Long-term Effects Of Smoking Research Articles

Comparative Evaluation of Hearing and Salivary Flow Rate in Smokers and Non-smokers: A Cross-Sectional Study.

Background Smoking is a major global health issue that is linked to varioushealth conditions, including hearing loss and reduced salivary flow. This study aims to explore the relationship between smoking, hearing loss, and salivary flow rate. Methods This cross-sectional study was conducted over two months at a tertiary healthcare institute in Central India, involving 100 participants (50 smokers and 50 non-smokers) aged 18-55 years. Hearing status was assessed using audiometry, and the salivary flow rate was measured. Statistical analyses were performed using SPSS version 21 (IBM Corp., Armonk, NY, US). Results Smokers had a significantly higher prevalence of hearing loss (40%) compared to non-smokers (10%). The salivary flow rate was significantly lower in smokers (mean 0.5540 ml/min) than in non-smokers (mean 0.9240 ml/min). However, no significant correlation was found between the duration and frequency of smoking with hearing loss or salivary flow rate. Conclusion Smoking significantly impacts both hearing and salivary flow rate, hence smokers show a higher risk of hearing loss and reduced salivary flow rate. Early hearing screenings and preventive measures are recommended for smokers. Further research with larger sample sizes is needed to explore the long-term effects of smoking on these health parameters.

The Impact of Smoking on Long-Term Protection Following Hepatitis B Vaccination: A 24-Year Cohort Study.

The hepatitis B vaccination-induced immune response has been demonstrated to be associated with a number of factors, including age, sex, BMI, and the presence of comorbidities. Additionally, modifiable determinants such as smoking have been identified as influencing the response to vaccination. However, despite the evidence that smokers are at an increased risk of not responding to vaccination, the long-term effects of smoking on antibody persistence remain poorly understood. This study aims to assess the impact of smoking habits on long-term immunity following the primary vaccination cycle. Participants were required to have received a standard three-dose vaccine schedule in childhood, without subsequent doses, and to be between 18 and 24 years of age. Data on age, sex, BMI, age of administration of the first vaccine dose, and time between doses were collected. An antibody concentration < 10 IU/L was considered as non-protective. A total of 2133 individuals were included, 14.2% of whom were smokers. The mean age was 20.28 ± 0.92 years. The probability of having a non-protective antibody concentration was significantly higher in smokers than in non-smokers (AOR: 1.287; 95% CI: 1.002-1.652). The detrimental effects of smoking extend beyond the immediate effects on the vaccine response, also impairing the long-term immune response in individuals who received vaccinations during childhood.

PENINGKATAN PEMAHAMAN BAHAYA ROKOK PADA REMAJA DALAM PENGENDALIAN HIPERTENSI

Hypertension is one of the causes of premature death in people around the world. One of the risk factors for hypertension is smoking habits. The long-term effects of smoking are increased blood pressure due to increased inflammatory substances, endothelial dysfunction, plaque formation, and vascular damage. Therefore, this community service aims to increase teenagers' understanding of the dangers of smoking so that they can hopefully be able to control the incidence of hypertension sufferers. This activity was attended by 30 teenagers in Setiling 3 Hamlet, Setiling Village, North Batukliang District, Central Lombok, West Nusa Tenggara using LCD projectors and leaflets as media. The method used is lecture and discussion. This service is able to increase the knowledge and understanding of teenagers regarding the dangers of smoking on health, especially in increasing the risk of hypertension.

Trends in lung cancer incidence in Spain (1990-2019): insights from Global Burden of Diseases data.

