Low Field Strength Research Articles

Development of a mobile low-field MRI scanner

Magnetic resonance imaging (MRI) allows important visualization of the brain and central nervous system anatomy and organization. However, unlike electroencephalography (EEG) or functional near infrared spectroscopy, which can be brought to a patient or study participant, MRI remains a hospital or center-based modality. Low magnetic field strength MRI systems, however, offer the potential to extend beyond these traditional hospital and imaging center boundaries. Here we describe the development of a modified cargo van that incorporates a removable low-field permanent magnet MRI system and demonstrate its proof-of-concept. Using phantom scans and in vivo T2-weighted neuroimaging data, we show no significant differences with respect to geometric distortion, signal-to-noise ratio, or tissue segmentation outcomes in data acquired in the mobile system compared to a similar static system in a laboratory setting. These encouraging results show, for the first time, MRI that can be performed at a participant’s home, community center, school, etc. Breaking traditional barriers of access, this mobile approach may enable imaging of patients and participants who have mobility challenges, live long distances from imaging centers, or are otherwise unable to travel to an imaging center or hospital.

Diagnostic value of MRI in the presurgical evaluation of patients with epilepsy: influence of field strength and sequence selection: a systematic review and meta-analysis from the E-PILEPSY Consortium.

MRI is a cornerstone in presurgical evaluation of epilepsy. Despite guidelines, clinical practice varies. In light of the E-PILEPSY pilot reference network, we conducted a systematic review and meta-analysis on the diagnostic value of MRI in the presurgical evaluation of epilepsy patients. We included original research articles on diagnostic value of higher MRI field strength and guideline-recommended and additional MRI sequences in detecting an epileptogenic lesion in adult or paediatric epilepsy surgery candidates. Lesion detection rate was used as a metric in meta-analysis. Eighteen studies were included for MRI field strength and 25 for MRI sequences, none were free from bias. In patients with normal MRI at lower-field strength, 3T improved lesion detection rate by 18% and 7T by 23%. Field strengths higher than 1.5T did not have higher lesion detection rates in patients with hippocampal sclerosis (HS). The lesion detection rate of epilepsy-specific MRI protocols was 83% for temporal lobe epilepsy (TLE) patients. Dedicated MRI protocols and evaluation by an experienced epilepsy neuroradiologist increased lesion detection. For HS, 3DT1, T2, and FLAIR each had a lesion detection rate at around 90%. Apparent diffusion coefficient indices had a lateralizing value of 33% for TLE. DTI fractional anisotropy and mean diffusivity had a localizing value of 8% and 34%. A dedicated MRI protocol and expert evaluation benefits lesion detection rate in epilepsy surgery candidates. If patients remain MRI negative, imaging at higher-field strength may reveal lesions. In HS, apparent diffusion coefficient indices may aid lateralization and localization more than increasing field strength. DTI can add further diagnostic information. For other additional sequences, the quality and number of studies is insufficient to draw solid conclusions. Our findings may be used as evidence base for developing new high-quality MRI studies and clinical guidelines.

A machine learning framework for low-field NMR data processing

Low-field (nuclear magnetic resonance) NMR has been widely used in petroleum industry, such as well logging and laboratory rock core analysis. However, the signal-to-noise ratio is low due to the low magnetic field strength of NMR tools and the complex petrophysical properties of detected samples. Suppressing the noise and highlighting the available NMR signals is very important for subsequent data processing. Most denoising methods are normally based on fixed mathematical transformation or hand-design feature selectors to suppress noise characteristics, which may not perform well because of their non-adaptive performance to different noisy signals. In this paper, we proposed a “data processing framework” to improve the quality of low field NMR echo data based on dictionary learning. Dictionary learning is a machine learning method based on redundancy and sparse representation theory. Available information in noisy NMR echo data can be adaptively extracted and reconstructed by dictionary learning. The advantages and application effectiveness of the proposed method were verified with a number of numerical simulations, NMR core data analyses, and NMR logging data processing. The results show that dictionary learning can significantly improve the quality of NMR echo data with high noise level and effectively improve the accuracy and reliability of inversion results. • A “data processing framework” is proposed to improve the quality of low-field NMR echo data. • Dictionary learning is employed for adaptive dictionary construction and available signal characteristics extraction for denoising noisy NMR echo data. • Simulations and practical applications have verified the performance of improving quality of NMR echo data and enhancing the accuracy and reliability of inversion results with dictionary learning.

