Male Current Drinkers Research Articles

692Association of drinking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population

Abstract Background Thioredoxin-interacting protein (TXNIP) inhibits the activity of thioredoxin (TXN), leading to increased oxidative stress. Expression of the TXNIP gene is regulated by DNA methylation. However, no study has reported the influence of lifestyle factors on TXNIP DNA methylation. Our goal was to determine the association between drinking habits and TXNIP DNA methylation levels in the general Japanese population. Methods We conducted a cross-sectional study of 404 subjects (176 males and 228 females) participating in a health examination. Subjects were divided into non-, moderate (male: 1-39g; female: 1-19g ethanol/day) and heavy (male: ≥40g; female: ≥20g ethanol/day) drinkers based on self-reported drinking habits. We used a pyrosequencing assay to determine TXNIP DNA methylation levels in leukocytes. Results Among men, the mean TXNIP DNA methylation level in heavy drinkers (73.2%) was significantly lower than that in non- and moderate drinkers (non: 76.7%, p<0.001; moderate: 75.8%, p=0.024). In multiple linear regression analysis adjusted for confounding factors, TXNIP DNA methylation levels showed significant negative association with alcohol consumption per day and cumulative alcohol consumption in male current drinkers. Conclusions We found that heavy drinkers had TXNIP DNA hypomethylation compared to non- and moderate drinkers in men. Moreover, alcohol consumptions were also negatively associated with TXNIP DNA methylation levels in male current drinkers. Key messages Heavy drinkers had decreased levels of TXNIP DNA methylation compared to non- and moderate drinkers in men.

Alcohol Use Among U.S. Adults by Weight Status and Weight Loss Attempt: NHANES, 2011–2016

Past research examining the relationship between alcohol use and weight status has not differentiated among classes of obesity. There is limited research investigating whether adults trying to lose weight consume less alcohol. In 2018-2019, the authors analyzed 2011-2016 National Health and Nutrition Examination Survey data for nonpregnant adults aged ≥20 years with BMI ≥18.5 kg/m2. Multinomial and binomial logistic regression and linear regression were used to test associations between (1) past-year alcohol use and current weight status, differentiating among Class 1, 2, and 3 obesity, and (2) past-year weight loss attempt and alcohol use, controlling for potential confounders. Analyses were stratified by sex. Male current drinkers versus nondrinkers had lower odds of Class 3 obesity versus healthy weight (AOR=0.62, 95% CI=0.42, 0.92); female current drinkers versus nondrinkers had lower odds of Class 1 (AOR=0.67, 95% CI=0.50, 0.90), Class 2 (AOR=0.62, 95% CI=0.46, 0.83), and Class 3 (AOR=0.66, 95% CI=0.49, 0.89) obesity versus healthy weight. Among current drinkers, less frequent alcohol use was associated with higher odds of Class 1-3 obesity versus healthy weight in both sexes (p<0.05), whereas higher continued volume (heavier drinking) was associated with higher odds of Class 1-3 obesity versus healthy weight in females (p=0.049). Females reporting a weight loss attempt had higher odds of current drinking and more frequent heavy drinking. Lower frequency of alcohol use (both sexes) and higher continued volume (female adults only) are associated with higher odds of higher weight status. Female adults trying to lose weight drink more, despite guidelines suggesting reducing caloric intake for weight control.

Alcohol consumption and the risk for renal hyperfiltration in the general Chinese population.

Glomerular hyperfiltration has been considered an early marker of kidney injury in prediabetes and prehypertension. Heavy alcohol consumption remains highly prevalent and is considered a major public health problem worldwide. The degree of glomerular hyperfiltration associated with alcohol consumption remains unclear. This study was conducted in three communities in China. A total of 15 390 participants (5396 males and 9994 females) aged 40-65 years were included in the study. Glomerular hyperfiltration was defined as estimated glomerular filtration rate >97.5th percentile value of the total population. Current drinkers had a 1.51 times higher risk for developing renal hyperfiltration (RHF) as compared with never drinkers, adjusted for age, body mass index, smoking status, systolic and diastolic blood pressure, physical activity and the levels of fasting glucose, triglyceride, total cholesterol, low-density lipoprotein and high-density lipoprotein. Furthermore, heavy alcohol consumption of >210 g per week was associated with an elevated risk for RHF in a dose-dependent manner among male current drinkers. In middle-aged Chinese men, heavy alcohol intake was associated with an elevated risk for RHF. On the other hand, former drinkers or light-moderate alcohol intake did not show any increased risks for these conditions.