This study examines lung cancer incidence in Spain (1990-2019) through age-period-cohort (A-P-C) analysis and Global Burden of Diseases (GBD) data, unravelling the complex interplay of age, period, and birth cohort in shaping these trends. Utilizing GBD and Spanish population data, the study calculates age-standardized incidence rates (ASIRs) and employs Joinpoint analysis to identify significant trends. A-P-C analysis dissects the individual effects of age, calendar period, and birth cohort on incidence patterns. Between 1990 and 2019, almost 738,000 cases of lung cancer were diagnosed in Spain, with an average annual increase of 1.7%. The ASIR of lung cancer in Spain from 1990 to 2019 showed a sustained upward trend in women (Average Annual Per cent Change: 2.5%, P < 0.05), reaching 23.3 cases per 100,000 in 2019, whilst men experienced a significant decrease in incidence rates (AAPC: -0.6%, P < 0.05), falling to 108.9 in 2019. The male-to-female incidence ratio decreased from 12.2 in 1992 to 4.9 in 2019. Joinpoint analysis identified distinct periods for both sexes, with men showing stability, decline and then a significant decrease, whereas women showed an initial increase followed by a decrease. The longitudinal age curves showed a consistently higher incidence risk in men, peaking in the 80-84 age group. Male cohorts since the 1920s showed a decreasing relative risk, whereas women showed fluctuations in risk over time. Lung cancer rates are falling in Spain, especially amongst men, due to lower smoking rates. The gender gap is closing, but prevention targeted at women is needed. Tighter tobacco control and research into other risk factors are essential. Understanding the long-term effects of smoking and early exposure is key to better prevention and treatment in Spain.

Investigating the Role of Race and Stressful Life Events on the Smoking Patterns of Pregnant and Postpartum Women in the United States: A Multistate Pregnancy Risk Assessment Monitoring System Phase 8 (2016–2018) Analysis

ObjectiveTo examine the smoking patterns of women who experienced stressful life events and the impact of racial disparities on the relationship between stressful life events, and prenatal/ postpartum smoking.MethodsThe study analyzed data from the Pregnancy Risk Assessment Monitoring System Phase 8 (2016–2018) survey across five states (CT, LA, MA, MO, WI). Four stressful life event categories were created using thirteen affiliated questions: financial, trauma, partner, and emotional. We assessed: 1) the association between smoking and stressful life events, 2) the impact of race on the relation between smoking and stressful life events, and 3) the long-term effects of smoking on health by assessing the association between smoking and maternal morbidity. Bivariate statistics and multivariate Poisson regression models were conducted.ResultsA total of 24,209 women from five states were included. 8.9% of respondents reported smoking during pregnancy, and 12.7% reported smoking postpartum. There was a significant association between all stressful life events and smoking. Trauma stressful life event had the strongest association with smoking during pregnancy (adjusted PR=2.01; CI: 1.79-2.27) and postpartum (adjusted PR= 1.80; CI: 1.64-1.98). Race and stressful life event interaction effects on smoking had varied significant findings, but at least one racial/ ethnic minority group (Black, Hispanic, Asian) had a higher smoking prevalence than non-Hispanic White per stressful life event category. Lastly, the prevalence of maternal morbidity was higher for smoking during pregnancy (adjusted PR= 1.28; CI: 1.19-1.38) and postpartum (adjusted PR= 1.30; CI: 1.22-1.38) compared to no smoking.Conclusions for PracticeCulturally congruent, multi-disciplinary care teams are needed to address both clinical and social needs to reduce stressful life events and smoking. Screenings for stress should be standardized with a referral system in place to provide ongoing support.

Study of the Effect of Smoking on Glycemic Status: A Clinical Study on Indian Sub-population

Smoking has been known to be a major risk factor for diabetes in several clinical studies. The present study aimed to investigate the effect of smoking cessation on glycemic status during diabetic treatment regimes. The study was carried out on 200 patients with type 2 diabetes mellitus and 30 healthy controls. Fasting blood sugar, HbA1C estimation and lipid profiling were examined. A significant (p &lt; 0.001) difference between 1st day and after 6 months of HbA1C value was observed in smoking cessation individuals. This study indicated the effect of short term cessation of smoking in diabetics also increase BMI and disturbs glycemic control. Tight glycemic control is recommended so that long term effects of smoking can be prevented.