Economic aspects of low-field magnetic resonance imaging : Acquisition, installation, and maintenance costs of 0.55 T systems

HintergrundNiederfeld-Magnetresonanztomographie(MRT)-Geräte bieten aufgrund niedrigerer Herstellungskosten und geringerer baulicher Anforderungen für Installation und Betrieb eine Chance zur Kostenreduktion.FragestellungMögliche Kostenreduktionen in Anschaffung, Einbringung und Unterhalt durch die Verwendung neuer Niederfeld-MRT-Systeme.Material und MethodenÜbersicht über die wichtigsten Kostenfaktoren und Evaluierung des Einsparpotenzials eines 0,55-T-Niederfeld-MRT der neuesten Generation im Vergleich zu 1,5‑ und 3‑T-MRT-Systemen in der klinischen Routine.ErgebnisseIm Anschaffungspreis liegt das Einsparpotenzial eines 0,55-T- im Vergleich zu einem 1,5-T-MRT-System bei etwa 40–50 %. Das um 25 % niedrigere Gewicht des Systems verringert die Transportkosten, die geringere Größe des Geräts erlaubt bei einem ebenerdigen Betriebsplatz die Einbringung mittels ferngesteuertem fahrbarem Robotersystem ohne Eröffnung der Außenfassade. Eine Quench-Leitung muss nicht installiert werden. Die Kosten für Einbringung und Installation sind insgesamt bis zu 70 % niedriger als bei Hochfeldsystemen. Die Wartungskosten eines 0,55-T-Geräts liegen etwa 45 % unter denen eines 1,5-T-Geräts bei vergleichbarem Servicevertrag. Weitere potenzielle Kostenreduktionen ergeben sich durch die geringere Raumgröße und einen potenziell geringeren Energieverbrauch für Untersuchungen und Kühlung.SchlussfolgerungDie Verwendung von MRT-Systemen mit niedrigerer Feldstärke bieten großes ökonomisches und ökologisches Potenzial für Kliniken und Praxisbetreiber.

Statistical Study of Foreshock Density Holes

AbstractDensity holes (DHs), characterized by the correlating depletion of plasma density and magnetic field strength, are one of the transient structures frequently observed upstream of Earth's bow shock. The low dynamic pressure of DHs may disturb the bow shock and magnetopause, and have potential geoeffects. In this paper, we perform a statistical study of 411 density hole events, identified by the Magnetospheric Multiscale Mission. The average occurrence rate of DHs is ∼5.4 events/day. All DHs are associated with foreshock ions. DHs tend to occur on the dawn side than on the dusk side. The occurrence rate is higher for faster solar wind, larger magnetic shear angle across DHs, and lower magnetic field strength. The spatial scale of DHs is several RE. Within DHs, electron heating and density depletion are correlated. Most DHs do not have significant flow deflections. Most DHs with discontinuities have the convection electric field pointing toward the discontinuity on at least one side. About two thirds of the 411 events show different characteristics compared to other types of foreshock transients that also have correlated density and field strength depletion.

New tools to investigate tumor metabolism by NMR/MRI

Changes in metabolism is an hallmark that characterizes tumour cells from healthy ones. Their detection can be highly relevant for staging the tumor and for monitoring the response to therapeutic treatments. Herein it is shown the readout of these changes can be achieved either by assessing the pH of the extracellular space in the tumour region and by monitoring real time transformations of hyperpolarized C-13 labelled substrates. Mapping pH in a MR image is possible by measuring the CEST response of an administered contrast agent such as Iopamidol that can provide accurate measurements of the heterogeneity of tumour acidosis. Direct detection of relevant enzymatic activities have been acquired by using Pyruvate and Fumarate hyperpolarized by the incorporation of a molecule of para-H2. Finally, it has been found that the tumour transformation involves an increase in the water exchange rate between the intra- and the extra-cellular compartments. A quantitative estimation of these changes can be obtained by acquiring the longitudinal relaxation times of tissue water protons at low magnetic field strength on Fast Field Cycling Relaxometers. This finding has been exploited in an application devoted to the assessment of the presence of residual tumour tissue in the margins of the resected mass in breast conservative surgery.

