Lipid Profile In Obese Children Research Articles

THE EFFECTS OF 12 WEEKS BASIC GYMNASTICS EXERCISES ON BODY COMPOSITION AND LIPID PROFILES IN OBESE CHILDREN

Obesity is a major health concern in the world because it is associated with many diseases. It has been shown that basic gymnastics exercises effectively prevent and treat this problem. Therefore, the present study investigated the effect of 12 weeks of basic gymnastics exercises on body composition and lipid profile in obese girls. In this quasi-experimental study, with a design pre-test-post-test and a control group, 30 obese girls with Body Mass Index (BMI) at or above the 95th percentile and the average age of 9.4 years, were selected purposefully and were divided into 2 groups (Basic gymnastics training, and control) randomly. The training protocol was implemented for 12 weeks, three times a week, and 45 minutes for each session incrementally. Body composition and lipid profile indices were measured in two stages: pre-test and post-test. In order to analyze the data, multivariate covariance tests were used. The results of the study showed that the exercise intervention significantly reduced the fat percentage and BMI index in obese children (p≤0.001). In addition, a significant decrease in total cholesterol, triglyceride, and Low Density Lipoprotein Cholesterol (LDL-C) and a significant increase in High Density Lipoprotein Cholesterol (HDL-C) were observed (p≤0.002). These findings indicate the beneficial effects of basic gymnastics training on body composition and lipid profile in obese children. Therefore, the use of basic gymnastics training is recommended to improve these factors.

Lipid profile in obese children

Lipid profile in obese children

Features of cardiometabolic disorders in obesity on the example of the children’s population of the Rostov region

Objective: to study the features of the blood lipid profile in obese children and adolescents, depending on the presence of insulin resistance, endothelial dysfunction and minimal diastolic dysfunction of the left ventricle. Materials and methods: the study involved 370 obese children and adolescents from 7 to 17 years of age (the main group) with a body mass index BMI > 30, the control group consisted of 123 children of the same age without obesity. Methods: clinical, paraclinical (biochemical blood test, blood pressure measurement, functional diagnosis of endothelial dysfunction, assessment of minimal diastolic dysfunction). Results: cardiometabolic disorders in obesity in childhood and adolescence are accompanied, first of all, by hypertriglyceridemia, which entails further violations of the lipid profile. There was also a positive correlation between changes in insulin and triglyceride levels in children and adolescents with obesity and endothelial dysfunction, as well as in patients with HOMA IR 3.2 and a combination of endothelial dysfunction and minimal dysfunction. Conclusions: based on the study of the nature of lipid spectrum disorders in obese children and adolescents and the presence of signs of endothelial dysfunction and/or minimal left ventricular dysfunction, it was concluded that obesity at this age is more often accompanied by minimal left ventricular diastolic dysfunction or a combination of endothelial dysfunction and left ventricular dysfunction. The development of insulin resistance leads to an increase in the combined pathology (ED and MDLj). Hypertriglyceridemia, which is associated with high levels of insulin and presumably determines the development of insulin resistance, plays an important role in the development of cardiometabolic disorders in obesity in childhood and adolescence.