The Effect of Smoking on Long-term Gray Matter Atrophy and Clinical Disability in Patients with Relapsing-Remitting Multiple Sclerosis.

Background and ObjectivesThe relationship between smoking, long-term brain atrophy, and clinical disability in patients with multiple sclerosis (MS) is unclear. Here, we assessed long-term effects of smoking by evaluating MRI and clinical outcome measures after 10 years in smoking and nonsmoking patients with relapsing-remitting MS (RRMS).MethodsWe included 85 treatment-naive patients with RRMS with recent inflammatory disease activity who participated in a 10-year follow-up visit after a multicenter clinical trial of 24 months. Smoking status was decided for each patient by 2 separate definitions: by serum cotinine levels measured regularly for the first 2 years of the follow-up (during the clinical trial) and by retrospective patient self-reporting. At the 10-year follow-up visit, clinical tests were repeated, and brain atrophy measures were obtained from MRI using FreeSurfer. Differences in clinical and MRI measurements at the 10-year follow-up between smokers and nonsmokers were investigated by 2-sample t tests or Mann-Whitney tests and linear mixed-effect regression models. All analyses were conducted separately for each definition of smoking status.ResultsAfter 10 years, smoking (defined by serum cotinine levels) was associated with lower total white matter volume (β = −21.74, p = 0.039) and higher logT2 lesion volume (β = 0.22, p = 0.011). When defining smoking status by patient self-reporting, the repeated analyses found an additional association with lower deep gray matter volume (β = −2.35, p = 0.049), and smoking was also associated with a higher score (higher walking impairment) on the log timed 25-foot walk test (β = 0.050, p = 0.039) after 10 years and a larger decrease in paced auditory serial addition test (attention) scores (β = −3.58, p = 0.029).DiscussionSmoking was associated with brain atrophy and disability progression 10 years later in patients with RRMS. The findings imply that patients should be advised and offered aid in smoking cessation shortly after diagnosis, to prevent long-term disability progression.

Smoking Is Associated With Microbial Translocation in the Miami Adult Studies on HIV (MASH) Cohort

ObjectivesThe prevalence of cigarette smoking is 2 to 3 times greater among people living with HIV (PLWH) than in the HIV uninfected population. Smoking has also been associated with deleterious effects on the gut leading to potential microbial translocation. Thus, we sought to use CD14 (sCD14) as a surrogate marker of microbial translocation to determine if smoking was associated with changes in microbial translocation.MethodsA cross-sectional analysis was completed with participants from the Miami Adult Studies on HIV (MASH) cohort. Demographic characteristics and cigarette smoking status were self-reported. Levels of sCD14 were analyzed using ELISA kits in Dr. Sherman's laboratory. HIV serostatus and viral load (VL) were abstracted from medical records with the participants’ consent. Statistical analyses included descriptive statistics, T-test, linear regression for sCD14 levels, and logistic regression to calculate the odds of having an sCD14 level above the sample median (1064.3 ng/mL). All analyses were conducted on SPSS 26.ResultsA total of 470 participants were included in the analysis. The mean age was 53 ± 8 years, 42.8% were females and 64.5% were Black. PLWH accounted for 76.8% of participants and 85.1% had a suppressed VL (<50 copies/mL). Smokers had significantly higher mean sCD14 levels than non-smokers (1025.8 ± 429.0 vs. 1183.4 ± 465.7, respectively; P = 0.002). This relationship remained significant after adjusting for sex, age, BMI, and HIV status (β = 166.70, SE = 52.36, P = 0.002). Also, smoking tended to be associated with 1.6 times the odds of having high sCD14 levels, adjusted for BMI, age, sex, and HIV status (β = 1.6, 95% CI = 1.0–2.6, P = 0.051).ConclusionsCigarette smoking appears to contribute to immune activation regards of HIV status which may contribute to microbial translocation, regardless of HIV status. The findings provide further evidence of the deleterious effect of cigarette smoking on physiological functions, including gut health. Further research is needed to determine the long-term effects of smoking on immune activation and microbial translocation.Funding SourcesSupported by the National Institute on Drug Abuse.

