Luteoma Of Pregnancy Research Articles

Sidonia and Nicu de Barcsy: a famous mother with post-partum hirsutism after giving birth to a famous son with idiopathic short stature.

At the end of the 19th century, an 18-year-old lady gave birth to a well-proportioned, though very small, son. After delivery, the mother developed a full-grown beard, whereas the son always remained of small stature. The mother developed diabetes mellitus and died, aged 59, from a complicated severe cold. The son died at the age of 91 because of chronic kidney disease. The differential diagnosis in the son is isolated growth hormone deficiency. The mother might have suffered luteoma of pregnancy, polycystic ovary syndrome (PCOS), or Sertoli-Leydig cell tumor(s). The two cases are apparently coincidental/not related in pathophysiology. Hirsutism occurring directly postpartum can have several causes. Patients with isolated growth hormone deficiency can live a long life without the substitution of growth hormone. Coincidence does not necessarily imply correlation. In the past, patients with endocrine disorders like severe hirsutism or small stature were employed at circuses and fairs to entertain the audience as curiosities.

Retrospective analysis of 26 cases of pregnancy luteoma.

Pregnancy luteoma is a rare hormone-dependent ovarian tumor-like lesion caused by increased androgenic activity during pregnancy. To explore the clinical history, ultrasound manifestations, and differential diagnosis of pregnancy luteoma. A retrospective analysis was conducted on 26 cases of pregnancy luteoma diagnosed by postoperative pathology, from 2009 to 2022. All cases were from two hospitals: Shanghai First Maternity and Infant Hospital and International Peace Maternity and Child Health Hospital. The clinical history data and ultrasound characteristics were analyzed and the relevant literature was reviewed. Among the 26 cases, five of them had preoperative ultrasound images. Among these five cases, three patients showed hyperechoic masses with less internal uniformity, while two demonstrated loculated anechoic zones, with clear boundary and regular morphology. Color Doppler showed no obvious internal blood flow signals, or that blood flow signals were visible within the cyst wall and hyperechoic mass. Among the cases, 16 had multiple gestations, while two visited the clinic due to sudden abdominal pain and a huge ovarian mass was found by ultrasonography. The ovarian lump was detected during routine obstetric ultrasound in three cases. The remaining were ovarian cysts found incidentally during caesarean section. Four patients presented with hairy manifestations and one patient had a deepened voice. There is no characteristic ultrasound of pregnancy luteoma, and its diagnosis is mainly based on clinical history data and laboratory tests.

Ovarian hyperstimulation syndrome and pregnancy luteoma mimicking malignant ascites: a rare case report

BackgroundDuring pregnancy, both ovarian hyperstimulation syndrome (OHSS) and pregnancy luteoma could manifest as massive ascites, enlarged ovaries, or elevated serum levels of cancer antigen 125 (CA125), and atypical cells may be found in the ascitic fluid of OHSS patients. Whether this should be treated aggressively as peritoneal carcinomatosis is controversial.Case presentationA 35-year-old G2P1A1 woman with secondary infertility had a successful pregnancy after one cycle of assisted reproductive technology. The patient complained of lower abdominal distension, oliguria, and poor appetite 19 days after embryo transplantation. She was diagnosed with late-onset OHSS. Although the size of the ovaries decreased bilaterally to the normal range at 12 weeks of gestation after prompt medical care, the ascites increased again after an initial decreasing trend. Elevated serum levels of CA125 (191.1 IU/mL), and suspected adenocarcinoma cells were observed in the ascitic fluid. Although further magnetic resonance imaging examination or diagnostic laparoscopy was recommended, the patient was provided with supportive treatment and closely monitored upon her request. Surprisingly, her ascites diminished, and serum level of CA125 started to decline at 19 weeks of gestation. During cesarean section, pathological examination of the solid mass in the right ovary revealed pregnancy luteoma, which was presumably the other cause of the intractable ascites.ConclusionsCaution should be exercised in cases of suspicious malignant ascites during pregnancy. This may due to OHSS or pregnancy luteoma, in which abnormalities usually regress spontaneously.

Incidental pregnancy luteoma: A case report

Introduction: Pregnancy luteoma is a physiologic pseudotumor of ovary because of hormonal influence during pregnancy. It will regress spontaneously after delivery. Awareness of this process will assist to get the correct diagnosis at the right clinical context and lead to the appropriate management and follow-up for the patient. Case Report: This is a brief case report on a multiparous pregnant woman who underwent emergent cesarean section and found an incidental right ovarian mass. Cystectomy was done for pathological evaluation, and the histomorphology and immunohistochemistry suggested pregnancy luteoma. Neither the patient nor her infant did not manifest any sign and symptoms including virilization effect during the hospital stay. Conclusion: The clinician and pathologist need to be aware of this physiological process in pregnant women and its possible complications.