Lipid profile of obese children with metabolic syndrome

Relevance. Disorders of lipid metabolism are closely related to abdominal (visceral) obesity and MS in adolescence, as well as the development of early cardiovascular complications in adulthood.The purpose of the study: to Study the features of the blood lipid spectrum in obese children, depending on the presence of signs of MS.Materials and methods: 483 obese children (SDS BMI ≥ 2.0) (349 boys and 234 girls) aged from 5 to 16 years were. I group — 237 children (145 boys and 92 girls) with MS (IDF, 2007), II group — 246 children (140 boys and 106 girls) with obesity without signs of MS. The examination included anamnesis collection, anthropometry, blood PRESSURE measurement, ultrasound examination of the abdominal organs, biochemical examination of blood serum and lipid profile.Results. Change in lipid profile were detected in 76.8% of children in I group and 43.9% of children in II group have 38,0% of children in I group the changes on a single metric, the 35.6% of children two, and 3.0% — three and more indicators, whereas in II group the most frequently recorded changes of only one (36,2%), at least two indicators (7,7%). In I group children, there was a significant increase in TG, the atherogenicity coefficient, and a decrease in HDL cholesterol. 53.6% of children of I group and only 8.5% of children of II group had an increase in the level of TG, and 52.8% and 24.0% of children had a decrease in HDL levels, respectively. The combination of hypertriglyceridemia and hypo-α-lipoproteidemia was diagnosed exclusively in I group (27.0%), of which boys –62.5%, girls –31.5%. In I group the frequency of hyperglyceridemia and hypo-α-lipoproteinemia regardless of age was significantly higher than II group, while in both groups a higher frequency compared to hyperglyceridemia had Hypo-α-lipoproteinemia. In II group, children under 10 years of age also had lipid profile disorders-hypo-α-lipoproteidemia in 27.8%, hypertriglyceridemia‑11,1%. An increase in the level of TG in children with signs of NAFLD in I group was diagnosed not only more often than in children without it, but also in comparison with children of II group. 46,5% of children in I group with NAFLD and 58.4% without it had a decrease in HDL cholesterol; in II group, these values were 15.7% and 17.6%, respectively. In I group, the combination of hypertriglyceridemia and Hypo-α-lipoproteidemia was observed in 28.9% of children with NAFLD and 22,5% of children without it; in II group, they were registered separately. Regardless of the group, 48,7% of children who were obese for 1–2 years and 60,1% of children with a disease duration of 5 years or more had lipid profile disorders. Violations of one component had 31,6% and 31.1% of children, respectively, the frequency of violations of two or more components as the duration of the disease significantly increased — from 17.1% to 29.0%.Conclusions. In half of children with MS, lipid metabolism disorders are detected in the form of an increase in the level of TG (53.6%) and a decrease in HDL (52.8%), which is significantly higher than in children with uncomplicated obesity (8.5% and 24.0%). Exclusively in children with MS, there is a combination of hypertriglyceridemia and hypo-α-lipoproteinemia (27%). In 28% of obese children under 10 years of age, hypo-α-lipoproteidemia was detected, in 11% — hypertriglyceridemia, which indicates that dyslipidemia is formed in them at a young age and progresses with the duration of the disease, and its early manifestation is a violation of the excretion of tissue cholesterol due to a decrease in HDL levels. The presence of a combination of MS and NAFLD in obese children is a prognostically unfavorable risk factor for the formation and progression of more pronounced disorders of lipid metabolism. Installed deterioration of the lipid spectrum of blood serum as the duration of obesity, manifested by a reliable increase in the frequency of combined violations of two or more indicators that indicates a need for complex treatment and preventive measures at earlier stages of the disease (first 1–2 years) to reduce the risk of formation of MS and atherogenic complications in the future.

Cross sectional study on patterns of lipid profiles in obese and normal children in south Indian private schools

Introduction: Childhood obesity affects both developed and developing countries of all socio-economic groups, irrespective of age, sex or ethnicity. Objective: to study the patterns of lipid profiles in obese and normal children. Materials and Methods: A total of 50 healthy children between the age group of 10-15 years were selected from private schools in Kurnool City. Schools were selected based on simple random sampling method. The study was conducted after taking clearance from Kurnool Medical College ethical committee. Then fasting blood samples of children were collected in the morning under aseptic conditions for the estimation of lipid profile. Lipid profile was estimated in Central Clinical Laboratory of Government General Hospital Kurnool with the Semi- Auto Analyzer using the CHOD POD method. Results: Total Cholesterol (TC), Serum Triglycerides (S.TG), High Density Lipoproteins (HDL–C), Low Density Lipoproteins (LDL-C) and TC/HDL ratio levels are significantly higher in obese children compared to normal children in the present study was noted.| Conclusion: Increased levels of Lipid profile in obese children may be due to high calorie intake and decreased physical activity of the children. The present study suggests that school children should take a balanced diet, try to avoid intake of fat food and increase their physical activity by playing outdoors. Keywords: Children, Lipid profile, Obesity.

