Mass Redistribution Research Articles

Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors.

G protein activation represents an early key event in the complex GPCR signal transduction process and is usually studied by label-dependent methods targeting specific molecular events. However, the constrained environment of such “invasive” techniques could interfere with biological processes. Although histamine receptors (HRs) represent (evolving) drug targets, their signal transduction is not fully understood. To address this issue, we established a non-invasive dynamic mass redistribution (DMR) assay for the human H1–4Rs expressed in HEK cells, showing excellent signal-to-background ratios above 100 for histamine (HIS) and higher than 24 for inverse agonists with pEC50 values consistent with literature. Taking advantage of the integrative nature of the DMR assay, the involvement of endogenous Gαq/11, Gαs, Gα12/13 and Gβγ proteins was explored, pursuing a two-pronged approach, namely that of classical pharmacology (G protein modulators) and that of molecular biology (Gα knock-out HEK cells). We showed that signal transduction of hH1–4Rs occurred mainly, but not exclusively, via their canonical Gα proteins. For example, in addition to Gαi/o, the Gαq/11 protein was proven to contribute to the DMR response of hH3,4Rs. Moreover, the Gα12/13 was identified to be involved in the hH2R mediated signaling pathway. These results are considered as a basis for future investigations on the (patho)physiological role and the pharmacological potential of H1–4Rs.

Time-Variable Gravity Field from the Combination of HLSST and SLR

The Earth’s time-variable gravity field is of great significance to study mass change within the Earth’s system. Since 2002, the NASA-DLR Gravity Recovery and Climate Experiment (GRACE) and its successor GRACE follow-on mission provide observations of monthly changes in the Earth gravity field with unprecedented accuracy and resolution by employing low-low satellite-to-satellite tracking (LLSST) measurements. In addition to LLSST, monthly gravity field models can be acquired from satellite laser ranging (SLR) and high-low satellite-to-satellite tracking (HLSST). The monthly gravity field solutions HLSST+SLR were derived by combining HLSST observations of low earth orbiting (LEO) satellites with SLR observations of geodetic satellites. Bandpass filtering was applied to the harmonic coefficients of HLSST+SLR solutions to reduce noise. In this study, we analyzed the performance of the monthly HLSST+SLR solutions in the spectral and spatial domains. The results show that: (1) the accuracies of HLSST+SLR solutions are comparable to those from GRACE for coefficients below degree 10, and significantly improved compared to those of SLR-only and HLSST-only solutions; (2) the effective spatial resolution could reach 1000 km, corresponding to the spherical harmonic coefficient degree 20, which is higher than that of the HLSST-only solutions. Compared with the GRACE solutions, the global mass redistribution features and magnitudes can be well identified from HLSST+SLR solutions at the spatial resolution of 1000 km, although with much noise. In the applications of regional mass recovery, the seasonal variations over the Amazon Basin and the long-term trend over Greenland derived from HLSST+SLR solutions truncated to degree 20 agree well with those from GRACE solutions without truncation, and the RMS of mass variations is 282 Gt over the Amazon Basin and 192 Gt in Greenland. We conclude that HLSST+SLR can be an alternative option to estimate temporal changes in the Earth gravity field, although with far less spatial resolution and lower accuracy than that offered by GRACE. This approach can monitor the large-scale mass transport during the data gaps between the GRACE and the GRACE follow-on missions.

Satellite soil moisture data assimilation for improved operational continental water balance prediction

Abstract. A simple and effective two-step data assimilation framework was developed to improve soil moisture representation in an operational large-scale water balance model. The first step is a Kalman-filter-type sequential state updating process that exploits temporal covariance statistics between modelled and satellite-derived soil moisture to produce analysed estimates. The second step is to use analysed surface moisture estimates to impart mass conservation constraints (mass redistribution) on related states and fluxes of the model using tangent linear modelling theory in a post-analysis adjustment after the state updating at each time step. In this study, we assimilate satellite soil moisture retrievals from both Soil Moisture Active Passive (SMAP) and Soil Moisture and Ocean Salinity (SMOS) missions simultaneously into the Australian Water Resources Assessment Landscape model (AWRA-L) using the proposed framework and evaluate its impact on the model's accuracy against in situ observations across water balance components. We show that the correlation between simulated surface soil moisture and in situ observation increases from 0.54 (open loop) to 0.77 (data assimilation). Furthermore, indirect verification of root-zone soil moisture using remotely sensed Enhanced Vegetation Index (EVI) time series across cropland areas results in significant improvements from 0.52 to 0.64 in correlation. The improvements gained from data assimilation can persist for more than 1 week in surface soil moisture estimates and 1 month in root-zone soil moisture estimates, thus demonstrating the efficacy of this data assimilation framework.

