Main Events Research Articles

A Case of Stevens-Johnson Syndrome Induced by Selpercatinib.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are fatal adverse skin reactions characterized by high fever, epidermal detachment, and mucositis. Selpercatinib is a highly selective inhibitor of tyrosine kinase, rearranged during transfection (RET), and is the first targeted therapy for solid tumors with RET gene alteration. The main adverse events of selpercatinib include hypertension, liver dysfunction, diarrhea, and QT prolongation on electrocardiograms. We present the case of 50-year-old male with medullary thyroid carcinoma who was treated with selpercatinib. On the 12th day of the treatment, he developed widespread erythema, which resulted in a referral to our department. Physical examination revealed disseminated erythematous macules, conjunctival congestion, and bloody crusting of the lips, and histopathological examination showed single-cell necrosis in epidermis. Based on these findings, he was diagnosed with SJS. After the discontinuation of selpercatinib and systemic administration of corticosteroids, his symptoms were improved. The patient showed positivity for selpercatinib in drug lymphocyte stimulation test, suggesting the diagnosis of SJS induced by selpercatinib. To the best of our knowledge, this is the first report of SJS caused by selpercatinib. We herein present and discuss this case to raise awareness.

Event schemas revisited – a few comments on Radden and Dirven (2007)

The aim of the paper is to discuss a few points of Radden & Dirven’s (2007) proposal regarding the main event schemas and their formal representations in the grammar of Modern English. It is argued that some of R&D’s proposals, such as the inventory of participant roles and the ordering of the “worlds” presented in their monograph should be modified while others require more serious revisions and/or extensions. In particular, it is suggested that schemas representing bodily and complex cognitive states should be added to the Psychological World and the number of the worlds should be extended to include the Social World with its own set of event schemas based on the experience of verbal communication.

Genesis of the large Hebaoshan gold deposit, Southeast China: Constraints from in situ U-Pb dating of hydrothermal apatite and monazite and geochemistry of pyrite and carbonates

The Cathaysia Block in southeastern China hosts significant lode gold deposits. Similar to other metamorphic terrains, these deposits formed through prolonged infiltration of compositionally diverse hydrothermal fluids. However, the connections between gold mineralization and regional tectonics, magmatism, and metamorphism remain elusive due to insufficient constraints on mineralization ages. Here, we present new U-Pb age data on hydrothermal apatite and monazite, combined with trace element and isotope analyses of multiple pyrite and carbonate generations, from the large Hebaoshan gold deposit (41.5 t Au) in the Cathaysia Block. These new data refine the metallogenic model for this important ore deposit in South China. Two distinct mineralization events are recognized: (1) low-grade Mineralization Event I, characterized by quartz‒carbonate‒pyrite veins, and (2) the main Mineralization Event II, marked by quartz‒carbonate‒sulfide‒hematite veins. Hydrothermal apatite texturally intergrown with pyrite from Event I yielded a U-Pb age of 395.3 ± 5.7 Ma, coinciding with host rock deformation, revealing a previously unrecognized late-stage hydrothermal event during the early Paleozoic orogeny. In contrast, hydrothermal monazite coexisting with auriferous sulfides in Event II veins yielded a significantly younger U-Pb age of 231.6 ± 2.6 Ma, representing the timing of the main gold mineralization. Pyrite from Event I (Py1) is enriched in Co and Ni, whereas Py2 and Py3 from Event II show elevated As concentrations. These chemical variations, attributed to distinct physicochemical conditions (primarily temperature) of the hydrothermal fluids, indicate higher formation temperatures for Event I than Event II. Carbonates from Event I exhibit insignificant Eu anomalies, suggesting precipitation under reduced conditions with dominant Eu2+. Conversely, Event II carbonates display positive Eu anomalies, indicative of crystallization from more oxidizing fluids. The main gold mineralization at Hebaoshan (ca. 232 Ma) predated granite emplacement in the region by >200 m.y., precluding their genetic link. Integrating our results with existing data, we propose that the Early Devonian and Late Triassic mineralization events at Hebaoshan correlate with regional metamorphism, deformation, and fluid circulation during the early Paleozoic and Indosinian orogenesis. Both events exhibit hallmark features of orogenic-type gold deposits. This study underscores the necessity of acquiring precise geochronological and geochemical data within robust geological and petrographic frameworks during early research stages. Such an approach ensures accurate determination of geological settings and the establishment of reliable metallogenic models for complex lode gold systems.

