Mean Change In Level Research Articles

Alveolar bone remodeling in virtually planned, bone-grafted vs non-grafted guided flapless implant surgery in the anterior maxilla: a cross-sectional retrospective follow-up study

PurposeIn patients who underwent virtual planning and guided flapless implant surgery for teeth missing in the anterior maxilla, we compared buccal bone loss between those treated with and without autogenous bone augmentation.MethodsOf 22 patients with teeth missing because of trauma or aplasia, 10 (18 implant sites) were reconstructed with buccally placed bone graft harvested from the mandibular ramus, and 12 were non-reconstructed (16 sites). Baseline cone-beam computed tomography allowed for implant planning using the NobelClinician® software and was performed again at 1 year after functional loading. The marginal bone level was assessed radiographically at post-implant baseline and at follow-up.ResultsAt follow-up, buccal bone loss differed significantly between groups at the central level of the implant (p = 0.0005) but not at the coronal level (p = 0.329). The mean marginal bone level change was 0.6 mm, with no significant between-group difference (p = 0.876). The actual implant position often deviated in the vertical or sagittal plane by an average of 0.3–0.6 mm from the planned position.ConclusionCompared with non-reconstructed patients, reconstructed patients experienced significantly more buccal bone loss at the central level of implants. The groups did not differ at the coronal level or in marginal bone loss, possibly because of the more augmented bone at the central level among reconstructed patients. Differences between planned versus actual implant positions should be considered in situations of limited bone volume at the planned implant site.

Development of self-concept clarity from ages 11 to 24: Latent growth models of Chinese adolescents

ABSTRACT This study examined the growth trajectory of self-concept clarity (SCC) and explored the influence of this trajectory on the development of life satisfaction (LS) and positive affect (PA) among Chinese adolescents (N = 2001, 56.97% females). Results of latent growth models showed no significant mean-level change of SCC across three waves in a year. However, significant inter-individual variability was presented in the developmental patterns of SCC over time. Specifically, older adolescents showed higher initial levels of SCC; and males were related to increased SCC in development rates. Moreover, we found gender-specific nature of the relationship between SCC and well-being outcomes (e.g., LS and PA). Our results have significant practical implications for mental health programs in adolescence.

Effect of Physical Exercise Under Different Intensity and Antioxidative Supplementation for Plasma Superoxide Dismutase in Healthy Adults: Systematic Review and Network Meta-Analysis.

BackgroundThe dynamic balance between oxidation and anti-oxidation in the body’s internal environment has a significant meaning for human health. Physical exercise and antioxidative supplementation could affect the balance of oxidation and anti-oxidation systems. The evidence on the effects of physical exercise and antioxidative supplementation is mixed.AimsTo identify the effects of physical exercise, antioxidative supplementation, and their combination on the dynamic balance between oxidation and anti-oxidation in different subgroups of healthy adults.MethodsAll studies which reported randomized controlled trials with healthy participants were screened and included from the databases of PubMed, Medline, Embase, and Ovid. All participants were reclassified according to their different daily life activities. All physical exercise interventions were reclassified according to the intensity. The effect size would be calculated in percent or factor units from the mean level change with its associated random-effect variance.ResultThere were 27 studies included in this review. The agreement between authors by using The Cochrane Collaboration Risk of Bias Assessment Tool reached a kappa-value of 0.72. Maintaining a regular physical exercise routine in an appropriate intensity would be beneficial to the body’s anti-oxidative potential. Anti-oxidative supplementation could have some positive but limited effects on the body’s anti-oxidative status and complex interaction with physical exercise.ConclusionKeeping a regular physical exercise routine and gradually increasing its intensity according to the individual’s daily life activity might be a better choice to maintain and enhancing the body’s antioxidation potential, only using anti-oxidative supplementation is not recommended. More research is needed to explore the best combination protocol.Registration NumberCRD42021241995.

Continuous Glucose Monitoring With Low-Carbohydrate Nutritional Coaching to Improve Type 2 Diabetes Control: Randomized Quality Improvement Program.