Evaluation of the effect of transcranial direct current stimulation on language impairments in the behavioural variant of frontotemporal dementia

The behavioural variant of frontotemporal dementia is a neurodegenerative disease characterized by bilateral atrophy of the prefrontal cortex, gradual deterioration of behavioural and executive capacities, a breakdown of language initiation and impaired search mechanisms in the lexicon. To date, only a few studies have analysed the modulation of language deficits in the behavioural variant of frontotemporal dementia patients with transcranial direct current stimulation, yet with inconsistent results. Our goal was to assess the impact on language performance of a single session of transcranial direct current stimulation on patients with the behavioural variant of frontotemporal dementia. Using a sham-controlled double-blind crossover design in a cohort of behavioural frontotemporal dementia patients (n = 12), we explored the impact on language performance of a single transcranial direct current stimulation session delivering anodal or cathodal transcranial direct current stimulation, over the left and right dorsolateral prefrontal cortex, compared with sham stimulation. A Letter fluency and a Picture naming task were performed prior and following transcranial direct current stimulation, to assess modulatory effects on language. Behavioural frontotemporal dementia patients were impaired in all evaluation tasks at baseline compared with healthy controls. Computational finite element method (FEM) models of cortical field distribution corroborated expected impacts of left-anodal and right-cathodal transcranial direct current stimulation over the dorsolateral prefrontal cortex and showed lower radial field strength in case of atrophy. However, none of the two tasks showed statistically significant evidence of language improvement caused by active transcranial direct current stimulation compared with sham. Our findings do not argue in favour of pre-therapeutic effects and suggest that stimulation strategies evaluating the modulatory role of transcranial direct current stimulation in the behavioural variant of frontotemporal dementia must carefully weigh the influence of symptom severity and cortical atrophy affecting prefrontal regions to ensure clinical success.

Binding energy, polarizability, and diamagnetic response of shallow donor impurity in zinc blende GaN quantum dots

In this theoretical investigation, the binding energy, the binding energy Stark-shift, the dipole moment, the polarizability, and the diamagnetic susceptibility related with a confined shallow donor impurity in zinc blende GaN conical-shaped quantum dots are calculated under the effect of an electric field applied along the z-direction. Calculations have been made by using a variational approach within the infinite confining potential model and considering the parabolic conduction band and the effective mass approximations. The results suggest important dependencies of the calculated physical properties on the variation of the dot dimensions, axial impurity position, and the intensity of the applied electric field. It is observed that: i) the binding energy Stark shift increases up to a maximum value and then decreases with increasing the strength of the electric field, and it is strongly influenced by the impurity position and geometrical parameters, ii) for a fixed electric field value, the binding energy Stark shift is always an increasing function of the dot height, and iii) for fixed electric field values, the binding energy Stark shift shows a mixed behavior concerning the dot radius, i.e., for low field strength, the binding energy is always a growing function of the radius, and for large field strengths, such physical quantity grows with the radius up to a maximum and then decreases. Furthermore, the electric field (the strong quantum confinement) enhances slightly (diminishes) the diamagnetic susceptibility of impurity.

