Long Bones In Children Research Articles

Duration of onset, body temperature and C-reactive protein can be used to predict the results of pus culture in children with acute osteomyelitis of long bones

BackgroundWith the application of PCR testing and Metagenomic Next-Generation Sequencing(mNGS), the detection rate of causative organisms in paediatric bone and joint infections has been greatly improved. The aim of our study is to identify some indicators that could be used to distinguish the culture results to optimize the use of PCR and mNGS.MethodsIn this study, a total of 117 cases of acute osteomyelitis of long bones in children who underwent pus culture were included. Patients were grouped as culture-negative (n:21) and culture-positive (n:96) groups according to the results of pus culture. Age, sex, duration of onset, maximum body temperature at onset, inflammatory indicators and D-dimer after admission were systematically collected for all patients and were compared for both groups. ROC curve (ROC) was used to evaluate the diagnostic efficiency of culture-negative. Logistic regression analysis was conducted to determine independent risk factors for culture-negative.ResultsThere was no significant difference in age, sex and erythrocyte sedimentation rate between culture-negative group and culture-positive group (P > 0.05). The duration of onset was longer, and the temperature, white blood cells, neutrophils count, C-reactive protein and D-dimer were less elevated in culture-negative acute osteomyelitis (P < 0.05). Duration of onset, maximum body temperature at onset, white blood cell count, neutrophil count, C-reactive protein, and D-dimer have certain diagnostic efficacy in judging the efficacy of negative culture. Logistic regression analysis indicated that the duration of onset more than 6.5 days, the maximum body temperature at onset lower than 38.35℃ and C-reactive protein lower than 78.40 mg/L were independent risk factors for negative culture (P < 0.05).ConclusionsOur study revealed that duration of onset more than 6.5 days, maximum body temperature at onset lower than 38.35℃ and C-reactive protein lower than 78.40 mg/L were independent risk factors for predicting negative culture. In children with this type of acute osteomyelitis, we recommend that the pus be tested by PCR or mNGS as a priority.

Periosteal Stripping and Periosteal Division for Leg Length Discrepancy After Proximal Femoral Intertrochanteric Osteotomy for Perthes Disease.

Background and objective Periosteal stripping and periosteal division (PSPD) can help promotethe growth of the long bone in children with leg length discrepancy (LLD). We performed PSPD in a cohort of patients when LLD was observed at the time of implant removal surgery after proximal femoral osteotomy for Perthes disease. This study aimed to clarify the efficacy and safety of PSPD for acquired LLD related to Perthes disease. Methods This retrospective study enrolled 10 patients treated with PSPD and six controls who declinedPSPD for LLD associated with Perthes disease. The lengths of the femur, tibia, and entire leg were measured in the full-length standing radiographs at baseline and final follow-up. The baseline was defined as the time of the last preoperative observation. LLD and changes in LLD (ΔLLD) were measured. The correlation of ΔLLD with age at the time of surgery, follow-up period, and extent of PSPD was investigated. Results In the PSPD group, the mean age of the patients was9.4 years and the mean LLD at baseline was 20.5 ± 4.6 mm, while it was 10.2 years and 11.5 ± 10.0 mm in the control group. With a mean follow-up period of 4.3 years, the PSPD group showed a mean ΔLLD decrease of 13.9 mm, which was significantly greater than that of the control group at 3.2 mm with a mean follow-up period of 5.4 years. Logistic regression analysis revealed that age at the time of surgery was a significant factor for obtaining >10 mm ΔLLD with PSPD and the cutoff value by the receiver operating characteristic curve was 9.6 years (sensitivity: 0.83; specificity: 0.83). Conclusions PSPD seems to be a safe and effective surgical option for LLD associated with Perthes disease. The age at the time of surgery negatively correlated with the amount of LLD correction. Obtaining >10 mm LLD correction is more likely if the patients are <10 years of age.

