The study was undertaken in Angot district, North Wollo Zone, Ethiopia from June 2019 up to March 2020. The objective of the study was of characterize the reproductive and productive performance of indigenous and crossbred dairy cow in Angot district. The participatory rural appraisal (PRA) method was used to generate information during exploratory survey and 100 households were selected for formal survey by using random and purposive sampling technique. The estimated daily milk yield of local and crossbred cow was found to be 1.32±0.11 and 4.62±0.35 liters, respectively. The mean lactation length for local and crossbred dairy cow were reported by the respondents were 9.15±0.63 and 10.8±1.02 months, respectively. The estimated lactation yield of local and crossbred dairy cow in the study area was 365.42±1.96 and 1565.65±11.98 liters, respectively. The average age at first service of local and crossbred dairy heifers in the study area was 34.5±2.71 and 23.41±1.54 months, respectively. The age at first calving (AFC) of the indigenous and crossbred was 45.13±2.31and 34.51±1.94 months, respectively. The average calving interval of local and crossbred dairy cows in the study area were 18.38±1.05 and 15.52±0.97 months, respectively. The estimated average number of calf per lifetime of cow in the study area was 6.21±0.32 (for local) and 9.59±0.49 (for crossbred). The average reproductive lifetime of local and crossbred dairy cows in the study rea ware 16.21±0.27 and 14.07±0.23 years, respectively. The calculated reproductive efficiency of local and crossbred dairy cows were 46% and 77.53%, respectively. In conclusion, the present study indicated that the reproductive performance of dairy cow in the study area was low, thus it calls attention to improve management system to improve the reproductive performance of dairy cows.