Main Mechanism Research Articles

Shifting equality from the margins: the Common European Asylum System and the making of trans rights in the European Union

This article investigates the role played by the main European cooperation mechanism on asylum, the Common European Asylum System, in the making of lesbian, gay, bisexual, trans and intersex rights in the European Union. Based on a one-year qualitative inquiry in Brussels and online, it shows that European Union asylum policies were a key arena for the consolidation, invention and renegotiation of European Union lesbian, gay, bisexual, trans and intersex rights, especially concerning trans recognition. This pioneering role, far from being fortuitous, was part of the conscious strategy of the lesbian, gay, bisexual, trans and intersex movement to use asylum as a ‘side door’ to the creation of a de facto recognition of ‘gender identity’ as a protected characteristic. Characterising this phenomenon as a ‘politics of interstices’ and analysing the importance of ignorance (and not just knowledge) as a tool for policy change, this article makes the case for an analysis of policymaking that acknowledges the importance of non-equality-specific arenas in the making of equality norms.

The Possible Roles of β-alanine and L-carnosine in Anti-aging.

β-alanine (BA), being a non-proteinogenic amino acid, is an important constituent of L-carnosine (LC), which is necessary for maintaining the muscle buffering capacity and preventing a loss of muscle mass associated with aging effects. BA is also very important for normal human metabolism due to the formation of a part of pantothenate, which is incorporated into coenzyme A. BA is synthesized in the liver, and its combination with histidine results in the formation of LC, which accumulates in the muscles and brain tissues and has a well-defined physiological role as a good buffer for the pH range of muscles that caused its rapidly increased popularity as ergogenic support to sports performance. The main antioxidant mechanisms of LC include reactive oxygen species (ROS) scavenging and chelation of metal ions. With age, the buffering capacity of muscles also declines due to reduced concentration of LC and sarcopenia. Moreover, LC acts as an antiglycation agent, ultimately reducing the development of degenerative diseases. LC has an anti-inflammatory effect in autoimmune diseases such as osteoarthritis. As histidine is always present in the human body in higher concentrations than BA, humans have to get BA from dietary sources to support the required amount of this critical constituent to supply the necessary amount of LC synthesis. Also, BA has other beneficial effects, such as preventing skin aging and intestinal damage, improving the stress-- fighting capability of the muscle cells, and managing an age-related decline in memory and learning. In this review, the results of a detailed analysis of the role and various beneficial properties of BA and LC from the anti-aging perspective are presented.

Network Pharmacology, Molecular Docking and Experimental Verification Revealing the Mechanism of Fule Cream against Childhood Atopic Dermatitis.

The Fule Cream (FLC) is an herbal formula widely used for the treatment of pediatric atopic dermatitis (AD), however, the main active components and functional mechanisms of FLC remain unclear. This study performed an initial exploration of the potential acting mechanisms of FLC in childhood AD treatment through analyses of an AD mouse model using network pharmacology, molecular docking technology, and RNA-seq analysis. The main bioactive ingredients and potential targets of FLC were collected from the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and SwissTargetPrediction databases. An herb-compound-target network was built using Cytoscape 3.7.2. The disease targets of pediatric AD were searched in the DisGeNET, Therapeutic Target Database (TTD), OMIM, DrugBank and GeneCards databases. The overlapping targets between the active compounds and the disease were imported into the STRING database for the construction of the protein-protein interaction (PPI) network. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of the intersection targets were performed, and molecular docking verification of the core compounds and targets was then performed using AutoDock Vina 1.1.2. The AD mouse model for experimental verification was induced by MC903. The herb-compound-target network included 415 nodes and 1990 edges. Quercetin, luteolin, beta-sitosterol, wogonin, ursolic acid, apigenin, stigmasterol, kaempferol, sitogluside and myricetin were key nodes. The targets with higher degree values were IL-4, IL-10, IL-1α, IL-1β, TNFα, CXCL8, CCL2, CXCL10, CSF2, and IL-6. GO enrichment and KEGG analyses illustrated that important biological functions involved response to extracellular stimulus, regulation of cell adhesion and migration, inflammatory response, cellular response to cytokine stimulus, and cytokine receptor binding. The signaling pathways in the FLC treatment of pediatric AD mainly involve the PI3K-Akt signaling pathway, cytokine‒cytokine receptor interaction, chemokine signaling pathway, TNF signaling pathway, and NF-κB signaling pathway. The binding energy scores of the compounds and targets indicate a good binding activity. Luteolin, quercetin, and kaempferol showed a strong binding activity with TNFα and IL-4. This study illustrates the main bioactive components and potential mechanisms of FLC in the treatment of childhood AD, and provides a basis and reference for subsequent exploration.

