Low Gradient Research Articles

Transcatheter aortic valve replacement outcomes in patients with low-flow very low-gradient aortic stenosis.

In patients with severe aortic stenosis (AS), low-flow low-gradient (LG) is a known predictor of worse outcomes. However, very LG may represent a distinct population with further cardiac dysfunction. It is unknown whether this population benefits from transcatheter aortic valve replacement (TAVR). We aimed to describe the patient characteristics and clinical outcomes of low-flow very LG severe AS. This single-centre study included all patients with low-flow severe AS between 2019 and 2021. Patients were divided into groups with very LG [mean pressure gradient (MPG) ≤ 20 mmHg], LG (20 < MPG < 40 mmHg), and high-gradient (HG) (MPG ≥ 40 mmHg). Composite endpoint of all-cause mortality and heart failure rehospitalization was compared. A total of 662 patients [very LG 130 (20%); LG 339 (51%); HG 193 (29%)] were included. Median follow-up was 12 months. Very LG cohort had a higher prevalence of comorbid conditions with lower left ventricular ejection fraction (45% vs. 57% vs. 60%; P < 0.001). There was a graded increase in the risk of composite endpoint in the lower MPG strata (P < 0.001). Among those who underwent TAVR, very LG was an independent predictor of the composite endpoint (adjusted HR 2.42 [1.29-4.55]). While LG and HG cohorts had decreased risk of composite endpoint after TAVR compared with conservative management, very LG was not associated with risk reduction (adjusted HR 0.69 [0.35-1.34]). Low-flow very LG severe AS represents a distinct population with significant comorbidities and worse outcomes. Further studies are needed to evaluate the short- and long-term benefits of TAVR in this population.

The submerged Palaeo-Ems River in the Quaternary stratigraphic context of the German North Sea

During the Late Pleistocene, the Palaeo-Ems system (PES) was one of the major tributary channels feeding the Elbe Palaeovalley (EPV) and formed an important part of the drainage system of the continental northwestern Europe unglaciated hinterland. In this study, a detailed interpretation of high-resolution 2D sub-bottom profiler and Boomer grids were used to map the overall course of the submerged PES channel, as well as its spatial and stratigraphic relationships with other Quaternary geological units in the German North Sea. Mapping of buried tunnel valleys, a lacustrine-fill unit, straight channel structures was also carried out. The sedimentary record of the PES is represented by a low gradient and meandering channel which branched into two major pathways as it approached the EPV western flank. Its upstream to downstream trends, coupled with seaward decreasing gradient and sinuosity, are similar to those visible in present-day river deltas. Both the PES and EPV subsequently formed a combined depositional system, which was successively drowned due to the fast-rising relative sea level that overwhelmed the adaptation capabilities of the joint drainage system. For the first time, this study sheds light onto the PES/EPV morpho-stratigraphic relationships which played a key role in the coastal landscape architecture of the German North Sea since the Late Pleistocene.

Response behavior of antibiotic resistance genes and human pathogens to slope gradient and position: An environmental risk analysis in sloping cultivated land

Soils, especially in farmlands, are key media for the transmission of antibiotic resistance genes (ARGs) and their hosts from the environment to humans. Sloping farmland is an important agricultural resource, but there lack of studies on the fate and risk of ARGs in sloping land. Also, the behavior and drivers of ARGs in response to slope gradient and position are unclear. Here, metagenomics was used to investigate the profiles of ARGs, mobile genetic elements, and microbial communities in soils from lands of five slope gradients (5°, 10°, 15°, 20°, and 25°) with two slope positions (uphill and downhill). Results showed that while the abundance (except 15°) and diversity (except 20°) of ARGs increased as the slope gradient increased, the diversity of ARGs with health risk, especially the high-risk ones, decreased. For slope positions, abundant and diverse ARGs were more likely to accumulate at downhill. Furthermore, 52 bacterial genera and 12 human pathogenic bacteria (HPB) species were identified as the potential hosts for ARGs with high risk, and abundant HPB species were also detected in the soils with low gradients at downhill. Moreover, the structural equation model analysis revealed that the slope gradient and the slope position have both direct and indirect effects on the abundance of ARGs. Further correlation analysis revealed that the slope gradient has a positive effect (p < 0.05) on nitrite nitrogen in the soils. Also, the slope position has a negative effect (p < 0.05) on total phosphorus and microbial nitrogen, while positively affected (p < 0.05) on particulate nitrogen and microbial carbon, which were the key factors driving the behavior of ARGs. Overall, this study provided comprehensive information on ARGs with health risks and their potential pathogenic hosts in sloping farmland. It can be important for controlling antibiotic resistance transmission and be consistent with the One Health framework.