Long term effects of smoking and alcohol consumption on hematological parameters of Indian men: A cross sectional study

Current study was carried out to cross check the hematological parameters among smokers and alcoholic population from Panipat (Haryana). The hematological examination is playing very important role in assessment during the medical examinations. In the present study reveals that the hematological parameters much important to cross check these parameters in the both the population for public awareness. To make sure if there is any changes in the parameters and if any kind of enhancement in the parameters due to the over consumptions of alcohols and smokers. Material and Methods: The blood samples of the examined population was taken in the EDTA vials by following the standard procedures as mentioned in the guidelines. Total 120 samples have been taken from each group. Samples collected in the EDTA vials for the assessment. The study has been carried out on three different population, Smokers, Alcoholic &amp; Smokers, Controls (Non-alcoholic and Non-Smokers). Results: The present study aims to evaluate the effects of alcohol and smoking on the hematological parameters of a population in the rural area of Panipat (Haryana). Participants with habit of consuming alcohol and smoke who are fulfilling inclusion and exclusion criteria will be considered for their hematological parameters.

Long-term effects of smoking on serum concentrations of oxidative stress biomarkers: Results of a large, population-based cohort study

IntroductionCross-sectional studies have consistently shown an association between current smoking and oxidative stress biomarkers. However, no longitudinal studies have been performed so far. MethodsThe oxidative stress biomarkers “total thiol groups of serum proteins” (TTP), and “derivatives of reactive oxygen metabolites” (D-ROM) were measured in serum samples of 3835 participants of a population-based, German cohort study of older adults (age: 60–84 years) with repeated measurements for 2834 participants three years later. Multivariable linear regression models were applied and β-coefficients with 95% confidence intervals were obtained. ResultsIn both cross-sectional and longitudinal analysis, current smoking was statistically significantly associated with increased D-ROM levels, and a dose-response relationship between the amount of daily tobacco consumption and the D-ROM concentrations was observed that plateaued at ≥15 g of tobacco consumption per day. Former smoking was also associated with D-ROM levels. Only former smokers who quitted smoking more than 10 years ago had no increased D-ROM levels compared to never smokers. There was neither a cross-sectional nor longitudinal association between any of the smoking variables and TTP levels. ConclusionThis large population-based cohort of older German adults suggests that smoking has long-term effects on the oxidative stress burden. The further increasing D-ROM levels of current smokers at an older age and the observation that it may take more than 10 years until the redox balance is restored are solid arguments for quitting smoking as soon as possible at any age.

Investigating the association between smoking, environmental tobacco smoke exposure and reward-related brain activity in adolescent experimental smokers.

Reduced anticipatory reward‐related activity, especially in the ventral striatum (VS), may underly adolescent vulnerability to develop nicotine dependence. It remains unclear whether nicotine uptake caused by environmental tobacco smoke (ETS) exposure, known to be associated with future smoking, might prompt similar changes in the brain's reward system, rendering adolescents vulnerable for development of nicotine dependence. To address this question, we tested whether current ETS exposure and monthly smoking are associated with VS hypoactivity for non‐drug rewards in experimental smoking adolescents. One‐hundred adolescents performed a monetary incentive delay task while brain activity was measured using fMRI. To test the hypothesized relationship, we used a variety of approaches: (1) a whole‐brain voxel‐wise approach, (2) an region‐of‐interest approach in the VS using frequentist and Bayesian statistics and (3) a small volume voxel‐wise approach across the complete striatum. The results converged in revealing no significant relationships between monthly smoking, ETS exposure and reward‐related brain activation across the brain or in the (ventral) striatum specifically. However, Bayesian statistics showed only anecdotal evidence for the null hypothesis in the VS, providing limited insight into the (non‐)existence of the hypothesized relationship. Based on these results, we speculate that blunted VS reward‐related activity might only occur after relatively high levels of exposure or might be associated with more long term effects of smoking. Future studies would benefit from even larger sample sizes to reliably distinguish between the null and alternative models, as well as more objective measures of (environmental) smoking via using devices such as silicone wristbands.

