Research Progress Of Mechanism Research Articles

Research progress in degradation mechanism of silicon anode materials for lithium-ion batteries

Silicon anode materials have very high theoretical specific capacity, hence become promising replacement for anode material of lithium-ion batteries. However, during charging and discharging, silicon anode materials suffer big volume deformation that may cause destruction and failure of the active material. This seriously affects the electrochemical cycle performance, and restricts wide applications in the field of lithium-ion batteries. In this paper, we introduce silicon anode materials of different structure form, and the degradation mechanism of the electrochemical properties during charging and discharging. We summarize the latest international research progress in mechanical properties evolution of charging and discharging process, the related theoretical analysis, numerical simulations, and prospects for research emphasis of the mechanical failure in silicon anode materials.

Research progress of mechanisms through which dipeptidyl peptidase-4 inhibitors regulate glycemia

Dipeptidyl peptidase-4 (DPP-4) inhibitors are promising new antidiabetic drugs. It had been proposed that DPP-4 inhibitors exert their antidiabetic effect by inhibiting the degradation of glucagon-like peptide 1(GLP-1) . However, new evidence has shown that the increase of GLP-1 is not notable after the use of these drugs in patients with type 2 diabetes. Therefore, the specific mechanisms via which DPP-4 inhibitors in controlling blood glucose has became questionable. In recent years, studies have revealed many possible mechanisms through which DPP-4 inhibitors regulate glycemia: DPP-4 inhibitors may selectively reduce DPP-4 activity in the intestine, causing the increase of portal plasma GLP-1 level and thus promoting the release of insulin via nerve reflex;also, they may decrease the cleavage product of GLP-1 and reduce the degradation of other bioactive peptides.

Research progress in mechanisms of drug resistance in cancer stem cells

Cancer is a stem cell disease.A major challenge in treating cancer is the resistance to conventional therapies,which is demonstrated to be related to the cancer stem cells(CSCs) that are responsible for the sustained cancer growth,survival and invasion.Identifying these stem cells in different cancers and defining the microenvironment and the biologic processes necessary for their existence is paramount in developing new clinical approaches with the goal of preventing disease recurrence.The alteration of local microenvironment(niche) around the CSCs,the aberrant activation of development associated signaling pathways,the excessive enhancement of DNA damage repair and the efflux of anticancer drugs mediated by ABC transporters are the main causes of clinical resistance to therapy.This review will briefly outline the cellular and molecular mechanisms underlying cancer progression,focusing on the resistance to therapy.

Research progress of mechanism of moxibustion in treating chronic gastritis

In summary of the information on the mechanism studies of moxibustin therapy for chronic gastritis in recent years, it mainly aims to process the review in the aspects to increase the gastric mucosal blood flow, regulate the gastrointestinal peptide hormone, adjust the gastrointestinal mobility, regulate the immunity of the body and resist helicobacter pylori, in order to provide scientific information to the moxibustion therapy for chronic gastritis.

Research Progress of Low-Frequency Vibration Cutting and Its Development Tendency

Low-frequency vibration cutting is a new kind of advanced manufacturing process with several features of advantages, compared with conventional cutting operation. Based on the review of the history of low-frequency vibration cutting, its special technological effects and applications were discussed, and presented in detail the research progress in mechanism and experiment study on low-frequency vibration cutting. Three primary problems, lack of unified awareness of mechanism, establishment of a unified standard for the choice of certain parameters, application level, still in expertise for low-frequency vibration cutting were explored and the development tendency as well as the prospect of low-frequency vibration cutting in future was foreseen.

Research progress in mechanism of sepsis-induced cardiac dysfunction

Myocardial dysfunction is a well-recognized manifestation of multiple organ dysfunction in sepsis.Although the underlying mechanisms of myocardial dysfunction during sepsis have been studied for more than 5 decades,the detailed pathophysiology of sepsis-induced myocardial dysfunction still remains unclear.The underlying mechanisms of myocardial dysfunction include mitochondrial dysfunction,circulating myocardial depressant factor,impaired calcium balance and etc. Key words: Sepsis; Cardiac dysfunction; Mechanism

Research progress in mechanisms of intestinal fibrosis in Crohn’s disease

The relationship between fibrosis and normal re pair are not understood. Acute injury may cause normal mesenchymal cells to convert to fibrogenic phenotype that may lead to fibrosis when inappropriately sustained. Crohn's disease (CD)associated fibrosis results from chronic transmu ral inflammation. Intestinal inflammation in CD is transmural, often associated with extracellular matrix changes, luminal narrowing and stricture formation. But the pathogenesis of stricture formation remains unclear. Current therapies do not alter its progression to intestinal fibrosis and obstruction. The aim of this review is to discuss the current understanding of fibrogenesis in CD.

Research progress in mechanism of stress-induced gastric mucosal lesions

The stress-induced gastric mucosal lesions, appearing as a consequence of surgical trauma, shocks and burns, are serious clinical complication that results in the imbalance between the aggressive factors promoting mucosal damage and the gastric mucosal defense mechanisms. The pathology of stress-induced gastric mucosal lesions show extensive and superficial erosion. Recent studies indicate that stress ulceration is a complex process, and it may be caused by many factors, such as neuroendocrine disorders, gastric mucosal barrier damage, injury factors increase, apoptosis, etc. This paper reviews the pathogenesis of stressinduced gastric mucosal lesions.

Research progress in mechanisms of the anticancer effects of green tea polyphenol (-)-epigallocatechin-3-gallate

Research progress in mechanisms of the anticancer effects of green tea polyphenol (-)-epigallocatechin-3-gallate

Advances in study on mechanism of neuropathic pain

Neuropathic pain is a severe choronic pain state which is resistant to rutine management and will greatly influence patients'quality of life. The causes resulting in such state may include trauma, compression, infection, autoimmune disease, tumors, deficiency of Vitamins and so on. Animal models mimicking most of above pathophysiological processes have been build up and facilitated the research on its specific mechanisms. Both peripheral and central sensitization are illuminated in the complicated mechanisms. In addition to the injured nerves, the intact nerves that share the innervational territory of the injured nerves and glial cells also contribute to the sensitization. This review will focus on the research progress in mechanisms of neuropathic pain. Key words: neuropathic pain; mechanism; hyperalgesia; allodynia

Research progress in mechanisms of lactobacillus adhering to intestinal epithelia

Research progress in mechanisms of <i>lactobacillus</i> adhering to intestinal epithelia

Recent research and development in the field of low‐moisture and intermediate‐moisture foods

The article reviews current state of knowledge and the most recent research and development in the following areas: the state of water in foods and its effect on food properties; recent developments in dehydration process other than freeze drying, with an emphasis on research on the role of physical properties of foods and how they affect the dehydration processes. Recent developments in freeze dehydration. Research progress in mechanisms of flavor retention in dehydrated foods. Recent developments in intermediate moisture foods.