Bone-sparing effects of rituximab and body composition analysis in a cohort of postmenopausal women affected by rheumatoid arthritis - retrospective study.

ObjectiveOsteoporosis is the most common bone tissue disease and it is characterized by a reduced bone mineral density (BMD). The main physiopathological mechanisms converge on the uncoupling between bone formation and resorption, thus leading to an enhanced risk of fractures. Several papers have documented the inverse relationships linking high inflammatory cytokines, anti-citrullinated protein antibodies, rheumatoid factor, and BMD in rheumatoid arthritis (RA). Rituximab (RTX) is a chimeric monoclonal antibody directed against the CD20 receptor of B cells. Since the Food and Drug Administration approved it for RA in 2006, there have been many clinical experiences regarding its use. Nevertheless, few studies evaluate the effect of rituximab on BMD. RA is a disease characterized by immune dysfunction with high levels of inflammatory cytokines, autoantibodies, and it is reasonable that a B cell depleting therapy could restore a physiological cytokine balance, thus exerting an osteoprotective effect on the bone tissue. The purpose of this paper is to highlight any difference in BMD and to assess differences in body composition over a retrospective 18-month follow-up period after RTX treatment with a B cell depleting therapy.Material and methodsWe analyzed by dual energy X-ray absorptiometry BMD expressed as g/cm2 and body composition modifications over 18 months with RTX treatment of 20 postmenopausal RA patients.ResultsAfter eighteen months of therapy with RTX, a statistically significant increase in vertebral (L1–L4) BMD and the stability of femoral BMD were documented.ConclusionsRituximab is associated with an improvement of vertebral and preservation of femoral BMD, suggesting a bone-sparing effect due to B cell depletion. Furthermore, patients displayed a redistribution of fat masses toward the hip region.

10Be and 14C data provide insight on soil mass redistribution along gentle slopes and reveal ancient human impact

PurposeSpatial and temporal patterns of past erosional events are a useful and needed information to explain observed soil patterns in different landscapes. Soil thickness reflects the overall expression of pedogenesis and erosion. Forested soils of Northern Germany exhibit varying soil thicknesses with thin soils on crest positions and buried soils at the footslope. The aim of this study is to reconstruct the complex soil mass redistribution and soil patterns of this forested area due to different periods of erosion and stability.MethodsWe explored the explanatory power of both 10Be (in situ and meteoric) on a hillslope and we 14C-dated buried horizons at different depths.ResultsThe 10Be depth profiles did not show an exponential decrease with depth. They had a ‘bulge’ shape indicating clay translocation and interaction with oxyhydroxydes (meteoric 10Be), bioturbation and soil mass redistribution (in situ 10Be). The combined application of both 10Be and 14C dating revealed progressive and regressive phases of soil evolution. Although Melzower Forest is protected (same vegetation) since the past 250 years, both 10Be clearly indicated major soil mass redistribution along the investigated catena.ConclusionA strong erosion impulse must have occurred between 4.5 and 6.8 kyr BP indicating an earlier human impact on soil erosion than previously postulated (~ 3 kyr earlier). Our findings correlate in fact with the first settlements reported for this region (~ 6.8 kyr BP) and show their immediate effect on soils. The overall soil redistribution rates in this forest are surprisingly similar to those obtained from a nearby agricultural area.

A multidisciplinary approach to study slope instability in the Alboran Sea shoreline: Study of the Tamegaret deep-seated slow-moving landslide in Northern Morocco

Coastal landslides cause great economic damage to human installations along the Mediterranean shoreline. In the Alboran Sea, this phenomenon is very common and causes many problems for residential resorts and road infrastructures in coastal areas. In the last two decades, such slope instability processes were the subject of many studies, which employed multidisciplinary approaches to understand their underlying mechanisms and surficial kinematics in Southern Spain and elsewhere in the Mediterranean. However, advanced and new investigation methods and techniques used in these studies have never been performed in Northern Morocco despite the geomorphological, geological and climatic resemblance between the two regions. In this paper we analyze the mechanisms and processes controlling the Tamegaret slow-moving deep-seated landslide (Northern Morocco) in order to bridge this knowledge gap and to understand landslide slope dynamics on their regional context. To do so, Electrical resistivity Tomography, field investigations and multi-temporal Synthetic Aperture Radar Interferometry (InSAR) were performed to characterize slope instability processes at the study area. The interpretation of Historic aerial photographs and UAV surveys was also conducted to study the major redistribution of mass caused by recent road widening work at the landslide headscarp. Results show that the Tamegaret landslide owes its existence to deep creep processes controlled by a rock flow type gravitational deformation. Extensional tectonic structures and marine erosion processes that eliminate landslide deposits from the foot area constitute the most relevant control factors of this dynamic. InSAR results show that this deep-seated landslide is currently (2017–2019) characterized by very slow displacement rates (2–3 cm/year maximum). Yet, the substantial deformation observed both in the field and on aerial/satellite photographs suggests that the acceleration occurred during the road-widening work which caused major changes to the natural topography in the period (2009–2012). This deformation phase was manifested by local shoreline advancement at the landslide foot area. Such results show that studying historic shoreline variations can be an effective low-cost time-saving tool allowing the reconstruction of active landslide kinematics in coastal areas. On a regional scale, findings of this study highlight the resemblance between the coasts of Southern Spain and Northern Morocco in terms of (i) the geomorphological processes controlling the coastal slope dynamics at the region; (ii) the displacement rates measured in Tamegaret compared to other unstable slopes in the Northern shore of the Alboran Sea and (iii) the bad-engineering on old dormant landslides which compromises their stability. Therefore, we suggest limiting construction work on coastal hillslopes of Northern Morocco in order to prevent bad construction practices from causing economic losses in the Southern shoreline of the Alboran Sea as well.

Analysis and prediction of polar motion using MSSA method

Polar motion is the movement of the Earth's rotational axis relative to its crust, reflecting the influence of the material exchange and mass redistribution of each layer of the Earth on the Earth's rotation axis. To better analyze the temporally varying characteristics of polar motion, multi-channel singular spectrum analysis (MSSA) was used to analyze the EOP 14 C04 series released by the International Earth Rotation and Reference System Service (IERS) from 1962 to 2020, and the amplitude of the Chandler wobbles were found to fluctuate between 20 and 200 mas and decrease significantly over the last 20 years. The amplitude of annual oscillation fluctuated between 60 and 120 mas, and the long-term trend was 3.72 mas/year, moving towards N56.79 °W. To improve prediction of polar motion, the MSSA method combining linear model and autoregressive moving average model was used to predict polar motion with ahead 1 year, repeatedly. Comparing to predictions of IERS Bulletin A, the results show that the proposed method can effectively predict polar motion, and the improvement rates of polar motion prediction for 365 days into the future were approximately 50% on average.

Monitoreo de la variación del almacenamiento de agua en la cuenca del Medio y Bajo Paraná a partir de datos GRACE, GRACE FO, TRMM y GLDAS

<p>GRACE (Gravity Recovery and Climate Experiment) is a satellite mission that can monitor mass distributions in the Earth system, which is closely related to the consequences of climate change. This gravimetric satellite allows to obtain monthly variations of the Earth’s gravity field, which can be associated with water mass variations, after removing the effects of oceanic tides and solid Earth, as well as non-tidal oceanic and atmospheric contributions. In this work, data from GRACE (2002-2017) and GRACE FO (since 2018) were used to analyze the variation of the water mass in the Middle and Low Paraná river basin. The interpretation of the results was carried out by associating the mass anomalies derived from GRACE data with information from the TRMM global rainfall mission. Monthly maps of GRACE water mass variations and TRMM precipitation were produced, which made possible a thorough analysis at a regional level of this mass redistribution in the basin, and its connection to the El Niño and La Niña events that took place in the period under study. The water deficits shown in the 2009 GRACE maps are, in fact, related to the intense episode of La Niña that occurred in the period 2008-2009; while the excess of water storage depicted on the 2016 and 2019 maps is connected to the El Niño phenomenon. Moreover, GRACE has also detected drought events in different sectors between 2011-2012, together with floods in the years 2007 and 2010. Monthly GRACE-derived water storage changes were compared with the independent components of the water balance in the region using different hydrological models estimates. Finally, the temporal variations of the groundwater and the soil part (surface water, soil moisture) were analyzed using the Global Land Data Assimilation System GLDAS. The variables showed a good correlation between them, reaching values of <span> ~</span>r = 0.80.</p>

ABOUT THE INFLUENCE OF VIBRATIONS OF THE CONVEYED LIQUID ON THE AREA OF STABILITY OF A CLOSED SYSTEM AUTOMATIC VEHICLE COURSE CONTROL

The existing publications that investigate vehicle course stability optimization were analyzed. A mathematical model, which describes the disturbed movement of a car with a tank, was compiled. This model allows to consider the liquid free surface oscillations and determine their effect on the car course stability during constant motion or emergency braking. There was described the main information regarding the car that was used to perform mathematical calculations. An algorithm was developed for deriving the characteristic equation for a complex system of differential equations describing dynamic changes in the movement parameters of a car, oscillations of partial layers of liquid in a tank and the operation of an electromagnetic drive of the control valve and an electronic PID controller for a two-circuit system for ensuring course stability. Based on the developed mathematical model, the influence of forced oscillations of the fluid on the stability area of the system built in the plane of variable parameters of the controller is investigated. It is shown that low-frequency oscillations of the free surface of a liquid lead to a significant reduction in the stability area, which indicates the need to consider such oscillations when solving problems of analysis and synthesis of this system. It was found that for a car with a tank, where low-frequency transverse oscillations of the liquid occur, which are accompanied by a redistribution of mass and disturb the movement, an increase of the speed unambiguously leads to a deterioration in directional stability. That enables exclusion of speed from the number of variable parameters and significantly simplify the problem being solved. The calculations for cases with different loading levels were performed. It was found out that the level of liquid in the tank, considering its relationship with the speed, has an ambiguous effect on the car course stability, and it is unacceptable to limit the research calculations to the case with 50 % load. Instead of this, it is necessary to find a line that bends from above the stability boundaries that correspond to many liquid levels.
 Keywords: fluid vibrations; exchange rate stability system; area of stability; tank; PID-controller; parameters.

Modelling sea-level fingerprints of glaciated regions with low mantle viscosity

Abstract. Global patterns of sea-level change – often termed “sea-level fingerprints” – associated with future changes in ice/water mass re-distribution are a key component in generating regional sea-level projections. Calculation of these fingerprints is commonly based on the assumption that the isostatic response of the Earth is dominantly elastic on century timescales. While this assumption is accurate for regions underlain by mantle material with viscosity close to that of global average estimates, recent work focusing on the West Antarctic region has shown that this assumption can lead to significant error where the viscosity is significantly lower than typical global average values. Here, we test this assumption for fingerprints associated with glaciers and ice caps. We compare output from a (1D) elastic Earth model to that of a 3D viscoelastic model that includes low-viscosity mantle in three glaciated regions: Alaska, southwestern Canada, and the southern Andes (Randolph Glacier Inventory (RGI) regions 1, 2, and 17, respectively). This comparison indicates that the error incurred by ignoring the non-elastic response is of the order of 1 mm in most areas (or about 1 % of the barystatic signal) over the 21st century with values reaching the centimetre level in glaciated regions. However, in glaciated regions underlain by low-viscosity mantle, the non-elastic deformation can result in relative sea-level changes with magnitudes of up to several tens of centimetres (or several times the barystatic value). The magnitude and spatial pattern of this non-elastic signal is sensitive to variations in both the projected ice history and regional viscosity structure, indicating the need for loading models with high spatial resolution and improved constraints on regional Earth viscosity structure to accurately simulate sea-level fingerprints in these regions. The anomalously low mantle viscosity in these regions also amplifies the glacial isostatic adjustment signal associated with glacier changes during the 20th century, causing it to be an important (and even dominant) contributor to the modelled relative sea-level changes over the 21st century.

Feature-Based Molecular Networking for the Targeted Identification of Gq-Inhibiting FR900359 Derivatives.

Both the soil bacterium Chromobacterium vaccinii and the bacterial endosymbiont Candidatus Burkholderia crenata of the plant Ardisia crenata are producers of FR900359 (FR). This cyclic depsipeptide is a potent and selective Gq protein inhibitor used extensively to investigate the intracellular signaling of G protein coupled receptors (GPCRs). In this study, the metabolomes of both FR producers were investigated and compared using feature-based molecular networking (FBMN). As a result, 30 previously unknown FR derivatives were identified, one-third being unique to C. vaccinii. Guided by MS, a novel FR derivative, FR-6 (compound 1), was isolated, and its structure unambiguously established. In a whole-cell biosensing assay based on detection of dynamic mass redistribution (DMR) as readout for Gq inhibition, FR-6 suppressed Gq signaling with micromolar potency (pIC50 = 5.56). This functional activity was confirmed in radioligand binding assays (pKi = 7.50). This work demonstrates the power of molecular networking, guiding the way to a novel Gq-inhibiting FR derivative and underlining the potency of FR as a Gq inhibitor.