A RARE CASE OF LUTEOMA OF PREGNANCY IN A PERITONEAL INCLUSION CYST.

Pregnancy luteomas are rare neoplasms of the ovary that are usually benign. The persumed cause of this benign neoplasm is the hormonal effects of pregnancy.They are found incidentally during imaging or surgeries like caesarean and tubal ligation (1). Usually they are asymptomatic neoplasms but there are reports of virilization of the mother or infant (2).In some cases they can cause hemorrhage or torsion.We report a case of luteoma of pregnancy that was found incidentally during the management of a middle aged female patient for pelvic inclusion cyst.

Clinicopathologic features of pregnancy luteoma.

This study aimed to explore the clinicopathological characteristics, immunophenotype, histological occurrence, diagnosis, and differential diagnosis of ovarian luteoma tumor of pregnancy. The clinical features, histomorphology, immunohistochemistry, and reticular fiber staining results of 18 cases of luteoma tumors of pregnancy were analyzed, and related published studies were reviewed. The 18 cases of luteoma tumors were all women who had undergone multiple pregnancies. The tumors were 1.3-15cm in size and brownish yellow or reddish brown in color, with a soft texture. Microscopic examination revealed the eosinophilic cytoplasm of tumor cells and diffuse hyperplasia. The results of the immunohistochemical analysis were as follows: α-inhibin, AE1/AE3, CD99, and vimentin were positive, while epithelial membrane antigen, S-100, HMB45, and MelanA were negative. One case was positive for MelanA. The staining results of reticular fibers showed that the argyrophilic reticular fibers were black surrounding the tumor cell nests. Luteoma tumor of pregnancy is a rare tumor-like lesion mostly appearing in late pregnancy. The gross, immunohistochemical staining, and reticular fiber staining results may help diagnose this disease. The disease needs to be differentiated from other diseases.

Pregnancy Luteoma: Pathophysiology and Clinical Concern

Luteoma is a benign ovarian neoplasm, usually incidentally found during pregnancy. It can produce androgenic hormones. Most cases are asymptomatic, while a few present with maternal and/or neonatal virilization. Its etiology is still unclear and may relate to human chorionic gonadotropin (hCG) stimulation. Pregnancy luteoma will resolve spontaneously after childbirth. The early recognition and prompt diagnosis can save the ovary from unnecessary surgery. Keywords: Pregnancy; Luteoma; Pathophysiology; Virilization

Sclerosing stromal tumour: a clinicopathological study of 100 cases of a distinctive benign ovarian stromal tumour typically occurring in the young.

Since the sclerosing stromal tumour (SST) of the ovary was first described in 1973, few studies have expanded upon its histological features or overlap with other tumours. We thus investigate these aspects based on our experience with 100 cases. The patients, 14 of whom were pregnant, ranged from 12 to 63 years (median = 26 years). Ten patients had hormonal manifestations (seven oestrogenic, three androgenic). Bilateral ovarian involvement was present in two cases. Size ranged from 1 to 23 cm (mean = 8.4 cm). Most tumours were solid and white with focal yellow areas; oedema with cystic degeneration (seen in 25 cases) resulted in eight being predominantly cystic. On microscopic examination, alternating cellular and paucicellular areas (pseudolobulation) were prominent in 94 cases but seen to a limited degree in the remaining neoplasms. Admixed spindled and luteinised cells were present in all tumours, but 13 demonstrated mainly spindled cells and 19 demonstrated mainly lutein cells; 14 of the latter were from pregnant patients. The stroma was typically oedematous or collagenous, but in 14 cases was prominently hyalinised and, in four, myxoid. Prominent vascularity was present in most cases. The mitotic rate ranged from 0 to 8/10 high-power fields (HPF), but most demonstrated <1/10 HPF. The differential diagnosis of SST is broad, including fibromas, thecomas, solitary fibrous tumours, pregnancy luteomas, myxomas, other ovarian sex cord-stromal tumours with sclerosis and, rarely, Krukenberg tumours. Strict adherence to the requirement of pseudolobulation, prominent (usually ectatic) vessels, and lutein cells and fibroblasts admixed in a jumbled manner, will distinguish the neoplasm from others in the differential.

Disorders of Sex Development.

Disorders of Sex Development.

