Lower Moments Research Articles

High tibial osteotomy effectively redistributes compressive knee loads during walking.

The objectives of this study were to estimate pre-and postoperative lower limb kinematics and kinetics and knee intra-articular forces during gait using musculoskeletal modeling in a cohort of patients with knee osteoarthritis (OA) undergoing high tibial osteotomy (HTO), compare these to controls, and determine correlations between changes in these parameters and Knee Injury and Osteoarthritis Outcome Score (KOOS) subscores after HTO. Sixteen patients with isolated, symptomatic medial compartment knee OA completed pre-and postoperative gait analysis (mean follow-up time: 8.6 months). Sixteen age- and sex-matched asymptomatic volunteers participated as controls. Musculoskeletal modeling was used to evaluate lower limb joint moments and knee contact forces during gait. While HTO had limited influence on sagittal plane kinematics and moments, significant changes in the load distribution at the knee after HTO were observed with a lower postoperative compressive load on the medial compartment during midstance and a higher compressive load on the lateral compartment during early and late stance. Moreover, the lateral shear force in midstance was significantly lower after HTO. Changes in the external knee adduction moment (KAM) did not always coincide with reductions in the knee compressive force in the medial compartment. Biomechanical changes did not correlate with improvements in KOOS subscores. Hence, HTO effectively unloaded the medial compartment by redistributing part of the overall compressive force to the lateral compartment during gait with limited influence on gait function. The KAM may not adequately describe compartmental load magnitude or changes induced by interventions at the compartment level.Clinical trial registration: ClinicalTrials. gov Identifier-NCT02622204. Clinical significance: This study provides important evidence for changes in joint level loads after corrective osteotomy as joint preserving surgery and emphasizes the need for additional biomechanical outcomes of such interventions.

Synthesis and characterisation of Fe-substituted Ni50Mn25Fe Ga25- single crystals—Development of the phase transformations with Fe content

Despite promising initial properties, the industrial applicability of magnetic shape memory alloys of the Ni-Mn-Ga family is distinctly limited by the temperature range it can operate in. Here we investigate the effects of minor substitutions of Fe for Ga on the thermodynamic, structural, and magnetic properties of Ni50Mn25FexGa25-x (3.0 < x < 7.5). Single crystals are essential for most intended applications, the studied compositions were prepared in single crystalline form. With increasing iron content, the melting point of the alloy decreases slightly from 1407(2) to 1394(2) K, while the structural B2’→L21 ordering transition increases in temperature from 1066(2) to 1082(4) K. Magnetisation measurements find that both the Curie temperature and the martensitic transformation temperature increase approximately linearly with Fe concentration, with Curie temperature increasing from 398(1) to 427(2) K, and martensitic transformation temperature increasing from 274(1) to 372(1) K when going from x = 3.0–7.5. The martensitic transformations above room temperature were confirmed by temperature-dependent single-crystal X-ray diffraction. These observations are compared with polycrystalline materials of the same series and support results of the previous studies. The shrinking gap between Curie and martensitic transformation temperatures, as well as the reduction in the low temperature saturated moment from 3.52(2) to 2.78(3) µB/f.u. make this substitution less industrially attractive but provide essential structural and property evolution details needed to improve and tune theoretical modelling of this important material family.

Improvement of energy efficiency in the drive system of an electric car with PMSM

Thanks to the advantages, i.e. high overload, high power density factor, wide range of rotational speed, low moment of inertia, as well as high torque-to-inertia ratio, PMSM AC motors are currently widely used in electric cars. The article presents a new method of PMSM control through the modification of the Clarke and Park transforms that enables to improve the efficiency of the mechatronic system due to the energy criterion. The article shows analytical tests confirming the possibility of maintaining the reactive power at zero level in the inverter-PMSM circuit. The analytical tests were supported by simulation tests with the use of the MATLAB-SIMULINK program.