Identification of novel hub gene and biological pathways associated with ferroptosis in In-Stent restenosis.

Identification of novel hub gene and biological pathways associated with ferroptosis in In-Stent restenosis.

Spinal cord injury repair based on drug and cell delivery: From remodeling microenvironment to relay connection formation.

Spinal cord injury repair based on drug and cell delivery: From remodeling microenvironment to relay connection formation.

PbrBGAL6 promotes pollen tube growth by influencing apical pectin level in Pyrus bretschneideri

Backgroundβ-galactosidase (BGAL), which is an important cell wall-degrading enzyme, participates in various biological processes, but its effects on pollen tube growth (PTG) remain unclear.ResultsWe identified 12 PbrBGAL genes (named PbrBGAL1–12) in the pear (Pyrus bretschneideri) genome. PbrBGAL members, containing three conserved domains and two enzyme active sites, were grouped into six subclasses. They were distributed in seven chromosomes, with dispersed duplication revealed as the main replication event. PbrBGAL genes contained 1 to 24 exons and 0 to 23 introns, with exon/intron structure mostly conserved within each subclass except for subclass E. Analyses of tissue-specific expression indicated that only PbrBGAL6 was highly expressed specifically in anther and pollen, with decreasing expression levels during PTG. The effective inhibition of PbrBGAL6 expression using antisense oligodeoxynucleotide technology dramatically decreased BGAL enzymatic activity, promoted PTG and increased cytoplasmic leakage and tip widths. Furthermore, suppressing PbrBGAL6 transcription decreased the apical total and methylated pectin contents in pollen tubes by significantly increasing transcription of PbrPME11, PbrPG14, PbrPG20, PbrPG21 and PbrPG24.ConclusionsWe identified 12 PbrBGAL genes in the pear genome, of which PbrBGAL6 precisely modulates the apical pectin content to mediate pear PTG through its effects on PbrPME11 and PbrPGs expression. This study provides direct evidence of the involvement of BGAL in the regulation of polar PTG.

Climate Effects on Phenology of Two Deciduous Forest Species Across Southern Europe

Monitoring vegetation phenology is crucial for understanding how plants respond to climate change and how the latter affects the role of vegetated ecosystems in biosphere cycles. It has been reported that the growing season has been extended, leading to an increase in global terrestrial productivity, but not much attention has been given to how different climatic variables affect specific tree species’ phenology. This study focuses on the main phenological events (SOS, Start Of Season; EOS, End Of Season; and LOS, Length Of Season) of two deciduous species (Fagus sylvatica L. and Castanea sativa Mill.) and the effects of temperature and precipitation on them. The analysis concerns a 23-year period (2000–2022) of various sites across southern Europe. The dates for each phenological event are estimated based on NDVI timeseries from MODIS satellite sensor. Both species show an elongation of their growing season, with SOS occurring 2.09 and 1.63 days/decade earlier and EOS 2.97 and 3.03 days/decade later for Fagus sylvatica and Castanea sativa, respectively, with this trend appearing more intense at lower altitudes. Temperature seems to be the major driver for these changes for both species, with higher temperatures before each phenological event leading to earlier SOS and delayed EOS. The effects of precipitation are less homogenous, showing different trends between sites and species.