A prospective study on tumor like ovarian masses associated with pregnancy

Introduction: Pregnancy luteomas are non-neoplastic tumor like masses found in the ovary. These pregnancy luteomas spontaneously regress after delivery. Luteomas are usually asymptomatic and found incidentally during cesarean section or radiological imaging. Materials and Methods: A two year prospective study was done on 450 pregnant women while undergoing cesarean section. While doing cesarean section surgeons found ovarian masses of varying size in a few patients, these masses we suspected to be an ovarian neoplasm. salpingo-oophorectomy was performed in these pregnant women. Post operatively the excised ovaries with fallopian tube were sent for histopathological examination. Results: Out of 450 cesarean section, ovarian mass were found incidentally in 16 (3.5%) cases out of which 3 (0.6%) were luteomas. Conclusion: Recognition of these luteomas is important during cesarean section, so that unnecessary oophorectomy is avoided which is risky and can prevent unnecessary complication for both the mother and the fetus. Keywords: pregnancy luteomas, Cesarean section, ovaries, Histopathological examination,

A Rare Case of Benign Luteomas of Pregnancy Masquerading as Malignancy

A luteoma is a benign ovarian mass that can have malignant characteristics on sonography. Pelvic sonography is used to help distinguish benign from malignant masses. The workup of adnexal masses during pregnancy may involve the use of both transabdominal and transvaginal sonography as well as Doppler imaging, magnetic resonance imaging, and serum tumor markers to identify the risk of malignancy. This study presents a case of a benign ovarian luteoma of pregnancy detected during sonography. The mass was removed during the first trimester due to malignant sonographic features. Counseling and treatment regarding ovarian masses should consist of a multidisciplinary team made up of physicians in maternal-fetal medicine, radiology, neonatology, and sonographers.

EP30.07: Luteoma of pregnancy as a challenging ovarian mass

EP30.07: Luteoma of pregnancy as a challenging ovarian mass

A Three-year retrospective analysis of tumour like conditions of the Ovary in Tirunelveli Medical College Hospital

The Ovaries Are Paired Oval Structures In Females, Developing From The Gonadal Ridges, And Located One On Each Side Of The Uterus In The Ovarian Fossa. These Are Very Complex Organs In Terms Of Embryology And Histology. It Undergoes Cyclical Changes From Adolescence To Menopause And Gives Rise To Different Types Of Cells, Each Of Which Has The Capacity To Produce Different Type Of Tumours1. Due To Constant Endocrine Stimulation And Subsequent Traumatic Insults By Ovulation, These Are The Primary Sites For Tumour Development. Different Types Of Tumours Tend To Occur In Different Age Group. Both Primary And Metastatic Tumours Occur In The Ovary With Variable Histomorphological Patterns.2 Ovarian Cancer Is One Of The Most Common Neoplasm In Developed Countries, Ranking 7th Position In Incidence And 6th Position In Mortality3.It Constitutes About 6.6% Of All Malignant Tumours Of The Female Genital Tract3.In India, Incidence Of Ovarian Cancers Come Next To Cervical And Endometrial Cancers Among The Gynaecological Cancers. According To National Cancer Registry Programme Of Indian Council Medical Research, The Proportion Of Ovarian Cancer Varied From 1.7-8.7 In Various Urban And Rural Areas, It Also Showed That Recent Increase In Incidence. Both Chennai Cancer Registry And Dindigul Ambilikkai Cancer Registry Showed An Age Adjusted Incidence Rate Of 6.0cases Per 10, 0000women4, Whereas It Was 16.23 In United States.3 Ovarian Cancers Area Heterogeneous Group Of Neoplasms Of Three Main Subtypes: - Surface Epithelial, Germ Cell And Sex Cord Stromal Tumours With Wide Morphological Variations. No Age Group Is Free From The Tumour. In Adult Age Group Surface Epithelial Tumours Are The Commonest Neoplasm Constituting 65.5% Of Ovarian Neoplasms. In Younger Age Group, Germ Cell Tumours Are The Commonest Ovarian Neoplasms And Constitute Two Third Of Ovarian Tumours Out Of Which, One Third Are Malignant. Sex-Cord Stromal Tumours Can Occur At Any Age Group And Are Usually Functional In Nature. So The Determination Of Various Histological Patterns Is Very Important In Diagnosis As Well As Prognosis Of Ovarian Tumors5. Ovarian Cancer Has Got A Poor Prognosis Among All Gynaecological Cancers. The Overall 5year Survival Rate Is Approximately 45% Due To Late Stage At Diagnosis6.Unlike Cervical Cancer, Identification Of High Risk Population For Ovarian Malignancy And Ideal Screening Method Is Not Available. A Number Of Non Neoplastic Lesions Can Occur From Neonatal Period To Postmenopausal Age Group. Most Are Functional In Nature And Resolve With Minimal Treatment. Some Of The Non Neoplastic Lesions Like Massive Edema Of Ovary, Stromal Hyperplasia, Large Follicular Cyst, Pregnancy Luteomas, And Granulomatous Inflammation Can Be Confused With Neoplasm Clinically, Intraoperatively Or On Morphological Examination. The Main Aim Lies In Distinguishing Ovarian Neoplasms From The Wide Spectrum Of Non-Neoplastic Lesions. Despite The New Techniques Like Imaging And Genetic Studies, The Diagnosis Of Ovarian Tumour Is Mainly Dependent Upon Histopathological Examination. The Present Study Is Being Undertaken To Review In Detail The Different Varieties Of Ovarian Lesions In And Around Tirunelveli And Assess Their Characteristics With Regards To Incidence, Age And Histopathological Appearances.

