Manufacturing systems are affected by uncertainties, such as machine failure or tool breakage, which result in system downtime and productivity deterioration. In machining processes, system downtime must be reduces. This study aims to establish an automated scheduling technique that flexibly responds to unforeseen events, such as machine failure, based on adaptive operations of the handling manipulator instead of an operation schedule for the machine tools. We propose an “adaptive manipulation” procedure for establishing a reactive revision policy. The reactive revision policy modifies a portion of the manipulator operation sequence, followed by the machine operation sequence. We conduct a physical scheduling simulation on a material-handling manipulator system imitating a job-shop manufacturing system. Through simulations involving machine breakdown scenarios, the applicability of the reactive revision policy based on adaptive manipulation is demonstrated.