Occurrence of deep liquid oil reservoirs in the Sichuan and Tarim basins as constrained by geological evidences and molecular simulation

The hydrocarbon phase state of deep to ultra-deep reservoirs in the Tarim and Sichuan basins has been of great interest in oil and gas exploration. Based on a combination of molecular dynamics simulation, gold-tube pyrolysis experiments, and geological-geochemical theory, this study discusses the mechanisms governing the stability of oils in deep reservoirs from the perspectives of their reservoir accumulation histories and chemical reactions. Generally, the reason for the existence of liquid oil in the Tarim Basin is widely considered to be only controlled by external geological conditions, mainly including low geothermal gradient, absence of thermal events, low maximum reservoir temperatures, and late hydrocarbon generation process. However, this study firstly proposed that the chemical composition of oil is an internal factor for its thermal stability. The simulation results reveal that the polycondensation reactions of asphaltene will release hydrogen atoms, which can provide a necessary hydrogen source for cracking of liquid chain hydrocarbons. It means that the presence of asphaltene components can promote the cracking of chain hydrocarbons and generate methane. The normal mature oil in the Sichuan Basin generally has higher contents of asphaltenes than that of the high-mature light oil of the Tarim Basin, so more hydrogen has historically been available for the cracking of oil to gas. By looking at the accumulation histories and chemical compositions of the crude oils, this study first explains the stable long-term storage of liquid hydrocarbons in the Tarim Basin, providing important guidance for future deep to ultra-deep oil and gas exploration.

Metamorphic P–T–t evolution deciphered from episodic monazite growth in granulites of the Chencai Complex and implications for the Early Paleozoic Orogeny, West Cathaysia terrane, South China

Abstract The Early Paleozoic Orogeny in eastern South China has been highly controversial. It has been alternatively interpreted to have formed in an intra-plate setting driven by far-field tectonic forces or at plate boundaries involving subduction–collision. The West Cathaysia terrane in the core of the orogen is characterized by extensive magmatism, intense deformation and especially high-grade metamorphism. Identifying early Paleozoic high-pressure (HP) metamorphism and establishing a complete P–T–t path from the high-grade metamorphic rocks could help us understand the tectono-thermal evolution process and nature of the Early Paleozoic Orogeny. Here, we present results from a felsic granulite from the Chencai Complex in the northeastern West Cathaysia terrane. Petrographic evidence, mineral compositions and phase equilibria modelling indicate that the granulite underwent a pre-peak HP stage with P–T conditions of 13.3–14.7 kbar/696–718°C and low geothermal gradients of 13–14°C km −1 , and a peak high-temperature stage with P–T conditions of 9.7–11.0 kbar/785–820°C. A clockwise P–T path involving pre-peak decompressional heating, post-peak near-isothermal decompression and near-isobaric cooling processes was constrained for the HP felsic granulite. In situ monazite U–Pb geochronology combined with previous results date these metamorphic processes at c. 440, c. 425 and c. 400 Ma, respectively. Our new metamorphic and geochronological data from the HP felsic granulite support the case that the Early Paleozoic Orogeny was a typical collisional one.