Unusual Course of Acne Conglobata as a Skin Manifestation due to Bilateral Luteoma of Pregnancy

Unusual Course of Acne Conglobata as a Skin Manifestation due to Bilateral Luteoma of Pregnancy

Luteoma del embarazo. Reporte de caso

El luteoma del embarazo es una patología no neoplásica del ovario, de incidencia poco frecuente. Suele presentarse como hallazgo incidental durante la evaluación de una paciente embarazada en el tercer trimestre o en el momento del acto quirúrgico de una cesárea. En ocasiones, puede llevar a sospechar una neoplasia maligna, derivando así en una resección quirúrgica innecesaria del ovario. Presentamos el caso de una mujer de 34 años que cursaba su tercera gestación y a quien, durante la cesárea, se le halló una tumoración ovárica derecha de 9 cm de diámetro que fue resecada. El estudio histológico fue compatible con luteoma del embarazo.

Pregnancy luteoma: a rare presentation and expectant management

Abstract Pregnancy luteoma (PL) is a rare cause of non-neoplastic masses in pregnancy. PLs are usually asymptomatic. However, general symptoms like pelvic pain, lumbalgia, constipation or virilization due to active hormone secretion can be detected as the clinical findings of these benign cysts. The definitive diagnosis of PL is most commonly possible with a pathological evaluation after surgical intervention. Therefore, we present a successful management of PL with close follow-up until delivery. Beside the suspicion of malignancy by ultrasonography and magnetic resonance imaging (MRI), the cytological evaluation of ascites revealed benign cells which was helpful to decide expectant management.

Unilateral luteoma of the ovary in a pregnant Risso's dolphin (Grampus griseus).

A white, lobular mass was found in the right ovary of a pregnant Risso’s dolphin (Grampus griseus) at necropsy. The mass was unilateral and occupied most of the pre-existing ovarian tissue. Histologically, the mass was composed of diffuse sheets of polyhedral cells with abundant eosinophilic cytoplasm and oval nuclei, separated by fibrous connective tissue. Only a few ovarian follicles were observed at the periphery of the mass. Immunohistochemically, the large eosinophilic cells were positive for vimentin and negative for pan-cytokeratins. Based on the histopathological features, the present case was diagnosed as luteoma. In human medicine, luteoma of pregnancy, a tumor-like proliferative lesion occurring in pregnant women, is well described. In veterinary medicine, luteoma associated with pregnancy has never been described. The present study would provide useful information for understanding the characteristics of luteoma in animals.

Ovarian Steroid-Cell Tumor in Pregnancy—A Rare Occurrence: Report of a Case and Review of the Literature

Abstract Background: Steroid-cell tumors of the ovary are very rare, especially during pregnancy, and they must be distinguished from luteoma of pregnancy. Case: An 18-year-old female, gravida 3, para 1-0-1-1, at 38 weeks' of gestation, had an adnexal mass that was discovered incidentally during a Caesarean section. The tumor was excised and her male infant was normal. Results: Histologic workup revealed the tumor to be a steroid-cell tumor, which is exceedingly rare in pregnancy. Conclusions: Ovarian steroid-cell tumors, which are malignant one-third of the time, are difficult to distinguish from luteoma of pregnancy. (J GYNECOL SURG 32:351)

Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report.

Luteoma of pregnancy is a rare, benign condition characterized by a tumor-like mass of the ovary that emerges during pregnancy and regresses spontaneously after delivery. It is usually asymptomatic and the diagnosis is generally incidental. Luteoma arises from the proliferation of luteinised cell under the influence of β-hCG and can be hormonally active, with production of androgens resulting in maternal and fetal hirsutism and virilisation. We report a case of a 25-year-old primigravida who presented at 28 weeks of gestation with virilisation symptoms. Serum androgen levels were seven-hundred-fold higher than normal. A diagnosis of pregnancy luteoma was made at the time of caesarean section. The ovarian mass, serum androgen levels, and the condition of the patient improved after delivery.

A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium.

A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium.