Meaningful Activities Research Articles

Association Between Mental Illness and Trajectories of Social Participation Over Time in Community-Dwelling Middle-Aged and Older Couples: A Retrospective Longitudinal Study.

Our study examined the association between social participation and mental illness in middle-aged and older couples, adopting a longitudinal, quantitative approach in a large sample. We analyzed the data of 3,504 middle-aged and older adults. Social participation was used as the dependent variable, and the time-varying variable was whether there was mental illness in the couple. Latent growth modeling was used to examine the association between these variables. Among the participants, 214 (6.11%) were middle-aged and older couples with at least one partner having a mental illness. An association was found between social participation and presence of a mental illness, except in the data for 2018 (estimate range = -0.078 to - 0.032; p-value range = <.0001 to 0.035). Our findings highlight the imperative of addressing the unique needs of middle-aged and older couples with mental illness. Therefore, the findings suggest the need for interventions that can be integrated to encourage couples to participate in meaningful social activities together.

Artificial Intelligence and the Human–Computer Interaction in Occupational Therapy: A Scoping Review

Occupational therapy (OT) is a client-centered health profession focused on enhancing individuals’ ability to perform meaningful activities and daily tasks, particularly for those recovering from injury, illness, or disability. As a core component of rehabilitation, it promotes independence, well-being, and quality of life through personalized, goal-oriented interventions. Identifying and measuring the role of artificial intelligence (AI) in the human–computer interaction (HCI) within OT is critical for improving therapeutic outcomes and patient engagement. Despite AI’s growing significance, the integration of AI-driven HCI in OT remains relatively underexplored in the existing literature. This scoping review identifies and maps current research on the topic, highlighting applications and proposing directions for future work. A structured literature search was conducted using the Scopus and PubMed databases. Articles were included if their primary focus was on the intersection of AI, HCI, and OT. Out of 55 retrieved articles, 26 met the inclusion criteria. This work highlights three key findings: (i) machine learning, robotics, and virtual reality are emerging as prominent AI-driven HCI techniques in OT; (ii) the integration of AI-enhanced HCI offers significant opportunities for developing personalized therapeutic interventions; (iii) further research is essential to evaluate the long-term efficacy, ethical implications, and patient outcomes associated with AI-driven HCI in OT. These insights aim to guide future research efforts and clinical applications within this evolving interdisciplinary field. In conclusion, AI-driven HCI holds considerable promise for advancing OT practice, yet further research is needed to fully realize its clinical potential.

Enhancing the Speech Delivery Skills of Grade 12 Learners Through Target Public Speaking Workshop

This study evaluates the implementation of a speech training workshop designed to enhance public speaking skills among senior high school learners at Bukidnon National High School. Recognizing the critical importance of communication skills in academic and professional settings, the workshop was developed using techniques from the Toastmasters International Competent Communication handbook. It was grounded in Kolb’s (1984) experiential learning theory, which emphasizes learning as a cyclical process comprising concrete experience, reflective observation, abstract conceptualization, and active experimentation. These stages were integrated into the workshop structure to ensure learners actively engaged in meaningful, reflective, and practice-oriented activities. Participants underwent pre- and post-assessments to measure improvements across eight critical aspects of public speaking: content, organization, vocal clarity, vocal variety, language use, eye contact and body gestures, persuasiveness, and adherence to time. The pre-assessment results revealed participants’ fair performance, with a mean score of 2.6, categorized as “fair.” However, the post-assessment demonstrated significant progress, with a mean score of 4.0, classified as “very good.” Statistical analysis using paired sample t-tests confirmed the significance of these improvements (p&lt;0.05), demonstrating the workshop’s effectiveness in developing public speaking competencies. In addition to quantitative data, qualitative insights were gathered through focus group discussions. These revealed that learners not only improved their technical skills but also developed greater confidence, reduced anxiety, and enhanced audience engagement. Participants particularly valued the experiential approach, which allowed them to practice speeches, receive feedback, and refine their techniques iteratively. Despite these successes, challenges remained, particularly in mastering impromptu speaking and achieving effective vocal variety. These were addressed through targeted activities, including real-time speech exercises and facilitator coaching. Overall, this research highlights the transformative potential of combining experiential learning theory with structured communication training. It provides valuable insights for educators seeking to foster critical communication skills among learners, which are essential for personal and professional success.

