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Related Topics

  • Soft Tissue Augmentation
  • Soft Tissue Augmentation
  • Hyaluronic Acid Filler
  • Hyaluronic Acid Filler
  • Nasolabial Fold
  • Nasolabial Fold
  • Tear Trough
  • Tear Trough
  • Dermal Fillers
  • Dermal Fillers
  • Fat Injection
  • Fat Injection
  • Tissue Augmentation
  • Tissue Augmentation

Articles published on Lip augmentation

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  • New
  • Research Article
  • 10.52076/eacad-v7i1.676
Escultura labial e as principais técnicas de preenchimento com ácido hialurônico
  • Feb 16, 2026
  • E-Acadêmica
  • Renata Gomes Macedo + 1 more

Facial harmonization is a highly sought-after aesthetic procedure in the medical and dental fields, aiming for an integrated functional and aesthetic balance, seeking to improve the face, given the complaints regarding the lips due to deficiencies in contour, volume, and lip projection. Lip augmentation with hyaluronic acid is used for this aesthetic lip improvement. It is effective in adding volume to the tissues when injected, restoring the three-dimensional relationship with the rest of the face, and is advantageous because it is a safe procedure due to its reversibility and few side effects. This study aims to conduct a literature review on the challenges of lip sculpting and augmentation, focusing on the main techniques for hyaluronic acid fillers. The results of this study concluded that the use of hyaluronic acid for lip augmentation is a proven and safe technique to improve the appearance and self-esteem of patients. With the continuous evolution of techniques and products, along with research, it is expected that lip augmentation procedures will become increasingly personalized, safe, and effective.

  • Research Article
  • 10.1111/jerd.70113
The Combo Strategy: Triple Approach for Gummy Smile-18-Month Case Series.
  • Jan 20, 2026
  • Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
  • Alain Romanos + 4 more

Gingival excess, also referred to as excessive gingival display (EGD), represents a multifactorial esthetic concern influenced by skeletal, dental, and soft tissue factors. Conventional orthodontic or orthognathic interventions, while effective, may present increased morbidity. This prospective case series evaluates a minimally invasive, interdisciplinary approach integrating periodontal and cosmetic techniques for managing multifactorial gingival excess. Twelve systemically healthy adult patients (mean gingival display: 5.3 mm) diagnosed with both altered passive eruption and hyperactive upper lip were treated in a private practice using a combined single-session protocol. The "combo technique" involved esthetic crown lengthening, botulinum toxin-A (Botox) injections, and hyaluronic acid-based lip augmentation. Diagnosis and treatment planning were based on comprehensive clinical and radiographic assessments. Outcome measures included gingival display reduction, patient satisfaction, and postoperative discomfort, evaluated at 6 and 18 months. The integrated "combo technique" offers a minimally invasive and highly effective alternative for correcting EGD. It enables individualized treatment planning, reduces the amount of Botox needed, and results in stable esthetic outcomes with high patient satisfaction and minimal postoperative discomfort. This interdisciplinary approach provides a predictable and long-lasting solution for complex GS cases in patients unwilling or unsuitable for orthognathic surgery.

  • Research Article
  • 10.1007/s00266-026-05642-4
Spare Parts: Repurposing Tissue in Facial Feminization Surgery.
  • Jan 20, 2026
  • Aesthetic plastic surgery
  • Sumun Khetpal + 8 more

Single-stage facial feminization surgery (FFS) offers a unique opportunity for intraoperative access to nearly every tissue type used for grafting in plastic surgery, opening the possibilities for creative repurposing of autologous tissues. In this work, we describe methods of utilizing calvarial bone, mandibular bone, thyroid cartilage, and dermal fat harvested from routinely accessed sites or typically excised and discarded during FFS. We summarize the usage of split calvarial bone from the parietal region and osteotomized gonial angles as grafts for the osteotomy sites of the anterior table of the frontal sinus and osseous genioplasty and as a septal graft in rhinoplasty. We also describe the repurposing of thyroid cartilage from the chondrolaryngoplasty as shield grafts for rhinoplasty. Lastly, we described the use of dermal fat grafts from excised, de-epithelialized forehead and hair-bearing scalp for lip augmentation and as a radix graft. These techniques highlight the availability of autologous tissue throughout the face and deliberate intraoperative sequencing when encountering the potential need for tissue supplementation. Our multi-year experience has shown these methods to be reliable and well-received by patients. As such, the current work presents the surgical technique and intraoperative usage of "spare parts" within single-stage FFS.Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  • Research Article
  • 10.1097/gox.0000000000007270
4D Lips Technique Based on Anatomy for Naturalization
  • Jan 15, 2026
  • Plastic and Reconstructive Surgery Global Open
  • Melina Kichler + 5 more