BackgroundType 2 diabetes mellitus (T2DM) is a leading cause of morbidity and mortality globally, with adverse health consequences largely related to hyperglycemia. Despite clinical practice guideline recommendations, effective pharmacotherapy, and interventions to support patients and providers, up to 60% of patients diagnosed with T2DM are estimated to have hemoglobin A1c (HbA1c) levels above the recommended targets owing to multilevel barriers hindering optimal glycemic control.ObjectiveThe aim of this study is to compare changes in HbA1c levels among patients with suboptimally controlled T2DM who were offered the opportunity to use an intermittently viewed continuous glucose monitor and receive personalized low-carbohydrate nutrition counseling (<100 g/day) versus those who received usual care (UC).MethodsThis was a 12-month, pragmatic, randomized quality improvement program. All adult patients with T2DM who received primary care at a university-affiliated primary care clinic (N=1584) were randomized to either the UC or the enhanced care (EC) group. Within each program arm, we identified individuals with HbA1c >7.5% (58 mmol/mol) who were medically eligible for tighter glycemic control, and we defined these subgroups as UC–high risk (UC-HR) or EC-HR. UC-HR participants (n=197) received routine primary care. EC-HR participants (n=185) were invited to use an intermittently viewed continuous glucose monitor and receive low-carbohydrate nutrition counseling. The primary outcome was mean change in HbA1c levels from baseline to 12 months using an intention-to-treat difference-in-differences analysis comparing EC-HR with UC-HR groups. We conducted follow-up semistructured interviews to understand EC-HR participant experiences with the intervention.ResultsHbA1c decreased by 0.41% (4.5 mmol/mol; P=.04) more from baseline to 12 months among participants in the EC-HR group than among those in UC-HR; however, only 61 (32.9%) of 185 EC-HR participants engaged in the program. Among the EC-HR participants who wore continuous glucose monitors (61/185, 32.9%), HbA1c was 1.1% lower at 12 months compared with baseline (P<.001). Interviews revealed themes related to EC-HR participants’ program engagement and continuous glucose monitor use.ConclusionsAmong patients with suboptimally controlled T2DM, a combined approach that includes continuous glucose monitoring and low-carbohydrate nutrition counseling can improve glycemic control compared with the standard of care.

Stability and change in the Big Five personality traits: Findings from a longitudinal study of Mexican-origin adults.

A large body of research has documented how personality develops across adulthood, yet very little longitudinal work has examined whether these findings generalize beyond predominantly middle-class, highly educated White American or Western European individuals. This preregistered study uses longitudinal data from 1,110 Mexican-origin adults who completed a well-validated personality measure, the Big Five Inventory, up to six times across 12 years. Individuals generally maintained their rank ordering on the Big Five over time (rs = .66-.80), and the relative ordering of the Big Five within persons was also highly stable (rs = .58-.66). All of the Big Five traits showed small, linear mean-level decreases across adulthood. These trajectories showed few associations with sociodemographic factors (sex, education level, and IQ) and cultural factors (generational status, age at immigration, Spanish/English language preference, Mexican cultural values, American cultural values, and ethnic discrimination). The statistically significant findings we did observe mostly concerned associations between cultural values and Extraversion, Agreeableness, and Openness. Acquiescence bias was also positively associated with Big Five personality trait scores at every wave. There was no evidence of mean-level change in the Big Five when including time-varying acquiescence scores as covariates in the models. Divergences between the present findings and previous research highlight the need to study personality development with diverse aging samples. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Comparison of Efficacy of Refrigerated Oxytocin with Oxytocin Kept at Room Temperature for the Prevention of Post-Partum Haemorrhage in Vaginal Deliveries in a Tertiary Care Setting

