Malignant Skin Tumors Research Articles

Basal cell carcinoma with extensive cerebellar invasion: A case report and literature review

Introduction: Basal cell carcinoma (BCC) is the most common malignant skin neoplasm with an increasing incidence worldwide. Its local destructive behavior can cause invasion to the deeper construction and reach the brain parenchyma. Case Report: A 62-year-old male presented with myiasis of the occipital part of the skull with a large skin defect. Brain images showed a mass lesion in the cerebellum. The histological diagnosis, by biopsy of the skin lesion, was BCC. Conclusion: Our case was an intradural infiltration of BCC, which was difficult to diagnose on initial presentation because the lesion was covered by myiasis. It is notable that neurosurgeons and oncologists should be aware of the natural history of BCC, since it could infiltrate into the brain, mimicking a case of intracranial tumor.

Metastatic melanoma to the small bowel causing intussusception: A case report.

Introduction and importanceMelanoma is a malignant skin neoplasm with a high metastatic potential. Several reports have shown that metastatic melanoma has a predilection to metastasize to the GI tract; however, diagnosing metastatic melanoma as a cause of intussusception has been reported in only few cases with variable presentations.Case presentationWe present the case of a 48-year-old woman with a long history of metastatic melanoma who presented with recurrent enteric intussusception due to a melanoma lesion acting as a pathologic lead point despite immunotherapy treatment. We contribute the management plan, diagnostic modalities, and surgical approach of this rare form of adult intussusception in guidance of future management plans.Clinical discussionThe variability in presentation of adult intussusception makes diagnosis difficult and the lack of consensus on management and surgical strategies poses challenging hurdles. A diagnostic laparoscopy followed by reduction and resection of the intussuscepted lesion in a small surgical field is an effective and beneficial palliative procedure with favorable outcomes. Our patient developed intussusception despite receiving a trial of dual immunotherapy after chemotherapy.ConclusionIt may be insufficient to control disease even with dual immunotherapy after chemotherapy. Further studies are needed to determine the optimal surgical and oncological management in treating gastrointestinal metastasis of malignant melanoma.

Predicting Mohs surgery complexity by applying machine learning to patient demographics and tumor characteristics.

Mohs micrographic surgery (MMS) is considered the gold standard for difficult‐to‐treat malignant skin tumors, whose incidence is on the rise. Currently, there are no agreed upon classifiers to predict complex MMS procedures. Such classifiers could enable better patient scheduling, reduce staff burnout and improve patient education. Our goal was to create an accessible and interpretable classifier(s) that would predict complex MMS procedures. A retrospective study applying machine learning models to a dataset of 8644 MMS procedures to predict complex wound reconstruction and number of MMS procedure stages. Each procedure record contained preoperative data on patient demographics, estimated clinical tumor size prior to surgery (mean diameter), tumor characteristics and tumor location, and postoperative procedure outcomes included the wound reconstruction technique and the number of MMS stages performed in order to achieve tumor‐free margins. For the number of stages complexity classification model, the area under the receiver operating characteristic curve (AUROC) was 0.79 (good performance), with model accuracy of 77%, sensitivity of 71%, specificity of 77%, positive prediction value (PPV) of 14% and negative prediction value (NPV) of 98%. The results for the wound reconstruction complexity classification model were 0.84 for the AUROC (excellent performance), with model accuracy of 75%, sensitivity of 72%, specificity of 76%, PPV of 39% and NPV of 93%. The ML models we created predict the complexity of the components that comprise the MMS procedure. Using the accessible and interpretable tool we provide online, clinicians can improve the management and well‐being of their patients. Study limitation is that models are based on data generated from a single surgeon.