Background:Lip augmentation has become a cornerstone of aesthetic procedures, particularly among younger patients seeking to enhance their natural lip features. A precise anatomical approach is essential to achieve balanced, natural-looking results while minimizing the risk of complications. This study introduced the 4D Lips technique, a multiphasic hyaluronic acid filler method designed to enhance lip shape while respecting anatomical landmarks. The technique is guided by 4 fundamental principles—dimension, distribution, dynamics, and desire—to ensure harmonious and individualized outcomes.Methods:Ten female patients underwent lip augmentation using a combination of subtechniques, including tubercle marking, vertical elongation, and vermilion border eversion. Two hyaluronic acid fillers with distinct viscoelastic properties were used: one with medium G’ for structural support and another with low G’ for contour refinement. Patient satisfaction and safety outcomes were systematically evaluated.Results:All patients reported satisfaction with the natural appearance of their enhanced lips. Mild and transient side effects, such as swelling, were observed and resolved spontaneously within a few days. No major complications were recorded. The structured, anatomy-based approach allowed for precise volumization, refined contouring, and preservation of natural lip dynamics.Conclusions:The 4D Lips technique underscores the value of an anatomy-informed and personalized approach to lip augmentation. By combining structural enhancement with a patient-centered perspective, this method achieves high satisfaction rates and a favorable safety profile. Nonetheless, the limitations of the study, including the small sample size, absence of a control group, and lack of long-term follow-up, warrant further investigation to validate these findings.

  • Research Article
  • 10.1155/ijod/2797836
Influence of Hyaluronic Acid Lip Filler Augmentation on Smile Design Parameters in Young Female Population: An Observational Study
  • Jan 1, 2026
  • International Journal of Dentistry
  • Ameer Biadsee + 4 more

ObjectiveTo evaluate the effect of hyaluronic acid (HA) lip augmentation on anterior tooth exposure and smile‐line characteristics using three‐dimensional (3D) facial scanning technology.Materials and MethodsTwenty‐five female participants were enrolled. All injections were performed by a single experienced clinician following a standardized protocol, with a total of 1.0 mL of HA filler administered to the lips. 3D facial scans were obtained before treatment, immediately after injection, and at a 4‐week follow‐up. Maxillary left central incisor and canine exposure during smiling, as well as upper lip volume, were measured at each timepoint using dedicated software.ResultsThe mean participant age was 26.2 years, and the mean follow‐up period was 28.8 days. At follow‐up, maxillary central incisor and canine exposure decreased by 0.1 mm compared to pre‐treatment values (p < 0.001). Upper lip volume increased by 0.79 mm3 at follow‐up (p < 0.001). An inverse correlation was observed between lip volume and central incisor exposure, indicating reduced tooth display with increased lip volume. No significant correlation was found between lip volume and canine exposure or between central incisor and canine exposure.ConclusionHA lip augmentation was associated with small but statistically significant changes in anterior tooth exposure during smiling. These findings highlight the influence of perioral soft tissue on smile‐related dental parameters and underscore the importance of considering lip volume when planning esthetic dental and restorative treatments.