Gender-specific relationship of circulatory measures with waterpipe smoking: The Irbid WiHi project

Tobacco and hypertension can increase the risk of cardiovascular diseases. However, the long-term effect of smoking, particularly waterpipe, on blood pressure (BP) is uncertain. Therefore, the current study compared heart rate (HR), systolic (SBP), diastolic (DBP), mean arterial pressure (MAP), pulse pressures (PP), and rate pressure product (RPP) in waterpipe versus never smokers. Self-reported questionnaire and automatic oscillatory device were used to obtain smoking status and BP measures, respectively, in 250 women and 261 men aged 20–85 years. Of these, 277 were waterpipe smokers (144 men and 133 women). The 2*2 (smoking status*gender) ANCOVA showed greater (P < 0.01) HR and lower (P < 0.01) SBP, MAP, and PP in the men, but not the women, smoking waterpipe. In conclusion, the current results indicate that waterpipe smoking is associated with altered cardiovascular measures, especially in men.

A Cost-Effectiveness Analysis of Smoking-Cessation Interventions Prior to Posterolateral Lumbar Fusion.

Smoking cessation represents an opportunity to reduce both short and long-term effects of smoking on complications after lumbar fusion and smoking-related morbidity and mortality. However, the cost-effectiveness of smoking-cessation interventions prior to lumbar fusion is not fully known. We created a decision-analytic Markov model to evaluate the cost-effectiveness of 5 smoking-cessation strategies (behavioral counseling, nicotine replacement therapy [NRT], bupropion or varenicline monotherapy, and a combined intervention) prior to single-level, instrumented lumbar posterolateral fusion (PLF) from the health payer perspective. Probabilities, costs, and utilities were obtained from published sources. We calculated the costs and quality-adjusted life years (QALYs) associated with each strategy over multiple time horizons and accounted for uncertainty with probabilistic sensitivity analyses (PSAs) consisting of 10,000 second-order Monte Carlo simulations. Every smoking-cessation intervention was more effective and less costly than usual care at the lifetime horizon. In the short term, behavioral counseling, NRT, varenicline monotherapy, and the combined intervention were also cost-saving, while bupropion monotherapy was more effective but more costly than usual care. The mean lifetime cost savings for behavioral counseling, NRT, bupropion monotherapy, varenicline monotherapy, and the combined intervention were $3,291 (standard deviation [SD], $868), $2,571 (SD, $479), $2,851 (SD, $830), $6,767 (SD, $1,604), and $34,923 (SD, $4,248), respectively. The minimum efficacy threshold (relative risk for smoking cessation) for lifetime cost savings varied from 1.01 (behavioral counseling) to 1.15 (varenicline monotherapy). A PSA revealed that the combined smoking-cessation intervention was always more effective and less costly than usual care. Even brief smoking-cessation interventions yield large short-term and long-term cost savings. Smoking-cessation interventions prior to PLF can both reduce costs and improve patient outcomes as health payers/systems shift toward value-based reimbursement (e.g., bundled payments) or population health models. Economic Level II. See Instructions for Authors for a complete description of levels of evidence.

Increased Risk of Short-Term Complications in Smokers Undergoing Primary Unicompartmental Knee Arthroplasty.