Noncommunicable diseases and risk factors in adult populations of several Pacific Islands: results from the WHO STEPwise approach to surveillance

Objective:To provide an overview of the prevalence of noncommunicable diseases (NCDs) and their risk factors in several Pacific island countries and territories (PICTs), in accordance with global NCD targets. Methods:For six risk factors, data for adults (aged 25–64 years) from published reports of the World Health Organization STEPwise approach to NCD surveillance, or methodologically similar surveys, were collated, age standardised and compared across fifteen PICTs. Results:In the majority of PICT populations, more than half of male current drinkers drank heavily and more than 40% of men and 20% of women were current smokers. In 10 populations, about 50% or more of women were insufficiently physically active. Prevalence of hypertension and diabetes exceeded 20% and 25%, respectively, in several populations. Near or more than half of men and women in all populations were overweight; in most, more than one‐third of both sexes were obese. Conclusions:The prevalence of NCDs and risk factors varies widely between PICTs and by sex. The evidence shows the high and alarming present and future burden of NCDs in the region. Implications:Strengthened political commitment and increased investment are urgently required to tackle the NCD crisis, successfully achieve targets and ensure continuing sustainable development in the Pacific islands.

Seroprevalence of Herpes Simplex Virus 1 and 2 in a Population-Based Cohort in Japan

BackgroundThere have been few population-based studies of the seroprevalence and correlates of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in Japan.MethodsWe enrolled a total of 1244 adults, aged 18–59 years, from a population-based cohort in southern Japan, and tested their serum samples using an ELISA kit containing HSV type-specific antigens to glycoproteins G1 and G2.ResultsThe seroprevalence of HSV-1 and HSV-2 was 55.4% and 7.4% in men and 63.3% and 9.3% in women, respectively. Overall, 4 percent of the participants (2.3% of men and 5.0% of women) were co-infected with HSV-1 and HSV-2. The seroprevalences of both HSV-1 and HSV-2 increased with age in both sexes, and were always higher among women than among men in each age bracket. The prevalence of HSV-2 infection among HSV-1 infected individuals was lower than that among uninfected individuals, both in men and women. Male current drinkers, and male and female current smokers, were more likely to be infected with HSV-1 and HSV-2, as compared to never drinkers and never smokers, respectively.ConclusionIt is hoped that the estimates produced in this study will help in understanding the burden of these infections in Japan.

Alcohol drinking pattern and subjective health in a population‐based study

Some patterns of alcohol consumption (e.g. binge drinking, drinking outside of meals) have been associated with detrimental effects on health outcomes. Subjective health provides a global assessment of health status and is a strong predictor of total mortality; however, little is known about its relationship with alcohol drinking pattern. The association between several drinking patterns (i.e. drinking intensity and frequency, frequency of intoxication, drinking outside of meals, and beverage type) and subjective health was examined in a random sample of 3586 women and men. A population-based cross-sectional study. Subjective health was assessed using the physical and mental health component summaries of the Short Form-36 health survey questionnaire. Alcohol consumption refers to the 30 days before the interview. Analysis of covariance compared gender-specific mean scores across alcohol drinking patterns. Overall, non-current drinkers reported poorer physical and mental health than life-time abstainers and current drinkers, while no consistent differences were found between life-time abstainers and current drinkers. In female current drinkers, daily drinking, beer and mixed beverage consumption were associated with better mental health. In male current drinkers, moderate alcohol consumption (2-2.9 drinks per day), wine and mixed beverage consumption were associated with better physical health. Intoxication and liquor consumption were associated with poorer mental health in women and poorer physical health in men. No consistent associations were found for drinking outside meals. Aspects of drinking pattern may affect subjective health differentially in women and men. Overall, intoxication and liquor drinking are associated with poorer self-perceived health status than regular, moderate consumption of other alcoholic beverages.

Diagnosis of alcohol dependence in epidemiological surveys: an epidemic of youthful alcohol dependence or a case of measurement error?