Lower extremity coordination and joint kinetic distribution during gait in adults with and without Prader-Willi Syndrome

Individuals with Prader-Willi Syndrome (PWS) have reduced mobility, which may be due to altered gait biomechanics. This study compared lower extremity intersegmental coordination and joint kinetics in adults with and without PWS. Walking biomechanics were evaluated in 10 adults with PWS and 10 controls without and 10 with obesity. The foot-shank and shank-thigh coordination was evaluated using modified vector coding and compared between groups using Kruskal-Wallis and Mann-Whitney U tests. The total support moment was summed from the ankle, knee, and hip extensor moments; and relative joint contributions were expressed as a percentage and compared between groups using one-way MANOVA. The group with PWS had greater exclusive shank segment rotation during later stance compared with controls with (p < 0.001) and without obesity (p < 0.001). The group with PWS also had a smaller absolute total support moment than controls with obesity during early and late stance (both p < 0.001), and lower normalized total support moment compared to controls without obesity during early stance (p = 0.019) and compared to controls with obesity during late stance (p = 0.004). Extensor moment contributions was similar between groups during early and late stance (all p > 0.05). Findings suggest a flat-footed gait pattern in PWS during late stance, which may negatively influence propulsion and speed. Moreover, those with PWS had lower total support moments than controls during early and late stance, but similar relative extensor contributions when walking at self-selected speeds. As such, improving overall torque generation in the lower extremity may be useful to improve stability and mobility during gait in PWS.

Biomechanics of running: A special reference to the comparisons of wearing boots and running shoes.

Boots are often used in sports, occupations, and rehabilitation. However, there are few studies on the biomechanical alterations after wearing boots. The current study aimed to compare the effects of running shoes and boots on running biomechanics. Kinematics and ground reaction forces were recorded from 17 healthy males during running at 3.3 m/s with shoe and boot conditions. Temporal distance gait variables, ground reaction force components as well as lower limb joints angle, moment, and power were compared using Paired t-test and Statistical Parametric Mapping package for time-series analysis. Running with boots was associated with greater stride, step, flight, and swing times, greater flight length, and smaller cadence (p<0.05). The only effect of boots on lower limb joints kinematics during running was a reduction in ankle range of motion (p<0.05). Significantly greater hip flexor, abductor, and internal rotator moments, greater knee extensor and abductor moments, and ankle plantar flexor moments were observed at push-off phase of running as well as greater ankle dorsiflexor moment at early-stance in boot condition (p<0.05). Also, knee joint positive power was greater with a significant temporal shift in boot condition, suggesting a compensatory mechanism in response to limited ankle range of motion and the inability of the ankle joint to generate the required power. Our findings showed that running with boots is physically more demanding and is associated with a greater net contribution of muscles spanning hip and knee joints in order to generate more power and compensate for the ankle joint limitations, consequently, may increase the risk of both musculoskeletal injuries and degenerative joint diseases.

Effects of Changing Center of Pressure Position on Knee and Ankle Extensor Moments During Double-Leg Squatting.

The effects of changes in the anterior-posterior center of pressure (AP-COP) position on the lower limb joint moments during double-leg squatting remain unclear. The purpose of this study was to determine the effects of AP-COP positional changes on the hip, knee, and ankle extensor moments during double-leg squatting. Sixteen male participants (22.1 ± 1.5 years) performed double-leg squatting under two conditions (anterior and posterior COP conditions) with visual feedback on their COP positions. Kinematics and kinetics were analyzed using a three-dimensional motion analysis system and force plates. The hip, knee and ankle flexion angles and extensor moments at peak vertical ground reaction force were compared between the two conditions using paired t tests. The COP position was 53.5 ± 2.4% of the foot length, starting from the heel, under the anterior condition and 44.4 ± 2.1% under the posterior condition (P < 0.001). The knee extensor moment was significantly smaller under the anterior than the posterior COP condition (P = 0.003, 95% confidence interval (CI) -0.087 to -0.021 Nm/kg/m), while the ankle extensor moment significantly larger under the anterior COP condition than under the posterior COP condition (P < 0.001, 95% CI 0.113 to 0.147 Nm/kg/m). There was no significant difference in hip extensor moment (P = 0.431). The ankle dorsiflexion angle was significantly larger under the anterior than the posterior COP condition (P = 0.003, 95% CI 0.6 to 2.6°), while there was no difference in trunk, hip, or knee flexion angle. The present results indicate that changes in the AP-COP position mainly affect the ankle and knee extensor moments during double-leg squatting, while the effect on the lower limb joint and trunk flexion angles was limited. Visual feedback on the AP-COP position could be useful for modifying the ankle and knee extensor moments during double-leg squatting.