Introduction: Postpartum haemorrhage is one of the leading causes of maternal death worldwide and it accounts for nearly one-quarter of all maternal deaths and almost half of all postpartum deaths in low-income countries. Primary postpartum haemorrhage (PPH) is the most common form of major obstetric haemorrhage. Materials and Methods: The study protocol was comprised of Consent, Measurement of Pre-delivery Hemoglobin, Administration of the Intervention, Measurement of postpartum blood loss and Measurement of Post-delivery (24-48 hours) Hemoglobin. Blood loss was measured using a calibrated drape. The drape was placed beneath the parturient buttocks and secured around her abdomen with ties. Blood loss was monitored for a minimum of one hour and was continued in the second hour in case of persistent bleeding. The drape with the collected blood was weighed on a scale. The weight of the drape and the container in which it is placed was deducted from the total recorded weight in order to obtain the weight of the blood collected in the drape. Blood loss weight in grams was converted to milliliters by dividing the figure in grams by 1.06 (blood density in grams per milliliter). Results: The cross tabulations were used to study the demographic, obstetrical and medical factors in women with obstetrical haemorrhage. Table 1 shows the selected sociodemographic characteristics of the study population. The mean age of cases and controls are 26.333.559 and 26.853.873 respectively. On comparison, they are statistically insignificant. (p=0.324). The educational, occupational and socioeconomic status was comparable between cases and controls (p &gt;0.05). Table 2 shows Antenatal, intra-partum and post-partum data in cases and controls. Discussion &amp; Conclusion: It is a study done in North India comparing the Oxytocin kept at room temperature with failure of maintenance of cold chain during transport and storage and the refrigerated Oxytocin. It is the common understanding and general training that Oxytocin must be stored in the refrigerator, failing which its efficacy reduces i.e. it, will not be effective in controlling PPH. During the study we compared the mean blood loss and change in hemoglobin levels in cases and control and despite the fact that major risk factor for PPH for example past history of PPH, past history of D&amp;C, prolonged third stage labour duration, manual removal of placenta were comparable in both cases and controls, still the mean blood loss and change in hemoglobin values was more in cases than controls. This could be attributed to usage of market oxytocin which had failed cold chain maintenance resulted in less effective oxytocin in prevention of PPH, Hence causing more blood loss and drop in hemoglobin values. This shows the need of room temperature stable uterotonic drug in LMIC’s like ours. Recently room temperature stable carbetocin shows the potential as an effective uterotonic drug for the prevention of PPH. However according to various studies carbetocin cannot be used for induction or augmentation of labour so it cannot replace oxytocin fully, rather it acts as a part of collective PPH reduction strategy

Monolithic zirconia single tooth implant-supported restorations with CAD/CAM titanium abutments in the posterior region: A 1-year prospective case series study.

PurposeTo assess the clinical, radiographic, and patient‐reported outcome measures, including the success of screw‐retained monolithic zirconia implant‐supported restorations with CAD/CAM titanium abutments in the posterior region during a 1‐year follow‐up.MethodsIn a prospective case series, 50 molar sites in the posterior region of 46 patients with a minimum age of 18 years and sufficient bone volume and anatomical conditions for placing an implant (≥8 mm) and an anatomical restoration were included. Parallel‐walled implants with a conical connection were inserted in a two‐stage surgical procedure. Implant uncovering and healing abutment placement occurred 12 weeks after insertion. Two weeks after mucosa healing, a screw‐retained monolithic zirconia restoration with a CAD/CAM titanium abutment was placed. Clinical, radiographic, and patient‐reported outcome measures were collected at baseline before implant placement and then during the 1 month and 1 year follow‐ups.ResultsAt the 1 year follow‐up, 49 restorations could be evaluated. The plaque accumulation, presence of calculus, bleeding tendency and peri‐implant inflammation indices were low, representing healthy peri‐implant conditions. The mean marginal bone level change between the 1 month and the 1 year follow‐up was −0.17 ± 0.46 mm. The mean patient satisfaction was high. The restoration success was, according to the modified USPHS criteria, 95.9%.ConclusionMonolithic zirconia implant‐supported restorations with CAD/CAM titanium abutments have very good clinical, radiographic and patient‐reported outcomes after 1 year in function.

Is personality stable and symptoms fleeting? A longitudinal comparison in adolescence

Few investigations have directly compared personality and internalizing symptoms stability within the same sample and have not included personality facets. This study examined rank-order stability and mean-level change of Big Five domains, facets of neuroticism and extraversion, and internalizing symptoms in a sample of 550 adolescent females. Personality and symptoms were assessed every nine months for three years. Three year rank-order stability was higher for personality domains and facets compared to symptoms. Notable exceptions included lower stability of depressivity and positive emotionality facets. Facets and symptoms showed similar mean level change. Overall, we observed modest and variable temporal differences between symptoms and traits; symptoms exhibited high rank-order stability and low mean-level change, but domains and facets were generally more stable.