Microneedle Patches Integrated with Biomineralized Melanin Nanoparticles for Simultaneous Skin Tumor Photothermal Therapy and Wound Healing

AbstractUnhealed wound after malignant skin tumor resection, characterized by full‐thickness cutaneous defects, large open cavities, and incomplete tumor tissue resection are the leading cause for long recovery times, poor prognoses, and high recurrence among patients. Herein, a hyaluronic acid (HA)‐based microneedle (MN) functionalized with biomineralized melanin nanoparticles is fabricated to concurrently administer tumor photothermal therapy (PTT) and promote skin tissue regeneration. Natural melanin nanoparticles derived from cuttlefish ink (CINP) possessing antioxidative and photothermal functionalities are employed to scavenge ROS and implement PTT. Further, CINPs are encapsulated within an amorphous silica shell that served as a source of bioactive to stimulate skin tissue regeneration. Due to the physical penetration characteristics of microneedles, the obtained CINP@SiO2‐HA MNs could exert photothermal eradication of the remaining subcutaneous tumor cells to avoid recurrence and inhibit Staphylococcus aureus infection in wound beds. Moreover, benefiting from ROS‐scavenging and release, inflammatory environment can be well controlled and angiogenic gene expression can be up‐regulated for skin tissue regeneration. With requisite biofunctionality, convenient synthesis, and excellent biocompatibility, CINP@SiO2‐HA MNs accompanied with clinically feasible irradiation meet the multiple demands of tumor eradication and wound healing, holding great potential as a supplementary therapy following skin tumor resection.

Laying the groundwork for the Biobank of Rare Malignant Neoplasms at the service of the Hellenic Network of Precision Medicine on Cancer.

Biobanks constitute an integral part of precision medicine. They provide a repository of biospecimens that may be used to elucidate the pathophysiology, support diagnoses, and guide the treatment of diseases. The pilot biobank of rare malignant neoplasms has been established in the context of the Hellenic Network of Precision Medicine on Cancer and aims to enhance future clinical and/or research studies in Greece by collecting, processing, and storing rare malignant neoplasm samples with associated data. The biobank currently comprises 553 samples; 384 samples of hematopoietic and lymphoid tissue malignancies, 72 samples of pediatric brain tumors and 97 samples of malignant skin neoplasms. In this article, sample collections and their individual significance in clinical research are described in detail along with computational methods developed specifically for this project. A concise review of the Greek biobanking landscape is also delineated, in addition to recommended technologies, methodologies and protocols that were integrated during the creation of the biobank. This project is expected to re-enforce current clinical and research studies, introduce advances in clinical and genetic research and potentially aid in future targeted drug discovery. It is our belief that the future of medical research is entwined with accessible, effective, and ethical biobanking and that our project will facilitate research planning in the '-omic' era by contributing high-quality samples along with their associated data.

Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors.

Mast cell tumors (MCTs) are hematopoietic neoplasms composed of mast cells. It is highly common in dogs and is extremely important in the veterinary oncology field. It represents the third most common tumor subtype, and is the most common malignant skin tumor in dogs, corresponding to 11% of skin cancer cases. The objective of this critical review was to present the report of the 2nd Consensus meeting on the Diagnosis, Prognosis, and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors, which was organized by the Brazilian Association of Veterinary Oncology (ABROVET) in August 2021. The most recent information on cutaneous and subcutaneous mast cell tumors in dogs is presented and discussed.

A Novel Ferroptosis-Related lncRNA Prognostic Model and Immune Infiltration Features in Skin Cutaneous Melanoma