NLDFT adsorption models for zeolite porosity analysis with particular focus on ultra-microporous zeolites using O2 and H2

The most often used gases for the PSD characterization of zeolites are N2 and Ar. According to the IUPAC Technical Report (2015), Ar is recommended as more reliable than N2, which molecules possess a significant quadrupole moment that may influence the adsorption isotherms on polar surfaces. In practice, however, using Ar as a cryogen for Ar adsorption measurements is not preferred due to its higher cost than liquid N2.We propose using O2 which has a much lower quadrupole moment than N2, and its adsorption can be measured using standard liquid N2 as a coolant. To support using O2, we demonstrate good agreement between the PSDs calculated from O2 and Ar adsorption.In the present work, we develop several semiempirical models based on nonlocald density functional theory (NLDFT) for the PSD characterization of several types of zeolites.We discuss the underlying difficulties in modeling gas adsorption on zeolites which adsorption potential field depends on both the pore width and the chemical structure of the zeolite.For the analysis of ultra microporous zeolites such as Chabazite and molecular sieve 5A, we apply H2 in combination with O2 at 77 K. H2 molecule has a smaller diameter than O2 and diffuses faster into ultra micropores, reducing the time of isotherm measurement. Moreover, we show that the dual gas analysis method can be used with O2 isotherms measurements omitting low-pressure points, making the analysis faster.

A DFT Study on the Activity Origin of Fe-N-C Sites for Oxygen Reduction Reaction.

Iron-nitrogen-carbon materials have been known as the most promising non-noble metal catalyst for proton-exchange membrane fuel cells (PEMFCs), but the genuine active sites for oxygen reduction reaction (ORR) are still arguable. Herein, by the thorough density functional theory investigations, we unravel that the planar Fe2 N6 site exhibits excellent ORR catalytic activity over both FeN3 and FeN4 sites, and the potential-determining step is determined to be the *OH hydrogenation step with an overpotential of 0.415 V. The ORR activity of Fe2 N6 site originates from the low spin magnetic moment (1.11 μB ), which leads to high antibonding states and low d-band center of the Fe center, further leads to weak binding strength of *OH species. The density of FeN4 sites only has little influence on the ORR activity owing to the similar interaction between active site and intermediates in ORR. Our research sheds light on the activity origin of iron-nitrogen-carbon materials for ORR.

The lower partial moments risk measure in a novel fuzzy framework based on possibility density function

As a comprehensive and flexible risk measure, the lower partial moments (LPM) can be converted into a wide range of the downside risk measures by modifying its target parameter and degree of moment. However, the distribution function of the return rate is hard to recognize, and the existing calculation methods have great calculation difficulties, so it has limited application. In previous studies, the historical data was mostly used to simulate the distribution function of return rate for approximate calculation of LPM risk, resulting in a huge computational complexity. In this paper, based on the possibility density function, the LPM risk measure is creatively defined in a novel fuzzy framework instead of a traditional random framework. By deriving the trapezoidal fuzzy number of return rate from the historical data, the LPM risk can be easily calculated according to its possibility density function, which can significantly improve the calculation process. Based on this idea, this paper derives the specific expression when the rate of return is a trapezoidal fuzzy number under the definition of fuzzy LPM. Furthermore, stock-driven and portfolio-driven methods are used to calculate the portfolio risk, and then two fuzzy mean-LPM models are constructed respectively. Finally, a numerical example based on global stock market index is used to illustrate the feasibility and validity of the proposed methods and models. Compared with the classic mean–variance model, our proposed model with adjustable target parameter and degree of moment is more flexible in reflecting investors’ attitude towards risk.

Effects of Bionic Pectoral Fin Rays’ Spanwise Flexibility on Forwarding Propulsion Performance

Oscillating pectoral fins’ spanwise flexibility is a key factor influencing the forwarding propulsion performance of bionic cownose rays, including thrust and heave-pitch stability. This study explores the effects of the bionic pectoral fin ray’s spanwise flexibility on its propulsion performance via experiments. Inspired by the cownose ray, a pair of bionic pectoral fins with fin rays and fabric skin was designed, and two motors drive the controllable flapping motion. The bionic pectoral fins’ flexibility can be quantified by using fin rays’ bending stiffness. The experiments were carried out in a water tank to measure the thrust, the lift force, and the pitch moment of the bionic cownose ray. The fin rays are divided into plastic sheets of five thicknesses and three fin rays with more obvious stiffness variations. The movement parameters included the following: the flapping frequency of 0.3–0.7 Hz, the flapping amplitude of 20–40°, and the phase difference of 20–40°. The experimental results show that the stiffness of the bionic pectoral fin rays plays an important role in the thrust, lift force, and pitch moment. The fin rays with high stiffness root segment and low stiffness tip segment have lower lift and pitch moment while maintaining a high thrust. This shows that the pectoral fins’ flexible characteristics of the cownose ray are of great significance to the design of the bionic prototype.