Refinement of ZnAl2O4 crystal in ZnO–Al2O3–SiO2 glass-ceramics by application of thermoelectric coupling field

Transparent glass-ceramics based on ZnO–Al2O3–SiO2 (ZAS) glass system exhibit excellent optical and mechanical properties that are dependent on crystal grains. Gahnite (ZnAl2O4) was the main phase that crystallized in ZAS glass-ceramics via thermoelectric coupling treatment. The morphology and size of ZnAl2O4 crystal were controlled by the electric field strength. Introduction of thermoelectric coupling field led to the refinement and dispersion of large and agglomerated ZnAl2O4 crystal grains, which improved the transmission and Vickers’ hardness of the ZAS-based glass-ceramics. Theoretical calculations revealed that crystal phase is the area of low electric field strength, which resulted in the migration of Zn ions (Zn2+) from glass phase to the ZnAl2O4 crystal regions under the effect of thermoelectric coupling field. The decrease in the amount of Zn2+ in glass phase further limited its grain growth, and refinement of ZnAl2O4 grains was achieved. This research shows an efficient and rapid approach to refine grains in ZAS glass-ceramics by application of thermoelectric coupling treatment.

Portable single-sided NMR measurements at variable temperatures: Implementation of a thermo-controlled device and application to the heating of bread dough.

A temperature control unit was implemented to vary the temperature of samples studied on a commercial Mobile Universal Surface Explorer nuclear magnetic resonance (MOUSE-NMR) apparatus. The device was miniaturized to fit the maximum MOUSE sampling depth (25 mm). It was constituted by a sample holder sandwiched between two heat exchangers placed below and above the sample. Air was chosen as the fluid to control the temperature at the bottom of the sample, at the interface between the NMR probe and the sample holder, in order to gain space. The upper surface of the sample was regulated by the circulation of water inside a second heat exchanger placed above the sample holder. The feasibility of using such a device was demonstrated first on pure water and then on several samples of bread dough with different water contents. For this, T1 relaxation times were measured at various temperatures and depths and were then compared with those acquired with a conventional compact closed-magnet spectrometer. Discussion of results was based on biochemical transformations in bread dough (starch gelatinization and gluten heat denaturation). It was demonstrated that, within a certain water level range, and because of the low magnetic field strength of the MOUSE, a linear relationship could be established between T1 relaxation times and the local temperature in the dough sample.

Application of a 2D frequency encoding sectoral approach to hyperpolarized 129Xe MRI at low field

Inhaled hyperpolarized 129Xe MRI is a non-invasive and radiation risk free lung imaging method, which can directly measure the business unit of the lung where gas exchange occurs: the alveoli and acinar ducts (lung function). Currently, three imaging approaches have been demonstrated to be useful for hyperpolarized 129Xe MR in lungs: Fast Gradient Recalled Echo (FGRE), Radial Projection Reconstruction (PR), and spiral/cones. Typically, non-Cartesian acquisitions such as PR and spiral/cones require specific data post-processing, such as interpolating, regridding, and density-weighting procedures for image reconstruction, which often leads to smoothing effects and resolution degradation. On the other hand, Cartesian methods such as FGRE are not short-echo time (TE) methods; they suffer from imaging gradient-induced diffusion-weighting of the k-space center, and employ a significant number of radio-frequency (RF) pulses.Due to the non-renewable magnetization of the hyperpolarized media, the use of a large number of RF pulses (FGRE/PR) required for full k-space coverage is a significant limitation, especially for low field (<0.5 T) hyperpolarized gas MRI.We demonstrate an ultra-fast, purely frequency-encoded, Cartesian pulse sequence called Frequency-Encoding Sectoral (FES), which takes advantage of the long T2* of hyperpolarized 129Xe gas at low field strength (0.074 T). In contrast to PR/FGRE, it uses a much smaller number of RF pulses, and consequently maximizes image Signal-to-Noise Ratio (SNR) while shortening acquisition time. Additionally, FES does not suffer from non-uniform T2* decay leading to image blurring; a common issue with interleaved spirals/cones. The Cartesian k-space coverage of the proposed FES method does not require specific k-space data post-processing, unlike PR/FGRE and spiral/cones methods.Proton scans were used to compare the FES sequence to both FGRE and Phase Encoding Sectoral, in terms of their SNR values and imaging efficiency estimates. Using FES, proton and hyperpolarized 129Xe images were acquired from a custom hollow acrylic phantom (0.04L) and two normal rats (129Xe only), utilizing both single-breath and multiple-breath schemes. For the 129Xe phantom images, the apparent diffusion coefficient, T1, and T2* relaxation maps were acquired and generated. Blurring due to the T2* decay and B0 field variation were simulated to estimate dependence of the image resolution on the duration of the data acquisition windows (i.e. sector length), and temperature-induced resonance frequency shift from the low field magnet hardware.