Military art of Kazakhs in the period of Kenesary Kasymov’s movement

This article studies the history of military art of Kazakhs in the period of national liberation movement under the leadership of khan Kenesary Kasymov. The protest of the Kazakh people under the leadership of Sultans Sarzhan (1824‒1836) and Kenesarу (1837‒1847) Kasymovs is one of the most large-scale military and polit-ical events of the first half of the XIX century not only in the history of Kazakhstan, but also in the whole Eurasia. In this movement, which lasted for more than 20 years (1824‒1847), the military talent of Kenesary, the grandson of Abylai Khan, was especially bright. Military art and weaponry are of great interest, as they reflect not only the level of technical achievements, but also the specifics of socio-economic and socio-political development of society, its military-theoretical thoughts. This article studies the topic of armament and military equipment of the Kazakhs, some tactics used by the rebels are also considered. Further, the arti-cle analyzes the peculiarities of the military art of the Kazakh people in the first half of the 19th century. By means of studying the armament and tactics of Kazakh warriors it is possible to trace the peculiarities of the state system and its structure. The paper shows the main events of military actions in the period from 1824 to 1847 in chronological sequence and military traditions. The appeal to military history and art has important scientific and practical significance. From time immemorial, our ancestors defended their native land at the cost of their lives, defended the independence and territorial integrity of our state. They bequeathed us a rich legacy that we are obliged to cherish and protect. In protecting our independence, we must ensure the national and military security of the country. Therefore, an appeal to the experience of the military art of our ances-tors, its research is necessary for the formation of a scientifically based approach to the study of military his-tory, ideological and patriotic education of the younger generation. The study of the historical experience of the military past of the Kazakhs in the XIX century shows that the nomads had a high level of military art. This statement is proved by the fact that the struggle of the tsarist troops against the Kazakh sultans of Sarzhan (1824‒1836) Kenesary (1837‒1847) Kasymovs did not achieve the main goal— the capture of the Kazakh sultans. Sarzhan Kasymov died at the hands of the ruler of Kokand, and Kenesary— Kyrgyz manaps. Numerous well-armed punitive detachments were sent against the rebels, but none of them managed to capture the leaders of the uprising and stop the rebellion. Excellent possession of weapons, knowledge and use of their own military tactics, strict discipline demonstrate the high level of military art of the nomads

The History of Sports Medicine

Sports medicine has developed as a specific field dedicated to the prevention, disease, and restoration of sports-accompanying harms. Its inceptions may be traced back to old civilizations, placing Greek and Roman physicians, in the way that Galen, stressed exercise and tangible preparation for claiming health. During the Renaissance, refreshed interest in cruel plant structure influenced a more exploratory approach to sports-connected harms. However, it was not until the late 19th and early 20th a period that sports medicines arose as additional healing punishment, driven by progress in agile depiction and harm stop. The 20th century endorsed significant growth, containing bureaucratic rules of loyal sports medicine organizations, research in biomechanics, and changes in both surgical and non-surgical situations. The launch of restoration programs, physiotherapy, and leading image techniques further transformed the field. The unification of sports medicine experts in main worldwide playful events emphasized the increasing significance of the regimen in guaranteeing player safety and peak performance. In the up-to-date term, mechanics progress, educational situations, and personalized preparation programs have extended the outlook of sports medicine. The inclusion of wearable science, depiction, and artificial intelligence-compelled analysis persists in shaping the field’s future. Additionally, the growing devoted effort to something harm prevention, improvement addition, and insane energy in sports focal points to the developing act of sports medicine in modern healthcare. As the regimen progresses, integrative cooperation with physicians, physiotherapists, nutritionists, and sports physicists debris essential for promoting agile endurance and overall prosperity.

Memory and Narratives of the Second World War in Polish Public Opinion (2000–2020)

In Polish public opinion Poland’s participation in the World War II remains one of the most important events in Polish history of the 20th century. However, largely due to the influence of historical politics, collective memory and public opinion undergone significant revision in assessments of the main events and the role of historical figures during this war. The main trend was a predominantly negative interpretation of Polish-Soviet relations across the entire spectrum of events: from the moving in of Soviet troops on the territory of western Belarus and Ukraine on September 17, 1939, to the liberation of German-occupied Poland by the Red Army in 1944–1945. In practice, this led to the revision of holiday dates, the dismantling of monuments to the Red Army soldiers, and equating of Nazi Germany’s and the USSR’s policies toward the Polish people.

A Cox's hazard model for new development of medication overuse headache in pure chronic migraine patients under migraine prophylaxis.