  • Research Article
  • 10.46889/jdr.2025.6319
A Minimally Invasive Approach to Cosmetic Management of Facial Changes in Acromegaly
  • Dec 31, 2025
  • Journal of Dermatology Research

Background: Acromegaly is characterized by growth hormone excess leading to progressive soft-tissue hypertrophy and distinctive facial changes. Even after successful endocrine treatment, many patients experience persistent disfigurement that negatively affects quality of life. Despite this, data on minimally invasive cosmetic approaches for post-treatment acromegaly are limited. Case Presentation: We report the case of a 41-year-old man with persistent acromegalic facial features approximately 12 months after achieving biochemical remission following pituitary adenoma resection. Preoperative Insulin-Like Growth Factor 1 (IGF-1) levels were markedly elevated (774 ng/mL on 8/4/2022), with progressive normalization following surgery (IGF-1 219-262 ng/mL in August 2023 and 164 ng/mL by March 2025). Growth Hormone (GH) levels similarly declined from 31.5 ng/mL preoperatively to &lt;0.2 ng/mL on serial postoperative testing. The patient expressed significant distress regarding forehead heaviness, deepened nasolabial folds, midface deflation and lower-face disproportion. Prior to his diagnosis of acromegaly, he had undergone limited cosmetic treatment with botulinum toxin injections and topical tretinoin but had not received any fillers or surgical aesthetic procedures. A staged treatment plan using hyaluronic acid fillers and botulinum toxin type A (abobotulinumtoxinA) was implemented to restore facial balance while maintaining natural contours. Neuromodulator treatment with abobotulinumtoxinA (Dysport®, Ipsen Biopharm Ltd, Wrexham, UK) was first performed to soften frontalis and glabellar muscle activity (total dose 180 units; dilution 3 U/0.1 mL). Fine-line filler consisting of a cross-linked hyaluronic acid filler approved for lip augmentation (Restylane Kysse®, Galderma, Fort Worth, TX, USA) was injected into the forehead to soften deep creases, followed by midface volumization with a moderately firm hyaluronic acid filler designed for cheek augmentation (Restylane Contour®, Galderma, Fort Worth, TX, USA) delivered with a cannula and correction of nasolabial folds with a flexible filler approved for nasolabial fold correction (Restylane Defyne®, Galderma, Fort Worth, TX, USA). Adjunctive botulinum toxin was used to enhance symmetry and reduce dynamic rhytids. The patient demonstrated marked improvement in facial harmony and rated his satisfaction as 5/5 (“very satisfied”). No adverse events occurred. Conclusion: This case highlights the utility of a minimally invasive, filler-based approach to address persistent facial changes in treated acromegaly. Hyaluronic acid fillers, combined with botulinum toxin, offer a safe, customizable alternative to surgical correction with immediate aesthetic benefit and minimal downtime. Careful selection of filler rheology and injection technique, tailored to the thickened soft tissue and altered bony framework seen in acromegaly, may help optimize outcomes and minimize risk. As cosmetic concerns increasingly influence long-term well-being in patients with acromegaly, additional research is needed to establish best practices for non-surgical facial restoration in this population.

  • Research Article
  • 10.1016/j.anplas.2025.11.001
Intraoral lip augmentation
  • Dec 30, 2025
  • Annales de chirurgie plastique et esthetique
  • V Mitz

Intraoral lip augmentation

  • Research Article
  • 10.1111/jocd.70563
Efficacy and Tolerability of a Topical Peptide‐Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation
  • Nov 22, 2025
  • Journal of Cosmetic Dermatology
  • Amir Moradi + 5 more

ABSTRACTBackgroundLips are prone to dehydration and aging. Effective noninvasive hyaluronic acid (HA) delivery remains challenging.AimTo evaluate topical Replenishing Lip Filler‐Tiered Release Vesicles (RLF‐TRV) in filler‐naïve and previously‐augmented lips.MethodsTwo single‐center trials evaluated efficacy and tolerability of RLF‐TRV Serum. Study 1 included filler‐naïve subjects or those without lip filler for 12 months. Study 2 enrolled subjects with prior HA lip augmentation (3–9 months earlier) in a double‐blind, placebo‐controlled design. Participants applied RLF‐TRV or placebo twice daily for 3 weeks, followed by a 2‐week regression period. Outcomes included grading of shine, texture, and vermilion border, Investigator and Subject Global Aesthetic Improvement Scale (I‐GAIS, S‐GAIS), and satisfaction. Imaging and tolerability assessments were conducted throughout the study.ResultsRLF‐TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. In Study 1, 94% of treated participants were “Improved” on I‐GAIS (p < 0.001), and 81% were “Much‐Improved” on S‐GAIS (p < 0.05). In Study 2, 88% of treated participants were “Improved” on both I‐GAIS and S‐GAIS. RLF‐TRV was well tolerated, with no recorded adverse events.ConclusionsRLF‐TRV significantly improved lip aesthetics, offering a noninvasive alternative or complementary treatment to injectable procedures.