Partial moments and indexation investment strategies

Index-linked investment strategies are developing rapidly. However, few studies distinguish between the returns of an indexation portfolio above and below a benchmark index. In this paper, we first use upper partial moments (UPMs) and lower partial moments (LPMs) to measure upside and downside deviations, respectively, against a benchmark index. Next, we use a balance parameter to connect the UPMs with the LPMs and thereby unify an enhanced index model and index tracking model. We prove that both UPMs and LPMs are convex functions of portfolio position and offer a nonparametric estimation method to construct computing models. We conduct simulations to show the UPMs and LPMs trade-off characteristics of our two models. Using six global key indexes, we show that our enhanced index model outperforms the Omega model in terms of cumulative returns. In addition, because the weights of the constituents are stable, the performance of our index tracking model is similar to that of the conventional mean absolute deviation model.

Microwave-induced Conversion of Electromagnetic Energy into Heat Energy in Different Solvents: Synthesis of β-lactams

In this work, the stereospecific synthesis of optically active cis β-lactams under diverse microwave-induced conditions using diverse solvents was reported. The effects of low tanδ values of the solvents are found to be more crucial than solvents with high dipole moments and dielectric constants. The results indicated that for the synthesis of β-lactams solvents with low tanδ and high dipole moment and high dielectric constant are necessary. Best of the knowledge this is the first report that examined the importance of tanδ values of the solvents in β-lactams synthesis.

Lewis Adduct-Dissociating Hydrolysis of Boratrane for Water-Triggered Dehydration of Copolymers with a Hydrophobic Moiety.

As a new example of intrinsically water-triggered phenomena, we report underwater dehydration of the statistical copolymers synthesized from triethanolamine borate (TEAB) methacrylate and styrene (St) induced by the hydrolysis of the pendant TEAB group. TEAB possesses high polarity owing to its internal Lewis adduct structure, which is lost by hydrolysis to triethanolamine (TEA) with a lower dipole moment. Therefore, the hydration of the copolymers became unfavorable through the hydrolysis of the pendant TEAB to TEA, despite polyol formation, and through a hydrophobic interaction based on St moieties becoming alternatively dominant. The dehydration behavior of the copolymers, along with the hydrolysis of the pendant TEAB group, was systematically investigated. The water solubility of the copolymers was found to be dependent on the gradient of the hydrolysis equilibrium of TEAB on the side chains and was the lowest for the TEA state. These findings offer a novel concept toward designing water-responsive materials.

The effects of foot orthosis and low-dye tape on lower limb joint angles and moments during running in individuals with pes planus

BackgroundPes Planus or Flat feet is one of the most common lower limb abnormalities. When runners with this abnormality participate in recreational running, interventional therapies could help in pain alleviation and enhance performance. To determine the most effective treatment, however, a biomechanical examination of the effects of each treatment modality is required. Research questionThe aim of the present study was to investigate the effects of Foot Orthoses (FOs) and Low-Dye Tape (LDT) on lower limb joint angles and moments during running in individuals with pes planus. Methodskinematic and kinetic data of 20 young people with pes planus were measured during running in three conditions: (1) SHOD (2) with shoes and FOs (3) with shoes and LDT. One-way repeated measure ANOVA was used to investigate the impacts of the FOs and LDT on the lower limb joint angles and moments throughout the stance phase of the running cycle. ResultsThe results showed that FOs reduced ankle eversion compared to SHOD and LDT (P < 0.001) and decreased the dorsiflexion angle (P = 0.005) and the plantarflexor moment compared to the SHOD (P < 0.001). FOs increased knee adduction angle (P = 0.021) and knee external rotator moment (P < 0.001) compared to both conditions and increased knee extensor and abductor moments compared to SHOD (P < 0.001). At the hip joint, FOs only increased hip external rotation compared with the LDT condition (P = 0.031); and LDT increased hip extensor moment compared to SHOD and FOs (P = 0.037) and also increased hip adduction angle compared to SHOD (P = 0.037). SignificanceFOs with a medial wedge appears to increase the external knee adduction moment and knee adduction angles, which are risk factors for the development and progression of knee osteoarthritis. Further, usage of FOs seems to reduce the ankle joint role in propulsion as it impacts the ankle sagittal angles and moments.

