Marker Placement Research Articles

Imaging Modalities for Breast Cancer: Role of the Radiologist

Breast cancer is the third most common cancer in the world after lung and colon , and overall the commonest cancer among women in India. Early detection and diagnosis help in providing early treatment to the patients thereby significantly impacting overall survival rate. The different imaging modalities at our disposal include ultrasonography, mammography and magnetic resonance imaging and computed tomography. Over and above, nowadays with emergence of breast conservative surgery for early stage cancers the role of the radiologist in performing various imaging guided breast interventions is also evolving. Imaging guided breast biopsies, marker placement, stereotactic biopsy, wire localization are some of the commonly performed procedures by breast radiologists in addition to other pain and palliation measures as described later in the article. In this review / perspective article, therefore, we try to discuss the salient features of the common imaging modalities available for breast cancer detection and staging as well as explore the emerging role of imaging guided interventions for breast cancer in this era of multidisciplinary approach.

Anatomical-Marker-Driven 3D Markerless Human Motion Capture.

Marker-based motion capture (mocap) is a conventional method used in biomechanics research to precisely analyze human movement. However, the time-consuming marker placement process and extensive post-processing limit its wider adoption. Therefore, markerless mocap systems that use deep learning to estimate 2D keypoint from images have emerged as a promising alternative, but annotation errors in training datasets used by deep learning models can affect estimation accuracy. To improve the precision of 2D keypoint annotation, we present a method that uses anatomical landmarks based on marker-based mocap. Specifically, we use multiple RGB cameras synchronized and calibrated with a marker-based mocap system to create a high-quality dataset (RRIS40) of images annotated with surface anatomical landmarks. A deep neural network is then trained to estimate these 2D anatomical landmarks and a ray-distance-based triangulation is used to calculate the 3D marker positions. We conducted extensive evaluations on our RRIS40 test set, which consists of 10 subjects performing various movements. Compared against a marker-based system, our method achieves a mean Euclidean error of 13.23 mm in 3D marker position, which is comparable to the precision of marker placement itself. By learning directly to predict anatomical keypoints from images, our method outperforms OpenCap's augmentation of 3D anatomical landmarks from triangulated wild keypoints. This highlights the potential of facilitating wider integration of markerless mocap into biomechanics research. The RRIS40 test set is made publicly available for research purposes at koonyook.github.io/rris40.

Model variations for tracking the trunk during sports testing in a motion capture lab.

As motion capture technology becomes more popular for athlete monitoring and return-to-play evaluation, it is imperative that trunk mechanics are modeled similarly across participants. The purpose of this study was to determine how adjusting marker placement at the sternum or removing potentially occluded markers for purposes of tracking the trunk segment influences trunk kinematics during gait and a drop vertical jump (DVJ). Sagittal plane trunk angles of 18 participants were computed for a Definition Model and three trunk model variations. Model variations were specifically chosen to avoid difficulties with placement of the sternum and/or thorax markers in female participants due to sports bra coverage and/or occlusion. Intraclass correlation coefficients were computed per trunk model variation to determine agreement with the Definition Model. The Mid-Sternum model, in which the xiphoid process marker was adjusted to the midpoint of the xiphoid process and jugular notch, exhibited the least discrepancies and excellent agreement with the Definition Model across both tasks. Alternatively, the No-Thorax model, in which the thorax marker was removed, exhibited the greatest kinematic differences during the DVJ and moderate to excellent agreement across both tasks. The marker set chosen to track trunk motion during dynamic tasks must include locations that can be placed similarly on all participants. Based on these findings, the xiphoid process marker may be adjusted superiorly prior to the collection of dynamic trials. The recommended model for tracking the trunk segment includes marker placements on the jugular notch, mid-sternum, and 1st and 10th thoracic spinous processes.

Assessing Accurate Placement of Non-Wire Localization Markers in Non- Palpable Breast Tumors Using Breast CT: A Technical Note

Assessing Accurate Placement of Non-Wire Localization Markers in Non- Palpable Breast Tumors Using Breast CT: A Technical Note

Clinical Study of Double Contrast-Enhanced Ultrasound Combined with Dye Method and Marker Placement to Identify and Locate Sentinel Lymph Nodes in Patients with Breast Cancer

Clinical Study of Double Contrast-Enhanced Ultrasound Combined with Dye Method and Marker Placement to Identify and Locate Sentinel Lymph Nodes in Patients with Breast Cancer

Endoscopic Ultrasound-Guided Fiducial Placement for Stereotactic Body Radiation Therapy in Patients with Pancreatic Cancer.