Background: Skin cutaneous melanoma (SKCM) is an aggressive malignant skin tumor. Ferroptosis is an iron-dependent cell death that may mobilize tumor-infiltrating immunity against cancer. The potential mechanism of long non-coding RNAs (lncRNAs) in ferroptosis in SKCM is not clear. In this study, the prognostic and treatment value of ferroptosis-related lncRNAs was explored in SKCM, and a prognostic model was established. Methods: We first explored the mutation state of ferroptosis-related genes in SKCM samples from The Cancer Genome Atlas database. Then, we utilized consensus clustering analysis to divide the samples into three clusters based on gene expression and evaluated their immune infiltration using gene-set enrichment analysis (GSEA) ESTIMATE and single-sample gene-set enrichment analysis (ssGSEA) algorithms. In addition, we applied univariate Cox analysis to screen prognostic lncRNAs and then validated their prognostic value by Kaplan–Meier (K-M) and transcripts per kilobase million (TPM) value analyses. Finally, we constructed an 18-ferroptosis-related lncRNA prognostic model by multivariate Cox analysis, and SKCM patients were allocated into different risk groups based on the median risk score. The prognostic value of the model was evaluated by K-M and time-dependent receiver operating characteristic (ROC) analyses. Additionally, the immunophenoscore (IPS) in different risk groups was detected. Results: The top three mutated ferroptosis genes were TP53, ACSL5, and TF. The SKCM patients in the cluster C had the highest ferroptosis-related gene expression with the richest immune infiltration. Based on the 18 prognosis-related lncRNAs, we constructed a prognostic model of SKCM patients. Patients at low risk had a better prognosis and higher IPS. Conclusion: Our findings revealed that ferroptosis-related lncRNAs were expected to become potential biomarkers and indicators of prognosis and immunotherapy treatment targets of SKCM.

Basal Cell Carcinoma

Background: Basal Cell Carcinoma (BCC) is a malignant neoplasm of non-keratinized cells in the basal layer of the epidermis, which is locally invasive, aggressive, destructive, and rarely metastasizes. BCC more commonly occurs in the elderly. Exposure to ultraviolet (UV) rays is the main risk factor for BCC, so predilection is areas of the body that are exposed to UV rays, especially the face, ears, and neck.Case presentation: The following is a case report of a 65-year-old female patient who works as a farmer. The patient was diagnosed with basal cell carcinoma (BCC) with complaints of black nodules on the face, itching, and bleeding easily. With Dermatological status obtained. The lesion ad regio Fascialis Dextra shows a solitary hyperpigmented nodule, nummular in size, well-circumscribed, and unilateral.Conclusion:Basal cell carcinoma is a malignant skin tumor originating from non-keratinizing cells in the basal layer of the epidermis.

Clinicopathological evaluation of intralesional methotrexate in different subtypes of basal cell carcinoma

Basal cell carcinoma (BCC) is the most common malignant skin tumor. While slowly growing, it can cause major skin disfigurement. Therefore, novel cosmetically acceptable treatment options, other than surgery require investigation. The aim of the study was to evaluate efficacy and safety of intralesional methotrexate (MTX) as a convenient modality for BCC treatment clinically and pathologicaly. A total of 20 patients with BCC of any clinical variant underwent intralesional MTX injection at a maximum 1mL of 25 mg/mL MTX per session. Histopathological assessments were performed before and 1month after treatment. Forty percent of patients showed >50% clinical improvement after 1-4 sessions. Intralesional MTX is a suitable and safe treatment modality for BCC and may be used as an adjuvant to surgery.

Prevalence of pathological skin-picking in dermatological patients

ObjectiveThe prevalence of pathological skin-picking (PSP) has predominantly been studied in students and the community, but not yet in dermatological patients. However, those may be at increased risk of PSP because it is often triggered by the feel or look of the skin. Thus, its prevalence among patients with a physician-diagnosed dermatological disease remains to be determined. MethodsA consecutive series of 460 adult patients attending a dermatological university outpatient clinic was administered the 8-item Skin Picking Scale-Revised (SPS-R). They also reported demographic data and rated the severity of their skin disease. The dermatologist evaluating the patient provided his/her diagnosis. ResultsPSP as defined by SPS-R scores ≥7 was reported by 121 participants (26.3%). It was significantly more frequent in patients with atopic dermatitis (AD, OR = 3.23; 95% CI: 1.95–5.68) and psoriasis (OR = 1.64; 95% CI: 1.00–2.67), but less frequent in those with malignant epithelial skin tumors (OR = 0.10; 95% CI: 0.02–0.43). PSP was not associated with female gender or younger age. ConclusionsOur findings indicate that PSP affects about one in four patients with skin disease. In particular, individuals suffering from atopic dermatitis may represent a high-risk population for PSP deserving early recognition and adequate treatment.

Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors.

Purpose: Magnetic hyperthermia is a treatment method based on eddy currents, hysteresis, and relaxation mechanisms of magnetic nanoparticles (MNPs). MNPs such as Fe3 O4 have the ability to generate heat under an alternating magnetic field. Heat sensitive liposomes (Lip) convert from lipid layer to liquid layer through heat generated by MNPs and can release drugs. Methods: In this study, different groups of doxorubicin (DOX), MNPs and liposomes were evaluated. The MNPs were synthesized by co-precipitation method. The MNPs, DOX and a combination of MNPs and DOX were efficiently loaded into the liposomes using the evaporator rotary technique. Magnetic properties, microstructure, specific absorption rate (SAR), zeta potential, loading percentage of the MNPs and DOX concentration in liposomes, in vitro drug release of liposomes were studied. Finally, the necrosis percentage of cancer cells in C57BL/6J mice bearing melanoma tumors was assessed for all groups. Results: The loading percentages of MNPs and concentration of DOX in the liposomes were 18.52 and 65% respectively. The Lip-DOX-MNPs at the buffer citrate solution, showed highly SAR as the solution temperature reached 42°C in 5 minutes. The release of DOX occurred in a pH-dependent manner. The volume of tumor in the therapeutic groups containing the MNPs significantly decreased compared to the others. Numerical analysis showed that the tumor volume in mice receiving Lip-MNPs-DOX was 9.29% that of the control and a histological examination of the tumor section showed 70% necrosis. Conclusion: The Lip-DOX-MNPs could be effective agents which reduce malignant skin tumors growth and increase cancer cell necrosis.

CLINICAL SIGNS AND TREATMENT MANAGEMENT IN MALIGNANT PROCESSES OF THE SKIN OF THE EXTERNAL NOSE

Diagnosis and treatment of malignant neoplasms of the head and neck is an urgent modern problem of oncology, as there is a steady increasing of this pathology. At the same time are untimely diagnosis and frequent recurrences take place. The purpose is to test the method of excision of the tumor of the skin of the external nose and assess its feasibility in radical surgical removal by using anemic Klein solution. Material and methods of research: 64 patients were examined with skin neoplasms that received surgical treatment options using Klein’s anematize solution at the ENT department from 2015 to 2020 years. Patients ranged in age from 28 to 65 years, 15 women and 49 men. Patients are divided into two groups depending on the morphology of the tumor. The first group — 50 (78.2%) patients with malignant skin lesions. From this sample, 17 (34%) with basal cell carcinoma of the nasal skin and 33 (66%) with squamous cell carcinoma (G1) of the nasal skin. The second group consists of 14 (21.8%) patients with melanoma of the skin of the nose and torso. Metastasis in the deep jugular chain were diagnosed in 6 (16.7%) patients from the group of patients with melanoma. Results of the study and discussion: observations of patients for 5 years showed a satisfactory quality of life of all patients with malignant skin tumors. No recurrence of nasal cancer in the first group was registered during the follow-up of patients. Among a group of patients with melanoma, 1 (7.1%) patient was diagnosed with recurrence in the visual organ and brain. Conclusions: 1. Clinically, skin cancer was non-aggressive, had a relatively slow growth and 100% of patients had no recurrence of cancer after surgery for 5 years (p<0.05). 2. Melanoma of the skin was aggressive in a year — 1 (7.1%) patient was diagnosed recurrence in the visual organ and brain. 3. The use of Klein’s solution 5 minutes before the surgery under the base of the tumor provided a pronounced hemostasis due to vasospasm and contributed to the prevention of intraoperative recurrence in 63 (98.4%) patients (p<0.05). Key words: malignant tumors, skin of the external nose, surgical treatment, recurrences.