The effects of smoking on unicompartmental knee arthroplasty (UKA) are unknown. The purpose of this study was to evaluate the effects of smoking on short-term outcomes following primary UKA. A query of the National Surgical Quality Improvement Project (NSQIP) database was used to identify cases of primary UKA performed during years 2006 to 2017. Patient demographics, operative times, and postoperative complications were compared between smoking and nonsmoking cohorts. Descriptive statistics, univariate analyses, and multivariate analyses were conducted to evaluate the effects of smoking on primary UKA. A total of 10,593 cases of UKA were identified; 1,046 of these patients were smokers. Univariate analysis demonstrated smokers to have higher rates of any complication (4.6 vs. 3.3%, p = 0.031), any wound complication (1.82 vs. 0.94%, p = 0.008), deep wound infection (0.57 vs. 0.13%, p = 0.006), and reoperation (1.34 vs. 0.68%, p = 0.018) relative to nonsmokers. Multivariate analysis demonstrated smokers to have higher rates of any wound complication (odds ratio [OR] = 1.79; 95% confidence interval [CI]: 1.06-2.95) and reoperation (OR = 2.11; 95% CI: 1.12-3.97). Smokers undergoing primary UKA are at higher risk for any wound complication and reoperation relative to nonsmokers in the first 30 days postoperatively. Further studies evaluating the long-term effects of smoking on outcome following UKA, as well as the impact of smoking cessation on outcomes following UKA, are needed.

The Long-Term Effect of Smoking on 10 Years' Survival and Success of Dental Implants: A Prospective Analysis of 453 Implants in a Non-University Setting.

Background: The purpose of this study was to compare the survival and peri-implant bone loss of implants with a fluoride-modified surface in smokers and non-smokers. Material and Methods: All patients referred for implant treatment between November 2004 and 2007 were scrutinized. All implants were placed by the same surgeon (B.C.). The single inclusion criterion was a follow-up time of at least 10 years. Implant survival, health, and bone loss were evaluated by an external calibrated examiner (S.W.) during recall visits. Radiographs taken at recall visits were compared with the post-surgical ones. Implant success was based on two arbitrarily chosen success criteria for bone loss (≤1 mm and ≤2 mm bone loss after 10 years). Implant survival in smokers and non-smokers was compared using the log-rank test. Both non-parametric tests and fixed model analysis were used to assess bone loss in both groups. Results: A total of 453 implants in 121 patients were included for survival analysis, and 397 implants in 121 patients were included for peri-implant bone-loss analysis. After a mean follow-up time of 11.38 years (SD 0.78; range 10.00–13.65), 33 implants out of 453 initially placed had failed in 21 patients, giving an overall survival rate of 92.7% and 82.6% on the implant and patient level, respectively. Cumulative 10 years’ survival rate was 81% on the patient level and 91% on the implant level. The hazard of implant loss in the maxilla was 5.64 times higher in smokers compared to non-smokers (p = 0.003). The hazard of implant loss for implants of non-smokers was 2.92 times higher in the mandible compared to the maxilla (p = 0.01). The overall mean bone loss was 0.97 mm (SD 1.79, range 0–17) at the implant level and 0.90 mm (SD 1.39, range 0–7.85) at the patient level. Smokers lost significantly more bone compared to non-smokers in the maxilla (p = 0.024) but not in the mandible. Only the maxilla showed a significant difference in the probability of implant success between smokers and non-smokers (≤1 mm criterion p = 0.003, ≤2 mm criterion p = 0.007). Taking jaw into account, implants in smokers experienced a 2.6 higher risk of developing peri-implantitis compared to non-smokers (p = 0.053). Conclusion: Dental implants with a fluoride-modified surface provided a high 10 years’ survival with limited bone loss. Smokers were, however, more prone to peri-implant bone loss and experienced a higher rate of implant failure, especially in the upper jaw. The overall bone loss over time was significantly higher in smoking patients, which might be suggestive for a higher peri-implantitis risk. Hence, smoking cessation should be advised and maintained after implant placement from the perspective of peri-implant disease prevention.

Permanence of Modifications in Oral Microcirculation in Ex-Smokers.