The Benefits of Facing Mortality

Awareness of one’s mortality can serve as a powerful motivator to live a more productive, purposeful, and fulfilling life. Rather than succumbing to the fear of death, embracing the limited time we have can lead to increased clarity, focus, and engagement in meaningful activities. This perspective encourages individuals to prioritize what truly matters, cultivate deep relationships, and pursue their passions with vigor, regardless of age.

Furmonertinib in uncommon EGFR-mutated non-small cell lung cancer with central nervous system metastases: A retrospective cohort study.

Uncommon EGFR mutations constitute 10%-20% of all EGFR mutations in non-small cell lung cancer (NSCLC), forming a molecularly distinct and clinically heterogeneous subgroup. This retrospective cohort study evaluated the efficacy and safety of furmonertinib in managing central nervous system (CNS) metastases among NSCLC patients with uncommon EGFR mutations (excluding exon 20 insertion variants). Thirty-one eligible patients treated at the Affiliated Brain Hospital of Nanjing Medical University between March 2022 and August 2024 were enrolled. Serial cerebrospinal fluid (CSF) samples were subjected to next-generation sequencing for circulating tumor DNA (ctDNA) profiling. Clinical endpoints included CNS objective response rate (ORR), disease control rate (DCR), intracranial progression-free survival (iPFS), overall survival (OS), and safety parameters. The cohort demonstrated a CNS ORR of 38.7% (95% CI, 21.8%-57.8%) and DCR of 64.5% (95% CI, 45.4%-80.8%), with a median iPFS of 6.97 months. Median OS remained immature at data cutoff. A total of 21 patients with leptomeningeal metastases had baseline EGFR-mutant ctDNA detected in their CSF, with ctDNA analysis indicating intracranial responses corresponded to decreased or cleared ctDNA abundance. Longitudinal CSF ctDNA monitoring in a representative case demonstrated significant temporal correlation between molecular response and radiographic/clinical improvement. The safety profile was favorable, with no grade ≥4 adverse events or treatment-related mortality. These findings suggest that furmonertinib provides clinically meaningful CNS activity with acceptable toxicity in uncommon EGFR-mutant NSCLC, particularly when integrated with CSF ctDNA dynamics as a potential pharmacodynamic biomarker. This study highlights the therapeutic implications of third-generation EGFR-TKIs in molecularly defined NSCLC subpopulations.

Meaningful Activity Approach for Persons with Dementia in Assisted Living

ABSTRACT Introduction Engagement in meaningful activity is beneficial for individuals with dementia who live in assisted living. The purpose of this study was to test the feasibility and preliminary efficacy of a theory-based approach, Meaningful Activity for Managing Behavioral Symptoms of Distress (MAC-4-BSD), for increasing engagement in meaningful activity, improving quality of life, and decreasing behavioral symptoms. Methods Using a cluster randomized controlled trial with repeated measure design, this study included 66 individuals with dementia from 5 communities. Outcomes were evaluated at the baseline and 4 months. Linear mixed models were used to determine the preliminary effectiveness of the MAC-4-BSD approach. Results Most of the participants were female (n = 49, 74%) and White (n = 58, 88%) with a mean age of 85 years (SD = 8.4). The MAC-4-BSD approach was feasible to implement for individuals with dementia who live in assisted living based on treatment fidelity data. At 4 months, preliminary effectiveness was demonstrated based on significant group-by-time interaction effects for engagement in meaningful activity (b = 7.95, p = .007) and number of behavioral symptoms (b = −2.21, p = .017) among those exposed to MAC-4-BSD versus the control group. Discussion These findings provide support for the feasibility and preliminary efficacy of MAC-4-BSD for optimizing meaningful engagement among individuals with dementia in assisted living.