Bubbles in Transformer Oil: Dynamic Behavior, Internal Discharge, and Triggered Liquid Breakdown

It is generally accepted that the presence of bubbles severely degrades the electric strength of liquid dielectrics, but the influencing factors and mechanisms have yet to be elucidated. Dynamic behavior, partial discharges (PDs) inside bubbles, and their effects on the breakdown of transformer oil are investigated experimentally and theoretically in this study. The results show that, under a nonuniform electric field, the presence of bubbles does not significantly affect the PD inception voltage (PDIV) and breakdown voltage (BV) of the liquid, as bubbles migrate to the region with lower field strength under dielectrophoretic force. In a uniform electric field, conversely, bubbles greatly reduce PDIV and BV; an increase in the number of bubbles or a slower voltage rise rate appears to exacerbate this effect. The PDIV observed in the experiment is much higher than the theoretical value calculated by the Townsend theory or streamer criterion, which may be due to the lack of free electrons inside the bubble, thus resulting in scarce internal discharge. The addition of X-rays enhances the radiation ionization and then eliminates the inconsistency between the theoretical and measured values of PDIV, which supports our hypothesis. The bubble-triggered breakdown of liquid dielectrics, namely, once a discharge occurs inside the bubble, likely triggering the breakdown of the liquid gap, is observed. The electric field enhancement caused by surface charges and the instability of the gas–liquid interface may account for this.

Statistical Study of Foreshock Bubbles, Hot Flow Anomalies, and Spontaneous Hot Flow Anomalies and Their Substructures Observed by MMS

AbstractForeshock transients such as foreshock bubbles (FBs), hot flow anomalies (HFAs), and spontaneous hot flow anomalies (SHFAs) display heated, tenuous cores and large flow deflections bounded by compressional boundaries. THEMIS and Cluster observations show that some cores contain local density enhancements which can be studied to better understand the evolution processes of foreshock transients. However, closer examinations of these substructures were not feasible until the availability of the higher resolution data from the Magnetospheric Multiscale mission (MMS). We identify 164 FB‐like, HFA‐like, and SHFA events from two MMS dayside phases for a statistical study to investigate their solar wind conditions, properties, and substructure properties. Occurrence rates of the three event types are higher for lower magnetic field strengths, higher solar wind speeds and Mach numbers, and quasi‐parallel bow shocks. Events usually span up to 3 RE along the bow shock surface and extend up to 6 RE upstream from the bow shock. Though events with and without substructures exhibit similar solar wind conditions, events with substructures are more likely to have longer core durations and larger sizes. Substructure densities display a positive correlation with bulk flows and a negative correlation with temperatures. Substructure sizes vary between 4 and 24 ion inertial lengths, indicating multiple formation mechanisms. Substructures could be the boundary between two foreshock transient events that have merged into a single event, fast‐mode variations, generated by slow or mirror mode instabilities, or produced from instabilities due to parameter gradients at the compressional boundaries or shocks.

Electrooptic, pyroelectric and dielectric spectroscopic studies of nematic and twist bend nematic phases of achiral hockey-shaped bent-core liquid crystal