Geomorphic complexity influences coarse particulate organic matter transport and storage in headwater streams

Coarse particulate organic matter (CPOM; organic matter 1–100 mm in diameter, excluding small wood) stored in streams provides an important energy source for aquatic ecosystems, and CPOM transport provides downstream energy subsidies and is a pathway for watershed carbon export. However, we lack understanding of the magnitude of and processes influencing CPOM storage and transport in headwater streams. We assessed how geomorphic complexity and hydrologic regime influence CPOM transport and storage in the Colorado Front Range, USA. We compared CPOM transport during snowmelt in a stream reach with high retentive feature (e.g., wood, cobbles, and other features) frequency to a reach with low retentive feature frequency, assessing how within-a-reach geomorphic context influences CPOM transport. We also compared CPOM transport in reaches with differing valley geometry (two confined reaches versus a wide, multi-thread river bead) to assess the influence of geomorphic variations occurring over larger spatial extents. Additionally, we compared CPOM storage in accumulations in reaches (n = 14) with flowing water or dry conditions in late summer and investigated how small pieces of organic matter [e.g., woody CPOM and small wood (&amp;gt;1 min length and 0.05–1 min diameter or 0.5–1 min length and &amp;gt;0.1 min diameter)] influence CPOM storage. We found that within-a-reach retentive feature frequency did not influence CPOM transport. However, valley geometry influenced CPOM transport, with a higher CPOM transport rate (median: 1.53 g min−1) downstream of a confined stream reach and a lower CPOM transport rate (median: 0.13 g min−1) downstream of a low gradient, multi-thread river bead. Additionally, we found that particulate organic carbon (POC) export (0.063 Mg C) in the form of CPOM was substantially lower than dissolved organic carbon (DOC) export (12.3 Mg C) in one of these headwater streams during the 2022 water year. Dry reaches stored a higher volume of CPOM (mean = 29.18 m3 ha−1) compared to reaches with flowing water (15.75 m3 ha−1), and woody CPOM pieces trapped 37% of CPOM accumulations. Our results demonstrate that the influence of geomorphic context on CPOM transport depends on the scale and type of geomorphic complexity, POC may be lower than DOC export in some headwater streams, and small woody organic material is important for trapping CPOM small streams.

Remimazolam anesthesia for off pump coronary artery bypass grafting and transfemoral transcatheter aortic valve implantation combined surgery in patients with angina pectoris with low flow, low gradient aortic stenosis

Remimazolam anesthesia for off pump coronary artery bypass grafting and transfemoral transcatheter aortic valve implantation combined surgery in patients with angina pectoris with low flow, low gradient aortic stenosis

On the Relationship Between Regions of Large‐Scale Field‐Aligned Currents and Regions of Plateau in Plasma Pressure Observed in the Equatorial Plane of the Earth's Magnetosphere

AbstractSince the discovery of the large‐scale field‐aligned currents it is widely acknowledged that gaps exist between the Region 1 (R1) and Region 2 (R2) currents in which the current values are relatively small as compared to neighboring regions. Assuming that the field‐aligned currents are generated by plasma pressure gradients, we analyzed data collected by the THEMIS satellites between 2007 and 2011 to identify regions with very low plasma pressure gradients (pressure plateaus), which could be responsible for the appearance of these gaps. It was found that the pressure profiles with low radial gradients are typically located between 8 and 10 Radii around the Earth. Projections of pressure plateau regions onto ionospheric altitudes, for both individual events and on a statistical basis, coincide with the locations of gaps between Iijima and Potemra field‐aligned currents. The role played by identified pressure plateaus in shaping the pattern of large‐scale field‐aligned currents is discussed.

TO THE STAGES OF THE DEVELOPMENT OF THE EARTH’S CRUST IN THE LIGHT OF MODERN KNOWLEDGE

Within the limits of the Southern Urals, the mechanism offormation of the earth’s crust is considered, represented by two geodynamicstages opposite in direction. One of them, which is primary, isdescribed as rift-spreading. In it, using modern developments and analysisof many years of factual material, the scientific provisions of theformation of the earth’s crust in the region, characterizing the geologicalconditions of extension in the pre-Paleozoic period, are substantiated.The second one, provided with the compression mode, presents the basisof the theory called the thrust-shock theory. The patterns in the developmentof fundamental geological processes are the following: magmaformation, metamorphization, sedimentation, folding and faulting, geodynamicsand tectonics, oil and gas accumulation, which formed themain essence of the general theory of the formation of the earth’s crustof the continent. It is based on: the fundamental doctrine of modernmobilism; the crust-forming role of thrusting and thrusting processes;availability of tectonics and geodynamics; assessment of the oil and gaspotential of the pre-Paleozoic of Bashkiria. It is shown that the junctionof the northeastern zone of the Bashkir uplift with the Archean-Proterozoic Taratash complex, known as the remnant of the ancientbasement of the platform, is accompanied by structural features andestimated prospects for the distribution of minerals. According to N.P.Kheraskova: outcrops of the Taratash structure show that at the base ofthe Ural structure lies a complex of highly metamorphosed rocks,largely consisting of gneisses and granites. The formation of such acomplex indicates a particularly important stage in the tectonic developmentof the Urals, a stage during which the earth’s crust was characterizedby high permeability and low geothermal gradients.