Using emotional awareness to facilitate reflection in nursing practice.

Reflection is considered an essential skill for nurses, but concerns have been raised that it may be ineffective in improving the delivery of care. This article discusses the importance of emotional awareness when reflecting on clinical practice to enable nurses to identify in-depth, honest insights into their responses and actions during challenging situations. The author argues that if reflection is undertaken without the necessary emotional awareness, there is a risk that it may become a superficial, task-oriented professional requirement, rather than a meaningful activity that supports professional and personal development. The article also explains how nurses can use emotions as a trigger for authentic reflection.

Learning music en la frontera: Translanguaging and multimodal assemblages in a community-based violin education program

This study explores translanguaging as it is entangled with human bodies and the non-human world in a music classroom at the U.S. and Mexico border. Such an approach is significant in that it departs from much of translanguaging research with its lingua-centric focus. In applying a translanguaging framework along with that of assemblage, findings show language to be inseparable from action and the cultural surround (including cultural artifacts such as violins). Through such assemblage, a teacher, along with her pupils, build a creative and affective environment that draws upon local cultural resources of the border for children to learn meaningful and aesthetic cultural activity—that of playing the violin. These findings have relevance to emergent bilingual populations who particularly benefit from arts settings where they can employ their dynamic and diverse repertories of meaning-making.

The Role Of Family in Shaping Social Values in the Digital Era

This study explores the vital role of families in shaping social values among children and adolescents within the increasingly dominant digital environment. Digital technology has transformed communication patterns and modes of cultural transmission, presenting new challenges for families in instilling core values while navigating technological influences. Using a qualitative case study approach, this research involved 15 Indonesian families from diverse socioeconomic backgrounds. Data collection methods included in-depth interviews, observations, and media diaries to understand the dynamics of value transmission in digital contexts.The findings reveal that family communication patterns—whether conversation-oriented, conformity-oriented, or laissez-faire—significantly influence children’s internalization of values. Effective strategies identified include parental digital co-learning, value-based guidance, and the promotion of critical media literacy. Major challenges include value conflicts between family teachings and digital culture, concerns over cultural preservation, and competition for children’s attention due to immersive technology.Nevertheless, the study also found that families can strategically leverage technology to reinforce values through careful media selection, engagement in meaningful digital activities, and fostering intergenerational connections. In conclusion, while families remain crucial socializing agents, the successful transmission of values requires thoughtful adaptation of traditional practices to meet the realities of the digital age.

Abstract 2257: A TGFβ-directed immune-modulatory vaccine induces T cell activation and drives antitumor activity by modulating the tumor microenvironment

Activation of the Transforming Growth Factor (TGF)β signaling cascade plays an essential role in a wide range of tumors and other diseases. Indeed, cancer cells and components of the tumor microenvironment (e.g. fibroblasts, myeloid cells, and blood vessels) exploit this pathway to support disease progression during tumor evolution. Nonetheless, global inhibition strategies targeting TGFβ pathway in clinical studies thus far fell short of the anticipated success. These clinical observations suggest that TGFβ modulation - rather than its inhibition - could be the key in sustaining meaningful antitumoral activity in the clinical setting. We report here an alternative approach, where TGFβ-expressing cells are targeted via a peptide vaccine directed against TGFβ-specific T cell epitopes. This is based on earlier studies reporting the existence of intrinsic T cell immunity against TGFβ in human1,2, thus supporting the rationale for targeting these T cells through a vaccine encoding TGFβ epitopes. To test this approach, we employed a range of murine platforms including the syngeneic Pan02 model of pancreatic adenocarcinoma (PDAC), and a CRISPR/Cas9-driven model of prostate cancer3. Collectively, treatment with the TGFβ vaccine significantly reduced the total tumor burden, without affecting the body weight and overall welfare of the animals. Ex vivo T-cell responses evaluated through interferon (IFN)-γ ELISpot confirmed expansion and activation of TGF-β-specific T cells upon immunization. Compared to overt malignant masses in the control cohort, TGFβ-directed immunization slowed down the progression of prostate tumors in the CRISPR/Cas9 model, as evinced by the numerous premalignant-like hyperplastic glands and resembling more physiological structures. Furthermore, smooth muscle actin (α-SMA) staining in the Pan02 model uncovered that the treatment ameliorated the fibrotic response - a hallmark of PDAC in the clinical setting - in this experimental setup, with an increased infiltration of CD8+ lymphocytes and F4/80+ macrophages into the TME. Currently, to clarify the mechanism of action, we are implementing the 4T1 model of mammary carcinogenesis to model metastatic disease and exploring spatial relationships to identify which cell types and tissue architectures are pivotal for meaningful responses.In conclusion, our data indicate the efficacy of TGFβ peptide vaccine in eliciting an immune response and tumor growth inhibition in mouse models of cancer. These observations warrant further preclinical investigation to better understand the efficacy and the safety profile of this novel TGFβ-targeting strategy.