Accurate delivery of stereotactic body radiotherapy (SBRT) to pancreatic tumors relies on successful EUS-guided placement of fiducial markers. The aim of this study is to report the technical feasibility and safety of EUS-guided fiducial placement and to evaluate the characteristics and technical benefit of SBRT in a cohort of patients with pancreatic cancer (PC). A retrospective chart review was performed for all (n = 82) PC patients referred for EUS-guided fiducial placement by a single endosonographer at a tertiary cancer center. Data regarding EUS-related technical details, SBRT characteristics, adverse events, and continuous visibility of fiducials were recorded and analyzed. Most patients included in the study had either locally advanced disease (32 patients, 39%) or borderline resectable disease (29 patients, 35%). Eighty-two PC patients underwent the placement of 230 fiducial markers under EUS guidance. The technical success rate of the fiducial placement was 98%. No immediate EUS-related adverse events were reported. The average time to the simulation CT after fiducial placement was 3.1 days. Of the 216 fiducial markers used for the SBRT delivery, 202 fiducial markers were visible on both the simulation CT and the cone beam CT scan. A median dose of 40cGY was given to all the patients in five fractions. Of these, 41% of the patients reported no SBRT-related toxicities during the follow-up. Fatigue and nausea were the most reported SBRT-related toxicities, which were seen in 35% of the patients post-SBRT. Our results demonstrate that EUS-guided fiducial placement is safe and effective in target volume delineation, facilitating SBRT delivery in PC patients. Further clinical trials are needed to determine the SBRT-related survival benefits in patients with pancreatic cancer.

A Perspective Taking Supported AR Learning Platform with a User Study on Learning Three-View Drawing

Perspective taking has various effects on students’ learning, including the development of innovative capabilities, improved communication efficiency in distance education, and enhanced learning performances in practical tasks. Current collaboration systems often provide only a single third-person or first-person perspective and require the placement of markers on physical objects to achieve perspective alignment. These limitations restrict users’ observation and participation in the collaboration process, resulting in a less-than-ideal experience. To address this issue, a perspective taking supported augmented reality collaboration learning platform centered around a general technology course is proposed in this article. Users have the ability to view each other’s perspectives and utilize various collaboration cues, including sketches, voice, models, gestures, and gaze. In addition, a comparative study was conducted for the first time, comparing the effects of different perspective collaborations on students’ learning performance, internal motivation, collaboration experience, and intention to continue using the system. The study revealed significant improvements in learning performance when using the proposed system. Students also reported higher levels of intrinsic motivation, better collaborative experiences, and a greater willingness to continue using the proposed system. User interviews further confirmed the preference for and enjoyment of the proposed system.

Reliability, accuracy, and minimal detectable difference of a mixed concept marker set for finger kinematic evaluation

The study of finger biomechanics requires special tools for accurately recording finger joint data. A marker set to evaluate finger postures during activities of daily living is needed to understand finger biomechanics in order to improve prosthesis design and clinical interventions. The purpose of this study was to evaluate the reliability of a proposed hand marker set (the Warwick marker set) to capture finger kinematics using motion capture. The marker set consisted of the application of two and three marker clusters to the fingers of twelve participants who participated in the tests across two sessions. Calibration markers were applied using a custom palpation technique. Each participant performed a series of range of motion movements and held a set of objects. Intra and inter-session reliability was calculated as well as Standard Error of Measurement (SEM) and Minimal Detectable Difference (MDD).The findings showed varying levels of intra- and inter-session reliability, ranging from poor to excellent. The SEM and MDD values were lower for the intra-session range of motion and grasp evaluation. The reduced reliability can potentially be attributed to skin artifacts, differences in marker placement, and the inherent kinematic variability of finger motion. The proposed marker set shows potential to assess finger postures and analyse activities of daily living, primarily within the context of single session tests.