  • Research Article
  • 10.69849/revistaft/dt10202511212218
IMPLICAÇÕES DO ÁCIDO HIALURÔNICO NA ESTÉTICA: UMA REVISÃO INTEGRATIVA
  • Nov 21, 2025
  • Revista ft
  • Adriane De Santana Da Silva + 1 more

ABSTRACT Hyaluronic acid, when injected, has been used for facial contouring, lip augmentation, under-eye correction, and overall facial rejuvenation—thus increasing its relevance to aesthetics and cosmetology. However, despite the reported benefits, there is also evidence pointing to complications and adverse effects associated with its use, as well as discussions about safety, professional training, and the ethical principles of invasive aesthetics. This is an integrative literature review on the implications of hyaluronic acid in aesthetics, emphasizing its benefits, mechanisms of action, risks, and possible complications. This review consisted of 7 articles. In general, the included studies reinforce that hyaluronic acid (HA) continues to be one of the most widely used biomaterials in facial aesthetic procedures, especially in the lips and nasal region, with high potential for aesthetic results and the advantage of reversibility through hyaluronidase. However, despite being widely considered safe, the use of HA is not without risks, and adverse events, although infrequent, can be significant – ranging from milder reactions (edema, hematoma, local pain, inflammation) to serious events such as ischemia and tissue necrosis after poorly executed techniques or application in vascularly critical regions, such as the nasal tip and upper lip. Case reports demonstrate that immediate action in the face of complications (especially early recognition of ischemic signs and timely use of hyaluronidase) is the determining factor in preventing permanent sequelae. Based on the findings of this integrative review, it is concluded that hyaluronic acid has established itself as one of the main biomaterials used in facial and body aesthetic procedures, fulfilling the proposed general objective, since it presents wide applicability, predictable results, immediate effect, reversibility, and great clinical and consumer acceptance. Keywords: Hyaluronic acid. Aesthetics. Facial fillers. Cosmetic procedures.

  • Research Article
  • 10.25259/jcas_90_2025
A comprehensive narrative review on lip filler techniques with practical tips for optimum outcomes
  • Nov 12, 2025
  • Journal of Cutaneous and Aesthetic Surgery
  • Jaishree Sharad + 1 more

Lips are widely regarded as the most esthetically significant feature of the face, particularly in females. With age, they tend to lose volume and definition as bone resorption, fat loss, and muscle thinning cause the upper lip to roll inward. Hyaluronic acid injections have become a popular intervention to restore volume, enhance shape, correct asymmetries, and define the lip margin and pout. Various injection techniques cater to different esthetic and functional concerns. By analyzing the latest literature, this review highlights best practices for achieving optimal outcomes in patients seeking lip fillers for indications such as volume loss, asymmetry, and perioral wrinkles. Additionally, it examines strategies to mitigate common adverse effects, including bruising, swelling, and overfilling. This study aims to provide a narrative review of the published medical literature on various techniques used in patients to inject lip fillers for different indications, with minimal side effects and natural-looking results. The literature research considered published journal articles (clinical trials or scientific reviews). Studies were identified by searching electronic databases (MEDLINE and PubMed) and reviewing the reference lists of relevant articles. Only articles available in English were considered for this review. Lip augmentation has gained popularity for enhancing esthetics and boosting confidence, focusing on three key areas: the vermilion border, the red lip region, and the philtrum. Fillers are injected to add volume, but excessive use can result in an unnatural appearance and restrict lip movement. Techniques such as needle injections offer precise filler placement, while blunt-ended cannulas are preferred for safer, deeper injections. Filler migration, particularly in the upper lip, can occur due to muscle movement, the type of filler used, poor technique, or external factors. Techniques such as the Paris and Russian Lip methods carry a higher risk of migration and unnatural results . Gradual augmentation with smaller amounts of filler is recommended for individuals with thin lips or those who are older, to ensure natural-looking outcomes. Proper technique, filler choice, and post-procedural care are essential for optimal, safe, and long-lasting results. This review highlights the significance of technique, filler choice, and patient anatomy in achieving optimal lip augmentation outcomes with minimal side effects. Advances in filler formulations and personalized approaches have improved stability, reduced migration risks, and enhanced patient satisfaction, while post-procedure care and education remain crucial for safe outcomes.