Experimental and theoretical investigations of the twist-bend nematic (NTB) phase in liquid crystals have recently received significant attention for reasons of unusual and interesting characteristics of the NTB. Though NTB was predicted to exist for rigid bent-core LCs by Ivan Dozov in 2001, nevertheless it has unambiguously been proven to exist only in a few bent-core systems so far. Here the characteristics of both the nematic (N) and NTB phases are investigated for a hockey shaped achiral rigid bent-core LC, called BCI, in planar and homeotropic aligned cells, using polarizing optical microscopy, electro-optics, pyroelectricity and wide band dielectric spectroscopy. Spontaneous polarization measured for a bias field of 2.2 V/μm of a chiral domain using the pyroelectric effect is found to be only ∼5 nC/cm2. A measurement of the spontaneous polarization using pyroelectricity in general is unaffected by the sample’s dc conductivity except when its conductance dominates the admittance. As helix of NTB is partially unwound by the field, results lead to the identification of NTB as polar and chiral. The first and the second harmonics of the applied field are observed of higher amplitudes in NTB and N phases, respectively. The hockey-shaped bent-core system exhibits a large negative dielectric anisotropy over a wide range of temperatures than observed for any other compound so far. The large negative dielectric anisotropy is the highly desirable characteristic parameter of the NTB for exploring the field induced phases at relatively lower field strengths. The orientational order parameter characteristically jumps at the N-NTB transition temperature. The complex dielectric permittivity is measured as a function of frequency in the range 1 Hz to 10 MHz, the analysis of results reveales two collective modes in the dielectric spectra. Amplitude of the lower frequency mode is much higher than of higher frequency, former is assigned to the hydrodynamic mode q=qzz^ with z-dependent rotation of the heloconical director n^(r), this in turn involves compression and dilation of the pseudo-layers. The higher frequency mode corresponds to fluctuations of the tilt director and closer to the transition temperature, it exhibits a typical soft mode characteristic feature.

Pulsed electric field promotes the growth metabolism of aerobic denitrifying bacteria Pseudomonas putida W207-14 by improving cell membrane permeability

ABSTRACT The purpose of this study was to explore the stimulation mechanism of low pulsed electric field (PEF) strength treatment to promote the growth metabolism of aerobic denitrifying bacteria Pseudomonas putida W207-14. The results indicated that compared with the control group, the strain W207-14 treated with PEF entered the logarithmic growth phase 5 h earlier, the growth time to reached the maximum cell optical density at 600 nm (OD600) of 1.935 ± 0.04 was only 24 h, which shortened by half. With the reduction of growth time, the metabolic rate of the strain increased significantly, in which the removal efficiency of COD, NO3 −–N and TN was 97.67 ± 1.12%, 90.34 ± 0.73% and 90.13 ± 0.10% in 24 h, respectively. The maximum nitrate removal rate increased from 3.49 mg/L/h to 7.53 mg/L/h. A large number of cells with simultaneous cell membrane damage and high physiological activity were observed by flow cytometry (FCM) in combination with fluorescence staining analysis, which confirmed the reversible electroporation on the cell membrane of strain W207-14 treated with PEF. Transcriptomic analysis indicated that PEF activated the highly significant differential expression of membrane porin (opdB, opdC, and oprB) and cytochrome oxidoreductase related genes (ccoP, ccoN, cioA and cioB) on the cell membrane, which promoted the transport of nutrients through the cell membrane and electron transfer during aerobic respiration and provided an explanation for the possible mechanism of PEF promoting the growth metabolism of strain W207-14 at the micro level. These results lay a foundation for the practical application of PEF enhanced aerobic denitrification technology.

Features of generation and propagation of the extremely low frequency waves excited in the ionosphere under the powerful HF radioemission influence

The experimental results of the extremely low frequency emission characteristics excited in the outer ionosphere under the ionospheric plasma heating by high-latitude EISCAT facility are presented. The experiments have been conducted in the period of 20062010 yr. using two main schemes of extremely low frequency generation including the impact of the heating facility amplitude modulated emission and two unmodulated pump waves with the frequency detuning. In-situ measurements of the plasma wave disturbances were performed at the outer ionosphere heights using on-board equipment of DEMETER microsatellite. In work the spatial, amplitude and spectral characteristics of the generated extremely low frequency emissions are determined. It is shown that the characteristic size of the extremely low frequency emission is about 400600 km along the trajectory of the DEMETER microsatellite. The registration area spatial position is determined by both the applied generation scheme and the background plasma density distribution. The extremely low frequency emission electric field strength at the Earths outer ionosphere heights is 50330 V/m.