Preoperative Templating for Total Hip Arthroplasty: A Method for Calibrating Digital Radiographs Using Patient Demographics and Anthropometric Measurements.

Background Preoperative templating aids the surgeon in estimating implant size and placement. Calibration markers are used to set the correct magnification of digital images before templating. Improper marker placement or complete absence can lead to inaccuracy or an inability to calibrate images altogether. Aims This study describes a method for calibrating images using a patient's femoral head size (FHS) predicted using demographics and anthropometric data. Materials and methods A formula predicting the FHS was derived from a cohort of 507 patients who underwent hemiarthroplasty for an intracapsular fractured neck of the femur through multivariate regression analysis. A separate validation cohort (n=50) who had undergone total hip arthroplasty (THA) had postoperative radiographs calibrated using the predicted FHS and the native contralateral hip as a surrogate calibration marker. The THA femoral head implant size was subsequently measured and compared with the actual implant size selected intraoperatively. Measurements were performed by two independent assessors to determine intra- and interobserver reliability. Results Multivariate regression analyses showed four variables significantly correlated with the size of the femoral head: gender (p < 0.001), height (p < 0.001), weight (p < 0.001), and race (Asian) (p = 0.01). Using these, a regression model to predict the FHS was obtained with an R2 value of 0.65 and a standard error of 2.18 mm. The validation cohort showed that THA head implant size could be accurately measured with an average root-mean-squared error (RMSE) of 1.41 mm (SD = 0.97 mm; %RMSE = 4.7%). The implant head size was measured to be within 5%, 10%, and 15% RMSE in 57.5%, 93.0%, and 100.0% of cases, respectively. There was excellent intraobserver (R2= 0.94 and 0.95) and interobserver (R2= 0.94) reliability. Conclusions The novel method proposed and validated in this study, using a predicted FHS to calibrate digital images, provides an alternative means of templating THA for fractured neck of the femur patients, in whom external calibration markers are often absent.

Clinical evaluation of a fluoroscopic image-based laser guidance system in bone tumor surgery: A technical note.

This study presents a laser guidance system developed to enhance surgical accuracy and reduce radiation exposure in orthopedic surgeries. The system can project the actual position corresponding to the appointed position selected by the surgeon on a fluoroscopic image using a line laser and has laser projection ability to mark the corresponding point using a line laser. The surgeon does not have to perform anatomical marker placement for calibration. Three patients with bone tumors underwent surgeries using the laser guidance system, and the projection accuracy was evaluated by measuring the distance error between the appointed and laser-marking positions. The installation time, including calibration, was also assessed for clinical usability. The average projection accuracy in bone tumor surgery was 2.86mm, and the average installation time was 7min. These results demonstrate that the laser guidance system, with a projection error of <3mm, could be useful in bone tumor surgeries.

Computed tomography and fluoroscopy versus radiographic guidance for internal fixation of simulated dorsomedial-plantarolateral central tarsal bone fractures in nonracehorses.

The aim of this study was to assess screw placement in simulated dorsomedial-plantarolateral central tarsal bone (CTB) fractures using two imaging guidance techniques - computed tomography (CT) with fluoroscopy compared to digital radiography alone (DR). Experimental study. Equine cadaver hindlimbs (n = 10 pairs). One tarsus per pair was randomly assigned to have a 4.5 mm cortical screw placed across the CTB using CT and fluoroscopy (CT/F group) or digital radiography alone (DR group). Postoperative CT was performed on all limbs. Variables related to marker placement, procedure time, and screw positioning were recorded and compared using a paired t-test for dependent means (p < .05). Time for marker placement was longer for the CT/F group (p = .001), with no difference in total procedure time (p = .12). CT/F was not superior to radiography alone (p > .05) for parameters related to screw positioning. Based on the 95% CI, there was greater range in relative screw length using radiography (76.5%-91.2%) versus CT/F (78.4%-84.0%). Internal fixation of CTB fractures can be successfully performed using either technique for imaging guidance. CT and fluoroscopy did not result in faster or more accurate screw placement compared to radiographs alone, except in determining screw length. Mild adjustments in fluoroscopic or radiographic angle appeared to be a point of variability in the perception of screw placement. While CT is recommended for improved understanding of fracture configuration and surgical planning, radiographic guidance may be a suitable alternative for internal fixation of dorsomedial-plantarolateral fractures.