Concreto com gradação funcional: gradação na porosidade para o aumento da durabilidade frente à carbonatação

Abstract The present paper evaluated the potential application of the functionally graded material (FGM) concept to develop more durable concrete to carbonation, one of the main degradation mechanisms of reinforced concrete structures. Accelerated carbonation tests with controlled temperature (27 ( 2°C), CO2 concentration (3 ( 0.5%) and humidity (65 ( 5%) were carried out in homogeneous concretes and with functional gradation in which the porosity of the material was varied across the slices. For the manufacture of graded concrete specimens, concretes with water/cement ratios equal to 0.35, 0.45, and 0.55 were produced, with lower porosity (w/c = 0.35) close to the surface of the specimen. The advance of the carbonation front was evaluated after 8, 9, 10, 14, and 24 weeks of accelerated exposure, using the chemical indicator phenolphthalein. The results show that the functionally graded concrete had a carbonation coefficient (K) slightly higher than that of the concrete with a w/c ratio equal to 0.35 (1.71 and 1.54 mm.week-0.5, respectively) and much lower than concrete with water-cement ratio equal to 0.45 (2.31 mm.week-0.5) and 0.55 (3.78 mm.week-0.5). This demonstrates that functional grading can be an efficient method to increase the durability of concrete elements subject to carbonation.

Insights into the Therapeutic and Pharmacological Properties of Resveratrol as a Nutraceutical Antioxidant Polyphenol in Health Promotion and Disease Prevention.

Resveratrol (3, 5, 4'-trihydroxystilbene) is a polyphenolic derivative with herbal origin. It has attracted considerable attention in recent decades. Many studies have revealed the benefits of Resveratrol over several human disease models, including heart and neurological diseases, nephroprotective, immune regulation, antidiabetic, anti-obesity, age-related diseases, antiviral, and anticancer in experimental and clinical conditions. Recently, the antioxidant and anti-inflammatory activities of Resveratrol have been observed, and it has been shown that Resveratrol reduces inflammatory biomarkers, such as tissue degradation factor, cyclooxygenase 2, nitric oxide synthase, and interleukins. All of these activities appear to be dependent on its structural properties, such as the number and position of the hydroxyl group, which regulates oxidative stress, cell death, and inflammation. Resveratrol is well tolerated and safe even at higher pharmacological doses and desirably affects cardiovascular, neurological, and diabetic diseases. Consequently, it is plausible that Resveratrol can be regarded as a beneficial nutritional additive and a complementary drug, particularly for therapeutic applications. The present review provides an overview of currently available investigations on preventive and therapeutic characteristics and the main molecular mechanisms of Resveratrol and its potent derivatives in various diseases. Thus, this review would enhance knowledge and information about Resveratrol and encourage researchers worldwide to consider it as a pharmaceutical drug to struggle with future health crises against different human disorders.

Targeting the Main Sources of Reactive Oxygen Species Production: Possible Therapeutic Implications in Chronic Pain.