New teeth of a basal Macronarian (Sauropoda) from the Jurassic–Cretaceous transition of Spain

In this work, a dentary, and several teeth from the Valdepalazuelos-Tenadas del Carrascal site (Burgos, Spain) are studied. Geologically,this site is situatedat the base of the Rupelo Formation (Cuenca de Cameros), of Tithonian–Berriasian age. This formation has been interpreted as lacustrine-palustrine deposits with low gradient margins and with periodic changes in the water level. MDS-VPCR,851 is a fragment of the rostral symphyseal zone of a right dentary, a robust bone with a rostral ridge on its lingual surface, large diameter foramina on the lingual surface, a wide Meckelian canal extending from the rostroventral margin, semicircular symphysis arranged rostrolingually, and with two alveoli preserving two erupting teetheach. Although the functional teeth have not been preserved, each alveolus could contain one active tooth and at least two replacement teeth. Eight maxillary and mandibular teeth are described, with a spatulate crown, a rough enamel surface, a D-shaped croos-section, and a very marked cingulum. The dentary and teeth from this site have evident differences with those of other taxa and specimens described in the Kimmeridgian-Berriasian of the Iberian Peninsula. Its greatest similarities are with Camarasaurus, but in the specimens from Valdepalazuelos there are characters that seem to be unique and differ from that taxon. Consequently. the specimens described here are identified as belonging to a basal macronarian, close to Camarasaurus. This work points to the existence of two macronarian sauropods in the Tithonian–Berriasian transit of the Cameros Basin, and increases the diversity of the Iberian record of that time period.

The application of distributed optical fiber sensors (BOTDA) to sinkhole monitoring. Review and the case of a damaging sinkhole in the Ebro Valley evaporite karst (NE Spain)

Distributed optical fiber sensors (DOFS) have been postulated as a suitable technique for long-range monitoring of sinkhole-related subsidence, and possibly for the anticipation of catastrophic collapse (early-warning systems). The strain data published in previous works refer to artificial experiments considering real and virtual cover collapse sinkholes characterized by rapid subsidence and sharp lateral deformation gradients. The influence of the subsidence mechanism (sagging, collapse, suffosion) on the capability of DOFS to satisfactorily detect active subsidence is discussed. Sagging sinkholes with poorly-defined lateral edges, low lateral deformation gradients and slow subsidence are identified as the most challenging scenario. The performance of BOTDA optical fiber for monitoring such type of sagging sinkholes is evaluated in the active Alcalá sinkhole, which affects a flood-control dike creating a high-risk and -uncertainty scenario. This sinkhole shows active subsidence in sections tens of meters long with maximum subsidence rates ranging between 5 and 35 mm/yr. The comparison of vertical displacement data measured by high-precision leveling and the strain recorded by two types of fiber optic cables shows good spatial and temporal correlation. The subsidence sections are captured in the strain profiles by: (1) troughs of negative strain (contraction) in the area affected by subsidence, with the maximum strain associated with the point of most rapid settlement; and (2) lateral ridges of positive values (extension) in the marginal zones. A subsidence acceleration phase associated with a flood is also captured by substantial increments in the strain values. In this challenging scenario, despite the reasonably good spatial and temporal correlation between the displacement and strain data, the unambiguous identification of the active subsidence area with the fiber optic data alone might be difficult. Better results could be obtained improving the monitoring system (e.g., tighter cable-ground coupling) and testing other types of sinkholes with more localized deformation zones and higher subsidence rates.