25-Hydroxy Vitamin D and Calcium Levels Section in Patients of Drug Resistant Tuberculosis: A Retrospective Study from a Tertiary Care Institute of Eastern India

Introduction: Drug Resistant Tuberculosis (DR-TB) is a rapidly escalating problem. Vitamin D and calcium serum levels can be an important determinant of Multidrug-Resistant Tuberculosis (MDR-TB) infection, progression to disease.The link between the serum level of 25-hydroxy vitamin-D {25(OH) D and MDR-TB is an emerging area for conducting evidencebased research. Aim: To assess the serum 25(OH)D and calcium levels and its deficiency in all the patients with drug resistant tuberculosis. Materials and Methods: This retrospective, observational study was conducted in the Department of Pulmonary Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India, from October 2019 to October 2020, in the newly detected 100 patients experiencing DR-TB. Patients sputum/body fluid samples were subjected for GeneXpert/Line Probe Assay (LPA) examinations to confirm resistance to anti-tubercular drugs. The frequency and prevalence of mean serum vitamin D and mean serum calcium levels were recorded based on age and gender. DR-TB categorised into H-Mono resistance, MDR-TB, Pre-Extensively Drug Resistant (Pre-XDR) and XDR-PTB, based on GeneXpert and LPA of sputum/body fluid. Descriptive statistics were used to determine the characteristics of all the patients. All the statistical analysis was done using the STATA software. Results: Mean age of study population was 31.12±15.49 years. Among them 63 were males and 37 were females. The mean serum vitamin D level of 10.87±8.49 ng/mL (deficient) and serum calcium level of 8.62±0.82 mg/dL (normal) was reported. Mean serum vitamin D levels were deficient in all the four types of DR-TB (p-value=0.04), while changes in mean serum calcium level was non significant (p-value=0.15). Conclusion: All patients with DR-TB have significant propensity to vitamin D deficiency. While changes in mean serum calcium level was non significant.

Outcomes of patients with end-stage kidney disease hospitalized with COVID-19: A single-center experience from Eastern India

Aim: This study aimed to describe the clinical characteristics, survival outcome, and its correlation with biochemical parameters in coronavirus disease-2019 (COVID-19)-infected patients with end-stage kidney disease (ESKD). Materials and Methods: A prospective observational study was on hospitalized patients with confirmed COVID-19 infection from September 1, 2020 to October 31, 2020. Data related to demographics, baseline history of comorbid conditions, dialysis-specific data, details on hospital admissions, COVID-19 treatment regimen, laboratory investigations, computed tomography (CT) severity score, COVID-19 Reporting and Data System score, and clinical outcomes (improved/death), duration of hospital stay, oxygen/vasopressor support were collected. Results: A total of 216 ESKD patients with COVID-19 infection were included in this study. The median age was 48.0 years (74.5% men, 25.5% women). Severe acute respiratory infection (44.7%), hypertension (28.2%), and type 2 diabetes mellitus (22.4%) were the most common comorbidities. Elevated levels of serum creatinine (9.3 mg/dL) and blood urea nitrogen (84.8 mg/dL) were observed in the patients with COVID-19 infection. The change in mean levels of serum creatinine and estimated glomerular filtration rate from baseline to post-treatment was significant (0.9 [95% CI: 0.7, 1.1; P < 0.001] and 3.4 [95% CI: 3.2, 3.6; P < 0.001], respectively). Approximately, 79.6% (n = 172) of patients improved post-treatment. Serum creatinine (1.786, 95% CI: 1.031, 3.095; 0.039) and ferritin levels (51.959, 95% CI: 7.901, 341.685; P < 0.001) remained significantly and independently associated with survival. The median time to clinical survival was 17.0 days. Conclusion: Serum creatinine and ferritin levels were independently associated with survival.

Temporal stability and change in manifest intelligence scores: Four complementary analytic approaches

The temporal stability of psychological test scores is one prerequisite for their practical usability. This is especially true for intelligence test scores. In educational contexts, high stakes decisions with long-term consequences, such as placement in special education programs, are often based on intelligence test results. There are four different types of temporal stability: mean-level change, individual-level change, differential continuity, and ipsative continuity. We present statistical methods for investigating each type of stability. Where necessary, the methods were adapted for the specific challenges posed by intelligence research (e.g., controlling for general intelligence in lower order test scores). We provide step-by-step guidance for the application of the statistical methods and apply them to a real data set of 114 gifted students tested twice with a test-retest interval of 6 months.• Four different types of stability need to be investigated for a full picture of temporal stability in psychological research• Selection and adaption of the methods for the use in intelligence research• Complete protocol of the implementation