Simulation-Driven Triple-Tuned Array for 1H, 31P and 23Na Using Composite Right- and Left-Handed Transmission Line for Rat Brain at 9.4T MRI

The use of ultrahigh-field-strength magnetic resonance imaging (MRI), such as 9.4T, is able to acquire multi-nuclear imaging with better image quality than lower field strengths. In particular the acquisition of sodium ( <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">23</sup> Na) or phosphorus ( <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> P) images could benefit with higher signal-to-noise ratio (SNR). The design of radiofrequency RF coils is required to achieve a uniform field and to operate at the corresponding frequency. The general method to make multiple frequency coils has the drawback of using multilayers or reducing the size of the coils, which impose restriction on the utilization of space. For the conventional multiple frequency array, the design for the coil size imposes a challenge for the optimization of SNR and field intensity. In addition, the use of multiple coils increases the coupling between each coil. To circumvent these problems, we propose the use of composite right-left handed (CRLH) transmission lines (TL), which are able to resonate to multiple frequencies. This work demonstrates a design of an array of four channels, in which each channel consists of a single CRLH element capable to resonate at three frequencies corresponding to <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> H at 400 MHz, <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> P at 162 MHz, and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">23</sup> Na at 105 MHz. The design was demonstrated with electromagnetic (EM) simulations and applied for rat brain for use in a 9.4T MRI system.

Sensitivity of portable low-field magnetic resonance imaging for multiple sclerosis lesions

Magnetic resonance imaging (MRI) is a fundamental tool in the diagnosis and management of neurological diseases such as multiple sclerosis (MS). New portable, low-field strength, MRI scanners could potentially lower financial and technical barriers to neuroimaging and reach underserved or disabled populations, but the sensitivity of these devices for MS lesions is unknown. We sought to determine if white matter lesions can be detected on a portable 64mT scanner, compare automated lesion segmentations and total lesion volume between paired 3T and 64mT scans, identify features that contribute to lesion detection accuracy, and explore super-resolution imaging at low-field. In this prospective, cross-sectional study, same-day brain MRI (FLAIR, T1w, and T2w) scans were collected from 36 adults (32 women; mean age, 50 ± 14 years) with known or suspected MS using Siemens 3T (FLAIR: 1 mm isotropic, T1w: 1 mm isotropic, and T2w: 0.34–0.5 × 0.34–0.5 × 3–5 mm) and Hyperfine 64mT (FLAIR: 1.6 × 1.6 × 5 mm, T1w: 1.5 × 1.5 × 5 mm, and T2w: 1.5 × 1.5 × 5 mm) scanners at two centers. Images were reviewed by neuroradiologists. MS lesions were measured manually and segmented using an automated algorithm. Statistical analyses assessed accuracy and variability of segmentations across scanners and systematic scanner biases in automated volumetric measurements. Lesions were identified on 64mT scans in 94% (31/33) of patients with confirmed MS. The average smallest lesions manually detected were 5.7 ± 1.3 mm in maximum diameter at 64mT vs 2.1 ± 0.6 mm at 3T, approaching the spatial resolution of the respective scanner sequences (3T: 1 mm, 64mT: 5 mm slice thickness). Automated lesion volume estimates were highly correlated between 3T and 64mT scans (r = 0.89, p < 0.001). Bland-Altman analysis identified bias in 64mT segmentations (mean = 1.6 ml, standard error = 5.2 ml, limits of agreement = –19.0–15.9 ml), which over-estimated low lesion volume and under-estimated high volume (r = 0.74, p < 0.001). Visual inspection revealed over-segmentation was driven venous hyperintensities on 64mT T2-FLAIR. Lesion size drove segmentation accuracy, with 93% of lesions > 1.0 ml and all lesions > 1.5 ml being detected. Using multi-acquisition volume averaging, we were able to generate 1.6 mm isotropic images on the 64mT device. Overall, our results demonstrate that in established MS, a portable 64mT MRI scanner can identify white matter lesions, and that automated estimates of total lesion volume correlate with measurements from 3T scans.