  • Research Article
  • 10.1093/asj/sjaf224
Efficacy and Safety of Hyaluronic Acid Lip Fillers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
  • Nov 3, 2025
  • Aesthetic surgery journal
  • Y Edward Wen + 6 more

Despite the growing demand for hyaluronic acid (HA) lip fillers, there is a paucity of robust, quantitative data across high-powered studies. This systematic review and meta-analysis aims to assess the efficacy and safety of HA lip fillers as reported by randomized controlled trials (RCTs). A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, utilizing PubMed, Embase, and Cochrane, and eligible studies included RCTs with human subjects utilizing HA filler for lip augmentation. Meta-analysis evaluated rates of improvement in lip fullness, aesthetic appearance, patient satisfaction, and adverse events. A comprehensive review initially identified 2,038 articles. Following screening by title and abstract, full-text review, and risk of bias assessment with the Cochrane risk-of-bias tool for randomized trials (RoB 2), sixteen articles were included in the study. Meta-analysis demonstrated that 60% (95% CI: 44-76%) had improvement in lip fullness, 82% (95% CI: 67-92%) had improvement in aesthetic appearance, 68% (95% CI: 58-78%) reported satisfaction, 50% (95% CI: 27-73%) had adverse events, and 1.5% (95% CI: 1.9-4.0%) had serious adverse events requiring treatment, needing follow-up, or lasting beyond 30 days. The most common adverse events were swelling (78%), firmness (48%), bruising (34%), and tenderness (33%). Across studies with the highest level of evidence, HA filler efficacy and patient satisfaction is moderate to high. Severe adverse reactions are rare, but adverse events are common.

  • Research Article
  • 10.1093/asjof/ojaf131
Universal Lip Integrity, Proportion, and Structure: A Framework for Achieving Consistent, Natural-Looking Lip Augmentation Using Hyaluronic Acid Fillers
  • Oct 25, 2025
  • Aesthetic Surgery Journal. Open Forum
  • Katherine Goldie + 4 more

The authors of this study present a standardized approach for achieving consistent, natural-looking lip augmentation using cohesive polydensified matrix hyaluronic acid (CPM-HA) fillers. Developed by a panel of 5 global experts, 8 core injection techniques were established to guide procedures, including supporting the oral commissures, enhancing the vermillion border, increasing lateral lip show, increasing vertical height and eversion, improving lip curvature, enhancing lateral structure, and defining the Cupid's bow. The approach outlines a 5-step process: patient interview, documentation, anatomical assessment, lip structure assessment, and treatment, promoting results that are tailored to the patient's unique aesthetic goals and anatomy. Two examples of the application of these core principles are highlighted through the Beautification and Restoration pathways, chosen based on patient-specific needs. Beautification enhances existing lip features, whereas Restoration rebuilds structure lost to aging. Three case studies illustrate how these core principles and techniques are applied in practice, demonstrating how individual patient requirements guide treatment. Case 1 involves a 45-year-old patient seeking subtle lip enhancement. Case 2 outlines the treatment of a 39-year-old patient aimed at restoring lip proportions. Case 3 highlights the treatment for a 57-year-old patient requiring structural support. This methodology provides a flexible, structured framework that adapts to individual patient needs, promoting safe, effective, and consistent outcomes.Level of Evidence: 5 (Therapeutic)