Cardiac Functions & Lipid Profile In Obese Children & Adolescents

Background: Obesity is a disease which results from genetic or lifestyle factors. Such diseases are called Non communicable diseases. The epidemic of obesity among youth is spreading at an alarming rate due to lack of physical activity, dietary habits. The percentage of youths who are at risk of becoming overweight continues to increase. National data indicates that 16% of children aged six to nineteen years are overweight.(1) Considering the high prevalence of obesity among children and adolescents and its associated cardiovascular complications like hypertension, left ventricular hypertrophy, increased left ventricular mass, decreased left ventricular ejection fraction, the present study was planned to assess cardiac functions and lipid profile in obese children and adolescents. Early detection and intervention can help in reducing the complications associated with obesity. Objective: Primary objective is to assess cardiac functions and lipid profile in obese children and adolescents. Methodology: 100 obese children and adolescents in the age group 6-18 years were taken after excluding obese children with evidence of endocrine disease, malformation syndromes and iatrogenic obesity (drug treatments). Results: In the present study 7% subjects were hypertensive while 8% were prehypertensive. 71.43% children with hypertension were performing physical activity for < 30 min in 1-3 days/week while 49.11% normotensive children were performing physical activity for > 30 min per day. 3% obese children were having abnormal LVEF on 2DECHO .All the 3 obese children with abnormal LVEF were having physical activity less than 30 min in 1-3 days /week and the difference was statistically significant. All the three children with abnormal LVEF were hypertensive and the difference was statistically significant. 6% children were having raised serum cholesterol >190mg/dl. Serum triglyceride >150mg/dl was observed in 17% obese children. HDL level <20mg/dl was observed in 7% children while LDL above 130mg/dl was observed in 6% children. The proportion among male and female children was comparable. Conclusion: Cardiovascular complications of adulthood in obese children and adolescents may be prevented by early identification and intervention in the form of healthy life style, dietary intake and physical activity.

Lipidomics Reveals Similar Changes in Serum Phospholipid Signatures of Overweight and Obese Pediatric Subjects.

Obesity is a public health problem and a risk factor for pathologies such type 2 diabetes mellitus, cardiovascular diseases, and nonalcoholic fatty liver disease. Given these clinical implications, there is a growing interest to understand the pathophysiological mechanism of obesity. Changes in lipid metabolism have been associated with obesity and obesity-related complications. However, changes in the lipid profile of obese children have been overlooked. In the present work, we analyzed the serum phospholipidome of overweight and obese children by HILIC-MS/MS and GC-MS. Using this approach, we have identified 165 lipid species belonging to the classes PC, PE, PS, PG, PI, LPC, and SM. The phospholipidome of overweight (OW) and obese (OB) children was significantly different from normal-weight children (control). Main differences were observed in the PI class that was less abundant in OW and OB children and some PS, PE, SM, and PC lipid species are upregulated in obese and overweight children. Although further studies are needed to clarify some association between phospholipid alterations and metabolic changes, our results highlight the alteration that occurs in the serum phospholipid profile in obesity in children.

A Seven Day Healthy Summer Camp Improved Body Composition And Lipid Profile In Obese Children

PURPOSE: To investigate the effects of lipid profile and anthropometric measures in obese children based on a seven day participation at a health education camp (KIDS). METHODS: Twenty children were enrolled in the KIDS (12 girls; 8 boys; 9.97±1.27 yrs.; 52.5±10.3 kg; 143.6±10.94 cm). The KIDS team was composed by a Physical Educator, Nutritionist, Psychologist, Physiologist and a Pedagogue which developed the multidisciplinary activities for parents and children. The parents attended the KIDS on the first two days to raise awareness about the healthy habits for the whole family. The children stayed for another five days. The blood sample for lipid profile and anthropometric data were collected before and after KIDS. The Student t test was applied to compare pre and post KIDS data. The level of significance was set at p<0.05. RESULTS: The results are presented at table 1.Table 1: - Anthropometric data and lipids profile (Mean±SD) before and after seven-day KIDS (n=20).CONCLUSIONS: A seven-day health educational summer camp with multidisciplinary team and parent involvement induced a significant improvement in the lipid profile and anthropometric data of obese children. Financial support: CNPq # 430012/2016-0

