crucial for improving protection within ballistic limits.

Performance of Monotonic Pile Penetration in Sand: Model Test and DEM Simulation

By integrating laboratory tests and three-dimensional discrete element methods, this research extensively explores the macroscopic and microscopic mechanisms of static pile penetration in standard sand. Initially, the mesoscopic parameters of standard sand were established via flexible triaxial compression tests, and a three-dimensional discrete element model was created using the particle size magnification technique. The study results confirm the rationality of parameter selection and numerical modeling by comparing penetration resistance and displacement obtained from laboratory model tests and discrete element simulations. Initially, penetration resistance swiftly increases, then stabilizes progressively with increasing depth. The lateral friction resistance grows with penetration depth, especially peaking near the cone tip. Moreover, horizontal stress quickly rises during pile penetration, mainly caused by the pile foundation compressing the adjacent soil particles. Displacement of the foundation particles is primarily focused around the pile side and cone tip, affecting an area roughly twice the pile diameter. Soil particle displacement exhibits a pronounced vertical downward movement, primarily driven by lateral friction. The distribution of force chains among foundation particles indicates that the primary stressed areas are at the pile ends, highlighting stress concentration features. This research offers significant insights into the mechanical behaviors and soil responses during pile foundation penetration.

Microneedling With RF-Assisted Skin Penetration Improves the Hard-to-Treat Periorbital Wrinkles: Nonrandomized Clinical Trial.

This prospective study evaluates the efficacy and safety of minimally invasive radiofrequency microneedling (RFMN) for the correction of periorbital wrinkles. This study aimed to address the challenges posed by the periorbital region's unique anatomy and the limitations of existing non-surgical treatments. Twenty-four subjects, ranging from 34 to 54 years old with Fitzpatrick skin types II-V, underwent a series of treatments using the Voluderm RF microneedling device. Participants were divided into two groups based on the severity of their wrinkles and treated with customized protocols over four sessions, with a 3-month follow-up to assess outcomes. Efficacy was determined through comparisons of pre-treatment and post-treatment wrinkle severity, using the Lemperle Classification of Facial Wrinkles (LFW) and the Global Aesthetic Improvement Scale, evaluated by both the investigators and the patients. Safety and tolerability were assessed through adverse event reporting and a Visual Analog Scale for treatment discomfort. The results demonstrated a statistically significant reduction in periorbital wrinkle severity, with an average 49% decrease of LFW score and improvements noted across all skin types in both groups. The aggregated facial LFW score decreased from baseline mean 13.00 ± 4.75 to 6.09 ± 3.90 (p < 0.05). The treatment was well tolerated without anesthetics, with minimal downtime and few adverse events, which were transient and resolved without intervention. The efficacy of Voluderm RF microneedling in improving periorbital wrinkles of variable severity was demonstrated in patients with diverse skin types. The unique RF-assisted mechanism of the skin penetration granted a high tolerability of the treatments, negligible downtime, and minimum number of adverse events with self-resolution.

Experimental studies on penetration process of high-speed water-jet into ballistic gelatin

To reveal the penetration mechanism and present the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3 mL into soft tissue, the present study conducted experimental research on high-speed water-jet penetration into ballistic gelatin. The free jet dynamics of an air-powered needle-free injector that can emit up to 1.27 mL of liquid at once and the penetration dynamics were visualized to reveal the details of the penetration process. In the early unstable stage, the jet is emitted in the form of pulses, and the first jet pulse can rapidly generate an initial slender channel in gelatin in a very short time. In the subsequent stable stage, energy input produces dispersion and further increases the penetration depth slowly. Changing the driving pressure by the power source mainly changes the penetration depth increment by dispersion; while changing the nozzle diameter mainly affects the penetration depth in the initial stage. The central position of the dispersion area in the injection direction was firstly defined in the present work and it was found that an approximate linear relationship between this position and the maximum penetration depth exits for different nozzle diameters and driving pressures when injecting the same liquid dose. These research results can provide a basis for a thorough understanding of the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3 mL into soft tissue, as well as the design and operation of the air-powered needle-free injector.