Abstract 5921: Correlation between MET amplification/overexpression status and response to MCLA-129 in advanced non-small-cell lung cancer (NSCLC): biomarker results from a phase 1 trial

Abstract Background: In this ongoing phase 1b study (NCT04930432) of the MET/EGFR bispecific antibody MCLA-129 in patients (pts) with advanced NSCLC, we aimed to gain a deeper insight into the relationship between MCLA-129 and efficacy in the MET amplification (METamp) or protein overexpression (OE) population. Methods: Eligible pts (≥18 years; ECOG PS 0-1; confirmed metastatic or unresectable NSCLC; and positive EGFR or MET alterations) received MCLA-129 (1500 mg biweekly) intravenously. MET OE was defined as IHC 2+/3+ and METamp was defined based on the gene copy number (GCN). Using a wide range of GCN cut-offs, we aimed to explore its relationship with efficacy outcomes.Results: At data cut-off (March 31, 2024), in 24 NSCLC pts, 6 with MET IHC 2+/3+ and 18 with METamp were evaluable for efficacy. Four out 6 pts with MET IHC 2+/3+ (median No. of previous lines: 1 [0-1]) achieved confirmed PRs (ORR: 66.7% [95% CI 22.3-95.7]), and all these 4 pts harbored concurrent mutations (3 METex14 skipping and 1 EGFR exon20ins). The median DOR and PFS were not reached. Eight out of 18 pts with METamp achieved confirmed PRs (median No. of previous lines: 2 [1-7]) (ORR: 44.4% [95% CI 21.5-69.2]; DOR: NR [2.8-NR]; PFS: 4.8 months [2.7-9.6]). Of 7 pts with METamp (METamp was detected prior to systemic antitumor therapy), 4 pts achieved confirmed PRs, with an ORR of 57.1% (95% CI 18.4-90.1), and all these 4 pts harbored concurrent mutations (2 EGFR exon20ins, 1 METex14 skipping and 1 L861Q). Among 9 pts that progressed on 3rd-generation EGFR-TKIs, 3 pts achieved confirmed PRs. Pts with different cut-offs of MET showed a differentiated ORR (Table). Conclusions: MCLA-129 showed clinically meaningful antitumor activity in advanced NSCLC with MET OE or METamp, particularly in pts with concurrent mutations. High GCN seemed to be associated with better efficacy in MET-amplified advanced NSCLC, suggesting its predictive properties. Citation Format: Jie Wang, Jia Zhong, Yu Yao, Di Wu, Xiujuan Qu, Guojun Zhang, Haibo Zhang, Yu Cao, Zhuang Yu, Kai Chen, Maoqiong Jiang, Zhihua Li, Jianlin Long, Xiubao Ren, Huijuan Wang, Zhehai Wang, Lin Wu, Bolin Chen, Aimin Zang, Haie Chen, Lin Ma, Kan Liu, Peiqi Li, Lieming Ding. Correlation between MET amplification/overexpression status and response to MCLA-129 in advanced non-small-cell lung cancer (NSCLC): biomarker results from a phase 1 trial [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 5921.