Magnetic particle imaging deblurring with dual contrastive learning and adversarial framework

Magnetic particle imaging (MPI) is an emerging medical imaging technique that has high sensitivity, contrast, and excellent depth penetration. In MPI, x-space is a reconstruction method that transforms the measured voltages into particle concentrations. The reconstructed native image can be modeled as a convolution of the magnetic particle concentration with a point-spread function (PSF). The PSF is one of the important parameters in deconvolution. However, accurately measuring or modeling the PSF in the hardware used for deconvolution is challenging due to the various environment and magnetic particle relaxation. The inaccurate PSF estimation may lead to the loss of the content structure of the MPI image, especially in low gradient fields. In this study, we developed a Dual Adversarial Network (DAN) with patch-wise contrastive constraint to deblur the MPI image. This method can overcome the limitations of unpaired data in data acquisition scenarios and remove the blur around the boundary more effectively than the common deconvolution method. We evaluated the performance of the proposed DAN model on simulated and real data. Experimental results confirmed that our model performs favorably against the deconvolution method that is mainly used for deblurring the MPI image and other GAN-based deep learning models.

Does a Shallow Magma Reservoir Exist in the Wudalianchi Volcanic Field? Constraints From Magnetotelluric Imaging

AbstractWe obtain new images of the 3D resistivity structure of the Wudalianchi volcanic field (WVF). No low‐resistivity structure is found beneath Laoheishan and Huoshaoshan volcanoes in the WVF, which challenges the hypothesis of one or more magma reservoirs in the upper crust of this region. We observe a low‐resistivity body beneath Weishan volcano; however, estimated magma emplacement rates conflict with the observed volume of that body. Due to the relatively low geothermal gradient and surface heat flow in the area, magma would cool rapidly and could not be sustained for a long time unless new magma was regularly introduced into the system, but our observations do not support this scenario. We suggest that the magma in the WVF mainly originates from the mantle or the base of the crust with little crustal residence, and that the low‐resistivity body in the upper crust is likely due to saline aqueous free fluids.

Low Complexity Gradient Computation Techniques to Accelerate Deep Neural Network Training.

Deep neural network (DNN) training is an iterative process of updating network weights, called gradient computation, where (mini-batch) stochastic gradient descent (SGD) algorithm is generally used. Since SGD inherently allows gradient computations with noise, the proper approximation of computing weight gradients within SGD noise can be a promising technique to save energy/time consumptions during DNN training. This article proposes two novel techniques to reduce the computational complexity of the gradient computations for the acceleration of SGD-based DNN training. First, considering that the output predictions of a network (confidence) change with training inputs, the relation between the confidence and the magnitude of the weight gradient can be exploited to skip the gradient computations without seriously sacrificing the accuracy, especially for high confidence inputs. Second, the angle diversity-based approximations of intermediate activations for weight gradient calculation are also presented. Based on the fact that the angle diversity of gradients is small (highly uncorrelated) in the early training epoch, the bit precision of activations can be reduced to 2-/4-/8-bit depending on the resulting angle error between the original gradient and quantized gradient. The simulations show that the proposed approach can skip up to 75.83% of gradient computations with negligible accuracy degradation for CIFAR-10 dataset using ResNet-20. Hardware implementation results using 65-nm CMOS technology also show that the proposed training accelerator achieves up to 1.69x energy efficiency compared with other training accelerators.

Long-Term Trends in Ice Fog Occurrence in the Fairbanks, Alaska, Region Based on Airport Observations