Medication Overuse Headache (MOH) occurrence during migraine preventive therapy is poorly known. The present study aims at identifying the rate and factors influencing MOH development in patients with Chronic Migraine (CM). Patients with a diagnosis of CM without MOH were consecutively recruited and followed at least three times for 1year under preventive therapy. The number of headache days and the use of acute medication were recorded; the occurrence of MOH was considered as the main event. Kaplan-Meier curves were used to determine the time of the event. After the third follow-up patients were censored. Proportional hazards Cox regression was used to identify predictors of MOH among demographic variables (e,g. age), main comorbidities (e.g. sleep disorders, epilepsy, thyroid dysfunctions), migraine features (e.g. aura, number of previous preventive therapies, headache days and number of medications). We recruited 260 first-visit patients with CM. 46 patients (17.70%) developed a new onset of MOH over 1year, with 35 at the first follow-up. No difference in MOH occurrence was found among different pharmacological groups (Chi-square = 2.99, p = 0.70). About 1/3 of non-responders developed MOH. Monthly headache days, number of acute medications, thyroid dysfunction, epilepsy, and MIDAS score were associated with MOH (Chi-square = 14.08; p = 0.01). Headache days (Wald test: 6.0; p = 0.014) and MIDAS score (Wald test: 4.07, p = 0.04) were the only stand-alone significant factors. The rate of new occurrence of MOH in patients without a previous history is 18%. Monthly number of headache days and MIDAS score are the most important predictors.

Valvular Heart Disease In Antiphospholipid Syndrome (Review)

The review concerns special aspects of valvular heart disease (VHD) in antiphospholipid syndrome (APS). In addition to epidemiological data and classification criteria for APS, information is provided on the prevalence, pathogenetic mechanisms, and pathomorphological features of VHD, which is characterized by verrucous endocarditis (or Libman-Sacks endocarditis), thickening of the leaflets and valve dysfunction. The main pathogenetic events of VHD are caused by the effects of antiphospholipid antibodies, local platelet aggregation, migration of inflammatory cells and deposition of immune complexes. The course of VHD in APS is often complicated by thromboembolic complications, including embolization of the cerebral arteries and coronary arteries. Diagnosis of VHD in APS is based primary on the results of echocardiography, which allows to identify leaflet thickening, verrucous vegetations and assess the function of the valve apparatus. The use of transesophageal echocardiography makes it possible to clarify the features of valvular lesions in case of inconclusive results of transthoracic echocardiography. The issues of management of patients with and VHD are discussed, with an assessment of the results of the use of antiplatelet, anticoagulant, immunosuppressive therapy and surgical correction of severe valvular pathology. Cardiac surgery is associated with an increased risk of postoperative complications due to bleeding or thrombosis, as well as mortality.

Англия «Великого века» и проблемы военного строительства (1603–1714)

The article shows the development of the idea and institution of standing army in Great Britain of the Stuart age. On the example of English militarization the process of formation of the military-fiscal state in the British Isles is shown. The main political event that led to the creation of a regular army was the Civil War. The navy was spawned by the confrontation with the United Provinces and France. It is concluded that the process of militarization of seventeenth-century England was an important part of state policy, both of the Crown and of its opponents.

Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn’s disease: a prospective trial

BackgroundClinical data on oral fecal microbiota transplantation (FMT), a promising therapy for Crohn’s disease (CD), are limited. Herein, we determined the short-term safety and feasibility of FMT for pediatric patients with active CD.MethodsIn this open-label, parallel-group, single-center prospective trial, patients with active CD were treated with oral FMT capsules combined with partial enteral nutrition (PEN) (80%). The control group comprised pediatric patients with active CD treated with PEN (80%) and immunosuppressants. Thirty-three patients (11.6 ± 1.82 years)—17 in the capsule and 16 in the control groups—were analyzed. Data regarding the adverse events, clinical reactions, intestinal microbiome composition, and biomarker parameters were collected and compared post-treatment.ResultsAt week 10, the clinical and endoscopic remission rates did not differ between the two groups. By week 10, the mean fecal calprotectin level, C-reactive protein level, erythrocyte sedimentation rate, simple endoscopic score for CD, and pediatric CD activity index decreased significantly in the capsule group (all P < 0.05). The main adverse event was mild-to-moderate constipation. Core functional genera, Agathobacter, Akkermansia, Roseburia, Blautia, Subdoligranulum, and Faecalibacterium, were lacking pre-treatment. Post-treatment, the implantation rates of these core functional genera increased significantly, which positively correlated with the anti-inflammatory factor, interleukin (IL)-10, and negatively correlated with the pro-inflammatory factor, IL-6. The combination of these six functional genera distinguished healthy children from those with CD (area under the curve = 0.96).ConclusionsOral FMT capsules combined with PEN (80%) could be an effective therapy for children with active CD. The six core functional genera identified here may be candidate biomarkers for identifying children with CD.Trial registration: ClinicalTrials.gov, retrospectively registered, ID# NCT05321758, NCT05321745, date of registration: 2022-04-04.

