Fourteen cases of sympathetic ganglionectomy are reported. In 7 cases dorsal ganglionectomy was done, using the removal of the second rib and transverse process as the approach. In the other 7 cases the lumbar ganglia were removed through a transabdominal approach. Four lumbar ganglionectomies for chronic polyarthritis resulted in relief of pain and marked progressive improvement in joint function. Three ganglionectomies for Buerger's disease with vasospasm 2 dorsal and 1 lumbar are reported. Two cases of amputation pains and one of brachial plexus avulsion are reported in which dorsal ganglionectomy gave some relief. Two cases of dorsal ganglionectomy for painful conditions of the face are reported. One case of trifacial neuralgia with recurrence of pain after severing of the sensory root has had complete relief for one year. Another case of atypical pain in the face gave inconclusive results. One case of megacolon and 1 case of spastic colon were entirely relieved by lumbar ganglionectomy.