Parameter importance assessment improves efficacy of machine learning methods for predicting snow avalanche sites in Leh-Manali Highway, India

Due to ongoing climate change, water mass redistribution and related hazards are getting stronger and frequent. Therefore, predicting extreme hydrological events and related hazards is one of the highest priorities in geosciences. Machine Learning (ML) methods have shown promising prospects in this venture. Every ML method requires training where we know both the output (extreme event) and input (relevant physical parameters and variables). This step is critical to the efficacy of the ML method. The usual approach is to include a wide variety of hydro-meteorological observations and physical parameters, but recent advances in ML indicate that the efficacy of ML may not improve by increasing the number of input parameters. In fact, including unimportant parameters decreases the efficacy of ML algorithms. Therefore, it is imperative that the most relevant parameters are identified prior to training. In this study, we demonstrate this concept by predicting avalanche susceptibility in Leh-Manali highway (one of the most severely affected regions in India) with and without Parameter Importance Assessment (PIA). The avalanche locations were randomly divided into two groups: 70% for training and 30% for testing. Then, based on temporal and spatial sensor data, eleven avalanche influencing parameters were considered. The Boruta algorithm, an extension of Random Forest (RF) ML method that utilizes the importance measure to rank predictors, was used and it found nine out of eleven parameters to be important. Support Vector Machine (SVM) based ML technique is used for avalanche prediction, and to be comprehensive, four different kernel functions were employed (linear, polynomial, sigmoid, and radial basis function (RBF)). The prediction accuracy for linear, polynomial, sigmoid, and RBF kernels, with all the eleven parameters were found to be 80.4%, 81.7%, 39.2%, and 85.7%, respectively. While, when using selected parameters, the prediction accuracy for linear, polynomial, sigmoid, and RBF kernels were 84.1%, 86.6%, 43.0%, and 87.8%, respectively. We also identified locations where occurrences of avalanches are most likely. We conclude that parameter selection should be considered when applying ML methods in geosciences.

Ivy leaves dry extract EA 575® mediates biased β2-adrenergic receptor signaling

Backgroundβ2-adrenergic receptor (β2-AR) stimulation activates the G protein/cAMP pathway, which is opposed by the GRK2/β-arrestin 2 pathway. The latter is undesirable in the treatment of respiratory diseases. Hypothesis/PurposeEA 575® is capable of mediating a biased β2-adrenergic signaling pathway. MethodsThe impact of the ivy leaves dry extract EA 575® on β2-adrenergic signaling was tested in a dynamic mass redistribution assay in HEK wild-type and in HEK β-arrestin knock-out cells. cAMP formation and recruitment of β-arrestin 2 were investigated using GloSensor™ and PathHunter® assays, respectively. NFκB transcriptional activity was determined in both HEK wild-type as well as HEK β-arrestin knock-out cells. ResultsEA 575® inhibits the recruitment of β-arrestin 2 and thereby enhances G protein/cAMP signaling under β2-stimulating conditions, as evidenced by a corresponding increase in cAMP formation. While β2-AR-mediated inhibition of NFκB transcriptional activity is β-arrestin-dependent, EA 575® leads to significant inhibition of NFκB transcriptional activity in β-arrestin knock-out cells and thus via a β-arrestin-independent signaling pathway. ConclusionEA 575® is the first active phytopharmaceutical ingredient for which biased β2-adrenergic activation has been described. This shift towards G protein/cAMP signaling provides the molecular basis for the clinically proven efficacy of EA 575® in the treatment of lower respiratory tract diseases. In this light, EA 575® could potentially reduce β-arrestin-mediated adverse effects in new combinatorial therapeutic approaches.