Evaluation of Radiolucent Lesions in Cortices of Long Bones in Osteogenesis Imperfecta Patients

BackgroundOsteogenesis imperfecta (OI), a rare genetic disorder of collagen synthesis and metabolism, is characterized by cortical bone thinning and decreased trabecular bone. We have noted individuals with OI develop radiolucent lesions in the cortices of the long bones and these have not been previously described. The prevalence of these lesions in the long bones of children and the significance of their appearance in relation to subsequent fractures is unknown. MethodsIn a retrospective study, upper and lower extremity radiographs of 328 pediatric patients with OI were examined to determine the occurrence and clinical course of these lesions in patients with various subtypes of OI. ResultsLesions were present in 55 (17%) of the 328 patients. A total of 89 lesions were identified in these 55 patients with 138 positive radiographs across the OI subtypes. Of the 138 positive radiographs, lesions were present in 90/138 (65%) tibiae, 10/138 (7%) fibulae, 24/138 (17%) femora, 4/138 (3%) ulnae, 1/138 (1%) radius, and 9/138 (7%) humeri. In affected patients, there was an average of 1.62 lesions per patient. In 99% (136/138) of the radiographs, the lesion was present on the diaphysis of the long bone and in 86% (119/138) of the x-rays, the lesion was located on the tension side. 64% (57/89) of the lesions developed after a previous fracture, and in 24% (21/89) of lesions, a fracture subsequently occurred through the area of the lesion. Discussion/ConclusionWe present that radiolucent lesions of long bone diaphyses are a characteristic finding in OI and often presage fractures.

Detorsional guided growth — modern concepts and perspectives of clinical application: a review

Background. Torsional deformities of the long bones in children are usually treated using correcting detorsional osteotomies with different types of osteosynthesis. However, this method is highly traumatic and can cause severe complications. Guided growth is the gold standard for frontal and sagittal planes deformities treatment in growing children. The technique is effective, minimally invasive, enables early weight-bearing and has lower complication rate. Recently, application of guided growth technique has been actively studied for horizontal plane deformities correction as well. The aim of the review — based on a scientific literature analysis, to present possibilities of using guided growth technique for correcting torsional deformities of the long bones, as well as to define the ways of its improvement for further clinical application. Methods. The search was performed in PubMed/MEDLINE, Google Scholar and eLIBRARY databases. For review, we included 8 articles (five animal experimental studies and three clinical studies), which were published from 2013 to 2023. Results. Analyzed studies demonstrated the possibility of applying detorsional guided growth for horizontal plane deformities correction in growing children. Three main surgical techniques were suggested. Correction efficiency mainly depends on the interplate angle, proper plate positioning and longitudinal growth potential. Limitations of these studies were: a small group number; absence of preoperative CT scans in animal studies; torsional profile measurement using computed tomography was performed only in one of three clinical studies. There was also no preoperative planning of deformity correction/creation amount, so it was not possible to evaluate the accuracy of the suggested methods. The main complications were secondary deformities and limb length discrepancy. Conclusions. Further clinical application of detorsional guided growth in children may be possible after solving the problem of secondary deformities and shortening and providing preoperative planning of the deformity correction amount.

Management of closed diaphyseal fractures in children in two black African countries: Preliminary results and epidemiological profile

Objectives: The objective of this study was to describe the clinical evolution and the epidemiological profile of long bone fractures in children in two African countries. Methods: This was a five-year retrospective study of closed fractures of long bones in children aged 9.7 years (Ranging 4–16). Seventy-two fractures were treated by elastic stable intramedullary nailing and plate osteosynthesis. The results were evaluated according to Oestern and Tscherne criteria, and parental satisfaction was assessed using an individual investigation form. Results: The treatment of closed fractures of long bones in children is marked by complications such as infection (16.6%), implant migration (19.4%), non-union (11.1%), and malunion (2.7%). According to the assessment criteria, 33.3% were excellent, 45.8% were good, and 20.8% were poor. Twenty percentages of parents were very satisfied, 61% were satisfied, and 18% were disappointed with the outcome. Conclusion: Osteosynthesis is only indicated in common pediatric trauma if the capabilities of remodeling a callous are insufficient. It should not be the first choice in children’s fracture therapeutic options.

Comparison of limb reconstruction with vascularized fibula flap versus induced membrane technique in 54 pediatric cases over 16 years

BackgroundChildren's bone loss of limbs represents a significant challenge for surgeons, especially given that children are growing individuals. In the pediatric population, we compared bone reconstruction using vascularized fibula flaps with the induced membrane technique. The primary purpose of this study was to evaluate the delay and quality of consolidation. Methods.Data from patients who underwent limb reconstruction using either the fibula flap or the induced membrane were retrospectively collected from files across two centers. Perioperative and long-term complications were documented, along with functional and aesthetic outcome. ResultsBetween 2004 and 2020, 31 children underwent limb reconstruction using a fibula flap, and 13 patients were treated using the induced membrane technique. The etiologies included 76% tumors, 20% congenital pseudarthroses, and 3.7% infections. The median size of the bone resection was 12.5cm (range: 1.8 to 31cm). The median time to consolidation after free fibula flap transfer was 10 months (range: 2 to 55 months) versus 7.5 months (range: 1 to 64 months) for the Masquelet technique (p=0.54). Limb length inequality occured in 52% of fibula cases and 39% of the induced membrane cases (p=0.55). ConclusionsBoth of free fibula flap and the induced membrane technique are effective options for bone reconstructing long bones in children. These techniques yield good functional outcomes and have comparable consolidation times.