CLINICAL-OBJECTIVE CHARACTERISTICS OF THE CONDITION OF MALIGNANT FORMATIONS OF THE SKIN

Relevance. The diagnosis of malignant neoplasms of the scalp and neck is an urgent problem of modern oncology, as there is a steady increase in this pathology. At the same time, late diagnosis and frequent recurrences remain. Objective. The purpose of the study is to determine the significance of clinical and objective characteristics of the signs of malignant neoplasms of the skin in comparison with morphological studies. Materials and methods. 110 patients with malignant skin tumors were examined: 80 (72.7%) patients with malignant neoplasms of the face and 30 (27.3%) patients with skin lesions of the body, aged 48–70 years. Of them 82 (74.5%) were men and 28 (25.5%) were women. At first differential diagnosis of skin tumors was performed on the basis of objective signs: contours, edges, color, size, ulcers, etc., and secondly by clinical symptoms: complaints of patients with tumors, pain, itching, bleeding. Results. All the patients underwent surgical treatment according to the radical program. The postoperative period proceeded without complications during the year. In addition, the immunohistochemical examination of the material was performed in 12 patients due to the need to confirm the diagnosis. The results of the morphological examination were confirmed in all patients. So, it should be determined that the clinical semiotics (diagnosis) of the examined patients in 100% is confirmed by morphological examination. Conclusion. 1. If there is a clinical suspicion to malignant skin tumor, a morphological examination should be performed in a specialized laboratory. 2. Our clinical examinations and objective signs in patients with suspected malignant skin disease were confirmed by morphological examination in 100%. 3. Knowledge of clinical objective features help in rapid detection of correct diagnosis and needed timely surgical treatment. Key words: malignant tumors, the skin of external nose and ear, clinical semiotics, and morphological diagnosis.

Cutaneous sebaceous carcinoma presenting as a fungating breast tumour

Background: Sebaceous carcinomas are rare malignant tumours which can either arise from, or differentiate into sebaceous glands. They are subclassified into ocular and extraocular subtypes and most commonly occur in the head and neck region. Tumours below the neck occur infrequently, and most commonly resemble benign skin lesions such as pyogenic granulomata and molluscum contagiosum, or malignant skin tumours like basal and squamous cell carcinomas.

Implementation of the organizational model for the prevention of malignant skin neoplasms in Moscow

<h3></h3> В статье затронуты вопросы оказания дерматоонкологической помощи населению Москвы. Предложены организационная модель оказания этого вида помощи и схема маршрутизации пациентов с новообразованиями кожи, включающая на первом этапе кабинет профилактики злокачественных новообразований кожи (ЗНК), на втором этапе — Центр неинвазивной диагностики кожи, а в случае невозможности исключить злокачественную природу опухоли — специализированное онкологическое учреждение (третий этап) Департамента здравоохранения Москвы (ДЗМ). В рамках реализации данной модели на базе МНПЦДК организована работа по обучению врачей-терапевтов правилам проведения обследования кожных покровов пациентов в целях выявления онкологических заболеваний кожи, включая дерматоскопию, в рамках медицинских осмотров и диспансеризации взрослого населения. Для врачей-дерматовенерологов кабинетов профилактики ЗНК на регулярной основе стали проводить образовательные вебинары по повышению их квалификации по дерматоонкологии; очные практические семинары «Основы дерматоскопии». Проанализирован трехлетний опыт функционирования данной модели, свидетельствующий о ее высокой эффективности: ЗНК исключены у 314,6 тыс. человек, или 85% всех обратившихся в кабинеты профилактики ЗНК. Высокая результативность работы дерматологов позволила избежать перегрузки специализированных онкологических учреждений непрофильными больными, способствуя повышению эффективности их работы. Полученный положительный опыт и разработанная модель оказания дерматоонкологической помощи могут быть масштабированы и на другие регионы России.