BackgroundThe aim of this study was to assess the long-term effects of smoking and to investigate the permanence of this damage to the oral microcirculation.Material/MethodsWe recruited 75 patients and divided them into 3 groups: group 1 was composed of 25 healthy non-smokers, group 2 was composed of 25 healthy current smokers, and group 3 was composed of 25 healthy ex-smokers. Video-capillaroscopic examination was performed on all patients.The video-capillaroscopic investigation was performed on patients in sitting position, always with the same light source, at the same room temperature (23°C), in the morning, with the same operator (GAS), and was repeated many times for every area under investigation. An enlargement of 200× allowed us to explore point-by-point all the morpho-structural characteristics of the capillaroscopic field. For non-parametric data, we evaluated the visibility of the loops and their position in relation to the surface of the mucosa. The evaluated parametric data were length of capillary loop, diameter of the loop, capillary tortuosity, and capillary density.ResultsOur study clearly shows there was no remission of vascular damage, even 13 years after smoking cessation.ConclusionsOur research shows that that the effects of smoking are still visible in ex-smokers, even at 13 years after cessation and also that ex-smokers are still subject to the risk of oral pathologies in the interval of time that we considered.

The Association of Smoking History and Outcomes following Left Ventricular Assist Device Implantation

IntroductionCigarette smoking has been associated with poor outcomes post-heart transplantation and is considered a contraindication for transplant candidacy at most cardiac transplant centers. Left Ventricular Assist Devices (LVAD) have proven to be durable options for patients with end stage heart failure as a bridge to transplant (BT) or destination therapy (DT); however little is known about the long-term effects of smoking on patients following LVAD implantation. The purpose of this study is to assess the impact of smoking history on the risk of complications following LVAD implantation.MethodsThis study was a single center retrospective review of 322 consecutive patients who underwent continuous-flow LVAD implantation from 5/1/2008 to 12/31/2017. Based on self-report, patients were categorized as never smokers or as having a history of smoking. Pre-LVAD implantation baseline characteristics were obtained, and summary characteristics were calculated. Hospitalizations for gastrointestinal bleeds (GIB), driveline infections, strokes, LVAD thrombosis, and heart failure re-admissions were collected. Chi square analysis was used to determine differences between never smokers and those with a history of smoking. The cumulative incidence competing risk method was used for survival analysis.ResultsMedian follow up was 228 days. Patients with a history of smoking were older, predominantly male, and more likely to be Caucasian. Smokers were more likely to be hypertensive and have dyslipidemia. There was no difference with regards to LVAD type. Over the study period (table 1), smoking history was associated with increased incidence of GIB (p = 0.008), driveline infections (p = 0.05), LVAD thrombosis (p = 0.0007), and HF hospitalizations (p = 0.039). Incidence of stroke was similar between groups (p = 0.50). There was no difference with regards to survival between the two groups (graph 1).ConclusionsA history of smoking is associated with an increased incidence of LVAD-related complications, but no difference in survival was observed. Further multivariate analysis is needed to assess persistence of effect. Cigarette smoking has been associated with poor outcomes post-heart transplantation and is considered a contraindication for transplant candidacy at most cardiac transplant centers. Left Ventricular Assist Devices (LVAD) have proven to be durable options for patients with end stage heart failure as a bridge to transplant (BT) or destination therapy (DT); however little is known about the long-term effects of smoking on patients following LVAD implantation. The purpose of this study is to assess the impact of smoking history on the risk of complications following LVAD implantation. This study was a single center retrospective review of 322 consecutive patients who underwent continuous-flow LVAD implantation from 5/1/2008 to 12/31/2017. Based on self-report, patients were categorized as never smokers or as having a history of smoking. Pre-LVAD implantation baseline characteristics were obtained, and summary characteristics were calculated. Hospitalizations for gastrointestinal bleeds (GIB), driveline infections, strokes, LVAD thrombosis, and heart failure re-admissions were collected. Chi square analysis was used to determine differences between never smokers and those with a history of smoking. The cumulative incidence competing risk method was used for survival analysis. Median follow up was 228 days. Patients with a history of smoking were older, predominantly male, and more likely to be Caucasian. Smokers were more likely to be hypertensive and have dyslipidemia. There was no difference with regards to LVAD type. Over the study period (table 1), smoking history was associated with increased incidence of GIB (p = 0.008), driveline infections (p = 0.05), LVAD thrombosis (p = 0.0007), and HF hospitalizations (p = 0.039). Incidence of stroke was similar between groups (p = 0.50). There was no difference with regards to survival between the two groups (graph 1). A history of smoking is associated with an increased incidence of LVAD-related complications, but no difference in survival was observed. Further multivariate analysis is needed to assess persistence of effect.

