Manifestation Of Neuroborreliosis Research Articles

Lyme Borreliosis Associated with Sensorineural Hearing Loss: A Case Report

Background: Lyme borreliosis is a tick-borne infection caused by Borrelia species. It has a geographic distribution that makes it more frequent in certain regions like like North America and Europe. It manifests in a wide range of symptoms but is often under-investigated in patients presenting with sensorineural hearing loss (SNHL). Case Report: In this report, we describe a case presenting with SNHL as a manifestation of neuroborreliosis in a female adult patient suffering from Lyme disease, with multiple metachronous symptoms, including arthritis and seizures. Lyme borreliosis (LB) was clinically diagnosed and supported by positive serologic tests, along with Babesiosis. The patient was treated with intravenous (IV) ceftriaxone and azithromycin, in addition to oral atovaquone. Improvement after 4 weeks of IV ceftriaxone was noted in all aspects, including SNHL and arthritis. Conclusion: LB is a possible, but rare, etiology of hearing impairment. It has been documented that if treatment is initiated early, improvement and even complete recovery are possible. Hence, in a patient presenting with SNHL and a high index of suspicion for LB, assessment for LB is warranted.

Peripheral facial nerve palsy as a manifestation of neuroborreliosis in children

Peripheral facial nerve palsy as a manifestation of neuroborreliosis in children

Epileptic seizure as initial and only manifestation of neuroborreliosis: case report

Epileptic seizure as initial and only manifestation of neuroborreliosis: case report

Facial palsy as an initial symptom of Lyme neuroborreliosis in an Austrian/INS; endemic area

Background: In areas endemic for Borrelia burgdorferi, facial palsy is a possible manifestation of neuroborreliosis. According to this all adult patients admitted with facial palsy to our hospital, are investigated for Lyme neuroborreliosis including CSF analysis.

Opsoclonus and multiple cranial neuropathy as a manifestation of neuroborreliosis

Opsoclonus and multiple cranial neuropathy as a manifestation of neuroborreliosis

Opsoclonus and multiple cranial neuropathy as a manifestation of neuroborreliosis

Neuroborreliosis can manifest with virtually any combination of central and peripheral neurologic symptoms, including the rare opsoclonus-myoclonus syndrome (OMS).1,–,3 In this report, we present a patient with opsoclonus without myoclonus, due to active neuroborreliosis, accompanied by a video registration. ### Case report. A previously healthy 50-year-old man consulted his general practitioner for a painful red right eye, present since 3 days, and diffuse unilateral headache since approximately 6 weeks. On physical examination, a right-sided conjunctivitis and irregularly jerking, gaze-evoked nystagmus-like conjugated movements of both eyes were noticed. One week later, the patient woke up with a right-sided drooping mouth and eyelid. He was referred to our clinic. The patient had not experienced involuntary jerky movements of his limbs, nor oscillopsia or diplopia. His headache was not accompanied by any other symptoms. The patient lived in the north of the Netherlands and had recently been on holiday in the south of Germany, both areas endemic for Lyme disease. However, he could …

Bannwarth's syndrome – A rare but important manifestation of neuroborreliosis in childhood

Bannwarth's syndrome – A rare but important manifestation of neuroborreliosis in childhood

Transverse myelitis and sixth cranial nerve palsy – Two rare presentations of neuroborreliosis

Introduction: Facial palsy and lymphocytic meningitis are the most common manifestations of neuroborreliosis in childhood. We would like to focus on two rare but important presentations of CNS borreliosis. Case 1: 13 year old boy with backache for 2 weeks and hyperesthesia in the 11th dermatom. On clinical examination there was localised pain over the fifth lumbar vertebra and reduced lumbar spine flexibility with neck stiffness. The spinal MRI showed central medullary edema from TH 7 to 11. In the CSF lymphocytic pleocytosis with intrathecal IgM-production was found. Transverse myelitis as a manifestation of CNS borreliosis was diagnosed, which was confirmed by microbiological testing. Case 2: 5 year old boy with esotropia of the left eye and double vision for 2 weeks. On neurological examination isolated palsy of the left sixth cranial nerve was found. CSF analysis showed typical finding for neuroborreliosis. Discussion: Both patients were treated with parenteral antibiotics. There was a complete and prompt resolution of the neurological symptoms. In both clinical manifestations the diagnosis of neuroborelliosis can be made by the typical laboratory results of lymphocytic pleocytosis and intrathecal IgM-production in the CSF. Early antibiotic treatment is curative with excellent prognosis for complete neurological recovery.

Thickening of the dura mater T3-T9- incidental finding or manifestation of neuroborreliosis?

Thickening of the dura mater T3-T9- incidental finding or manifestation of neuroborreliosis?

Evaluation of the polymerase chain reaction for the detection of Borrelia burgdorferi in cerebrospinal fluid of children with acute peripheral facial palsy.

Neuroborreliosis occasionally represents a diagnostic problem, especially in the early stage of the infection. The polymerase chain reaction (PCR) offers an attractive alternative to antibody testing. The aim of our study was to investigate the diagnostic potential of PCR in comparison to antibody tests in CSF of children with facial palsy. In contrast to other manifestations of neuroborreliosis, facial palsy is a well-defined clinical entity in which CSF findings allow an early distinction according to aetiology. The study included 17 children with neuroborreliosis, defined by the detection of specific IgM antibodies in CSF, and 20 children with facial palsy of unknown cause. Primers used for the nested PCR were generated from conserved sequences of the OspA-gene. Most of the cases in both subgroups have been examined within a few days after the onset of the paresis. Only in 2 out of 17 cases with neuroborreliosis could specific DNA be amplified. The PCR gave negative results in all cases of the control group. The IgM capture ELISA is superior to PCR to support the clinical diagnosis of neuroborreliosis.