Invasomes: An Artificial Vesicle Nanocarrier to Enhance Transdermal Drug Delivery

Abstract: The greatest and most noticeable organ in the body is the skin. The stratum corneum, or top layer of skin, acts as a vital barrier to prevent skin penetration for many drugs. To over-come this barrier, numerous nanocarrier frameworks have been developed, which are important for the functioning of active agents. Vascular systems known as invasomes contain low levels of ethanol as well as terpenes or terpene combinations, which have a higher skin penetration rate and function as potential carriers. Improved drug delivery via the skin using a carrier that can pene-trate these barriers presents a wide range of difficulties and possibilities for further study and the creation of new and better treatment options. The main objective of an invasome-based delivery system is to significantly improve patient compliance and therapeutic value, in addition to bol-stering the safety and efficacy of the drug. This article gives a summary of the synthesis process, invasome characterizations, penetration mechanisms, and applications. This review paper also in-cludes phospholipids and their classification. Phospholipids are present in the cell membrane and provide ceramide, a bioactive molecule that moisturizes skin and protects against environmental damage in transdermal drug delivery systems. Pharmaceutical studies demonstrate that many drug molecules have less solubility, stability, bioavailability, and penetrating power. Invasomes repre-sent a novel dosage form with promising properties for enhancing transdermal drug delivery.

Impact response of 3D printed cornstalk-inspired structures: The effect of indenter shape on penetration

This paper reports the mechanical response and damage tolerance of 3D-printed cornstalk-inspired structures subjected to impact loading. Specimens were subjected to dynamic indentation tests at multiple impact energies with flat, hemispherical, and conical indenters. The mechanical properties of the base material (ABS) were measured across varying strain rates using a Shimadzu® Universal Testing Machine and a Split Hopkinson Pressure Bar. The effect of geometrical variations of the constituents on energy-absorbing capability was also investigated. Damage characteristics were interrogated through X-ray CT scans and provided detailed failure modes associated with each indenter shapes. Further, finite element simulations provided insights into the penetration mechanisms associated with the different indenter shapes. The results demonstrated that test specimens impacted by flat indenters absorbed ∼25 % less energy than those impacted by hemispherical and conical indenters. Among the various indenters, the conical shape had the highest duration of contact force within the specimen before experiencing failure by matrix cracking and complete perforation.

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition.

Monoclonal antibody therapies for cancer have demonstrated extraordinary clinical success in recent years. However, these strategies are thus far mostly limited to specific cell surface antigens, even though many disease targets are found intracellularly. Here we report studies on the humanization of a full-length, nucleic acid binding, monoclonal lupus-derived autoantibody, 3E10, which exhibits a novel mechanism of cell penetration and tumor specific targeting. Comparing humanized variants of 3E10, we demonstrate that cell uptake depends on the nucleoside transporter ENT2, and that faster cell uptake and superior in vivo tumor targeting are associated with higher affinity nucleic acid binding. We show that one human variant retains the ability of the parental 3E10 to bind RAD51, serving as a synthetically lethal inhibitor of homology-directed repair in vitro. These results provide the basis for the rational design of a novel antibody platform for therapeutic tumor targeting with high specificity following systemic administration.

Microscopic mechanistic study of the penetration distributions for plasma reactive oxygen and nitrogen species based on sialic acid targeting on the cell membrane surface

The ability of cold atmospheric plasmas (CAPs) to produce a wide range of active constituents while maintaining a low or even room temperature of the gas has made it a novel research area of great interest. During plasma action, cancer cell membrane surface components are susceptible to oxidative modification by reactive oxygen and nitrogen species (RONS). In this study, the process of oxidative modification of membrane surface components sialic acid by RONS was investigated based on molecular dynamics simulations, and the penetration mechanism of long-lived particles ONOOH and its homolytic products at the membrane-water interface and the effect of appropriate electric field action were studied. The results showed that cancer cells with high sialic acid expression were less stable than healthy cells. Plasma treatment may promote the ONOOH homolysis process, and its homolysis product OH free radical is more likely to adsorb near sialic acid molecules by hydrogen bonding, resulting in oxidative modification. The interaction force between OH free radical and sialic acid molecules is stronger than ONOOH, which helps to further understand the oxidative modification reaction in membrane environment. At the same time, appropriate electric field stimulation can enhance the depth of penetration of RONS to more effectively treat the pathological state of biological tissues. The study proposes the use of membrane surface sialic acid as a cancer therapeutic target and provides guidance for improving the depth of RONS penetration and maximizing the survival of healthy cells, which contributes to the further clinical translation of plasma biomedicine.