An Outcome Analysis of Pediatric Diaphyseal Fractures Treated Surgically With the Titanium Elastic Nailing System.

Introduction Pediatric fractures account for one-fourthof all pediatric injuries. Stabilizing the fracture, regulating the length and alignment, encouraging bone healing, and minimizing morbidity and problems for the child and family are the objectives of treatment for diaphyseal fractures of long bones in children. Our goal is to investigate how pediatric diaphyseal long bone fractures are treated with a titanium elastic nailing system (TENS). Methods A prospective interventional study was conducted on 24 children who had displaced diaphyseal fractures of major long bones, involving 31 diaphyseal fractures of long bones. Utilizing Flynn's grading standards, the result was examined. Results The mean age was 12.20 years. The youngest child was seven years old and the eldest child was 16 years old. There were 20 boys (83.33%) and four girls (16.67%). The male-to-female ratio was noted to be 5:1. The commonest mode of injury was road traffic accidents (12 cases, 50%), followed by falls while playing (10 cases, 41.67%). Other causes included falls from height (one case, 4.17%)and blunt trauma (one case, 4.17%). The commonest bone to get fractured was the femur (37.50%), followed by both bones of the forearm (29.17%), tibia (20.83%), humerus (8.33%), and ulna alone (4.17%). The middle third (21 fractures, 67.74%) was the most prevalent location for fractures. Five fractures each (16.13%) accounted for in the proximal and distal thirds. Twelve fractures (38.71%) were detected on the left side, while the majority of fractures (19 fractures, 61.29%) were seen on the right side. Most of the fractures in this group were transverse fractures (18 fractures, 58.06%) followed by oblique fractures (eightfractures, 25.81%). Comminuted fractures accounted for five fractures (16.13%). Of the 31 fractures, open reduction had to be done in two fractures, after unsuccessful attempts at closed reduction. Closed reduction was done in 29 fractures. There were 15.12 weeks in the average union term. The range is six weeks to 39 weeks. The most frequent side effect was discovered to be skin irritation at the entry site. The extraosseous portion of nails caused irritation at two entry sites (6.45%). A case had delayed union (3.23%) and restricted knee range of movements. Conclusion For the treatment of juvenile diaphyseal fractures of the long bones, the TENSis the best option. It is a quick, straightforward, safe, dependable, and efficient way to treat pediatric long-bone fractures in patients aged five to 16 years. The healing process takes a fair amount of time, while the surgery takes less time. It does away with the necessity for extended bed rest and significantly shortens hospital stays. It provides stability and elastic mobility, which is perfect for early mobilization and quick union at the fracture site. It has a low rate of complications and produces excellent functional results.

Correction of rotational deformities in long bones using guided growth: a scoping review.

The objective of this scoping review was to describe the extent and type of evidence of using guided growth to correct rotational deformities of long bones in children. This scoping review was conducted in accordance with the JBI methodology for scoping reviews. All published and unpublished studies investigating surgical methods using guided growth to perform gradual rotation of long bones were included. Fourteen studies were included: one review, three clinical studies, and ten preclinical studies. In the three clinical studies, three different surgical methods were used on 21 children. Some degree of rotation was achieved in all but two children. Adverse effects reported included limb length discrepancy (LLD), knee stiffness and rebound of rotation after removal of tethers. Of the ten preclinical studies, two were ex vivo and eight were in vivo. Rotation was achieved in all preclinical studies. Adverse effects reported included implant extrusions, LLD, articular deformities, joint stiffness and rebound of rotation after removal of tethers. Two of the studies reported on histological changes. All studies conclude that guided growth is a potential treatment for rotational deformities of long bones. There is great variation in animal models and surgical methods used and in reported adverse effects. More research is needed to shed light on the best surgical guided growth method, its effectiveness as well as the involved risks and complications. Based on current evidence the procedure is still to be considered experimental. 4.