Abstract 3507: Discovery and preclinical characterization of novel TCR-mimetic T-cell engagers targeting TERT peptide-HLA complex for the treatment of solid and hematologic malignancies

Abstract TERT (telomerase reverse transcriptase) is highly expressed in 85-95% of all tumors, making it a compelling target for cancer therapy. Although several TERT-targeting approaches are being investigated in clinical trials, only one therapeutic (RYTELO®, imetelstat) has received FDA approval for the treatment of low-risk myelodysplastic syndrome. Targeting HLA-restricted peptides (pHLA) derived from intracellular cancer antigens allows for broader exploration of the cancer proteome. The HLA-A*02:01-restricted TERT540 peptide is presented by human tumors and can be a target for T cell-mediated tumor lysis. TCR mimicking (TCRm) antibodies recognize pHLA complexes and are capable of re-directing T cells once incorporated into a T Cell Engager (TCE) format. Here we report the preclinical characterization of potent and specific TCRm-based TCEs targeting TERT540 pHLA. TERT540-targeted TCEs consist of a single humanized CD3 binding domain and either one or two fully human TCRm domains, thus recognizing TERT540/HLA-A*02:01 in either monovalent or bivalent forms. Monomeric affinity for TERT540 pHLA was found to be in sub-nM range, and target binding was greatly enhanced through avidity effects in the presence of two TCRm binding domains. Alanine/glycine scan identified multiple amino acid residues in the TERT540 peptide sequence that are required for TCE binding. Extensive specificity profiling revealed no meaningful activity of TERT540 TCEs against cells pulsed with supra-physiological levels of computationally predicted HLA-A*02:01 cross-reactive peptides or multiple unrelated HLAs (alloreactivity). Furthermore, both TERT540 TCEs showed no interactions with a large panel of normal primary cells from multiple vital tissues and organs in vitro. A modest IFNγ response was noted against bone marrow (BM) CD34+ hematopoietic stem cells at high concentrations of TERT540 TCEs. In contrast, both compounds induced potent, target-dependent T cell activation and T cell-mediated killing of multiple TERT- and HLA-A*02:01- positive leukemia, lung, and ovarian cancer cell lines, achieving sub-nM EC50 values in vitro. Consistent with the specificity profile of TERT540 TCEs, no activity was observed against TERT-negative or HLA-A*02:01-negative cells. In vivo efficacy studies with TERT540-targeted TCEs are currently in progress. Comprehensive analytical and biophysical assessments revealed favorable developability profiles for both TCEs. In summary, these data provide strong preclinical evidence of potency, specificity, safety, and developability of novel, TCRm-based TCEs for TERT-targeted cancer therapy. Citation Format: Yu Huang, Bhupal Ban, Jessica Jimenez, Preethi Sankaran, Christine A. Devlin, Melissa Bikowitz, Qunyan Yu, Ricard Masia, Delainey O’Connor, Emily McNally, Sarah Jaffe, Tanzila Rahman, Jennifer Helble, Alona Kulesha, Andrew Wolpert, Brendan Whalen, Shawn O’Malley, Yue Li, Michael Jennings, Galina Gabriely, Amanda Mak, Tao Wang, Benjamin Lee, Michi Schebesta, Michael Princiotta, Geraldine L. Paulus, Dmitri Wiederschain. Discovery and preclinical characterization of novel TCR-mimetic T-cell engagers targeting TERT peptide-HLA complex for the treatment of solid and hematologic malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 3507.