To review the literature on the prevalence of alcohol dependence according to age, presenting data suggesting that the increased prevalence of alcohol dependence among young adults may be inflated because of measurement error. Household surveys with random selection of respondents. General population. Survey respondents 12 years of age and older. Alcohol dependence. Data for male current drinkers show that 4.6% of adolescents (aged 12-17 years) meet criteria for past year dependence, and the rate increases to 8.5% in the 18-23 age group, decreasing thereafter. Symptom level prevalence estimates indicate that younger age groups report higher rates of tolerance and withdrawal symptoms than older age groups. Young adults may be reporting tolerance and withdrawal symptoms partly because the wording of structured interview schedules leads to confusion of binge drinking and its sequelae with physical symptoms of alcohol dependence. There is a need to examine whether young adults are confusing the sequelae of acute intoxication with alcohol withdrawal, and rapid initial tolerance with the classical tolerance reported by alcoholics. Epidemiologists and clinicians need to be cautious of the tendency of structured psychiatric interviews to classify young adults as being alcohol-dependent. It may be useful to characterize individuals who meet alcohol dependence criteria at a young age (e.g. prior to age 25 years) as manifesting a form of 'adolescent alcohol dependence', which may represent a less severe form of alcohol use disorder than that observed in adults.

Risk of death due to hepatocellular carcinoma among drinkers and ex-drinkers. Univariate analysis of JACC study data.

Hazard ratios (HR) of death due to hepatocellular carcinoma (HCC) were analyzed by gender and age strata (40-59 and 60-79) among drinkers and ex-drinkers in 66,974 eligible subjects from a a large cohort of male and female subjects aged 40-79 years, based on information about several drinking related characteristics. The HR of dying from HCC for ex-drinkers was 4 to 8 times higher than for those who had never consumed alcohol at the baseline survey. When the subjects were restricted to those without history of liver disease (LD), the HR was still high for ex-drinkers among younger males, though the difference was not statistically significant. It appeared that the earlier drinking habits were established, the higher the HR, especially for younger males without LD. Among total current drinkers, the amount ingested per occasion and the cumulative amount ingested at the baseline did not show significantly increased HRs. Among subjects without LD, larger amounts ingested per occasion and larger cumulative amount seemed to have higher HRs in older male current drinkers. Frequent drinking and later age (50 to 79) at cessation of drinking were associated with higher HRs among both genders and both age strata. After restricting the analysis to subjects without LD, many of these increased HRs remained among males. The results suggested that the association between alcohol drinking history and HR of HCC differs depending on the presence of LD. Major confounders other than age and gender associated with both drinking and HCC, e.g. smoking, hepatitis virus infection, or history of diabetes, were not considered in this analysis, and the observed associations might be confounded by any of these factors. To clarify the net association between alcohol drinking and HCC, further analysis is needed to control potential confounders, including past history of liver disease, and to consider probable effect modifiers.

Alcohol use among Australian secondary students in 1996.

This research estimates the prevalence of alcohol use among Australian secondary students in 1996 and examines trends in alcohol prevalence over a 12-year period. A national randomly selected representative sample of 434 secondary schools participated in the 1996 study. Eghty students were selected randomly from each school and completed a questionnaire anonymously. Current drinking (drinking alcohol in the week before the survey) increased with age from 17% of boys and 10% of girls aged 12 to 56% of boys and 50% of girls aged 17. Comparisons with data collected by similar surveys in 1984, 1987, 1990 and 1993 showed that while fewer 12-15-year-olds were current drinkers in 1996 than in 1984 or 1987, the 1996 proportion was no different from the 1993 proportion. In 1996, there were more hazardous drinkers among male current drinkers aged 12-15 than in any other survey period. Among 16-and 17-year-olds, there were more current drinkers in 1996 than in 1993 or 1990, and more male and female current drinkers were drinking at hazardous levels in 1996 than in 1987 and 1990. Extrapolating from the 1996 findings, nearly 424000 students aged 12-17 years were current drinkers.

Relationship Between Age and Drinking Patterns and Drinking Problems Among Japanese, Japanese‐Americans, and Caucasians

Comparing alcohol consumption patterns by age and gender among Japanese in Japan and Japanese-Americans and Caucasians in the United States, this study examined the associations between age and both heavy drinking and social problems using logistic regression for each ethnic group of male current drinkers. As reported in previous studies of Caucasians, men drink more alcohol than women, older respondents are more likely than younger ones to be abstainers, and the percentages of heavier drinkers and problem drinkers are higher among the young than among older people. Although Japanese-Americans reported consuming less alcohol than Caucasians, their drinking patterns by age were similar: among both United States populations, younger respondents are at higher risk for drinking problems than older respondents, even when alcohol consumption and sociodemographic variables are controlled by logistic regression. However, this association of age and drinking patterns and drinking problems is not universal. Japanese men consumed more alcohol and had a higher proportion of heavier drinkers in the middle age groups; the association between age and drinking problems also varied in this group. In addition to aging, sociocultural factors such as drinking norms probably account for the differences in drinking behavior among different age groups. This study may stimulate further cross-cultural comparison of drinking patterns and problems.