Lipid profile in obese children with and without insulin resistance

Obesity is increasing nowadays including in children and there is lack of information on the pathophysiology and their complication such as insulin resistance and dyslipidemia. This study was aimed to investigate the comparison of lipid profile in obese children with and without insulin resistance. A crossectional study held at an elementary school in Denpasar, Bali from August until September 2015. Independent t-test, Mann-Whitney test, and Multivariate analysis of covariance (MANCOVA) were performed to compare lipid profile in obese children with and without insulin resistance. A P-value less than 0.05 was considered statistically significant. A total of 50 obese children were analyzed. In this study, we found 12 subjects (24%) with insulin resistance. Nonsignificant associations were found between insulin resistance with total cholesterol, HDL, LDL, and ratio of HDL/LDL. A significant association was found between insulin resistance and triglyceride level after adjusted age and sex. There was a significant mean difference of triglycerides in the insulin resistance and noninsulin resistance groups in obese children.

Investigation of ischemia modified albumin and coenzyme Q10 levels in obese children with metabolic syndrome

Abstract Introduction The aim of this study was to analyze serum ischemia modified albumin (IMA) and plasma CoQ10 levels and to evaluate their correlation with insulin resistance (homeostatic model assessment, HOMA) and lipid profile in obese children with and without metabolic syndrome (MS). Methods Thirty-one obese with MS, 30 obese without MS and 34 healthy children aged 6–18 years were included in the study. Serum IMA was measured by colorimetric method, plasma CoQ10 levels were measured by HPLC. Serum glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and insulin were analyzed. Results IMA levels were found to be significantly higher (p&lt;0.001) while the CoQ10 levels were significantly lower (p&lt;0.001) in obese children with and without MS compared to controls. IMA and CoQ10 significantly correlated with each other and metabolic parameters. Furthermore, IMA and CoQ10 levels did not significantly differ between obese children with and without MS, while glucose, insulin levels and HOMA were significantly higher (p&lt;0.001) in obese children with MS than obese without MS and controls. Conclusions Based on the high levels of IMA, low CoQ10 and association with HOMA and lipid profile; we suggest that obese children may have oxidative damage, lipid peroxidation and cardiometabolic risk.

Serum magnesium status among obese children and adolescents

Background and objectivesSerum magnesium is involved in the pathogenesis of obesity and its related diseases. The aim of the present study was to evaluate serum magnesium status in obese children and adolescents and to study its relationship with the degree of obesity and serum lipid profile. Design and settingsA cross-sectional study was conducted at the general pediatric out-patient clinic of a university hospital, over a period of 5months from May to September 2013. Methods50 obese subjects of ages 2–16years and 50 healthy normal weight subjects of matched age and sex as controls were consecutively enrolled. Comprehensive history, anthropometric measurements and blood pressure were taken. BMI and degree of obesity were calculated. Fasting total serum magnesium, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were measured. ResultsObese cases compared to normal weight controls showed significantly lower serum magnesium and HDL-cholesterol levels and significantly higher total cholesterol, LDL-cholesterol, triglycerides, systolic and diastolic blood pressures. Serum magnesium showed a significant, strong inverse correlation with the degree of obesity (r=−0.8, p<0.001); significant, moderate inverse correlation with total cholesterol and LDL-cholesterol; and non-significant correlation with triglycerides and HDL-cholesterol. The degree of obesity showed a significant, moderate positive correlation with total cholesterol and LDL-cholesterol and a non-significant correlation with triglycerides and HDL-cholesterol. ConclusionSerum magnesium levels are inversely correlated with the degree of obesity, and is related to an unfavorable serum lipid profile in obese children and adolescents, who also show a trend to higher systemic blood pressure.