Positioning Cybersecurity as a Pillar of Safety in Occupational Therapy

The rapid digitalization of society has transformed occupational therapy practice, introducing both opportunities and challenges. As occupational therapists increasingly rely on electronic documentation, telehealth, and assistive technologies, cybersecurity is emerging as a critical concern. This position paper argues that occupational therapy is a vital domain for the integration of cybersecurity education, emphasizing the need to safeguard sensitive patient information, enhance digital literacy, and address the unique vulnerabilities faced by occupational therapy clients. The paper outlines the key intersections of occupational therapy and cybersecurity education, highlighting the impact of cyber threats on healthcare, the importance of digital literacy, and the role of occupational therapy in educating and protecting vulnerable populations. Recommendations are provided for integrating cybersecurity education into occupational therapy curricula and fieldwork education to better prepare practitioners for the evolving digital landscape. By integrating cyber safety principles into occupational therapy education, the field can fulfill its mission of enhancing individuals’ participation in meaningful activities by equipping practitioners with the skills necessary to protect patient data, manage evolving digital risks, and ensure safe, effective care in a technology-driven world.

“Loved Seeing the Students’ Participation. Great Bunch of Kids.”: Understanding Older Adults’ Experiences with Intergenerational Activities

ABSTRACT This study aimed to understand the experiences of older adults who participated in a interorganizational and intergenerational initiative, the Senior to Senior Dinner Dance. Responses to open-ended survey questions from 69 older adult participants were analyzed using a thematic analysis, which elucidated three themes: (a) remaining active; (b) instigating social interactions; and, (c) adjusting to new social roles. Findings suggest opportunities for social workers to partner with others in community-based organizations to facilitate meaningful intergenerational activities for older adults who wish to remain physically and socially active in later life.

Advances in Therapeutic Vaccines for Cervical Cancer: Innovations and Future Prospects

Introduction: Cervical cancer remains a basic around the world prosperity challenge, with Human Papillomavirus (HPV) defilement being the fundamental etiological calculate. Though vaccination strategies for the evasion of HPV-related maladies have showed up noteworthy triumph, therapeutic antibodies centering on existing cervical cancer remain a promising zone of examine. Afterward impels in immunotherapy and counter acting agent advancement have opened unused streets for treating cervical cancer, with a few creative approaches indicating to overhaul secure responses against tumor cells. These helpful antibodies are laid out not as it were to target HPV-related antigens but besides to stimulate the safe system to recognize and attack cancerous cells. Objectives: The objective of this paper is to explore and provide an overview of the latest innovations and developments in therapeutic vaccines targeting cervical cancer, focusing on mechanisms of action and efficacy. This review will cover various therapeutic vaccine strategies in development for treating HPV-associated lesions and cancers. Methods: The Secondary data were collected from the online database from 2000 to 2024. In the process, an attempt has been made to review some of the academic articles, research material, conference papers, material available in the public domain, and other published material on the subject. The research methodology employed in this study involved a comprehensive search of relevant academic databases, including Research Gate, Elsevier, the International Journal of Advances in Social Science, NCBI, and Google Scholar. Conclusion: In conclusion, therapeutic vaccines for cervical cancer represent a promising frontier in cancer immunotherapy, with significant progress in vaccine design, clinical trials, and immune response enhancement. Future agenda A therapeutic HPV-16/18 vaccine with optimum stability, safety, durability, accessibility, affordability, efficacy, and immunogenicity should be aimed at combating this deadly and growing public health threat. Completed HR-HPV 16/18 therapeutic vaccines and ongoing clinical trials should get space to be communicated and converted into meaningful activities. Furthermore, continuous clinical trials and designing strategies to develop immunogenic and effective therapeutic vaccines shall be top agenda items for the scientific community.