Isolation and characterization of the decreased cuticular penetration mechanism of fluralaner resistance in the house fly, Musca domestica

Decreased cuticular penetration has been documented as a mechanism of resistance in several insects, yet this mechanism remains poorly understood. Levels of resistance conferred, effects of the physicochemical properties on the manifestation of resistance and the effects of different routes of exposure are largely unknown. We recently selected a strain (FlurR) of house fly that was >11,000-fold resistance to fluralaner, and decreased cuticular penetration was one of the mechanisms of resistance (Norris et al., 2023). We sought to isolate the decreased penetration mechanism from FlurR into the background of the susceptible aabys strain, and to characterize the protection it conferred to fluralaner and other insecticides. We successfully isolated the decreased penetration mechanism and found that it conferred 7.1-fold resistance to fluralaner, and 1.4- to 4.9-fold cross-resistance to five other insecticides by topical application. Neither mass, metabolic lability, vapor pressure, nor logP explained the differences in the resistance ratios. The mechanism also conferred cross resistance by residual and feeding exposure, although at reduced levels compared to topical application. Remaining data gaps in our understanding of this mechanism are discussed.

Effect of spinning for different nose shape projectiles undergoing normal impact on Al 7075-T651 target

PurposeThe effect of spinning has been studied and analysed for different projectile shapes such as ogive, blunt, cylindrical and conical by using numerical simulations.Design/methodology/approachProjectile shape is one of the important parameters in the penetration mechanism. The present study deals with the failure mechanisms and ballistic evaluation for different nose-shaped projectiles undergoing normal impact with spinning. Materials characterization has been made by Johnson–Cook strength and failure models, and LS-DYNA simulations are used to analyse the impact of steel projectiles on an Al 7075-T651 target at different impact velocities under normal impact conditions. The experimental results from the literature are used to validate the model. Based on the residual velocity values, the Recht-Ipson model has been curve-fitted and approximate ballistic limit velocity has been evaluated. The approximated ballistic limit velocity is found to be 3.4% higher than the experimental results and compared well with the experimental results. Subsequently, the validated model conditions are used to study and analyse the effect of spinning for different nose-shaped projectiles undergoing normal impact conditions.FindingsThe ductile hole failure is observed for the ogive nose projectile, petals are formed and fragmented for the conical projectile, and plugging is observed for cylindrical projectiles. A Recht-Ipson curve is presented for each spinning condition for each projectile shape and the ballistic limit has been evaluated for each condition.Originality/valueThe proposed research outputs are original and innovative and, have a lot of importance in defence applications, particularly in arms and ammunition.

The energy absorption characteristics and structural optimization of titanium/UHMWPE fiber metal laminates under high-speed impact

Fiber-metal laminates (FMLs), known for their lightweight and high strength, are widely used in structural protection in the fields of shipbuilding, military, and aerospace. Experiments were conducted using 12.7 mm hard spherical projectiles at speeds ranging from 915.7 – 1290 6 m per second to study the high-speed impact on FMLs composed of titanium and Ultra-high Molecular Weight Polyethylene(UHMWPE). The primary failure modes of the fibers were tensile failure and compressive shear failure. With increasing impact velocity, the proportion of tensile failures in the fibers gradually decreased, transitioning to shear plug failure as the main failure mode, while the titanium alloy primarily experienced erosive perforation and petal-shaped tearing. At a speed of 1290 6 m/s, the titanium alloy began to exhibit significant adiabatic shear tearing in four directions. Further, a three-dimensional numerical model was established, which, through theoretical analysis and experimental validation, proved to be highly reliable. Using this theoretical model, a deeper analysis of the dynamic response and penetration mechanism of the structure was conducted, explaining the energy distribution mechanism and dynamic response mechanisms of various parts. Based on this model, improvements and optimizations were made to the laminar structure of the UHMWPE/titanium alloy FML. Placing metal at the back maximized energy absorption but led to more pronounced bulging.