  • Research Article
  • Cite Count Icon 1
  • 10.1097/gox.0000000000007149
Prospective Clinical Evaluation of Cross-Linked Hyaluronic Acid Dermal Filler (30 mg) for Facial Rejuvenation
  • Oct 3, 2025
  • Plastic and Reconstructive Surgery Global Open
  • Debraj Shome + 7 more

Background:Cross-linked hyaluronic acid dermal fillers are being used increasingly for aesthetic enhancements, including lip enhancement, cheekbone augmentation, and nasolabial fold improvement. This study aimed to assess the safety and performance of a newly introduced dermal filler across different skin types.Methods:This is a prospective, single-arm clinical study that evaluates the safety and effectiveness of cross-linked sodium hyaluronate injection in patients undergoing treatment for facial wrinkles and lip enhancement. Participants underwent assessments at baseline; immediately at postoperative day 0; and at 3 months, 6 months, and 1 year after the procedure. The safety and effectiveness were evaluated through physical examinations, wrinkle severity ratings, full face global aesthetic assessments, cheekbone augmentation, nasolabial fold severity, and lip enhancement evaluations.Results:The study cohort included 122 participants, 41 men and 81 women, predominantly with Fitzpatrick skin types 3 (59%) and 4 (41%). Physical examinations revealed a significant reduction in facial wrinkles, with 81.14% (left side) and 84.42% (right side) of patients showing no wrinkles after 1 year. Full face aesthetic improvements were noted, with 36.88% of patients being “very much improved.” Cheekbone augmentation showed no wrinkles in 55.74% of patients (left side) and 72.13% (right side) at 1 year. Nasolabial fold severity decreased most significantly between 6 months and 1 year.Conclusions:The novel cross-linked hyaluronic acid dermal filler is safe and effective for enhancing lips, augmenting cheekbones, and improving nasolabial folds across various skin types. Significant improvements were observed in wrinkle severity, overall facial aesthetics, and specific enhancement areas.

  • Research Article
  • 10.1093/asj/sjaf192
Anatomical Depth of Labial Arteries in Dermal Filler Procedures: A Meta-analysis With Clinical Implications.
  • Sep 24, 2025
  • Aesthetic surgery journal
  • Mateusz Trzeciak + 7 more

Lip augmentation procedures are increasingly popular in aesthetic medicine, and precise knowledge of labial arterial anatomy is essential for safe outcomes. The superior labial artery (SLA) and inferior labial artery (ILA) serve as critical anatomical landmarks for these procedures, and their positioning guides injection techniques. But despite their importance, there has been uncertainty about the precise depths of these vessels across different facial regions, creating potential risks during procedures. Therefore, we conducted a comprehensive meta-analysis to quantitatively compare arterial depths at three distinct levels of the SLA and evaluate average depths of both the SLA and ILA. Analysis of multiple arterial measurements (277, 218, 252, 414, and 295 arteries) at key locations - between the cheilion and cupid's bow peak, at the cupid's bow peak, and at the facial midline - revealed consistent average depths ranging from 4.59 mm (95% CI: 3.91-5.10) to 4.90 mm (95% CI: 4.57-5.61). These findings demonstrate that the vessels maintain relatively consistent depth beneath the vermilion surface, supporting safe injection guidelines of up to 3.5 mm in most lip regions and up to 4 mm in the superior vermilion. While the SLA and ILA showed similar average depths, practitioners should consider using high-resolution ultrasonography before extensive augmentation procedures for additional safety assurance.