Shape-model scaling is more robust than linear scaling to marker placement error

When reconstructing bone geometry to calculate joint kinematics, shape-model scaling can be more accurate and repeatable than linear scaling given the same anatomical landmarks. This study perturbed anatomical landmarks from optical motion capture and determined the robustness of shape-model scaling to misplaced markers compared to a traditional approach of linear scaling. We hypothesised that shape-model scaling would be less susceptible to variance in marker positions compared to linear scaling. The positions of hip joint centres and femoral/tibial segment lengths across perturbations were compared to determine each scaling method’s range of geometric variation. The standard deviation (SD) of the hip joint centre location from the shape model had a maximum of 1.4 mm, compared to 4.2 mm for linear scaling. Femoral and tibial segments displayed SD’s of 5.4 mm and 5.2 mm when shape-model scaled, compared to 9.2 mm and 9.5 mm with linear scaling, respectively, thus supporting our hypothesis. Geometric constraints within a shape model provide robustness to marker misplacement providing potential improvements in repeatability and data exchange.

Liver stereotactic body radiation therapy without fiducial or retained ethiodized oil guidance warrants greater than 5 mm planning target volumes.

For liver stereotactic body radiation therapy (SBRT), the placement of fiducial markers or retained ethiodized oil by transarterial chemoembolisation (TACE) provides a landmark for consistent target localisation. TACE and fiducial markers are invasive procedures that harbour additional risks. We hypothesise that liver SBRT can be accurately delivered without the use of these invasive surrogate markers. We retrospectively identified 50 consecutive patients who underwent liver SBRT with respiratory motion management to a single lesion which exhibited retained ethiodized oil per prior TACE delivery. For each SBRT fraction, two manual rigid image registrations were performed by the treating physician. One using the liver contour as a surrogate for the target and second aligning only to the radio-opaque retained ethiodized oil of the treated lesion. The magnitude of the displacement vector between the two registration methods was used to assess the accuracy of target localisation if ethiodized oil was not present. For the 50 patients, a total of 244 analysable cone-beam CTs (CBCTs) were included (six CBCTs excluded due to poor ethiodized oil visualisation). Respiratory motion management techniques consisted of active breathing control for 13 and abdominal compression for 37 patients. Forty-two patients had peripheral lesions and eight had central lesions (<2 cm from left and right portal veins). The average target localisation offset between the two registration methods (i.e. liver contour vs. retained ethiodized oil alignment) for patients with a single peripheral or central liver lesion was 5.8 and 5.3 mm, respectively. Across all patients, the average change in target position exceeded 5 mm for image registration methods based on the liver contour alone versus the retained ethiodized oil region. This suggests that margins greater than 5 mm may be required for respiratory motion-managed liver SBRT treatments in patients who do not undergo prior TACE or fiducial placement.

Endoscopically placed fiducial markers for image-guided radiotherapy in preoperative gastric cancer: Technical feasibility and potential benefit.

Background and study aims Fiducial markers have demonstrated clinical value in radiotherapy in several organs, but little is known about markers in the stomach. Here, we assess the technical feasibility of endoscopic placement of markers in gastric cancer patients and their potential benefit for image-guided radiotherapy (IGRT). Patients and methods In this prospective feasibility study, 14 gastric cancer patients underwent endoscopy-guided gold (all patients) and liquid (7 patients) marker placements distributed throughout the stomach. Technical feasibility, procedure duration, and potential complications were evaluated. Assessed benefit for IGRT comprised marker visibility on acquired imaging (3-4 computed tomography [CT] scans and 19-25 cone-beam CTs [CBCTs] per patient) and lack of migration. Marker visibility was compared per marker type and location (gastroesophageal junction (i.e., junction/cardia), corpus (corpus/antrum/fundus), and pylorus). Results Of the 93 marker implantation attempts, 59 were successful, i.e., marker in stomach wall and present during entire 5-week radiotherapy course (2-6 successfully placed markers per patient), with no significant difference (Fisher's exact test; P >0.05) in success rate between gold (39/66=59%) and liquid (20/27=74%). Average procedure duration was 24.4 min (range 16-38). No procedure-related complications were reported. All successfully placed markers were visible on all CTs, with 81% visible on ≥95% of CBCTs. Five markers were poorly visible (on <75% of CBCTs), possibly due to small marker volume and peristaltic motion since all five were liquid markers located in the corpus. No migration was observed. Conclusions Endoscopic placement of fiducial markers in the stomach is technically feasible and safe. Being well visible and positionally stable, markers provide a potential benefit for IGRT.