SCOPING REVIEW OF ROTATIONAL GUIDED GROWTH IN THE GROWING BONE

The aim of this scoping review is to understand the extent and type of evidence in relation to the use of guided growth for correcting rotational deformities of long bones. Guided growth is routinely used to correct angular deformities in long bones in children. It has also been proven to be a viable method to correct rotational deformities, but the concept is not yet fully examined. Databases searched include Medline, Embase, Cochrane Library, Web of Science and Google Scholar.All identified citations were uploaded into Rayyan.ai and screened by at least two reviewers. The search resulted in 3569 hits. 14 studies were included: 1 review, 3 clinical trials and 10 pre-clinical trials. Clinical trials: a total of 21 children (32 femurs and 5 tibiae) were included. Surgical methods were 2 canulated screws connected by cable, PediPlates obliquely oriented, and separated Hinge Plates connected by FiberTape. Rotation was achieved in all but 1 child. Adverse effects reported include limb length discrepancy (LLD), knee stiffness and rebound of rotation after removal of tethers. 2 pre-clinical studies were ex-vivo studies, 1 using 8-plates on Sawbones and 1 using a novel z-shaped plates on human cadaver femurs. There were 5 lapine studies (2 using femoral plates, 2 using tibial plates and 1 using an external device on tibia), 1 ovine (external device on tibia), 1 bovine (screws and cable on metacarp) and a case-report on a dog that had an external device spanning from femur to tibia. Rotation was achieved in all studies. Adverse effects reported include implant extrusions, LLD, articular deformities, joint stiffness and rebound. All included studies conclude that guided growth is a viable treatment for rotational deformities of long bones, but there is great variation in models and surgical methods used, and in reported adverse effects.

A Systemic Review of Primary Malignant Long Bone Tumors in Children and Adolescents.

Managing bone tumours is complex, relying on limited evidence, expert opinions, and retrospective reviews. Multidisciplinary approaches and early diagnosis are crucial for better outcomes, especially in young patients with growing skeletons. The aim of this systemic review and meta-analysis is to give a comprehensive review of common malignant tumors affecting long bones in children and adolescents. A PubMed/Medline search for "primary malignant long bone tumours in children" initially retrieved 1120 papers, which were subsequently narrowed down to 110 articles based on inclusion and exclusion criteria. These articles were reviewed, focusing on clinical presentation, diagnostic workup, treatment options, surgical planning, and variations in presentation, including rare tumours. The two most commonly reported tumours were osteosarcoma and Ewing sarcoma, leading to the division of studies into five groups. The inclusion criteria encompassed malignancies in patients aged 2-25 years, work-up, imaging, surgical treatment, rare tumour case reports, and surgical management principles, resulting in a heterogeneous group of articles. To enhance categorisation, it was clarified that studies with 10 or more cases were considered retrospective reviews. Reviewing of results thus demonstrate that the two likely tumours in children under consideration were osteosarcoma and Ewing sarcoma. Their presentation findings and clinical features were discussed in detail in the review. It is worth noting here that in case of differential diagnosis this should be the first on the list. Although focus of literature is more on the two most common tumours. However, rare tumours should be considered as they can mimic these common tumors. primary, malignant, bone tumors, children, adolescent.

Radiological Criteria for Acceptable Alignment in Paediatric Mid-Shaft Forearm Fractures: A Systematic Review.

Forearm fractures are common in children. The remodelling capacity of growing long bones in children makes these potentially forgiving injuries, recovering with good outcomes despite minimal intervention. Clinicians rely on radiological characteristics that vary with age to guide treatment decisions and minimise adverse sequelae. The purpose of this review was to consolidate the evidence base of radiological indications for intervention in paediatric mid-shaft forearm fractures. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed for this review. Citable research output reporting radiological criteria for mid-shaft forearm fractures in paediatric patients (age ≤16 years) was screened and analysed to ascertain acceptable radiological criteria for non-operative management. A total of 2,059 papers were initially identified; 14 were selected following screening. Sagittal angulation >15°, coronal angulation >10°, and/or >50% (or >1cm) translation were the most common radiological indications for intervention in children aged 0 to 10 years. For children over 10 years of age, the most common radiological indication for intervention was sagittal angulation >10°, coronal angulation >10°, and/or >50% (or >1cm) translation. This study revealed a scarcity of high-quality evidence to guide management and significant variation in outcome reporting throughout the published literature. Since Noonan and Price's 1998 recommendations, there has been no significant evolution in the evidence-base guided threshold for intervention in paediatric mid-shaft forearm fractures. There remains a pressing need for a robust multicentre observational study using the patient-reported outcome measurement information system (PROMIS) to address this complex and controversial area of uncertainty in paediatric trauma management.