Prognosis and treatment of HIV-associated malignant skin tumors

<h3></h3> В последние десятилетия во всем мире отмечается неуклонный рост заболеваемости злокачественными опухолями кожи. Количество ВИЧ-инфицированных пациентов также ежегодно увеличивается. В связи с данными исследований о более агрессивном течении, повышенной встречаемости некоторых онкологических заболеваний кожи у ВИЧ-инфицированных пациентов, а также о влияния иммуносупрессивных состояний на клиническое течение новообразований кожи изучение данной проблемы является весьма актуальным и перспективным направлением в онкологии и дерматовенерологии. <h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Описание частоты встречаемости, особенностей клинического течения в лечении злокачественных опухолей кожи у ВИЧ-ассоциированных пациентов. Сбор и анализ литературы проведены на крупном иностранном агрегаторе статей www.pubmed.com, русскоязычный вариант исследований проведен на сайте www.eLibrary.ru. Основные результаты исследования<b></b> показали, что различные иммуносупрессивные состояния могут служить факторами риска развития злокачественных опухолей кожи у взрослых; среди ВИЧ-инфицированных пациентов риск развития рака кожи повышен в 3—5 раз, наиболее распространены лимфомы, меланома, саркома Капоши, плоскоклеточный и базальноклеточный раки; плоскоклеточный рак кожи при ВИЧ-инфекции манифестирует в более молодом возрасте и ассоциируются с высоким риском местного рецидива, метастазирования и смертности; базально-клеточный рак характеризуется более агрессивным течением, включая отдаленное метастазирование в отличие от пациентов с не скомпрометированным иммунитетом; меланома кожи характеризуется более неблагоприятным прогнозом и низкими показателями общей выживаемости. Сделаны выводы о том, что основой лечения злокачественных опухолей кожи, ассоциированных с ВИЧ-инфекцией, является восстановление иммунной функции с помощью антиретровирусной терапии, подавление вируса и предотвращение дополнительной иммуносупрессии. Комплексное воздействие с применением противовирусных и иммуномодулирующих препаратов на фоне противоопухолевого лечения должно быть важной частью в снижении агрессивности течения онкологических заболеваний у ВИЧ-инфицированных пациентов при наличии у них иммуносупрессии.

Nose Reconstruction Using Bilobed Flap: A Case Report

This document illustrates the formatting process for authors, who would be preparing their papers for publication in the International Journal of Scientific Advances (IJSCIA). It behooves the prospective authors the skillset, scientific or scholarly acumen and wherewithal to ensure that their manuscript contents are original and have never been submitted to other journals while under review in the IJSCIA. Background: Basal cell carcinoma (BCC) is a slow-growing, locally destructive malignant skin tumor. The nasal location is considered a high-risk feature of BCC because of its anatomical features and problems in identifying the tumor preoperatively. Surgery is the cornerstone of nasal BCC treatment and various techniques have been developed to combine full 3D tumor removal with good aesthetic and functional results. Case Presentation: We report a circular black discoloration of a 64-year-old male patient on the left side of the nose within 2 years. The patient was scheduled for surgical removal and reconstruction of the defect using a bilobed flap. The flap consists of two lobes with a common semicircular base marked around the transverse portion of the nasalis muscle and its aponeurosis. The flap then removes the skin from the triangular peninsula at the base of the defect. After removal, the flap is moved into the defect and placed with 5-0 Prolene with a simple suture. Conclusion: The bilobed flap has multipurpose in all ways. The main benefit of this flap include the similarity color and texture relative to the defect site, ease of reproducibility, low complication rates, and the ability to design it in different sizes and tissue compositions.

Management of basal cell carcinoma with excision followed by rotation advancement flap

Background: Basal cell carcinoma (BCC) is the most common malignant skin tumor and is derived from pluripotent cells in the basal layer of the epidermis. One of the BCC management options is surgery followed by a skin flap to close the wound defect. Case Illustration : We present a 43-year-old woman with a major complaint of non-healing sores on the left zygomatic region, close to the medial canthus, with frequent episodes of bleeding and itching since one year before admission. The lesion was excised and followed by histopathological examination, which revealed the BCC diagnosis with tumor-free edges. Closure of the defect with a rotation advancement flap was performed with good results. Discussion : The diagnosis of BCC in this patient was based on history taking, dermatological and histopathological examination. According to the dermatological examination, the patient presented with superficial ulcers with hyperpigmented bases, irregular margins and raised edges, partly covered by crust in the left zygomatic region, consistent with typical clinical manifestation of BCC. Histopathological findings of BCC may vary according to the subtype. However, most cases of BCCs usually have similar histological characteristics. Conclusion : The functional and cosmetic result of BCC following excision and defect closure with rotation advancement flap yielded good results with a shorter healing time. &nbsp; Keywords : basal cell carcinoma, excision, management, rotation advancement flap