Abstract Ice fog typically occurs at temperatures below approximately −30°C. Ice fog formation and persistence are affected by atmospheric processes at different spatial and temporal scales and can be influenced by anthropogenic activities that add vapor to the near-surface atmosphere. Based on meteorological observations from Fairbanks International Airport and Eielson Air Force Base (Alaska) from 1948/49 to 2021/22, we provide an overview of general ice fog climatology at the sites, changes over time, and synoptic-scale upper-level weather patterns common during ice fog occurrence. On average, ice fog occurrence has decreased by 60%–70% over the study period (median number of ice fog days at Fairbanks airport in the period 1950/51–1979/80: 16.5; median in the period 1990/91–2019/20: 6). The average lengths of ice fog events and of the ice fog season have also decreased. Trends are not linear, and rates of change vary over time. The greatest reduction in ice fog occurred during the 1970s and 1980s. Trends in ice fog hours roughly track decreasing trends in hours with cold temperatures. However, the percentage of cold hours in which ice fog occurs has decreased since approximately the 1980s. This result suggests that local changes in air pollution or near-surface moisture may also play an important role in trends in ice fog occurrence. We use self-organizing maps to assess recurring synoptic-scale weather patterns in the upper atmosphere during ice fog conditions in Fairbanks. Ice fog is typically associated with a northerly flow or low pressure gradients over the study area. Significance Statement We aim to show when and how often ice fog occurs in the Fairbanks region, how this has changed over time, and what kind of larger-scale weather patterns are common during ice fog. Ice fog strongly reduces visibility and represents a hazard to aviation and other traffic. The number of ice fog hours and days per winter has decreased substantially over the 70-yr period of record. Ice fog is, on average, less persistent now than in the past. The reduction is related to fewer days with cold temperatures, but changes in air pollution and other local factors may also play an important role. Further study is needed to fully attribute the causes of the observed changes.

Surface-subsurface connectivity in the morphological evolution of sandstone-capped tabular hills – How much analogy to karst?

This paper presents geomorphic evidence for the significant role of surface-subsurface connectivity in the geomorphological evolution of tabular hills (mesas) capped by moderately thick sandstone beds. The study area is located in Central Europe, in the Sudetes mountain range (Poland, Czechia), in an area built of a clastic succession of Late Cretaceous age. Research involved analysis of high-resolution LiDAR DTM and its various derivatives, providing insights into characteristics of drainage routes and patterns of ruiniform relief, as well as fieldwork. The latter included landform recognition and mapping, surveying representative cleft and cave systems. Specific surface landforms indicative of drainage diversion underground and subterranean pathways of sand removal include boulder-filled troughs and hollows, open clefts and plazas, pseudo-sinkholes and tilted blocks. Further evidence is provided by abundant, joint-aligned roofed slots and boulder caves, whose origin is attributed to selective sandstone weathering, sand evacuation by groundwater, and gradual subsidence. Sandy cones and sheets below exits of slots and fractures are the complementary sedimentary evidence. The percentage of caprock area drained via subterranean outflow varies from 16 % to 89 %. Reasons for the high efficacy of subterranean water and sediment transport include both structural factors (regular jointing pattern, high porosity) and, very likely, pre-conditioning role of dissolution of cement in the quartz arenites (arenization), which facilitates detachment of individual grains even by low flows under low hydraulic gradient. Thus, the sandstone-capped mesas show numerous analogies to the karst proper, especially silicate karst. They are manifested in both similar landform inventories, main preparatory processes, and considerable surface-subsurface connectivity.

Deep and ultra-deep basin brittle deformation with focus on China

This volume describes progress in understanding brittle structures in deep and ultra-deep (>4 km to > 7 km) sedimentary basins. Under deep conditions in sandstone, carbonate rocks, shale, and other rocks, fluid charge and resource recovery are sensitive to faults and opening-mode fractures. In China, work is in progress on deep, deformed, and tectonically active basins including drilling of wells expected to exceed 10 km in depth. Papers describing fractures in horizontal wells indicate locally highly clustered spatial arrangements. Orientation patterns record protracted superposed deformation. Despite deep settings, open fractures are abundant, and wide (>1 mm) fractures with varying amounts of sealing calcite are common. Differences in cement abundances are due to the diagenetic history of fractures, not their origins (e.g., tectonic loading or elevated pore fluid pressure). In carbonate rocks, solution enhanced strike-slip faults and fractures with cavernous porosity are present, and in sandstone enigmatic enhanced host-rock porosity halos a few mm wide locally surround sealed fractures. Owing to differences in thermal exposure due to recent (>6 Ma to present) rapid deep burial (in some cases >2000 m) and locally low geothermal gradients, some fractures at great depths are less diagenetically altered than those at shallower depths in the North American Cordillera. Contrasts in diagenesis may affect fracture size, spatial arrangement, and connectivity.

