The Northern Thermaikos Gulf is a semi-enclosed coastal region of the Aegean Sea, characterized by anthropogenic and natural stresses such as intense industrial and agricultural activities, urban outflows, and several river discharges facing severe pollution events. The main motivation of this study is to investigate the prevailing oceanographic conditions of Northern Thermaikos Gulf, which are associated with the quality of the semi-enclosed basin's water masses. The hydrography and the hydrodynamic circulation patterns are revisited, based on the findings of a multi-platform observational study, conducted during a recent annual cycle, from June 2021 until May 2022. The observational findings are supported by a three-dimensional high-resolution hydrodynamic model (Deltf3D-Thermaikos) with updated freshwater input from all important land sources. The physical connectivity between the sub-basins of Thermaikos, the renewal of its northern coastal areas and the seawater quality are strongly related to the variability of wind-induced circulation. Northerly and southerly winds affect the spreading of the nutrient-rich riverine waters, discharged at the west coast of the gulf. The prevailing northerly winds contribute to the southward removal of the polluted sea surface and riverine waters, enhancing the cyclonic circulation around the gulf, allowing the inflow of clearer Aegean Sea Waters along the eastern coasts of the gulf. Northerlies also promote a connectivity pathway between the environmentally stressed Thessaloniki Bay (urban seafront) and the commonly less polluted southeastern coasts of the central basin. Southerlies mainly confine riverine waters in the western and northern coastal regions, weaken the renewal ability of the enclosed basins, and impose the formation of anticyclonic, mesoscale, circulation eddies in the outer and central areas.
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