Сравнительный анализ результатов соревнований женщин-тяжелоатлеток на Олимпийских играх и чемпионате России 2024 года

The purpose of the study is to conduct a comparative analysis of the sports results of leading female weightlifters on the world stage at the 2024 Olympic Games in France and the Russian Championship in Novosibirsk. Research methods and organization. The study employed methods of analysis and generalization of scientific and methodological literature, examination of competition protocols, and methods of mathematical statistics. Based on the sports results of elite weightlifters at the world and Russian levels, the authors conducted a comparative analysis of the winning kilograms they achieved at the Olympic tournament in Paris and at the national championship in Novosibirsk. Research results and conclusions. The identified lag of domestic female athletes during the research provides grounds for an objective assessment of the situation in which they find themselves at this specific moment in time. The current situation in elite sports within the national teams of Russia across all sports has had a most negative impact on the training system for the strongest athletes in preparation for the main event of the four-year cycle – the Olympic Games.

A review on the lncRNA-miRNA-mRNA regulatory networks involved in inflammatory processes in Alzheimer's disease.

A review on the lncRNA-miRNA-mRNA regulatory networks involved in inflammatory processes in Alzheimer's disease.

Therapeutic Process Through an Analysis of Significant Events in Psychodramatic Family Therapy.

Significant events are defined as relevant moments in therapy that help in understanding how changes occur. Scene-based psychodramatic family therapy follows a multiple-family-group format based on systemic therapy and psychodrama, aimed at families with adolescents exhibiting externalizing problems. This study aimed to identify the significant events and analyze therapeutic processes through a joint analysis of significant events from the client's perspective. Fourteen multiple-family groups were evaluated (122 adolescents and 107 parents in total) through focus groups at the end of the treatment. Using thematic analysis, we identified six types of significant events, the phase of treatment in which they occurred, the clients' involvement during the identified events, the modality of the intervention in which the events occurred, and their impact. The results confirm enactment, conflict dramatization, emotional expression, and catharsis as the main events in multiple-family groups. The participants reported significant events, particularly during the middle and final phases of the treatment, notably moments related to enactment and role-playing situations. Moreover, adolescents identified significant events both in group moments without their parents and in group situations with their parents. These findings highlight key mechanisms of change in families with adolescents exhibiting externalizing behaviors that participate in multiple-family groups with a systemic approach and psychodramatic techniques.

Evaluation of the safety and efficacy of isotretinoin in treatment of COVID-19 : A randomized controlled clinical trial.

Evaluation of the safety and efficacy of isotretinoin in treatment of COVID-19 : A randomized controlled clinical trial.

Diagnosis and management of bispecific T cell-engaging antibody toxicity: A primer for emergency physicians.

Diagnosis and management of bispecific T cell-engaging antibody toxicity: A primer for emergency physicians.

Angiogenic Events Positively Modulated by Complex Magnetic Fields in an In Vitro Endothelial Cell Model.

The vascular system is primarily responsible for orchestrating the underlying healing processes to achieve tissue regeneration, thus the promotion of angiogenic events could be a useful strategy to repair injured tissues. Among several approaches to stimulate tissue regeneration, non-invasive devices are currently widely diffused. Complex Magnetic Fields (CMFs) are innovative pulsed multifrequency electromagnetic fields used for their promising results in clinical applications, such as diabetic foot treatment or edema resorption. Nevertheless, few papers are available demonstrating the biological mechanisms involved. In this paper, in order to understand CMFs' capability to promote angiogenic events, Regenerative Tissue Program (RTP) was applied to an in vitro Endothelial Cells (ECs) model. ECs were stimulated with (I) 2 RTP consecutive cycles, (II) with an interval of 8 h (T0 + T8), or (III) 24 h (T0 + T24) from one cycle to another. Results demonstrate that (I) extracellular matrix degradation is promoted through matrix metalloproteinases 2 and 9 modulation, leading to an increased cell migratory capability; (II) CMFs support EC growth, activating Integrin β1-Erk-Cdk2 pathway and sustaining G1/S transition; (III) vessel morphogenesis is promoted when CMFs are applied. In conclusion, the promising clinical results are supported by in vitro analyses which evidence that main angiogenic events are stimulated by CMFs.