Global Citizenship Education towards Fostering a Resilience Future and Cross-Cultural Understanding in Nigeria

The paper advocated that Global Citizenship Education represents a transformative educational approach aimed at preparing students for a resilient future to navigate and contribute to an increasingly interconnected world. The paper adopted the use of theoretical and literature review to explain the need for Global Citizenship Education, by focusing on global awareness, respect for cultural diversity, and active engagement by the individual students. The paper opined that a deep understanding of Cross-Cultural dynamics is required to equip students with essential skills in tackling global challenges. Global Citizenship Education might possibly help students to develop resilience, empathy, enhance their global competency, and actively engage in meaningful activities. Implementation of Global Citizenship Education can be a crucial educational framework for the 21st century; offering students with the tools and attitude necessary for responsible global citizenship and resilient in a rapidly evolving world.

“Why do people have to talk loud? He’s not deaf”: How do people with aphasia experience and manage listening and comprehension impairments in daily life?

ABSTRACT Background Comprehension impairments impact the way people with aphasia (PWA) engage with activities. Such impairments can go undiagnosed and there is limited knowledge of the impact of comprehension impairments on daily activities and how PWA manage and adapt to problems comprehending speech and language. This work explores the experiences and views of PWA and their Communication Partners (CPs) on the impact of comprehension impairments during participation in daily activities and the self-generated strategies and changes that support participation. Methods &Procedures Four PWA and four CPs participated in semi-structured interviews over videoconferencing. The interviews were transcribed and analysed using reflexive thematic analysis. Outcomes &Results Four main themes were identified: (1) Spaces, places and adaptations: thriving and surviving: participants described common barriers and adaptationsthat supported communication; (2) Living well: keeping busy and enjoying activities: participants described finding meaning andenjoyment in activities and discussed common adaptions that supported activities; (3) Managing emotions and changing identities: participants described the impact of frustration and social isolation that resulted from comprehension impairments; (4) Knowing me knowing you: forming and maintaining relationships; participants shared that familiar communication partners facilitated understanding while communicating with unfamiliar communication partners could be more challenging or was avoided, a lack of public awareness of aphasia was also discussed. Conclusions &Implications Comprehension impairments resulted in concerns of stigmatisation, a significant emotional burden and a negative impact on wellbeing. However, PWA and CPs identified numerous strategies and adaptations which promoted participation in daily activities. These ranged from adapting the environment and CP communication strategies to changes in activities in order to reduce comprehension burden. When these adaptations were combined, they promoted participation in meaningful activities. While some adaptations were universal (e.g. reducing background noise), others were individualised (e.g. use of technology). Participants indicated a need for clinical guidance to successfully implement strategies/adaptation. Aphasia adapted materials are provided summarising the practical changes that PWA have successfully implemented.

Promoting creative writing in seventh grade students through literature

Writing is a skill that is developed in the early years of learning. The study aimed to promote the development of creative writing in seventh-grade students through the literature of the Dr. Gonzalo Abad Grijalva Educational Unit from September to December 2023. The methodology has a quantitative approach; scientific information on the development of creative writing and literature was contrasted as a component to improve skill deficiencies in students. In addition to research instruments, a survey and an interview were applied. and an observation sheet that experts in Language and Literature validated to determine the problem and try, through the proposal, to improve the problems that arise in teaching practice. The results showed that students exposed to creative writing through literature demonstrated significant improvements in writing skills, including idea elaboration, grammar, and sentence structure. There are difficulties such as the limited promotion of creative writing through literature by the Educational Institution, in addition to the fact that technological tools are not used. However, teachers use meaningful educational strategies and activities, such as motivation, that foster the student's internal inspiration.

Promoting Daily Engagement in Meaningful Activity (DEMA) for people with cognitive impairment and their caregivers: Protocol for a randomized clinical trial.

Promoting Daily Engagement in Meaningful Activity (DEMA) for people with cognitive impairment and their caregivers: Protocol for a randomized clinical trial.

Effectiveness and cost-effectiveness of a home-based functional exercise programme for community-dwelling frail older adults, ACTIVE-AGE@home, provided by professionals and volunteers: protocol of a pragmatic randomised controlled trial

Between 2020 and 2050, the world’s population aged 80 years and over will triple, drastically increasing the prevalence of frailty and associated healthcare costs. Multimodal exercise programmes have proven to...