The effects of continuous vs intermittent exercise on lipid profile in obese children

Methods: A randomised pretest–posttest design was implemented to compare the effects of continuous and intermittent exercise, measuring lipid profiles in obese children before and after the intervention. Thirty obese children (11 male and 19 female; age range: 12–15 years; body mass index ≥25) were randomised into two exercise intervention groups to engage in an 8-week exercise programme consisting of either continuous exercise (Group A) or intermittent exercise (Group B). Results: Data showed that there was a significant decrease in total cholesterol, triglycerides and low-density lipoprotein (LDL) cholesterol and a significant increase in high-density lipoprotein (HDL) cholesterol in both groups following intervention. There was a significant improvement in the lipid profile results of Group B compared with Group A. Conclusions: Intermittent exercise programmes are more effective than continuous exercise programmes in improving lipid profiles in children with obesity. Findings from this research could lead to improved health outcomes in obese patients by increasing aerobic capacity, wellness and metabolic fitness.

Nutrition Intervention Program Improves Serum Lipid Profile of Obese Children in Select Schools from Chennai

Objective: The objective of this study was to devise an intervention program to improve body mass index (BMI) and serum lipid profile of obese school children in the age group of 10 to 15 years. Materials and Methods: The study comprised of a survey and pretest and posttest experimental design and was conducted over the course of a year. The total of 4289 children from 11 schools were screened for obesity based on age and gender specific cut-off values for BMI. Of the 193 children found to be obese, 49 children enrolled for the intervention program and were assigned to three specific groups using purposive sampling. Group I (Control), Group II (Nutrition Counseling) and Group III (Nutrition counseling and Exercise) comprised of 13, 19, and 17 children-at-risk, respectively. Descriptive analysis was used for assessing details regarding their dietary and physical activity pattern. Paired t-test was used to assess data pertaining to anthropometric measurements such as height, body weight, BMI, waist circumference and serum lipid parameters (total cholesterol [TC], high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], very low-density lipoprotein cholesterol, ratio of TC/HDL-C and serum triglycerides). Results: Post intervention, BMI was found to be stable, and there was a significant increase (P < 0.01) in serum HDL-C levels and a significant decrease (P < 0.01) in the ratio of TC/HDL-C in Group III and a significant increase (P < 0.05) in serum HDL-C levels alone in Group II subjects. Conclusion: The intervention study highlights the maintenance of BMI and improvement in serum lipid parameters of children-at-risk who received periodic nutrition counseling.

Physical exercise, detraining and lipid profile in obese children: a systematic review.

Detraining is the loss of improvements obtained through the participation in physical exercise/training after training cessation, an aspect that has been poorly studied in obese child population. Therefore, the purpose of this study was to assess the effects of detraining on the lipid profile (HDL, LDL, total cholesterol and triglycerides) of obese children. Studies were collected through a search across seven databases. The search was limited to physical exercise programs that lasted, at least, eight weeks and the corresponding detraining, with an assessment of obese children lipid profile. Effect size (ES), 95% confidence intervals and study heterogeneity were estimated using Cochran's Q test (random effects model). Five studies complied with the inclusion criteria and were selected for review (n= 330). In general, intra-group results (posttest versus detraining) indicated that, following detraining, blood levels of HDL cholesterol (ES= 0.12) and total cholesterol (ES= 1.41) were increased. Likewise, inter-group results (experimental group versus control group) confirmed the increase of HDL cholesterol following detraining (ES= 0.49). The results of this systematic review suggest that detraining after a physical exercise program does not lead to a significant loss of the benefits gained in relation to the lipid profile of obese children. However, given the number of analyzed studies and the heterogeneity observed in the analyses and the period defined as detraining (12 to 48 weeks), a higher number of well designed studies is required to obtain more conclusive results.