Constraints on deformation mechanisms of the Barberton Greenstone Belt from regional stratigraphic and structural data of the synorogenic Moodies Group

Understanding the deformation styles and mechanisms which affect the Barberton Greenstone Belt (BGB) contributes to our ability to interprete the dynamic evolution of Paleoarchean greenstone belts and of the continental lithosphere. A variety of actualistic and non-actualistic, in part contradictory tectonic settings and processes (including gravitational collapse, terrane accretion, foreland basin shortening, continental rifting, doubly-vergent subduction and partial convective overturn) have been proposed to explain BGB deformation at a variety of scales. We compare these models and their regional 3-D predictions with emphasis on the BGB’s youngest deformed stratigraphic unit, the Moodies Group (ca. 3.21 Ga), also adding new structural data.We find that none of the tectonic models accounts for all major structural features of the BGB nor can any model adequately explain the regionally and temporally heterogeneous distribution of deformation styles within the greenstone belt. However, the partial convective overturn model, despite some weaknesses and oversimplifications, appears to be suited best to explain the geometry, orientation and formation of the dominating structural element of the BGB, the vertically-plunging Onverwacht Anticline (OA) with its 10-km-thick fold limbs. The formation and deformation of the adjacent smaller, commonly steeply doubly-plunging synclines filled with synorogenic siliciclastic sediment of the Fig Tree and Moodies groups could be partially explained as spatial adjustments to the rise and tilting of the OA although disparate processes acting at different scales need to be considered. In comparison to this large-scale vertical redistribution of mass by several tens of km, (sub-)horizontal displacements may have played a subordinate role at greenstone-belt scale, except along the regionally highly strained southern BGB margin in Eswatini.

Evidence for differentiation of the most primitive small bodies

Context. Dynamical models of Solar System evolution have suggested that the so-called P- and D-type volatile-rich asteroids formed in the outer Solar System beyond Neptune’s orbit and may be genetically related to the Jupiter Trojans, comets, and small Kuiper belt objects (KBOs). Indeed, the spectral properties of P- and D-type asteroids resemble that of anhydrous cometary dust. Aims. We aim to gain insights into the above classes of bodies by characterizing the internal structure of a large P- and D-type asteroid. Methods. We report high-angular-resolution imaging observations of the P-type asteroid (87) Sylvia with the Very Large Telescope Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) instrument. These images were used to reconstruct the 3D shape of Sylvia. Our images together with those obtained in the past with large ground-based telescopes were used to study the dynamics of its two satellites. We also modeled Sylvia’s thermal evolution. Results. The shape of Sylvia appears flattened and elongated (a/b ~1.45; a/c ~1.84). We derive a volume-equivalent diameter of 271 ± 5 km and a low density of 1378 ± 45 kg m−3. The two satellites orbit Sylvia on circular, equatorial orbits. The oblateness of Sylvia should imply a detectable nodal precession which contrasts with the fully-Keplerian dynamics of its two satellites. This reveals an inhomogeneous internal structure, suggesting that Sylvia is differentiated. Conclusions. Sylvia’s low density and differentiated interior can be explained by partial melting and mass redistribution through water percolation. The outer shell should be composed of material similar to interplanetary dust particles (IDPs) and the core should be similar to aqueously altered IDPs or carbonaceous chondrite meteorites such as the Tagish Lake meteorite. Numerical simulations of the thermal evolution of Sylvia show that for a body of such a size, partial melting was unavoidable due to the decay of long-lived radionuclides. In addition, we show that bodies as small as 130–150 km in diameter should have followed a similar thermal evolution, while smaller objects, such as comets and the KBO Arrokoth, must have remained pristine, which is in agreement with in situ observations of these bodies. NASA Lucy mission target (617) Patroclus (diameter ≈140 km) may, however, be differentiated.

Geophysical Challenges for Future Satellite Gravity Missions: Assessing the Impact of MOCASS Mission

The GRACE/GRACE-FO satellites have observed large scale mass changes, contributing to the mass budget calculation of the hydro-and cryosphere. The scale of the observable mass changes must be in the order of 300 km or bigger to be resolved. Smaller scale glaciers and hydrologic basins significantly contribute to the closure of the water mass balance, but are not detected with the present spatial resolution of the satellite. The challenge of future satellite gravity missions is to fill this gap, providing higher temporal and spatial resolution. We assess the impact of a geodetic satellite mission carrying on board a cold atom interferometric gradiometer (MOCASS: Mass Observation with Cold Atom Sensors in Space) on the resolution of simulated geophysical phenomena, considering mass changes in the hydrosphere and cryosphere. Moreover, we consider mass redistributions due to seamounts and tectonic movements, belonging to the solid earth processes. The MOCASS type satellite is able to recover 50% smaller deglaciation rates over a mountain range as the High Mountains of Asia compared to GRACE, and to detect the mass of 60% of the cumulative number of glaciers, an improvement respect to GRACE which detects less than 20% in the same area. For seamounts a significantly smaller mass eruption could be detected with respect to GRACE, reaching a level of mass detection of a submarine basalt eruption of 1.6 109 m3. This mass corresponds to the eruption of Mount Saint Helens. The simulations demonstrate that a MOCASS type mission would significantly improve the resolution of mass changes respect to existing geodetic satellite missions.