Humans have long been combating chronic pain. In clinical practice, opioids are firstchoice analgesics, but long-term use of these drugs can lead to serious adverse reactions. Finding new, safe and effective pain relievers that are useful treatments for chronic pain is an urgent medical need. Based on accumulating evidence from numerous studies, excess reactive oxygen species (ROS) contribute to the development and maintenance of chronic pain. Some antioxidants are potentially beneficial analgesics in the clinic, but ROS-dependent pathways are completely inhibited only by scavenging ROS directly targeting cellular or subcellular sites. Unfortunately, current antioxidant treatments do not achieve this effect. Furthermore, some antioxidants interfere with physiological redox signaling pathways and fail to reverse oxidative damage. Therefore, the key upstream processes and mechanisms of ROS production that lead to chronic pain in vivo must be identified to discover potential therapeutic targets related to the pathways that control ROS production in vivo. In this review, we summarize the sites and pathways involved in analgesia based on the three main mechanisms by which ROS are generated in vivo, discuss the preclinical evidence for the therapeutic potential of targeting these pathways in chronic pain, note the shortcomings of current research and highlight possible future research directions to provide new targets and evidence for the development of clinical analgesics.

Comparison of fracture behavior of set concretes based on natural and crushed aggregates

Abstract The studies were carried out to diagnose the effects of coarse aggregate type on the mechanical behavior of plain concretes under incremental loading. During the studies mechanical parameters including compressive strength (f cm) and splitting tensile strength (f ctm), as well as fracture parameters involving critical stress intensity factor ( K Ic S ) and critical crack tip opening displacement (CTOD c) were evaluated. The aim of the study was to accurately assess the impact of the type of mineral aggregates on the fracture toughness of ordinary concretes. In order to obtain the most reliable comparison of the obtained test results, mineral aggregates, both natural and crushed, from the same geographic area (most commonly used in plain concretes) were used in the experiments. Hence, crushed aggregates covered: basalt (BA), granite (GT) and limestone (LM) and natural pebble gravel aggregate (GL) were used in the concrete mixtures. For better understanding of the crack initiation and propagation in concretes with different coarse aggregates, a macroscopic failure surfaces examination of the tested beams is also presented. Both of the analyzed fracture mechanics parameters, i.e. K Ic S and CTOD c increased significantly in the case of concretes which were manufactured based on crushed aggregates. They amounted in comparison to concrete based on gravel aggregate at levels ranging from 20% for concrete with limestone aggregate, to over 30% for concrete with a granite aggregate, and to as much as over 70% for concrete with basalt aggregate. The fracture process in each series of concrete was: quasi-plastic in the case of gravel concrete, semi-brittle in the case of limestone concrete, and clearly brittle in the case of the concretes based on granite and basalt aggregate. The results obtained help to explain how the coarse aggregate type affects the strength parameters and fracture toughness at bending.

Dynamics of drug delivery determines course of evolution of antibiotic responses in bacteria.

To adjust to sudden shifts in conditions, microbes possess regulated genetic mechanisms that sense environmental challenges and induce the appropriate responses. The initial evolution of microbes in new environments is thought to be driven by regulatory mutations, but it is not clear how this evolution is affected by how quickly conditions change (i.e. dynamics). Here, we perform experimental evolution on continuous cultures of tetracycline resistant E. coli in different dynamical regimens of drug administration. We find that cultures evolved under gradually increasing drug concentrations acquire fine- tuning mutations adapting an alternative efflux pump to tetracycline. However, cultures that are instead periodically exposed to large drug doses evolve transposon insertions resulting in loss of regulation of the main mechanism of tetracycline resistance. A mathematical model shows that sudden drug exposures overwhelm regulated responses, which cannot induce resistance fast enough. These results help explain the frequent loss of regulation of resistance in clinical pathogens.

Emotional changes and outcomes in psychotherapy: A systematic review and meta-analysis.