Personality States of the Union

Fluctuations in the average daily personality of the United States capture both meaningful affective responses to world events (e.g., changes in anxiety or well-being) and broader psychological responses. We estimate the change in national personality in the months following the onset of the COVID-19 pandemic and investigate fluctuations in personality states during the year 2020 using data from an ongoing personality assessment project. We find significant and meaningful change in personality traits since the beginning of the pandemic, as well as evidence of instability in personality states. When evaluating changes from the first few months of 2020 to the period of social distancing related to COVID-19 restrictions, the social traits reflected an unexpected “deprivation” effect such that mean self-ratings increased in the wake of restricted opportunities for social interaction. Changes in mean levels of the affective traits were not significant over the same months, but they did differ significantly from the average levels of prior years when looking at shorter time intervals (rolling 7-day averages) around prominent national events. This instability may reflect meaningful fluctuations in national personality, as we find that daily personality states are associated with other indices of national health, including daily COVID-19 cases and the S&amp;P index. Overall, the use of personality measures to capture responses to global events offers a more holistic picture of the U.S. psyche and of personality change at the national level.

One-year outcomes of dental implants with a hybrid surface macro-design placed in patients with history of periodontitis: A randomized clinical trial.

To evaluate the radiological, clinical, and microbiological outcomes of implants with a hybrid surface macro-design in patients with a history of periodontitis. The study was designed as a 12-month, parallel-arm, randomized controlled trial where patients with a history of treated periodontitis in need of dental implants for single-unit or short-span prosthesis were randomly allocated to a test [implants with a machined titanium surface in the coronal collar (hybrid; HS)] or a control group [conventional implants with moderately rough surface up to the implant shoulder (RS)]. Patients were followed at 3, 6, and 12 months after loading with assessment of radiological, clinical, and microbiological outcomes, as well as patient-related outcome measures (PROMs). Forty patients were randomly assigned to either the RS group (n=20) or the HS (n=20) group. At 1 year, the mean marginal bone level changes were 0.22 [standard deviation (SD) 0.36] mm for the HS group and 0.22 (SD 0.29) mm for the RS group, with no significant differences between them (p=.961). Similarly, no significant differences in clinical, microbiological, or PROMs were observed between groups. HS implants demonstrated radiographic, clinical, and microbiological characteristics equal to RS implants in patients with a history of periodontitis. ClinicalTrials.gov (identifier NCT05010382).

Efficacy and safety of recombinant human erythropoietin (Hema-Plus®) for management of anemia in Thai patients on peritoneal dialysis.

BACKGROUNDHema-Plus, a recombinant human erythropoietin (rHuEPO) or epoetin alfa has shown effectiveness in correction of anemia in Thai population in clinical practice. This study was aimed to demonstrate efficacy and safety under the evidence-based approach.AIMTo evaluate the efficacy and safety of rHuEPO (Hema-Plus) for treatment of anemia over 12 wk in Thai patients with Stage V chronic kidney disease (CKD) on peritoneal dialysis (PD).METHODSThis study was an open-label, multi-center study to enroll 30 CKD patients identified to start PD with hemoglobin (Hb) less than 9.5 g/dL, serum ferritin more than 100 ng/mL, serum transferrin saturation more than or equal to 20% and who had not previously received epoetin. Patients with conditions that could increase the risk of adverse effects from study participation or interfere with study outcomes, were using concomitant androgens or had secondary hyperparathyroidism were excluded. All eligible patients started Hema-Plus by SC injection at 4000 IU once or twice weekly (week 0) and with follow-up at weeks 2, 4, 8, and 12. Dosage adjustment could be done to achieve Hb level of 11-12 g/dL. Primary end point was mean change in Hb level from baseline to end of treatment (week 12). Safety was assessed throughout the study. Quality of life (QoL) was assessed using KDQOL-36.RESULTSAll 30 enrolled patients completed the study. Mean (standard deviation) Hb at baseline (week 0) to the end of 12 wk was significantly increased from 7.39 (1.29) g/dL to 11.15 (1.73) g/dL (paired t-test, P value < 0.001). Overall change of Hb means from baseline over the other 4 visits was statistically significantly increased (repeated measure ANOVA, P value < 0.001). Ten out of 39 adverse events (AEs) were serious. Two serious AEs were probably related to study medication by investigators’ assessment. At week 12, the QoL scores in all domains were significantly increased from baseline. CONCLUSIONHema-Plus administered for 12 wk for treatment of anemia in patients on PD effectively increased Hb levels with acceptable safety profile.

