An analysis of military conflicts indicates a sharp increase in maneuvering capabilities, the number of armored targets and anti-weapon capabilities. This makes us look for the possibility of increasing the effectiveness of fire weapons. The existing means of destruction in the Armed Forces of Ukraine require a significant expenditure of ammunition and the use of a large number of fire weapons, for example, to suppress a platoon stronghold, which, as a rule, will include 3-4 infantry fighting vehicles and 1 tank must involve at least artillery division of 152 mm howitzers, with a consumption of 1,440 high-explosive fragmentation shells. In addition, in the course of the gradual transition of the Armed Forces of Ukraine to the standards of NATO member countries, bringing artillery caliber standards to these standards, the development (modernization) of artillery systems, there is a need to revise combat kits, which will be used to equip promising artillery systems (complexes). When substantiating the need for the formation of new combat kits for artillery systems that are being developed (modernized), their military-economic effectiveness is assessed. In connection with the foregoing, there is a need to develop a scientific and methodological apparatus, which will assess the feasibility of making changes to the combat kits of artillery systems. The article discusses a universal methodology for assessing the military-economic effectiveness of combat systems of promising artillery systems that are being developed (modernized). The developed methodology of military-economic evaluation of the effectiveness of combat kits allows you to take into account the economic component in the development (modernization) of artillery systems (complexes). Keywords: combat set, artillery system, military-economic efficiency.