  • Research Article
  • 10.26574/maedica.2025.20.3.560
Anatomical Variations of Palmaris Longus Muscle and Its Clinical Implications: a Cadaveric Study.
  • Sep 15, 2025
  • Maedica
  • Kumar Sambhav + 4 more

Palmaris longus (PL) is the most superficial flexor muscle of the anterior compartment of the forearm in humans, which exhibits frequent anatomical variance. It has been observed that the complete absence of PL is the most commonly reported variance, followed by reversed, duplicated and hypertrophied muscle variants. The incidence of the complete agenesis of PL varies from 0.6% to 26.6%. So, it may be considered as an inconstant muscle. It is known to be more commonly absent unilaterally than bilaterally. The prevalence of unilateral absence of the PL is more commonly found on the left side. Unilateral agenesis of the PL is relatively more widely encountered in males compared to females. During the routine cadaveric dissections at the Department of Anatomy, AIIMS, Jodhpur, we observed palmaris longus muscle variations in 64 upper limbs of 32 cadavers (22 males and 10 females). We observed agenesis of the palmaris longus muscle in six (9.4%) upper limbs out of 64 cadaveric upper limbs. The bilateral absence of palmaris longus was observed in two cadavers (6.25%), while unilateral absence was also observed in two cadavers (6.25%). We also observed agenesis of the PL was more prevalent in males (11.33%) in comparison to females (5%). Palmaris longus is significant surgically as it is employed for various tendon graft procedures, lip augmentation, ptosis correction and management of facial palsy.

  • Research Article
  • 10.1097/scs.0000000000011837
In Vitro Analysis of Hyaluronidase Degradation of Commercial Hyaluronic Acid Fillers: Considerations in Lip Augmentation.
  • Aug 20, 2025
  • The Journal of craniofacial surgery
  • Ahmet Demir + 1 more

Hyaluronic acid (HA) fillers are widely used for lip augmentation, but inadvertent intravascular injection may result in serious complications such as ischemia or necrosis. Timely degradation using hyaluronidase is crucial in such scenarios. To evaluate the enzymatic degradation kinetics of 6 commercially available HA lip fillers using hyaluronidase, and to assess their relative susceptibilities in vitro. Six HA-based lip filler formulations (Luminera Hydryalix Lips, Yvoire Volume Plus, Restylane Kysse, Neauvia Intense Lips, Fillmed Artfiller Lips, and Juvederm Ultra 3) were incubated with hyaluronidase (167U/mL) at 37°C. Degradation was quantified by measuring N-acetyl-D-glucosamine (NAG) release over time using the Morgan-Elson colorimetric assay. Absorbance was recorded at 585nm, and degradation values were calculated through a standard calibration curve. Statistical analyses included one-way ANOVA with Tukey post hoc tests (P<0.05). Significant differences in degradation rates were observed at both 7 and 45 hours (P<0.001). At 7 hours, Restylane Kysse exhibited the highest enzymatic degradation, followed by Yvoire Volume Plus and Neauvia Intense Lips. At 45 hours, the ranking remained similar. Luminera Hydryalix Lips and Juvederm Ultra 3 demonstrated the lowest degradation profiles. HA fillers vary in their susceptibility to hyaluronidase, likely due to differences in crosslinking and formulation. Fillers with higher degradability, such as Restylane Kysse, may be preferable in high-risk areas or emergency reversal situations. These findings underscore the importance of filler selection in clinical practice and warrant further in vivo studies.

  • Research Article
  • 10.1007/s00266-025-05121-2
Rheological Properties of Hyaluronic Acid Fillers for Lip Volumization.
  • Aug 6, 2025
  • Aesthetic plastic surgery
  • Patricia Miranda Sousa Nogueira + 2 more

Hyaluronic acid (HA) is widely used for facial rejuvenation and soft tissue volumization, with lip augmentation being one of its primary applications. The rheological properties of HA fillers are essential to ensure the efficacy and safety of procedures, directly influencing the aesthetic outcome and material longevity. This study aims to evaluate the rheological properties of three hyaluronic acid-based fillers indicated for lip volumization: Belotero Intense (Merz), Kysse (Galderma), and Volift (Allergan). Twenty-four syringes of fillers were analyzed, with 8 samples from each brand. The rheological properties investigated included storage modulus (G'), loss modulus (G''), complex modulus (G*), phase angle (Tan(delta)), and cohesiveness. Measurements were conducted using the Kinexus PRO rheometer with parallel plate geometry. The results revealed significant differences among the three fillers. Volift exhibited higher resistance to deformation, reflected by the higher G* values, while Kysse stood out for its greater cohesiveness. These rheological variations suggest that each filler may be more suitable for different clinical applications, such as lip augmentation or deeper tissue filling. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  • Research Article
  • 10.1016/j.pdpdt.2025.104760
A 675 nm laser for lip augmentation and perioral rejuvenation treatment.
  • Aug 1, 2025
  • Photodiagnosis and photodynamic therapy
  • Paolo Bonan + 3 more

A 675 nm laser for lip augmentation and perioral rejuvenation treatment.