Impact of acute exposure to cigarette smoke on airway gene expression

Understanding effects of acute smoke exposure (ASE) on airway epithelial gene expression and their relationship with the effects of chronic smoke exposure may provide biological insights into the development of smoking-related respiratory diseases. Bronchial airway epithelial cell brushings were collected from 63 individuals without recent cigarette smoke exposure and before and 24 h after smoking three cigarettes. RNA from these samples was profiled on Affymetrix Human Gene 1.0 ST microarrays. We identified 91 genes differentially expressed 24 h after ASE (false discovery rate < 0.25). ASE induced genes involved in xenobiotic metabolism, oxidative stress, and inflammation and repressed genes related to cilium morphogenesis and cell cycle. While many genes altered by ASE are altered similarly in chronic smokers, metallothionein genes are induced by ASE and suppressed in chronic smokers. Metallothioneins are also suppressed in current and former smokers with lung cancer relative to those without lung cancer. Acute exposure to as little as three cigarettes and chronic smoking induce largely concordant changes in airway epithelial gene expression. Differences in short-term and long-term effects of smoking on metallothionein expression and their relationship to lung cancer requires further study given these enzymes' role in the oxidative stress response.

Hubungan Kebiasaan Merokok Dengan pH Saliva Pada Mahasiswa Perokok di Asrama Mahasiswa Kalimantan Selatan di Yogyakarta

Long-term smoking effects can cause a decrease in salivary pH to be more acidic. To investigate the correlation of smoking habit and salivary pH on smoker students in the South Kalimantan Student Dormitory in Yogyakarta. This research is an analytical survey with a cross-sectional design, sampling was done by purposive sampling method and the sample used was 39 smoking students who have smoked with a minimum period of 1 year. The results were analyzed using Kendall-Tau correlation test with SPSS program.&#x0D; Smoking habits in the student smokers are included in heavy smoking habits (61.5%), whereas saliva pH was mostly included in the acid salivary pH criteria (64.1%). Results of cross-tabulation as many as 56.4% of smoker students have a heavy smoking habit with acid salivary pH. The test of statistical analysis obtained significance value (p) of 0.000 with Kendall-Tau correlation coefficient of -0.727. The p-value (0.000) &lt; 0.05, meaning that the results showed a significant relationship between smoking habit and salivary pH. There is a significant correlation between smoking habit and salivary pH on smoker students in the South Kalimantan Student Dormitory in Yogyakarta.

Smoking and early retirement due to chronic disability

This paper considers the long-term effects of smoking on disability retirement in Sweden. Smoking is known to have damaging effects on health, but there is limited evidence on how the effects of smoking translate into worse labour market outcomes, such as the inability to work. In contrast to the few previous studies on smoking and disability retirement, we use a large population sample with registry information on smoking, which is recorded for all women who give birth in Sweden. Thanks to these comprehensive data, we are able to account for a much broader range of potential confounders. In particular, by the use of sibling and twin fixed effects, we account for unobserved heterogeneity in childhood environment and family characteristics. Given that smoking is often initiated in adolescence, one would suspect such factors to play important roles.Among individuals aged 50–64 in 2011, a simple model suggested smokers to have a 5 percentage point higher probability of receiving (full) disability pension, making them more than twice as likely as non-smokers to receive this. However, in a model with sibling fixed effects, the size of the effect was reduced by more than a third. The results point to the importance of confounders, such as childhood circumstances or behaviours, which were not accounted for by previous studies. We also consider effects on disability due to different health conditions. In relative terms, effects are the largest for circulatory conditions and tumours. Results are largely driven by health problems severe enough to merit hospitalization, and there is no evidence of a role played by financial incentives.