Accuracy and Reliability of Cortical Buckling or Bulging: A Reliable Indicator of Ultrasound in Diagnosing Buckle or Torus Fracture of Long Bones in Children

Accuracy and Reliability of Cortical Buckling or Bulging: A Reliable Indicator of Ultrasound in Diagnosing Buckle or Torus Fracture of Long Bones in Children

Outcomes of Surgical Treatment of Diaphyseal Fractures of Long Bones in Children and Adolescents through Open Reduction and Intramedullary K-Wire Fixation at Yopougon Teaching Hospital, Abidjan (Côte d’Ivoire)

Outcomes of Surgical Treatment of Diaphyseal Fractures of Long Bones in Children and Adolescents through Open Reduction and Intramedullary K-Wire Fixation at Yopougon Teaching Hospital, Abidjan (Côte d’Ivoire)

Abstract 2339: Exploration of multiple immunotherapy modalities in ostesarcoma

Abstract Osteosarcoma (OS) is the most common primary bone malignancy affecting long bones in children and the third most frequent in adults in the United States. It is highly invasive and metastatic. The survival rates over the last 20 years are unchanged. Therefore, it is essential to develop novel, targeted therapeutic approaches to treat OS. In pursuit of that goal, novel models are needed. Due to the high similarity in cancer genetics, the spontaneous occurrence of tumors, and the presence of an intact immune system, dogs are deemed an excellent cancer immunotherapy model. OS is also the most common malignant bone tumor (80%) in dogs. Monotherapies like oncolytic viruses and immune checkpoint inhibitors have been shown to be insufficient for effective cancer treatment. Therefore, we propose a combination of immune checkpoint inhibition and oncolytic virotherapy to target osteosarcoma tumor cells. In this combined therapy, the oncolytic virus will serve to both stimulate an inflammatory response and transmit the checkpoint inhibitor, which in turn will block PD-1-directed down-regulation of T cells, allowing the adaptive immune system to respond better to tumors. In order to evaluate this approach in the canine model, we have developed an oncolytic virus (CAV2-AU-M2) based on canine adenovirus type 2 and armed with an immune checkpoint inhibitor, an anti-canine PD1 single domain camelid antibody (sdAb). Four canine osteosarcoma cell lines, D17, D22, MCKOS, and CF11, were cultured in two-dimensional (2D) and three-dimensional (3D) cultures and were infected with CAV2-AU-M2 to analyze the infective and lytic effects of the virus. CAV2-AU-M2 infected and lysed the cells in 2D. The virus also produced anti-PD1 sdAb upon infecting the cells. Similarly, results were evident in 3D cultures. The virus infected the spheroids in the outer layers on Day 4 and slowly diffused towards the core in 7 days. The spheroids infected started showing some cell death on day 4, which progressed significantly by Day 7. This approach to oncolytic virotherapy makes the tumor more visible to the immune system and abrogates tumor-induced immune suppression. Citation Format: Aliaa A. Ismail, Daniel J. Patton, Theresa A. Higgins, Maninder Sandey, Bruce F. Smith, Payal Agarwal. Exploration of multiple immunotherapy modalities in ostesarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2339.

Comparison of the use of intramedullary telescopic system and titanium elastic rods in children with osteogenesis imperfecta I and III types

Comparison of the use of intramedullary telescopic system and titanium elastic rods in children with osteogenesis imperfecta I and III types

IoMT-Based Osteosarcoma Cancer Detection in Histopathology Images Using Transfer Learning Empowered with Blockchain, Fog Computing, and Edge Computing.