Ejercicio físico, desentrenamiento y perfil lipídico en niños obesos: una revisión sistemática

Detraining is the loss of improvements obtained through the participation in physical exercise/training after training cessation, an aspect that has been poorly studied in obese child population. Therefore, the purpose of this study was to assess the effects of detraining on the lipid profile (HDL, LDL, total cholesterol and triglycerides) of obese children. Studies were collected through a search across seven databases. The search was limited to physical exercise programs that lasted, at least, eight weeks and the corresponding detraining, with an assessment of obese children lipid profile. Effect size (ES), 95% confidence intervals and study heterogeneity were estimated using Cochran's Q test (random effects model). Five studies complied with the inclusion criteria and were selected for review (n= 330). In general, intra-group results (posttest versus detraining) indicated that, following detraining, blood levels of HDL cholesterol (ES= 0.12) and total cholesterol (ES= 1.41) were increased. Likewise, inter-group results (experimental group versus control group) confirmed the increase of HDL cholesterol following detraining (ES= 0.49). The results of this systematic review suggest that detraining after a physical exercise program does not lead to a significant loss of the benefits gained in relation to the lipid profile of obese children. However, given the number of analyzed studies and the heterogeneity observed in the analyses and the period defined as detraining (12 to 48 weeks), a higher number of well designed studies is required to obtain more conclusive results.

IGF2 Methylation Is Associated with Lipid Profile in Obese Children

Aim: Our aim was to investigate the relationships between the degree of IGF2 methylation and the metabolic status in obese children and adolescents. Subjects and Methods: Eighty-five obese subjects aged 11.6 ± 2.1 years were studied. Anthropometry, metabolic parameters, blood pressure and body composition were assessed. DNA methylation analysis was performed by restriction enzyme digestion assay. The study population was subdivided into two groups according to the percentage of IGF2 cytidine-guanosine (CpG) island methylation. Results: Twenty-two subjects showed intermediate methylation (a percentage of CpG site methylation comprised between 10 and 60%), 56 were hypomethylated (percentage of methylation lower than 10%), and only 1 showed a high rate of hypermethylation (percentage of methylation above 60%). Children with intermediate methylation showed significantly higher levels of triglycerides (107.6 ± 41.99 vs. 76.6 ± 30.18 mg/dl, p < 0.005) and a higher triglyceride/high-density lipoprotein-cholesterol ratio (2.23 ± 0.98 vs. 1.79 ± 0.98, p < 0.02) compared with hypomethylated children. Conclusions: These preliminary findings show for the first time a relationship between IGF2 methylation pattern and lipid profile in obese children. Although the correlation does not imply causation, if our findings are confirmed in further studies, IGF2 methylation might represent an epigenetic marker of metabolic risk.

Peroxisome proliferator activated receptor (PPAR)-gamma concentrations in childhood obesity

Background. Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that regulate transcriptional responses to peroxisome proliferators. There has been limited research concerned with the childhood expression of these receptors. In this study, we aimed to evaluate PPAR-gamma (PPAR-γ) concentrations and their relationship to body mass index (BMI), ratio of waist and hip, blood pressure levels, insulin resistance and lipid profile in obese children and adolescents. Subjects and methods. Children aged 8–16 years old were included in the study; 44 obese children and 25 healthy children were taken into the study. Blood pressure and waist-hip circumference of obese patients were measured. Following a 12-hour nighttime fasting, venous blood samples were taken, including blood glucose, insulin, lipid profile, liver function tests and PPAR-γ concentrations, and all samples were analyzed at the same time. Findings. PPAR-γ concentrations were 0.226 + 0.128 in obese children and 0.547 + 0.546 in the control group. PPAR-γ concentrations were lower in obese children and this difference was statistically significant (p = 0.008). PPAR-γ concentrations of control children were 2.42-fold higher than obese children. There was a negative correlation between PPAR-γ concentrations and waist circumference, and a positive correlation between birth weight and PPAR-γ concentrations in obese children. Conclusion. In our study we found that PPAR-γ concentrations were low in obese children. In adults, treatment modalities aimed at enhancing the activation of PPAR in obesity lead to a decrease in obesity, insulin resistance, dyslipidemia and cardiovascular disease and this gives hope that similar treatment modalities can be used for children.