CT-guided Transgluteal Prostate Fiducial Marker Insertion for Localized Radiation Therapy.

To Evaluate the safety and technical success of transgluteal CT-guided fiducial marker implantation into the prostate as an alternative method to transperineal and transrectal approaches. We retrospectively identified all patients who had undergone CT-guided transgluteal fiducial marker insertion between 2020 and 2022. Four patients with confirmed prostate cancer were identified. One radiologist performed all procedures via a bilateral transgluteal approach under the guidance of real-time CT-fluoroscopy. Twenty cm long pre-waxed 18G guiding needles, preloaded with smooth gold fiducial markers, were used to implant markers. Technical success was defined as the successful placement of the fiducial markers into the planned positions. The mean age of patients was 70years. The mean procedure time was 19.25 (SD: 6.75)min, and the mean total dose length product (DLP) was 801.75 (SD: 291.17) mGycm, which is compatible with the 12mSv estimated effective dose. All procedures were technically successful (100%). All patients tolerated the procedure and did not require any analgesia for pain, and there were no requests to stop or pause the procedure. Only one patient reported hematuria one day after the procedure, which required no treatment. Transgluteal CT-guided fiducial marker implantation into the prostate is an alternative method to transperineal and transrectal approaches. In this technique, the risk of septic complications is minor, and general anesthesia is not required. Thus, transgluteal CT-guided marker insertion is a feasible and well-tolerated method for image-guided radiation therapy (IGRT) in patients with prostate cancer.

Australia and New Zealand Clinical Motion Analysis Group (ANZ-CMAG) clinical practice recommendations

Clinical motion analysis involves quantitative measurement of gait patterns to identify gait anomalies that currently or have the potential to impact function, activities of daily living and participation. Clinical motion analysis services are equipped with motion capture technology and comprise specialised staff who deliver 3-dimensional motion analysis services to children and adults who present with varying levels of gait impairment. Data is then used to inform intervention recommendations to clinicians with a view to maintaining independent, functional and pain free walking (or appropriate mobility).The ANZ-CMAG (established in 2013) identified a need to establish recommendations to assist in standardising practice guidelines for both current and new clinical motion analysis services within the region. The group serves to promote collaboration between services in quality assurance processes, clinical practices, data sets and research activities. The clinical practice recommendations described in this paper cover: i) requirements for a motion analysis service (including staffing, facilities and equipment), ii) patient assessments (requirements, clinical information and data gathered, reporting and interpretation of patient data), iii) quality assurance processes (including motion capture system / biomechanical models & limitations, marker placement, data storage / record keeping, creation of normative dataset); iv) helpful resources.Better outcomes for children and adults with gait deviations is dependent upon accurate measurement and evaluation of walking and requires input from multidisciplinary clinical teams with specialist knowledge and skills. The ANZ-CMAG hopes these clinical practice recommendations are beneficial to motion analysis services with an aim to improve clinical practices, patient outcomes, and support research collaboration.

Foot Sole Contact Forces vs. Ground Contact Forces to Obtain Foot Joint Moments for In-Shoe Gait-A Preliminary Study.