This systematic review and meta-analysis summarize current knowledge on emotional change processes and mechanisms and their relationship with outcomes in psychotherapy. We reviewed the main change processes and mechanisms in the literature and conducted meta-analyses of process/mechanism-outcome associations whenever methodologically feasible. A total of 121 studies, based on 92 unique samples, met criteria for inclusion. Of these, 85 studies could be subjected to meta-analysis. The emotional change processes and mechanisms most robustly related to improvement were fear habituation across sessions in exposure-based treatment of anxiety disorders (r = .38), experiencing in psychotherapy for depression (r = .44), and emotion regulation in psychotherapies for patients with various anxiety disorders (r = .37). Common methodological problems were that studies often did not ascertain representative estimates of the processes under investigation, determine if changes in processes and mechanisms temporally preceded outcomes, disentangle effects at the within- and between-client levels, or assess contributions of therapists and clients to a given process. The present study has identified a number of emotional processes and mechanisms associated with outcome in psychotherapy, most notably fear habituation, emotion regulation, and experiencing. A common denominator between these appears to be the habitual reorganization of maladaptive emotional perception. We view this as a central pan-theoretical change mechanism, the essence of which appears to be increased differentiation between external triggers and one's own affective responses, which facilitates tolerance for affective arousals and leads to improved capacity for adaptive meaning-making in emotion-eliciting situations. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Thermal Treatment Effects on Structure and Mechanical Properties of Polybutylene Terephthalate and Epoxy Resin Composites Reinforced with Glass Fiber.

In this study, two types of composites, polybutylene terephthalate (PBT) and epoxy resin (ER), reinforced with 20% of glass fiber (GF) are used as the comparative research objects. Their mechanical properties after thermal aging at 85~145 °C are evaluated by tensile strength and fracture morphology analysis. The results show that the composites have similar aging laws. The tensile strength of GF/PBT and GF/ER decrease gradually with the increase of aging temperature, while their elastic moduli are independent of the thermal treatment temperature. Scanning electron microscopy study of the fracture surface shows that separation of glass fiber from PBT and ER matrix becomes more obvious at higher aging temperature. The fibers on the matrix surface appear clear and smooth, and the whole pulled out GFs can be observed. As a main mechanical strength degradation mechanism, the deterioration of interface adhesion between the matrix and GF is discussed. A large difference in coefficients of thermal expansion of the matrix and GF is a main factor of the mechanical degradation.

Topographic variation and fluid flow characteristics in rough contact interface

Understanding flow characteristics of fluid near rough contact is important for the design of fluid-based lubrication and basic of tribology physics. In this study, the spreading and seepage processes of anhydrous ethanol in the interface between glass and rough PDMS are observed by a homemade optical in-situ tester. Digital image processing technology and numerical simulation software are adapted to identify and extract the topological properties of interface and thin fluid flow characteristics. Particular attention is paid to the dynamic evolution of the contact interface morphology under different stresses, the distribution of microchannels in the interface, the spreading characteristics of the fluid in contact interface, as well as the mechanical driving mechanism. Original surface morphology and the contact stress have a significant impact on the interface topography and the distribution of interfacial microchannels, which shows that the feature lengths of the microchannels, the spreading area and the spreading rate of the fluid are inversely proportional to the load. And the flow path of the fluid in the interface is mainly divided into three stages: along the wall of the island, generating liquid bridges, and moving from the tip side to the root side in the wedge-shaped channel. The main mechanical mechanism of liquid flow in the interface is the equilibrium between the capillary force that drives the liquid spreading and viscous resistance of solid wall to liquid. In addition, the phenomenon of “trapped air” occurs during the flow process due to the irregular characteristics of the microchannel. This study lays a certain theoretical foundation for the research of microscopic flow behavior of the liquid in the rough contact interface, the friction and lubrication of the mechanical system, and the sealing mechanism.

Establishing the Main Mechanisms for the Accounting Information Governance: Delphi study with accounting experts

This study aims to identify the main mechanisms of Accounting Information Governance. The Delphi method was applied in three stages with accounting experts to evaluate a set of mechanisms for managing accounting information. As a result, a ranking of priority mechanisms is presented, which indicates a list of necessary conditions for better data and information management. Such evidence could be useful for both the practice of accounting and for the training of future professionals who need to be able to face the challenges related to the impact of new technologies and the increasing volume of data and information. In terms of Information Governance, this study adds field evidence to the remaining gaps on this subject regarding the identification of the best mechanisms for using data and information and creating value.