Atypical Lower Limb Mechanics During Weight Acceptance of Stair Descent at Different Time Frames After Anterior Cruciate Ligament Reconstruction

Background: An anterior cruciate ligament (ACL) rupture may result in poor sensorimotor knee control and, consequentially, adapted movement strategies to help maintain knee stability. Whether patients display atypical lower limb mechanics during weight acceptance of stair descent at different time frames after ACL reconstruction (ACLR) is unknown. Purpose: To compare the presence of atypical lower limb mechanics during the weight acceptance phase of stair descent among athletes at early, middle, and late time frames after unilateral ACLR. Study Design: Controlled laboratory study. Methods: A total of 49 athletes with ACLR were classified into 3 groups according to time after ACLR—early (<6 months; n = 17), middle (6-18 months; n = 16), and late (>18 months; n = 16)—and compared with asymptomatic athletes (control; n = 18). Sagittal plane hip, knee, and ankle angles; angular velocities; moments; and powers were compared between the ACLR groups’ injured and noninjured legs and the control group as well as between legs within groups using functional data analysis methods. Results: All 3 ACLR groups showed greater knee flexion angles and moments than the control group for injured and noninjured legs. For the other outcomes, the early group had, compared with the control group, less hip power absorption, more knee power absorption, lower ankle plantarflexion angle, lower ankle dorsiflexion moment, and less ankle power absorption for the injured leg and more knee power absorption and higher vertical ground reaction force for the noninjured leg. In addition, the late group showed differences from the control group for the injured leg revealing more knee power absorption and lower ankle plantarflexion angle. Only the early group took a longer time than the control group to complete weight acceptance and demonstrated asymmetry for multiple outcomes. Conclusion: Athletes with different time frames after ACLR revealed atypically large knee angles and moments during weight acceptance of stair descent for both the injured and the noninjured legs. These findings may express a chronically adapted strategy to increase knee control. In contrast, atypical hip and ankle mechanics seem restricted to an early time frame after ACLR. Clinical Relevance: Rehabilitation after ACLR should include early training in controlling weight acceptance. Including a control group is essential when evaluating movement patterns after ACLR because both legs may be affected.

Isometric fascicle behaviour of the biceps femoris long head muscle during Nordic hamstring exercise variations

ObjectivesTo compare biceps femoris long head (BFlh) muscle tendon unit and fascicle function during Nordic hamstring exercise (NHE) variations with different hip range of motion. DesignCross-sectional. MethodsTwelve healthy volunteers (age: 24 ± 4 years; mass: 77 ± 6 kg; height: 177 ± 4 cm) performed two NHE variations: NHE with hips in neutral (fixed) position (conventional NHE); and NHE with hip flexion/extension. BFlh fascicle length behaviour was assessed using a dual transducer ultrasound configuration. BFlh and semitendinosus muscle electromyography, lower limb kinematics and knee flexion moment were also recorded. A biomechanical model was used to estimate BFlh muscle-tendon unit (MTU) length. Statistical Parametric Mapping was used to assess timing differences in outcome variables across the movement. ResultsIn both variations, during much of the exercise (~30–80% of movement phase), BFlh fascicles undergo little length change (isometric) while the MTU lengthens. Fascicles stretched considerably just in the last ~20% of the exercise, and changes in fascicle length (<2 cm stretch) were smaller in comparison to changes in MTU length (<4 cm stretch). Hip flexion resulted in the muscle tendon unit and fascicles operating at longer lengths until approximately 80% of the movement phase. ConclusionsThe decoupling between fascicle and MTU length seen during the NHE variations suggests that stretch of the elastic tissue of the MTU has an important role in absorbing energy during Nordic hamstring exercises. This may be important when considering adaptations to BFlh muscle and connective tissues that might occur from NHE training.

Synthesis, Theoretical Calculation, and Biological Studies of Mono- and Diphenyltin(IV) Complexes of N-Methyl-N-hydroxyethyldithiocarbamate.