RECOG RL01: correcting GRACE total water storage estimates for global lakes/reservoirs and earthquakes

Abstract. Observations of changes in terrestrial water storage (TWS) obtained from the satellite mission GRACE (Gravity Recovery and Climate Experiment) have frequently been used for water cycle studies and for the improvement of hydrological models by means of calibration and data assimilation. However, due to a low spatial resolution of the gravity field models, spatially localized water storage changes, such as those occurring in lakes and reservoirs, cannot properly be represented in the GRACE estimates. As surface storage changes can represent a large part of total water storage, this leads to leakage effects and results in surface water signals becoming erroneously assimilated into other water storage compartments of neighbouring model grid cells. As a consequence, a simple mass balance at grid/regional scale is not sufficient to deconvolve the impact of surface water on TWS. Furthermore, non-hydrology-related phenomena contained in the GRACE time series, such as the mass redistribution caused by major earthquakes, hamper the use of GRACE for hydrological studies in affected regions. In this paper, we present the first release (RL01) of the global correction product RECOG (REgional COrrections for GRACE), which accounts for both the surface water (lakes and reservoirs, RECOG-LR) and earthquake effects (RECOG-EQ). RECOG-LR is computed from forward-modelling surface water volume estimates derived from satellite altimetry and (optical) remote sensing and allows both a removal of these signals from GRACE and a relocation of the mass change to its origin within the outline of the lakes/reservoirs. The earthquake correction, RECOG-EQ, includes both the co-seismic and post-seismic signals of two major earthquakes with magnitudes above Mw9. We discuss that applying the correction dataset (1) reduces the GRACE signal variability by up to 75 % around major lakes and explains a large part of GRACE seasonal variations and trends, (2) avoids the introduction of spurious trends caused by leakage signals of nearby lakes when calibrating/assimilating hydrological models with GRACE, and (3) enables a clearer detection of hydrological droughts in areas affected by earthquakes. A first validation of the corrected GRACE time series using GPS-derived vertical station displacements shows a consistent improvement of the fit between GRACE and GNSS after applying the correction. Data are made available on an open-access basis via the Pangaea database (RECOG-LR: Deggim et al., 2020a, https://doi.org/10.1594/PANGAEA.921851; RECOG-EQ: Gerdener et al., 2020b, https://doi.org/10.1594/PANGAEA.921923).

Health and sustainability of glaciers in High Mountain Asia

Glaciers in High Mountain Asia generate meltwater that supports the water needs of 250 million people, but current knowledge of annual accumulation and ablation is limited to sparse field measurements biased in location and glacier size. Here, we present altitudinally-resolved specific mass balances (surface, internal, and basal combined) for 5527 glaciers in High Mountain Asia for 2000–2016, derived by correcting observed glacier thinning patterns for mass redistribution due to ice flow. We find that 41% of glaciers accumulated mass over less than 20% of their area, and only 60% ± 10% of regional annual ablation was compensated by accumulation. Even without 21st century warming, 21% ± 1% of ice volume will be lost by 2100 due to current climatic-geometric imbalance, representing a reduction in glacier ablation into rivers of 28% ± 1%. The ablation of glaciers in the Himalayas and Tien Shan was mostly unsustainable and ice volume in these regions will reduce by at least 30% by 2100. The most important and vulnerable glacier-fed river basins (Amu Darya, Indus, Syr Darya, Tarim Interior) were supplied with >50% sustainable glacier ablation but will see long-term reductions in ice mass and glacier meltwater supply regardless of the Karakoram Anomaly.