  • Research Article
  • 10.1093/asj/sjaf135
Effectiveness and Safety of RHA3 vs a Comparator Product for Lip Augmentation: A Randomized, Controlled, Prospective, Multicenter Clinical Study
  • Jul 14, 2025
  • Aesthetic Surgery Journal
  • Susan Weinkle + 8 more

BackgroundLip augmentation using dermal fillers is increasingly popular, but often requires large volumes and regular touch-ups, whereas poor techniques and product selection can result in unnatural-looking lips. The RHA collection was designed to have less rigidity, allowing the products to adapt to facial animation. In particular, RHA3 has been approved in Europe for lip volumization.ObjectivesThe authors of this study aimed to evaluate the effectiveness and safety of RHA3 vs an active comparator for lip augmentation in the US population.MethodsThis was a randomized, controlled, double-blinded, multicenter clinical study. The primary endpoint aimed to demonstrate the noninferiority of RHA3 vs the comparator using the Teoxane Lip Fullness Scale (TLFS), assessed by the blinded live evaluator, 12 weeks after treatment. Secondary objectives included improvement on the TLFS, Global Aesthetic Improvement Scale, patient satisfaction, and natural look/feel of the lips up to 52 weeks. Safety assessment covered adverse events (AEs), common treatment reactions, and injection site pain.ResultsA total of 202 patients were enrolled. RHA3 was considered statistically noninferior to the comparator for lip augmentation among patients with TLFS Grades 1 to 3. It provided sustained lip volume enhancement over time, with high rates of aesthetic improvement and patient satisfaction. Most RHA3-treated patients achieved a natural look and feel of the lips that was maintained throughout the study period. Most AEs were mild to moderate, with no late-onset reactions or angioedema reported.ConclusionsRHA3 was effective for lip augmentation, providing sustained aesthetic improvement, high satisfaction, and good tolerability. These findings support the use of RHA3 as a uniquely dynamic option for natural-looking lip augmentation.Level of Evidence: 1 (Therapeutic)

  • Research Article
  • Cite Count Icon 1
  • 10.1097/scs.0000000000011567
The Relationship Between Lip Augmentation and Teeth Visibility: A Cosmetic Perspective.
  • Jun 27, 2025
  • The Journal of craniofacial surgery
  • Fazilet Altin + 3 more

This paper aims to describe the ideal relationship between lips and teeth as 2 critical facial features to guide young doctors keen on lip augmentation. The literature survey was performed in PubMed, EBSCO, UpToDate, Proquest Central databases of Kirikkale University, and Google and Google Scholar databases. There is a relationship between the visibility of teeth and the amount of tooth show and its attractiveness, but only if the gingival exposure is within the standard setting and between the upper central incisor tips if the buccal corridor is not exceeding 1mm. A smile's visual expression and aesthetics do not simply involve the lips alone. Facial esthetics result from harmony between several minor factors, the combination of which determines the patient's overall appearance. For instance, when laughing with an open mouth, a person's teeth become visible. The need for lip enhancement is based on the patient's aesthetic goals, infrastructural tooth position/visibility, and stage of facial aging. To help achieve lip augmentation goals, facial aesthetic subunits, soft-tissue patterns, and bony landmarks should be considered. Lip augmentation is typically performed by adding volume through various means and materials. The authors must offer essential new data on the relationship between lip augmentation and teeth visibility. A given upper lip enhancement will make the maxillary incisors visible to a greater or lesser extent. However, there is limited research on what constitutes a prioritized single most crucial factor in promoting maxillary incisor visibility.

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