Leptomeningeal enhancement in multiple sclerosis and other neurological diseases: A systematic review and Meta-Analysis

BackgroundThe lack of systematic evidence on leptomeningeal enhancement (LME) on MRI in neurological diseases, including multiple sclerosis (MS), hampers its interpretation in clinical routine and research settings. PurposeTo perform a systematic review and meta-analysis of MRI LME in MS and other neurological diseases. Materials and MethodsIn a comprehensive literature search in Medline, Scopus, and Embase, out of 2292 publications, 459 records assessing LME in neurological diseases were eligible for qualitative synthesis. Of these, 135 were included in a random-effects model meta-analysis with subgroup analyses for MS. ResultsOf eligible publications, 161 investigated LME in neoplastic neurological (n = 2392), 91 in neuroinfectious (n = 1890), and 75 in primary neuroinflammatory diseases (n = 4038). The LME-proportions for these disease classes were 0.47 [95%-CI: 0.37–0.57], 0.59 [95%-CI: 0.47–0.69], and 0.26 [95%-CI: 0.20–0.35], respectively. In a subgroup analysis comprising 1605 MS cases, LME proportion was 0.30 [95%-CI 0.21–0.42] with lower proportions in relapsing-remitting (0.19 [95%-CI 0.13–0.27]) compared to progressive MS (0.39 [95%-CI 0.30–0.49], p = 0.002) and higher proportions in studies imaging at 7 T (0.79 [95%-CI 0.64–0.89]) compared to lower field strengths (0.21 [95%-CI 0.15–0.29], p < 0.001). LME in MS was associated with longer disease duration (mean difference 2.2 years [95%-CI 0.2–4.2], p = 0.03), higher Expanded Disability Status Scale (mean difference 0.6 points [95%-CI 0.2–1.0], p = 0.006), higher T1 (mean difference 1.6 ml [95%-CI 0.1–3.0], p = 0.04) and T2 lesion load (mean difference 5.9 ml [95%-CI 3.2–8.6], p < 0.001), and lower cortical volume (mean difference −21.3 ml [95%-CI −34.7–-7.9], p = 0.002). ConclusionsOur study provides high-grade evidence for the substantial presence of LME in MS and a comprehensive panel of other neurological diseases. Our data could facilitate differential diagnosis of LME in clinical settings. Additionally, our meta-analysis corroborates that LME is associated with key clinical and imaging features of MS.PROSPERO No: CRD42021235026.

Simulated diagnostic performance of low-field MRI: Harnessing open-access datasets to evaluate novel devices

The purpose of this study is to demonstrate a method for virtually evaluating novel imaging devices using machine learning and open-access datasets, here applied to a new, low-field strength portable 64mT MRI device. Paired 3 T and 64mT brain images were used to develop and validate a transformation converting standard clinical images to low-field quality images. Separately, 3 T images were aggregated from open-source databases spanning four neuropathologies: low-grade glioma (LGG, N = 76), high-grade glioma (HGG, N = 259), stroke (N = 28), and multiple sclerosis (MS, N = 20). The transformation method was then applied to the open-source data to generate simulated low-field images for each pathology. Convolutional neural networks (DenseNet-121) were trained to detect pathology in axial slices from either 3 T or simulated 64 mT images, and their relative performance was compared to characterize the potential diagnostic capabilities of low-field imaging. Algorithm performance was measured using area under the receiver operating characteristic curve. Across all cohorts, pathology detection was similar between 3 T and simulated 64mT images (LGG: 0.97 vs. 0.98; HGG: 0.96 vs. 0.95; stroke: 0.94 vs. 0.94; MS: 0.90 vs 0.87). Pathology detection was further characterized as a function of lesion size, intensity, and contrast. Simulated images showed decreasing sensitivity for lesions smaller than 4 cm2. While simulations cannot replace prospective trials during the evaluation of medical devices, they can provide guidance and justification for prospective studies. Simulated data derived from open-source imaging databases may facilitate testing and validation of new imaging devices.