Bone tumors, such as osteosarcomas, can occur anywhere in the bones, though they usually occur in the extremities of long bones near metaphyseal growth plates. Osteosarcoma is a malignant lesion caused by a malignant osteoid growing from primitive mesenchymal cells. In most cases, osteosarcoma develops as a solitary lesion within the most rapidly growing areas of the long bones in children. The distal femur, proximal tibia, and proximal humerus are the most frequently affected bones, but virtually any bone can be affected. Early detection can reduce mortality rates. Osteosarcoma’s manual detection requires expertise, and it can be tedious. With the assistance of modern technology, medical images can now be analyzed and classified automatically, which enables faster and more efficient data processing. A deep learning-based automatic detection system based on whole slide images (WSIs) is presented in this paper to detect osteosarcoma automatically. Experiments conducted on a large dataset of WSIs yielded up to 99.3% accuracy. This model ensures the privacy and integrity of patient information with the implementation of blockchain technology. Utilizing edge computing and fog computing technologies, the model reduces the load on centralized servers and improves efficiency.

Indications for transosseous osteosynthesis and the limits of its use for fractures of long bones in children

The results of treatment of 3067 children with long bone fractures were analyzed. The method of transosseous osteosynthesis was used in 114 children (116 fractures). The frequency of its use was, depending on the type and location of the fracture, from 0.9 to 21%. On the basis of a comprehensive study involving radiography, scintigraphy, polarography, echoosteometry, thermography, indications for the use of compression-distraction osteosynthesis in children have been developed and substantiated: the method is indicated for fractures of long bones with a complicated course - improperly fused fractures with unacceptable displacements, fractures with circulatory disorders and bone formation in the damaged area, multiple and difficult to reposition fractures. The choice of the type of apparatus was carried out individually

Salmonella Osteomyelitis in Two Immunocompetent Children

Intraosseous infection of Salmonella species typically occurs in long bones in children with hemoglobinopathies, like sickle cell anemia. Osteomyelitis of the pelvis or vertebral body in healthy children is extremely rare. This is especially so when occurring in the same period in the same geographical area. Antibiotic treatment alone can be effective; however, in case of a persistent ongoing infection or foreign body in situ , surgical drainage should be considered. We present two cases of young adolescents, both 15 years old, presenting with Salmonella infection causing osteomyelitis and late hardware infection in Curacao. Int J Clin Pediatr. 2022;11(2):60-65 doi: https://doi.org/10.14740/ijcp487

Primary Subacute Osteomyelitis Affecting the Epiphysis in Children

Primary subacute osteomyelitis affecting the long bones in children is rare. Subacute osteomyelitis has obscure clinical findings, and an accurate diagnosis requires appropriate radiological examination.Herein.

The role of modified Glasgow prognostic score in prognosing the life expectancy figures of osteosarcoma patient at general hospital H. Adam Malik

Introduction: Osteosarcoma is a malignant neoplasm originating from poorly differentiated cells in the metaphyseal area long bones of children, with a 5-year survival rate below 20%. The evaluation of patient?s prognosis with osteosarcoma using the modified Glasgow Prognostic Score (mGPS) determine the albumin and C-Reactive Protein values to assess inflammation of a tissue. The mGPS scores are 0,1,2 with the higher the score the worse the prognosis. Researchers want to know the role of mGPS in osteosarcoma patients and the prognosis of life expectancy in a general hospital. Material and Method: A retrospective cohort study with a population of osteosarcoma patients at General Hospital H. Adam Malik Medan, which was examined for albumin and C-Reactive Protein (CRP). Using the total sampling method, patients? data was obtained through hospital medical records from January 2012 to December 2017 and a mGPS assessment (0,1,2) was recorded. Then a follow-up was carried out recording patients who were found to survive at >2 years and >5 years. Results: There were 34 patients, of which 26(76%) were male and 8(24%) were female. With the highest age group in the 2nd decade (n=20, 59%) followed by the 3rd decade (n=6, 17%) and the 1st decade (n=5, 15%). The predilection for tumor location was often the same in the distal femur and proximal tibia (n=12, 35%) followed by the proximal humerus (n=5, 15%), and proximal femur (n=4, 12%). Meanwhile, the number of patients based on the mGPS 0-2 value was overal the same (n=11-12, 32-36%). In the 2-year survival rate group (p=0.033), there were 9 (45.0%), 7 (35.0%), and 4 (20.0%) patients with mGPS scores of 0, 1, and 2. Meanwhile, there were 5 (71.4%), 2 (28.6%), and 0 (0.0%) patients with mGPS scores of 0, 1 and 2 in the 5-year survival rate group (p=0.009). Conclusion: Based on the results of data analysis, it was found that there was a significant relationship (p <0.05) between the mGPS assessment and the patient's life expectancy in 2 years and 5 years.