New high-quality paleomagnetic data from the Borborema Province (NE Brazil): Refinement of the APW path of Gondwana in the Early Cambrian

The Neoproterozoic-Paleozoic transition (~541 Ma) was a turning point in Earth’s history resulting in great biological changes between the microbial Precambrian life and the Ediacaran biotic revolution with the occupation of the sedimentary substrate, the dawn of biomineralization and the appearance of the earliest multicellular organisms. In parallel, this period is marked by a large plate reorganization leading to the assembly of Gondwana and by major climatic changes (extreme glacial events). Due in part to a poor paleomagnetic database for the different cratons in the Ediacarian-Cambrian times, the global paleogeography at that time remains controversial. In this study we present a new high-quality paleomagnetic pole (R = 7) for the Monteiro dyke swarm in the Borborema Province (NE Brazil) located at 18.2°S and 344.9°E (A95 = 11.7° K = 9.3). They are fine-grained hornblende dolerite dated by U-Pb on zircon at ~538 Ma. Rock magnetic data indicate that magnetite and pyrrhotite are the main remanence carriers. Positive baked-contact tests support the primary remanence obtained for these dykes (19 sites). A positive reversal test (classified C) was also obtained from the 14 sites with negative inclination and the 5 sites with positive inclination, indicating that the paleosecular variation was eliminated. Our new key pole is not consistent with the classical apparent polar wander path of the Gondwana which consists of a long track from a southern polar position at ~590 Ma to an equatorial position at ~520 Ma, and suggests instead rapid and small oscillations of the APW, after the end of the large IITPW at ca. 560 Ma. These TPWs are supposedly caused by changes in the inertia tensor of the Earth due to internal mass redistribution, related to rapid changes in subduction velocity. Links of these rapid oscillations and the timing of the Cambrian radiation could be crucial to understand the early history of animal life

Effect on Kidney Function During Gender Affirming Hormonal Treatment in Transgender Individuals

Background: Accurate interpretation of laboratory values with sex-specific reference ranges presents a challenge in transgender individuals on gender affirming hormone therapy (GAHT). Creatinine (Cr), the most common marker used for kidney function, varies significantly with body mass and composition. Both Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) equations account for sex in estimating glomerular filtration rate. GAHT can effect Cr values in 2 potential ways: 1) by causing changes in muscle mass and body fat redistribution as early as 3 months after GAHT initiation and 2) by direct effects of sex hormones on kidney function. Previous studies have shown Cr values approaching affirmed gender identity as early as 6 months when on GAHT without mention of sex steroid levels. In this study we sought to describe the changes in serum Cr after initiation of GAHT in an effort to better understand expected changes and interpretation of lab data in TG individuals. Methods: A retrospective chart analysis on all adult TG patients initiated on GAHT at our institution from January 2011 to 2020 was completed. We reviewed demographics, baseline health information, body mass index, and lab values including Cr, sex hormone levels, A1C, and fasting blood glucose. Lab values were obtained prior to GAHT, at the start of GAHT, at 3, 6, and 12 months after GAHT. Matched pair testing was conducted with sex steroid levels and Cr values in transgender men (TM) on testosterone and transgender women (TW) on estradiol in order to compare the median pre GAHT Cr to median Cr levels at 3, 6, and 12 months. Results: 84 TW with a median age of 30 and 24 TM with a median age of 23 were included for analysis. TW and TM had a low rate of existing kidney disease (4.9%, 0%), diabetes mellitus (4.8%, 0%), and hypertension (10.8%, 4.5%) respectively. TW on GAHT achieved a goal estradiol level (≥100 pg/ml) at a rate of 37.3%, 51.7%, and 71.1% and suppressed testosterone to a goal level (<60ng/ml) at a rate of 44.4%, 54.7%, and 76.5% at 3, 6, and 12 months respectively. There was no significant change in Cr values at 3 months, but significantly decreased on average by -0.07 (p<0.001) at 6 months, and by -0.09 (p<0.001) at 12 months. TM on GAHT achieved a goal testosterone level (≥240 ng/dl) at a rate of64.3%, 80.0%, and 72.3% at 3, 6, and 12 months respectively. Cr values increased significantly on average by 0.14 (p=0.036) at 3 months, by 0.21 (p=0.004) at 6 months, and by 0.15 (p=0.003) at 12 months. Conclusions: In TW on GAHT, clinicians can consider using affirmed gender Cr reference ranges as early as 6 months. Similarly in TM on GAHT, affirmed gender Cr reference ranges can be used as early at 3 months. It remains to be seen whether changes in Cr levels reflect changes in sex steroid levels or sex steroid direct effects. Additionally, research is needed to determine if change in Cr levels reflect true changes in GFR.