Predictors of worsening TR severity after right ventricular lead placement: any added value by post-procedural fluoroscopy versus three \u2013dimensional echocardiography?

BackgroundThe effect of right ventricular (RV) leads on tricuspid valve has been already raised concerns, especially in terms of prognostic implication. For such assessment, three-dimensional transthoracic echocardiography (3D-TTE) has been used previously but there was no data on the use of post-procedural fluoroscopy in the literature.MethodsWe prospectively enrolled 59 patients who underwent clinically indicated placement of pacemaker or implantable cardioverter defibrillator (ICD). Vena contracta (VC) and tricuspid regurgitation (TR) severity were measured using two-dimensional transthoracic echocardiography (2D-TTE) at baseline. Follow up 3D-TTE was performed 6 months after device implantation to assess TR severity and RV lead location.ResultsLead placement position in TV was defined in 51 cases.TR VC was increased after the lead placement, compared to the baseline study (VC: 3.86 ± 2.32 vs 3.18 ± 2.39; p = 0.005), with one grade worsening in TR in 25.4% of cases. The mean changes in VC levels were 1.14 ± 0.67 mm. Among all investigated parameters, VC changes were predicted based on lead placement position only in 3D-TTE (p < 0.001) while the other variables including fluoroscopy parameters were not informative.ConclusionThe RV Lead location examined by 3D-TTE seems to be a valuable parameter to predict the changes in the severity of the tricuspid regurgitation. Fluoroscopy findings did not improve the predictive performance, at least in short term follow up.

Expectant Parents’ Emotions Evoked by Pregnancy: A Longitudinal Dyadic Analysis of Couples in the Swedish Pregnancy Panel

Background: Holistic antenatal care requires knowledge of individuals’ emotional response to pregnancy. Little is known about how a pregnant woman and her partner influence each other emotionally during a pregnancy. This study examines six discrete emotions that expectant couples experience during pregnancy, how these emotions change during pregnancy, and whether the partner’s emotional responses influence each other. Methods: A longitudinal dyadic study where pregnant women and their partners (1,432 couples) rated the extent to which the pregnancy evoked joy, strength, security, worry, shame, and anger at pregnancy weeks 12–19, 22–24, and 36. Latent curve models with structured residuals identify levels of and change in these emotions over time, while accounting for between- and within-couple variance. Findings: Pregnancy evoked mainly joy, strength, security and worry, and to the same extent in both groups. Levels of anger and shame were low, but higher for pregnant women than partners. There was little to no mean-level change in all six measured emotions evoked by pregnancy, and no reciprocal effects between the partners. Interpretation: Emotions in early pregnancy are felt also in late pregnancy. Furthermore, the pregnant woman and her partner have individual emotional trajectories. The results can assist healthcare professionals and researchers target interventions to expectant mothers and partners, specifically by understanding emotional response to pregnancy as a stable confound and by not approaching the couple as one emotional unit. Funding Information: This study was funded by The Swedish Research Council (2015-01546), Knut and Alice Wallenberg Foundation (KAW2017.0245), and the University of Gothenburg. Declaration of Interests: We declare no competing interests. Ethics Approval Statement: The Swedish Ethical Review Authority approved the SPP on April 15, 2019 (Dnr: 1061-18).

Effectiveness of implant-supported fixed partial denture in patients with history of periodontitis: A systematic review and meta-analysis.

This systematic review investigates the effectiveness of implant-supported fixed partial denture (IS-FPD) in patients with history of periodontitis (HP) vs. patients with no history of periodontitis (NHP). A literature search was performed on different databases on May 2020. Prospective and retrospective studies assessing survival (primary outcome), success and biological/mechanical complications of IS-FPDs in HP vs. NHP patients at ≥1year after implant loading were evaluated. Meta-analyses were conducted by estimating hazard ratio (HR), risk ratio (RR) and standardized mean differences (SMD) with 95% confidence intervals (CI) using random effect models. Of the initially identified 4096 articles, 349 underwent a full-text evaluation. Finally, 17 were included. Pooled data analyses showed that overall implant survival was significantly higher in the NHP than the HP group (HR=2.06; 95% CI=1.37-3.09; I2 =0%). This difference was noted when follow-up ≥5years. The risk of peri-implantitis was higher in HP than NHP patients (RR=3.3; 95% CI=1.31-8.3; I2 =0%), whereas the mean marginal bone level change over time was not different between the groups (SMD=-0.16mm; 95% CI=-1.04-0.73; I2 =98%). In partially edentulous patients receiving IS-FPDs, a history of periodontitis is associated with poorer survival rate and higher risk of peri-implantitis during a 5-10years period after implant loading.