In-shoe models are required to extend the clinical application of current multisegment kinetic models of the bare foot to study the effect of foot orthoses. Work to date has only addressed marker placement for reliable kinematic analyses. The purpose of this study is to address the difficulties of recording contact forces with available sensors. Ten participants walked 5 times wearing two different types of footwear by stepping on a pressure platform (ground contact forces) while wearing in-shoe pressure sensors (foot sole contact forces). Pressure data were segmented by considering contact cells' anteroposterior location, and were used to compute 3D moments at foot joints. The mean values and 95% confidence intervals were plotted for each device per shoe condition. The peak values and times of forces and moments were computed per participant and trial under each condition, and were compared using mixed-effect tests. Test-retest reliability was analyzed by means of intraclass correlation coefficients. The curve profiles from both devices were similar, with higher joint moments for the instrumented insoles at the metatarsophalangeal joint (~26%), which were lower at the ankle (~8%) and midtarsal (~15%) joints, although the differences were nonsignificant. Not considering frictional forces resulted in ~20% lower peaks at the ankle moments compared to previous studies, which employed force plates. The device affected both shoe conditions in the same way, which suggests the interchangeability of measuring joint moments with one or the other device. This hypothesis was reinforced by the intraclass correlation coefficients, which were higher for the peak values, although only moderate-to-good. In short, both considered alternatives have drawbacks. Only the instrumented in-soles provided direct information about foot contact forces, but it was incomplete (evidenced by the difference in ankle moments between devices). However, recording ground reaction forces offers the advantage of enabling the consideration of contact friction forces (using force plates in series, or combining a pressure platform and a force plate to estimate friction forces and torque), which are less invasive than instrumented insoles (which may affect subjects' gait).

Factors related to fixedness after transbronchial fiducial marker placement for image-guided proton therapy: A retrospective study

BackgroundThe usefulness of transbronchially inserted gold fiducial markers has been reported in radiation therapy and proton therapy for mobile lesions, such as lung tumors. However, there is occasional dropout of inserted markers. This retrospective study investigated the factors related to dropout of markers inserted for image-guided proton therapy (IGPT). MethodsBetween June 2013 and October 2021, 535 markers were inserted in 171 patients with lung tumors. We investigated whether marker dropout was affected by the location of marker insertion, distance between the marker and the chest wall (DMC), and difference in forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC). Marker dropout from the time of planning computed tomography (CT) to follow-up CT was also evaluated. ResultsOf the 535 inserted markers, 417 were confirmed on planning CT and 356 on follow-up CT after IGPT. Multivariate analysis revealed that marker insertion into the upper lobe and FEV1/FVC ≥70% were factors associated with total marker dropout. Marker dropout between planning CT and follow-up CT was associated with DMC, FEV1/FVC ≥70%, and planning CT performed within 4 days of marker insertion. ConclusionsMarker dropout can be minimized by inserting markers more peripherally, by considering the planned insertion location, and FEV1/FVC. Additionally, planning CT should be scheduled at least 5 days after marker insertion.

Endoscopic ultrasound-guided placement of fiducial markers for stereotactic body radiation therapy of pancreatic metastases from renal cell carcinoma.

Endoscopic ultrasound-guided placement of fiducial markers for stereotactic body radiation therapy of pancreatic metastases from renal cell carcinoma.

Can the evaluation of marker placement confidence be used as an indicator of gait kinematic variability?

Three-dimensional gait analysis is widely used for the clinical assessment of movement disorders. However, measurement error reduces the reliability of kinematic data and consequently assessment of gait deviations. The identification of high variability is associated with low reliability and those parameters should be ignored or excluded from gait data interpretation. Moreover, marker placement error has been demonstrated to be the biggest source of variability in gait analysis and may be affected by factors intrinsic to the evaluators such as the evaluator's expertise which could be appraised through his/her experience and confidence in marker placement. In the present study, we hypothesized that confidence in marker placement is correlated with kinematic variability and could potentially be used as part of a score of reliability. Therefore, we have proposed a questionnaire to evaluate qualitatively the confidence of evaluators in lower-limb marker placement. The primary aim of this study was to evaluate the reliability and validity of the presented questionnaire. The secondary objective was to test a possible relationship between marker placement confidence and kinematics variability. To do so, test-retest gait data were acquired from two different experimental protocols. One protocol included data from a cohort of 32 pathological and 24 asymptomatic subjects where gait analysis was repeated three times, involving two evaluators. A second protocol included data from a cohort of 8 asymptomatic adults with gait analysis repeated 12 times, per participant, and involving four evaluators with a wider range of experience. Results demonstrated that the questionnaire proposed is valid and reliable to evaluate qualitatively the confidence of evaluators in placing markers. Indeed, confidence scores were correlated with the actual variability of marker placement and revealed the evaluator's experience and the subjects' characteristics. However, no correlation was observed between confidence scores and kinematic variability and the formulated hypothesis was not supported.