Impact of leptin and leptin‐receptor gene polymorphisms on serum lipids in Japanese obese children

Leptin is one of the factors affecting serum lipid profile. We investigated the association between serum lipids and leptin/leptin receptor (LEPR) gene polymorphisms in obese Japanese children. One hundred and thirty-six obese children (99 males and 37 females, relative weight over than 20%) from 5 to 17 years of age were recruited from 10 institutes. Four known polymorphisms in leptin gene [(+19)A G, (-2548)G A, (-188)C A, (-633)C T] and four known polymorphisms in LEPR gene [Lys109Arg, Gln223Arg, Pro(G)1019Pro(A), Ser(T)343Ser(C)] were determined using polymerase chain reaction-restriction fragment length polymorphism-based analyses. No associations were found between leptin gene polymorphisms and serum lipid profile. On the other hand, Lys109Arg and Ser343Ser polymorphism in LEPR gene, but not Gln223Arg or Pro1019Pro, had significant relationships with serum lipid profile; lower total and low-density lipoprotein cholesterol levels in Arg109Arg homozygotes, and lower TG levels in Ser343Ser(C/C) homozygotes. In addition, LEPR gene also associated with relative weight; Arg109Arg homozygotes had higher relative weight and Ser343Ser(C/C) homozygotes had lower one. These results suggest that LEPR gene polymorphisms may partly contribute to serum lipid profile in obese children.

The effect of dietary intervention and physical activities on the lipid profile of obese children

Background Obesity is defined as body weight increase due toexcessive fat accumulation. Obesity during childhood and teenageyears is related to cardiovascular risks including hyperinsulinism,hypercholesterolemia, decreased high density lipoprotein (HOI),and hypertension. The principles of managing obesity are reducingenergy intake and increasing energy use, e.g., by increasing physicalactivities, changing life habits and, most importantly by involvingfamily in the therapeutic process.Objective To evaluate the effect of dietary intervention andphysical activity on obese children.Methods Seventy-six obese primary school children wererandomly allocated to either receive intervention (diet andphysical activities) or no intervention. At the beginning of thestudy, lipid profile was measured in all subjects. Subjects in theintervention group were asked to reduce calorie intake by 200 -500 kCal per day, and participating in a walk of 20-30 minutes forfive days per week over a period of one month. After one month,the lipid profile of both groups was remeasured and compared.Results After one month, 7 3 children had successfully completedthe study and had complete data for analysis. There was asignificant change in the mean HOL level before intervention(47.3 [SO 36.2] mg/dl) compared with after intervention (100.5[SO 35.7] mg/dl, P&lt;0.05) in the group where intervention wasimplemented.Conclusion There are no significant differences in serum lipidvalues after intervention in both groups.

Plasma visfatin concentrations in childhood obesity: relationships with insulin resistance and anthropometric indices.

The aim of this study was to investigate the relationships between plasma visfatin, insulin resistance, lipid profile and anthropometric measurements in obese children. Plasma levels of visfatin, insulin, glucose, lipid profile and anthropometric indices were determined in 30 obese children and compared with those in 30 age- and gender-matched non-obese children. Visfatin was measured with enzyme-linked immunosorbent assay and logarithmically transformed to log visfatin for parametric comparisons. The obese group had significantly elevated plasma visfatin, fasting glucose and insulin and homeostasis model assessment (HOMA) values, as well as elevated lipid concentrations, compared with non-obese children. In the obese group log visfatin correlated positively with weight (p = 0.007), waist circumference (p = 0.007), hip circumference (p = 0.034), BMI (p = 0.005), insulin (p = 0.041) and HOMA (p = 0.044). No correlation was found between visfatin and lipid profile in obese children (p >0.05). Linear regression analysis revealed significant positive relationships between log visfatin and BMI (p = 0.005), insulin and BMI (p <0.001), and between HOMA and BMI (p <0.001) in the obese group but not in the control group. Multivariate regression analysis with log visfatin as a dependent variable showed that only BMI (p = 0.005) and bodyweight (p = 0.014) correlated positively with log visfatin in obese children. An increased visfatin concentration may be associated with BMI and insulin resistance in obese children. Although these findings may lay a foundation for further hypotheses, the limited sample size in the present study means that longitudinal studies with more patients are needed.