Mean sea level and tidal change in Ireland since 1842: a case study of Cork

Abstract. Knowledge of regional changes in mean sea level and local changes in tides are crucial to inform effective climate adaptation. An essential element is the availability of accurate observations of sea level. Sea level data in the Republic of Ireland, prior to the establishment of the National Tide Gauge Network in the mid-2000s, are limited but belie a wealth of historical data available in archival form. In this study, we digitize records located in Cork Harbour, Ireland, from 1842 and show how short-duration (6–8 weeks), high-quality data with a large interval to the present can accurately inform tidal and mean sea level changes. We consider error sources in detail. We estimate for the main M2 tidal constituent that the accuracy of these historical measurements is 1 % and 2 min for amplitude and phase, respectively, once adjustments for seasonal and nodal effects are made. Our mean sea level estimates are accurate to the 2 cm level, once adjustments for atmospheric and seasonal effects are made. Our results show tidal stability with a 2 % change in the amplitude of the M2 component, 4 min change in the phase over a period of 177 years, and mean sea level rise of 40 cm in the Cork Harbour area from 1842 to 2019, approximately in line with global mean sea level trends plus local glacial isostatic adjustment. More broadly, we show that with careful seasonal, nodal, and atmospheric corrections, together with knowledge of benchmark provenance, these historic, survey-oriented data can accurately inform of sea level changes.

Effect of combined periodontal and orthodontic treatment of tilted molars and of teeth with intra-bony and furcation defects in stage-IV periodontitis patients: A systematic review.

To assess the effect of combined periodontal and orthodontic treatment (OT) in stage-IV periodontitis patients. Three focused questions were addressed using the Population, Intervention, Comparison, Outcome, and Study Design criteria. Randomized controlled trials (RCTs), controlled clinical trials, follow-up studies, case series, and controlled/uncontrolled before/after studies were assessed for inclusion. Primary outcomes included mean changes in pocket probing depth (PPD) and clinical attachment level (CAL). Qualitative synthesis of results was performed and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Out of 916 records, 1 retrospective case series study reported the effect of OT of tilted molars, 2 RCTs and 10 prospective and 2 retrospective case series studies reported the effect of OT of treated intra-bony defects and 0 articles reported the effect of OT of treated furcation defects. Mean PPD changes were reported in 14 articles, and mean CAL changes were reported in 8 articles. Risk of bias was high in both included RCTs, critical in nine articles, and serious in four articles. No articles included patient-reported outcomes, and three articles reported harms/adverse effects. Evidence is limited by (i) the lack or low number of included studies, (ii) the apparent methodological and clinical heterogeneity, and (iii) the high risk of bias of the retrieved studies. No solid conclusions could be drawn concerning OT in stage-IV periodontitis patients with respect to tilted molars, teeth with treated intra-bony defects, and teeth with treated furcation defects.

Can exposure to arguments pro and contra extraversion affect self-reports of the trait and the attitude toward it?

Changeability of personality over short-term intervals has increasingly become a focus of research. However, the role played by argumentation interventions in short-term variations has scarcely been examined. In two experiments (N=363 and 320), we investigated how processing positive and negative argumentation regarding extraversion (Study 1: watching a lecture; Study 2: elaborating self-invented arguments) affects self-reports on this trait and attitude toward it. The experiments included three waves of measurements with argument manipulation (in favor of or against extraversion) immediately prior to Time 2 (Study 2 also included a control group). Mean-level changes in extraversion across time moments, measured with the longitudinal confirmatory factor analysis, were consistently negligible. Conversely, there were some indications that argumentation about extraversion could have immediate short-term effects on attitudes toward this trait. The random-intercept cross-lagged model showed that rank-order consistency stemmed from a trait-like intercept, which was particularly large for trait extraversion compared with the attitude. The autoregressive and cross-lagged effects of residual within-person variation were consistently small and mostly nonsignificant. Our findings suggest that extraversion and the attitude toward it maintained their temporal continuity within 3months, even under a single exposure to arguments pro and contra this trait.