In this study, chlorophenyltin(IV) [(C6H5)(Cl)Sn(L)2] and diphenyltin(IV) [(C6H5)2Sn(L)2] of N-methyl-N-hydroxyethyldithiocarbamate were prepared and characterized using various spectroscopic methods (FTIR, 1H, 13C, and 119Sn NMR) and elemental analysis. The FTIR and NMR spectral data, used to establish the structure of the compounds, showed the formation of the complexes via coordination to the two sulfur atoms from the dithiocarbamate ligand and the respective phenyltin(IV) derivatives. This coordination mode was further explored by DFT calculations, which showed that the bonding around the Sn center in [(C6H5)2Sn(L)2] was more asymmetric compared to the bonding around [(C6H5)(Cl)Sn(L)2]. However, the Sn–S bonds in [(C6H5)(Cl)Sn(L)2] were found to be more covalent than those in [(C6H5)2Sn(L)2]. Furthermore, the charge density of the frontier orbitals showed that the Sn atom in the complexes is relatively electrophilic and the Sn atom in [(C6H5)2Sn(L)2] has a lower atomic dipole moment than that of [(C6H5)(Cl)Sn(L)2]. The cytotoxicity and anti-inflammatory study revealed that [(C6H5)2Sn(L)2], with the higher number of phenyl substituents, has a higher potency than [(C6H5)(Cl)Sn(L)2]. The bio-efficacy study of these complexes as cytotoxic and anti-inflammatory agents showed that the complexes possessed moderate to high activity in comparison to the camptothecin and diclofenac in each case. Nevertheless, the diphenyltin(IV) derivative [(C6H5)2Sn(L)2] was found to possess a better activity than its counterpart due to the number of phenyl rings attached to the Sn center.

Role of Knee and Ankle Extensors' Muscle-Tendon Properties in Dynamic Balance Recovery from a Simulated Slip.

Participants exposed to a simulated slip with forward loss of balance (FLB) develop large lower limb joint moments which may be a limiting factor for those whose muscle-tendon units’ (MTUs) properties are deteriorated. Whether the age-related decline in these properties limits participants’ capacity to recover their balance following a slip with FLB remains unclear. We combined isokinetic dynamometry, ultrasound and EMG to understand how knee extensor and ankle plantarflexor muscle strength and power, rate of moment development, electromechanical delay, and tendon stiffness affected the balance of young (25.3 ± 3.9 years) and older adults (62.8 ± 7.1 years) when recovering from a single slip with FLB triggered whilst walking on a split-belt instrumented treadmill. Except for the patellar tendon’s stiffness, knee extensor and ankle plantarflexor electromechanical delays, older adults’ MTUs properties were deteriorated compared to those of young participants (p < 0.05). We found no significant relationship between age or the MTUs properties of participants and balance recovery. These findings provide additional support that neither maximal nor explosive strength training are likely to be successful in preventing a fall for healthy older adults, and that other type of interventions, such as task-specific training that has already proved efficacious in reducing the risk of falling, should be developed.

Stability analysis of multiplayer games on adaptive simplicial complexes.

We analyze the influence of multiplayer interactions and network adaptation on the stability of equilibrium points in evolutionary games. We consider the Snowdrift game on simplicial complexes. In particular, we consider as a starting point the extension from only two-player interactions to coexistence of two- and three-player interactions. The state of the system and the topology of the interactions are both adaptive through best-response strategies of nodes and rewiring strategies of edges, respectively. We derive a closed set of low-dimensional differential equations using pairwise moment closure, which yields an approximation of the lower moments of the system. We numerically confirm the validity of these moment equations. Moreover, we demonstrate that the stability of the fixed points remains unchanged for the considered adaption process. This stability result indicates that rational best-response strategies in games are very difficult to destabilize, even if higher-order multiplayer interactions are taken into account.

In Silico Investigation of Some Glucose-Aspirin as COX Inhibitor

Monosaccharide derived glucose-aspirin (GA) can be prepared by conjugation between glucose and aspirin (ASA). The GA is reported to show higher analgesic and anti-inflammatory properties than ASA itself. In this perspective, six GAs which are composed of β-D-glucopyranose, ASA and acetyl groups are considered for the present investigations. The glucose unit in these GAs possesses regular chair conformation with slightly lower dipole moments. Molecular orbitals indicated a higher HOMO-LUMO gap of the molecules. All GAs showed more prone to electrophilic interactions than aspirin. Overall, glucose-aspirin esters are found to have better non-steroidal anti-inflammatory properties than the original aspirin. These GAs are better inhibitors of cyclooxygenase-2 (COX2, 5f19) compared to cyclooxygenase-1 (COX1, 6y3c) indicating that these GAs are potential drug candidates for COX2 related inflammation. Additionally, aspirinyl group at C-6 or C-3 position of the glucopyranose unit is found more suitable for anti-inflammatory activities as compared to C-4 position.