Affective and Cognitive Impairments in Rodent Models of Diabetes.

Diabetes and related acute and long-term complications have a profound impact on cognitive, emotional, and social behavior, suggesting that the central nervous system (CNS) is a crucial substrate for diabetic complications. When anxiety, depression, and cognitive deficits occur in diabetic patients, the symptoms and complications related to the disease worsen, contributing to lower quality of life while increasing health care costs and mortality. Experimental models of diabetes in rodents are a fundamental and valuable tool for improving our understanding of the mechanisms underlying the close and reciprocal link between diabetes and CNS alterations, including the development of affective and cognitive disorders. Such models must reproduce the different components of this pathological condition in humans and, therefore, must be associated with affective and cognitive behavioral alterations. Beyond tight glycemic control, there are currently no specific therapies for neuropsychiatric comorbidities associated with diabetes; animal models are, therefore, essential for the development of adequate therapies. To our knowledge, there is currently no review article that summarizes changes in affective and cognitive behavior in the most common models of diabetes in rodents. Therefore, in this review, we have reported the main evidence on the alterations of affective and cognitive behavior in the different models of diabetes in rodents, the main mechanisms underlying these comorbidities, and the applicable therapeutic strategy.

Electronic governance in EU member states and candidate countries (using the exampleS of Poland and Ukraine): comparative legal analysis

The article addresses the issue of further improvement and development of Electronic Governance in Ukraine through the analysis of experience gained by various countries. It has been established that Electronic Governance currently plays a pivotal role in the development of society, which necessitates the need for superior and effective improvement of this sphere to ensure the maximum level of its development and support for society. Comprehensive utilization of information technology is the main mechanism in achieving this goal, as it can meet the needs of society at the highest level. However, the further development and improvement of Electronic Governance in Ukraine is currently hindered by the conditions in which the country has found itself due to the war. These conditions necessitate the search for fundamentally new solutions and approaches related to the most effective use of information resources, and the provision of effective, efficient and high-quality support and assistance for society. Efforts are currently focused on finding the optimal solution for the operation, improvement and future effective development of Electronic Governance. For Ukraine, this is the path it must travel from the idea of transformational changes in the field of information technology and resources to the gradual alignment of Electronic Governance with European standards. This path involves declaring this direction as a top priority at the highest level. The introduction of Electronic Governance as a form of organization of public administration began in Ukraine a few years ago, and has been gaining increasing public support.Analysis of the main foreign initiatives and practices in this regard provides evidence of an above-average level of development of Electronic Governance in the countries of the European Union and other states, which enables the rapid and efficient fulfilment of public needs. At the same time, it has been established that the most effective (in the context of improving electronic governance) has been Poland, which has already fully established its Electronic Government, operating efficiently and providing various electronic services to society. This system is transparent, flexible and convenient. It allows users to save time and avoid unnecessary bureaucratic procedures, and society now has easier access to the necessary information. It has been established that improving Electronic Governance in Ukraine by drawing on Poland’s experience in this regard has the potential to modernize public administration and, on a practical level, provide more opportunities for direct access to information. This will allow for the implementation of new initiatives, including the digitalization of the country, democratization of society, and achieving goals of sustainable development.