Histomorphological Pattern of Malignant Skin Tumors – A Cross-sectional Study in a Teaching Hospital

Introduction: The incidence of skin cancer is increasing exponentially around the world. This study aims to analyze different malignant skin tumors concerning age pattern, gender, and site-wise distribution.&#x0D; Materials and Methods: This is a descriptive cross-sectional hospital-based study carried out in the Department of Pathology, a tertiary care center for over ten years from April 2011 to March 2021. All malignant skin tumors arising from the epidermis along with melanocytic and adnexal tumors were included in the study.&#x0D; Results: A total of 208 cases of skin malignancies among which 117 (56.3%) cases were males and 91 (43.8%) females with a male to female ratio of 1.3:1. Overall, the majority were seen in the sixth decade 49 (23.6%) with head and neck region 113 (54.3%) being the commonest site of involvement. Basal cell carcinoma 79 (38%) was the most frequent non-melanoma skin cancer followed by squamous cell carcinoma 75 (36.1%). A maximum number of basal cell carcinoma were observed in the sixth decade 19 (24.1%) whereas squamous cell carcinoma in the seventh decade 21 (28%) cases. Other skin cancers were malignant melanoma 31 (14.9%), verrucous carcinoma 13 (6.3%), trichilemmal carcinoma five (2.4%), sebaceous carcinoma two (1%), and one case each of eccrine carcinoma, malignant nodular hidradenoma, and malignant proliferating trichilemmal tumor.&#x0D; Conclusions: Skin malignancies were seen in the sixth decade with male preponderance. Overall, the head and neck region was the commonest site of involvement. Basal cell carcinoma was the most frequent non-melanoma skin cancer followed by squamous cell carcinoma.

ДОСЛІДЖЕННЯ ВИПАДКІВ РАКУ СЕРЕД ДОВГОЖИТЕЛЬОК У ЛЬВІВСЬКІЙ ОБЛАСТІ (УКРАЇНА) ПРОТЯГОМ 1991–2019 РОКАХ

Cancer is the second leading cause of death worldwide. Aim of our study was to describe the spectrum of cancer among longlivers women in Lviv region (Ukraine) from database during 1991-2019. Material and methods. We studied 444 longlivers women aged 90+ who were diagnosed of cancer, treated and followed-up. Results. 104 women (23%) were diagnosed cancer to stage I, II -142 (32%), III -71 (10%), IV -57 (13%):other malignant neoplasms of skin (38.29%), breast (9.46%), colon (6.98%) and pancreas (4.95%) cancer. Diagnosis was confirmed cytology -169 (38.1%), histology-139 (31.3%). CT and MRI were used in rare cases in older women – 11(2.5%). Half of the women (227 or 51.13%) lived beyond 1 year after diagnosis. The rest is from 1 to 13 years. The relationship between life expectancy after diagnosis of cancer and type of treatment is weak (Сramer ratio ; Pearson's criterion ). Detected that the relationship between life expectancy after diagnosis and the age of patients at the time of oncologic diagnosis is weak too (Сramer ratio ; Pearson's criterion ). The relationship between life expectancy after diagnosis and stage of cancer is strong (Сramer ratio ; Pearson's criterion ). Conclusion. Aggressive anticancer treatments are less commonly used in cancer patients aged 90+, which may be one of the reasons for poorer survival due to comorbidities and natural causes. Life expectancy has relationship on the stage of the cancer, but does not have relationship on the age of the long-lived women and the type of treatment.