From sequence to function: Exploring biophysical properties of bacteriophage BFK20 lytic transglycosylase domain from the minor tail protein gp15

Bacteriophages have evolved different mechanisms of infection and penetration of bacterial cell walls. In Siphoviridae-like viruses, the inner tail proteins have a pivotal role in these processes and often encode lytic protein domains which increase infection efficiency. A soluble lytic transglycosylase (SLT) domain was identified in the minor tail protein gp15 from the BFK20 bacteriophage. Six fragments containing this SLT domain with adjacent regions of different lengths were cloned, expressed and purified. The biophysical properties of the two best expressing fragments were characterized by nanoDSF and CD spectroscopy, which showed that both fragments had a high refolding ability of 90 %. 3D modeling indicated that the bacteriophage BFK20 SLT domain is structurally similar to lysozyme. The degradation activity of these SLT proteins was evaluated using a lysozyme activity assay. BFK20 might use its transglycosylase activity to allow efficient phage DNA entry into the host cell by degrading bacterial peptidoglycan.

Development of an Intranasal In Situ System for Ribavirin Delivery: In Vitro and In Vivo Evaluation.

Recently, ribavirin has demonstrated effectiveness in treating glioblastoma through intranasal administration utilizing the nose-to-brain delivery route. Enhancing ribavirin's bioavailability can be achieved by utilizing intranasal stimuli-responsive systems that create a gel on the nasal mucosa. The research examined thermosensitive, pH-sensitive, and ion-selective polymers in various combinations and concentrations, chosen in line with the current Quality by Design (QbD) approach in pharmaceutical development. Following a thorough assessment of key parameters, the optimal composition of gellan gum at 0.5%, Poloxamer 124 at 2%, and purified water with ribavirin concentration at 100 mg/mL was formulated and subjected to in vivo testing. Through experiments on male rats, the nose-to-brain penetration mechanism of the active pharmaceutical ingredient (API) was elucidated, showcasing drug accumulation in the olfactory bulbs and brain.

Influence of Soil Pollution by Lead on Plants

The issues related to the problem of soil contamination with lead and the effect of this pollution on plants are considered. It is shown that the widespread use of this metal in the economy causes the spread of soil contamination with lead and a possible potential increase in the degree of environmental pollution in the foreseeable future. The forms of lead in the soil and the factors affecting its bioavailability for plants are described. The mechanisms of penetration of metal ions into plants, their effect on the formation of seedlings, adult plants, as well as physiological and biochemical processes in plants are considered.

Non-therapeutic laparotomies in military trauma (2009-2014).

Combat casualties are frequently injured in austere settings where modern imaging modalities are unavailable. Exploratory laparotomies are often performed in these settings when there is suspicion for intra-abdominal injury. Prior studies of combat casualties reported non-therapeutic laparotomy (NTL) rates as high as 32%. Given improvements in combat casualty care over time, we evaluated NTLs performed during later years of the wars in Iraq and Afghanistan. Military personnel with combat-related injuries (6/1/2009-12/31/2014) who underwent exploratory laparotomy based on concern for abdominal injury (i.e. not performed for proximal vascular control or fecal diversion) and were evacuated to Landstuhl Regional Medical Center (Germany) before being transferred to participating U.S. military hospitals were assessed. An NTL was defined as a negative laparotomy without substantial intra-abdominal injuries requiring repair. Characteristics, indications for laparotomy, operative findings, and outcomes were examined. Among 244 patients who underwent laparotomies, 41 (16.8%) had NTLs and 203 (83.2%) had therapeutic laparotomies (i.e. positive findings). Patients with NTLs had more computed tomography scans concerning for injury (48.8% vs 27.1%; p = 0.006), less penetrating injury mechanisms (43.9% vs 71.9%; p < 0.001), and lower Injury Severity Scores (26 vs 33; p = 0.003) compared to patients with therapeutic laparotomies. Patients with NTLs were also less likely to be admitted to the intensive care unit (70.7 vs 89.2% for patients with therapeutic laparotomies; p = 0.007). No patients with NTLs developed abdominal surgical site infections (SSI) compared to 16.7% of patients with therapeutic laparotomies (p = 0.002). There was no significant difference in mortality between the groups (p = 0.198). Our proportion of NTLs was lower than reported from earlier years during the wars in Iraq and Afghanistan. No infectious complications from NTLs (i.e. abdominal SSIs) were identified. Nevertheless, surgeons should continue to have a low threshold for exploratory laparotomy in military patients in austere settings with concern for intra-abdominal injury.