Анализ действующей модели налогообложения доходов физических лиц в Российской Федерации

The article is devoted to the main instruments of tax incentives for investment activities in the Russian Federation; the analysis of the main mechanisms of tax incentives for investment activity is given; the instruments of tax incentives for investment activities in foreign countries are analyzed, ways of improvement are proposed within the framework of state support for tax incentives for investment activities

Decontamination of tetracycline from aqueous solution using activated carbon/Fe3O4/ZIF-8 nanocomposite adsorbent

Decontamination of tetracycline from aqueous solution using activated carbon/Fe3O4/ZIF-8 nanocomposite adsorbent

Migration and Knowledge Diffusion: The Effect of Returning Refugees on Export Performance in the Former Yugoslavia

Abstract During the early 1990s, Germany offered temporary protection to 700,000 Yugoslavian refugees fleeing war. By 2000, many had been repatriated. We exploit this natural experiment to investigate the role of returning migrants in boosting export performance upon their return. Using confidential German administrative data, we find that industries with 10% more returning refugees exhibit larger exports between the pre- and postwar periods by 1% to 1.6%. We use exogenous allocation rules for asylum seekers within Germany as an instrument to deal with endogeneity concerns. We show evidence pointing to productivity shifts as the main mechanism behind our results. Consistently, we find our results are driven by refugees in occupations more likely to transfer knowledge, technologies, and best practices.

Growth of multiferroic γ-BaFe2O4 thin films by Pulsed Electron Deposition technique

Growth of multiferroic γ-BaFe2O4 thin films by Pulsed Electron Deposition technique

A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin-induced hepatotoxicity in mice.

Cantharidin (CTD) is a widely used anticancer compound, but its clinical use is mainly limited due to hepatotoxicity. Ginsenoside Rb1 (GRb1) shows potential hepatoprotective effects. Nonetheless, the protective effect and underlying mechanism of GRb1 against CTD-induced hepatotoxicity in mice have not been investigated. This study aims to elucidate the effect and mechanism of GRb1 on CTD-induced hepatotoxicity using network pharmacology and in vivo experiments. Network pharmacology studies have shown that 263 targetswere the main mechanisms by which GRb1 alleviates CTD-induced hepatotoxicity. KEGG enrichment analysis revealed that 75 hub genes were mainly enriched in TNF, IL-17 and apoptosis signalling pathways. Molecular docking analysis showed that GRb1 exhibited high affinity with Akt1, Tnf, Il6, Bcl2 and Caspase3. In addition, results from animal studies demonstrated that GRb1 could ameliorate CTD-induced hepatotoxicity by inhibiting protein expression of Caspase-3, Caspase-8, Bcl-2/Bax, GRP78, ATF6, ATF4, CHOP, IRE1α and PERK. This research revealed the mechanism of GRb1 against CTD-induced hepatotoxicity by inhibiting apoptosis and endoplasmic reticulum stress (ERS) and it may provide a scientific rationale for the potential use of GRb1 in the treatment of hepatotoxicity induced by CTD.

Perspectives About Ascorbic Acid to Treat Inflammatory Bowel Diseases.

It is known that reactive oxygen species cause abnormal immune responses in the gut during inflammatory bowel diseases (IBD). Therefore, oxidative stress has been theorized as an agent of IBD development and antioxidant compounds such as vitamin C (L-ascorbic acid) have been studied as a new tool to treat IBD. Therefore, the potential of vitamin C to treat IBD was reviewed here as a critical discussion about this field and guide future research. Indeed, some preclinical studies have shown the beneficial effects of vitamin C in models of ulcerative colitis in mice and clinical and experimental findings have shown that deficiency in this vitamin is associated with the development of IBD and its worsening. The main mechanisms that may be involved in the activity of ascorbic acid in IBD include its well-established role as an antioxidant, but also others diversified actions. However, some experimental studies employed high doses of vitamin C and most of them did not perform dose-response curves and neither determined the minimum effective dose nor the ED50. Allometric extrapolations were also not made. Also, clinical studies on the subject are still in their infancy. Therefore, it is suggested that the research agenda in this matter covers experimental studies that assess the effective, safe, and translational doses, as well as the appropriate administration route and its action mechanism. After that, robust clinical trials to increase knowledge about the role of ascorbic acid deficiency in IBD patients and the effects of their supplementation in these patients can be encouraged.