Hyperconcentrated floods cause extreme gravel transport through the sandy rivers of the Gangetic Plains

The Gangetic Plains comprise steep gravelly river channels that transition to low gradient sandy channels 10-40 km downstream of the mountain front. This “gravel-sand transition" is characterized by an abrupt greater-than-one-order-of-magnitude drop in both gradient and sediment grain size, suggesting a degree of long-term stability. However, the stratigraphic record of the gravel-sand transition in the Miocene Siwalik Group demonstrates intermittent transport of coarse gravels tens of kilometres downstream of the transition; such events in contemporary channels would drive channel avulsion(s) and increase flood risk, devastating communities across the plains. We combine sedimentological analysis of Siwalik deposits with entrainment calculations which demonstrate that hyperconcentration is required to transport coarse bedload over low-gradient plains. Transport conditions are attainable when intense monsoon precipitation (a 200- to 1000-year event) is combined with increased suspended sediment concentrations in channels. Predicted climate change and ongoing seismicity increase the likelihood of such extreme events within this century.

Outcomes among patients undergoing transcatheter aortic valve replacement with very low baseline gradients.

While there is evidence that patients with low-flow, low-gradient aortic stenosis (AS) benefit from transcatheter aortic valve replacement (TAVR), data are lacking regarding outcomes of patients with a very low gradient (VLG). In this retrospective, single-center study of patients with severe AS who underwent TAVR, three groups were defined using baseline mean aortic valve gradient: VLG (≤25 mmHg), low gradient (LG, 26-39 mmHg), and high gradient (HG, ≥40 mmHg). The primary outcome was the composite of Kansas City Cardiomyopathy Questionnaire (KCCQ)-12 of <45, decrease in KCCQ-12 of ≥10 compared with baseline, or death at 1 year. One-thousand six patients were included: 571 HG, 353 LG, and 82 VLG. The median age was 82.1 years [interquartile range (IQR) 76.3-86.9]; VLG patients had more baseline comorbidities compared with the other groups. The primary outcome was highest at 1 year in the VLG group (VLG, 46.7%; LG, 29.9%; HG, 23.1%; p = 0.002), with no difference between groups after adjustment for baseline characteristics. At baseline, <30% of VLG patients had an excellent or good (50-100) KCCQ-12, whereas more than 75% and 50% had an excellent or good KCCQ-12 at 30-day and 1-year follow-up, respectively. Although patients with VLG undergoing TAVR have a higher rate of poor outcomes at 1 year compared with patients with LG and HG severe AS, this difference is largely attributable to baseline comorbidities. Patients with severe AS undergoing TAVR have significant improvement in health status outcomes regardless of resting mean gradient.

Quaternary stratigraphy of southern Vietnam continental margin

This study investigates the stratigraphic architectures of the South Vietnam continental margin (SVCM) from the Pliocene to the recent period. We have utilized high-resolution seismic data and sediment core data to achieve this. The study reveals that the Quaternary sequences on the continental margin are bounded by composite erosional surfaces, which were formed due to sub-aerial erosion during periods of sea level fall and subsequent reworking processes during sea level rise. The Quaternary sequence can be divided into two subsequences: the Early Pleistocene and the Middle Pleistocene-Holocene. The Middle Pleistocene-Holocene sequences can be subdivided into six fourth-order sequences, each lasting approximately 100 to 120 thousand years. These sequences are well-preserved on the outer shelf at a modern water depth of around 100 to 120 meters. Seismic stacking patterns indicate that regressive deposits predominantly dominate the Quaternary stratigraphy of the SVCM. This means that sediment deposition during the Quaternary period was more pronounced during periods of sea-level fall. The outer shelf margin of the modern continental margin shows a south-to-southeastward migration of prograding clinoforms, indicating sediment progradation in these directions. The thick Quaternary regressive deposits preserved on the outer shelf are attributed to various factors. These factors include the low shelf gradient, tectonic subsidence, regional hinterland uplift, monsoon strengthening, and high sediment supply from the Palaeo-Mekong Delta during sea-level fall. The interaction of these factors facilitated the accumulation of thick sedimentary deposits during falling sea levels. The mid-late Pleistocene stratigraphy of the SVCM shows similarities to many other continental margins worldwide. These margins are mainly shaped under the influence of asymmetric 4th-order Milankovitch cycles. These cycles are driven by variations in Earth's orbital parameters and are characterized by longer phases of relative sea-level fall followed by shorter periods of stabilization and rise.