Spatial distribution of active compounds in stratum corneum—partitioning between corneocytes and lipid matrix

The interaction of active substances with molecular structures in stratum corneum (SC) is crucial for the efficacy and safety of cosmetic formulations and topical drugs. However, the molecular architecture of SC is highly complex and methods to unambiguously localize exogenous molecules within SC are lacking. Consequently, little is known about the distribution of actives within SC, and proposed penetration mechanisms through SC are typically limited to simple diffusion via a tortuous (lipid only) or transverse (across corneocytes and lipid matrix) pathway. In this work, 3D mass spectrometry imaging is used to determine the spatial distributions of four active substances at subcellular resolution in SC, including partitioning between the corneocytes and the intercellular lipid matrix. The results indicate that caffeine, 2-methyl resorcinol and oxybenzone are homogeneously distributed in the corneocytes but largely absent in the lipid matrix, despite considerable differences in lipophilicity. In contrast, the distribution- of jasmonic acid derivative is more inhomogeneous and indicates considerable localization to both the lipid phase and the corneocytes.

Inverted Glasses As Ductile Lithium Ion Conductors for Solid State Batteries

Inorganic electrolytes for solid state batteries with Li metallic anodes must combine properties such as high ionic conductivity, chemical stability, and resistance to failure due to propagation of Li dendrites. Abundance of experimental evidence suggests that cracking of the solid electrolytes due to pressure exerted by lithium plating into the material defects is the primary source of failure [1]. This is due to inherent brittleness of the ceramic ionic conductors, i.e. their inability to reduce stress by means other than fracture. Unlike ceramics, plastic deformation in glass can be achieved via shear and (or) by densification. Both mechanisms can be operational in glasses with reduced content of glass formers relative to the content of glass modifiers – i.e. inverted glasses. Using the example of lithium phosphorous oxynitride, Lipon, we demonstrate how these two mechanisms are capable of accommodating applied stress while avoiding creation of new surfaces by cracking. We investigate the resistance to fracture in Lipon-like glasses and the underlying connection to their composition via instrumented nano-indentation, Raman spectroscopy, and numerical simulations. We observe enhancement of isochoric shear with increase of Li content, similarly to the reports of increased plasticity in sodium aluminoborate glases with high alkali content [2]. Nano-indentation demonstrates that Lipon is extremely resistant to fracture, compared to other inorganic solid electrolytes [3].[1] Porz, T. Swamy, B.W. Sheldon, D. Rettenwander, T. Fromling, H.L. Thaman, S. Berendts, R. Uecker, W.C. Carter, Y.-M. Chiang, Mechanism of lithium metal penetration through inorganic solid electrolytes. Adv. Energy Mater. 7, 1701003 (2017)[2] Sellappan, T. Rouxel, F. Celarie, E. Becker, P. Houizot, R. Conradt, Composition dependence of indentation deformation and indentation cracking in glass. Acta Mater. 61, 5949–5965 (2013)[3] Kalnaus, A. Westover, M. Kornbluth, E.J. Herbert, N.J. Dudney, Resistance to fracture in the glassy solid electrolyte Lipon. J. Mater. Research, 36, 787-795 (2021)