Light-based Treatments Research Articles

808nm diode laser in the treatment of Hidradenitis Suppurativa: a retrospective study.

Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory disease characterized by painful lesions such as nodules, abscesses, and sinus tracts, primarily affecting intertriginous areas. Traditional treatments range from antibiotics and hormonal therapies to biologics and surgical options. Recently, lasers and light-based treatments has gained attention as a non-systemic treatment for HS, targeting hair follicles to potentially alleviate symptoms and improve quality of life. This study evaluated the efficacy of 808nm Diode laser therapy in managing HS by retrospectively reviewing data from 16 patients (13 men, 3 women) aged 23-61 who underwent between two and four sessions. Patients had not received systemic treatment in the three months preceding or during the therapy. Key outcome measures included the Modified Hidradenitis Suppurativa Score (MHSS), Hidradenitis Suppurativa Physician's Global Assessment (HS-PGA), Hidradenitis Suppurativa Clinical Response (HiSCR), and Dermatology Life Quality Index (DLQI). Results indicated a significant reduction in MHSS from a median of 20.0 before treatment to 9.0 at six months (p = 0.001). The HS-PGA score also significantly decreased from a median of 3.0 to 2.0 (p = 0.012). Of the 10 patients evaluated for HiSCR, 8 showed a positive response. DLQI scores improved from a median of 4.5 to 1.0 (p = 0.002). The treatment was well-tolerated, with only mild pain reported and no severe adverse effects. In conclusion, 808nm Diode laser therapy appears to be an effective modality for reducing disease severity and enhancing quality of life in HS patients, likely due to its anti-inflammatory effects. These findings suggest that Diode laser therapy could be a valuable addition to current HS management strategies, with further research needed to explore its long-term efficacy.

Oral Tranexamic Acid for Prevention and Treatment of Postinflammatory Hyperpigmentation.

Postinflammatory hyperpigmentation (PIH) is a skin disorder characterized by hyperpigmentation resulting from heightened inflammation and/or damage to the basement membrane, melanocytes, and keratinocytes, leading to abnormal and excessive pigment deposition. Oral tranexamic acid (TXA), originally used as an antifibrinolytic for managing excessive bleeding, has garnered attention for its demonstrated safety and efficacy in treating melasma. There is a growing body of evidence regarding the use of TXA in the treatment of PIH. To review the mechanism of action of oral TXA in treating PIH and examine the use of oral TXA in preventing and/or treating PIH associated with laser-based and light-based treatments in individuals with skin color. Review of relevant articles from 2000 to present found in the Cochrane Library, PubMed, Embase, and Google Scholar, regarding the use of oral TXA in the treatment of PIH. Studies reviewed investigated the efficacy of oral tranexamic acid (TXA) in treating postinflammatory hyperpigmentation (PIH) and use in preventing PIH when used in conjunction with other treatments. All studies demonstrated significant improvement in PIH without significant adverse effects and side effects. Oral tranexamic acid is emerging as a safe and effective treatment in the prevention and treatment of postinflammatory hyperpigmentation.

Light Therapy in Chronic Migraine.

This review assesses the effectiveness and safety of light therapy, particularly green light therapy, as an emerging non-pharmacological treatment for chronic migraine (CM). It aims to highlight alternative or complementary approaches to traditional pharmacological remedies, focusing the need for diverse treatment options. Despite sensitivity to light being a defining feature of migraine, light therapy has shown promising signs in providing substantial symptom relief. Studies have provided insights into green light therapy's role in managing CM. These studies consistently demonstrate its efficacy in reducing the frequency, severity, and symptoms of migraines. Additional benefits observed include improvements in sleep quality and reductions in anxiety. Importantly, green light therapy has been associated with minimal side effects, indicating its potential as a suitable option for migraine sufferers. In addition to green light, other forms of light therapy, such as infrared polarized light, low-level laser therapy (LLLT), and intravascular irradiation of blood (ILIB), are also being explored with potential therapeutic effects. Light therapies, especially green light therapy, are recognized as promising, safe, and non-pharmacological interventions for treating CM. They have been shown to be effective in decreasing headache frequency and enhancing the overall quality of life. However, current studies, often limited by small sample sizes, prompt more extensive clinical trials to better understand the full impact of light therapies. The exploration of other light-based treatments, such as LLLT and ILIB, warrants further research to broaden the scope of effective migraine management strategies.

Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates malignant melanoma

Photodynamic therapy (PDT) relies on a series of photophysical and photochemical reactions leading to cell death. While effective for various cancers, PDT has been less successful in treating pigmented melanoma due to high light absorption by melanin. Here, this limitation is addressed by 2-photon excitation of the photosensitizer (2p-PDT) using ~100 fs pulses of near-infrared laser light. A critical role of melanin in enabling rather than hindering 2p-PDT is elucidated using pigmented and non-pigmented murine melanoma clonal cell lines in vitro. The photocytotoxicities were compared between a clinical photosensitizer (Visudyne) and a porphyrin dimer (Oxdime) with ~600-fold higher σ2p value. Unexpectedly, while the 1p-PDT responses are similar in both cell lines, 2p activation is much more effective in killing pigmented than non-pigmented cells, suggesting a dominant role of melanin 2p-PDT. The potential for clinical translational is demonstrated in a conjunctival melanoma model in vivo, where complete eradication of small tumors was achieved. This work elucidates the melanin contribution in multi-photon PDT enabling significant advancement of light-based treatments that have previously been considered unsuitable in pigmented tumors.

Comparison between local abdominal and transcutaneous tail vein photobiomodulation in experimental rat model of ulcerative colitis.

Ulcerative colitis (UC) is a chronic autoimmune disease that impacts the quality of life, but current pharmacological treatments are limited. Photobiomodulation (PBM) is a light-based treatment that can be applied either locally or systemically. Here, we compare the effects of local and vascular PBM (VPBM) in an experimental rat model of UC. Male Wistar rats were induced with UC by rectal instillation of acetic acid and treated with either local abdominal PBM or VPBM to the tail vein using a 660-nm LED. The findings indicated that local PBM but not VPBM reduced intestinal histological scores. Both local and VPBM increased mucus production, decreased mast cell degranulation, and modulated TNF-α and IL-1 β levels in the intestines. Local PBM also affected the expression of the mRNAs for IL-6, TNF-α, and IFN-γ. In conclusion, we suggest that local PBM appears to be more promising than VPBM for treating UC. However, further research is needed to fully understand the mechanisms and to optimize the parameters of PBM for UC treatment.

Advancements in Dermatological Therapies

Dermatology has witnessed remarkable advancements in therapeutic approaches, revolutionizing the field and transforming the landscape of skin health. From innovative treatment modalities to novel drug discoveries, the realm of dermatological therapies has expanded exponentially, offering new hope and improved outcomes for patients. These advancements have not only revolutionized the way we address various skin conditions but have also opened doors to personalized and targeted treatments. Exploring and embracing these advancements is crucial for dermatologists to provide the highest level of care and enhance the quality of life for their patients. The advent of biologics and targeted therapies has been a game-changer in dermatology. Conditions such as psoriasis, atopic dermatitis, and various autoimmune disorders now have targeted treatment options that specifically address the underlying mechanisms of the disease. Biologics, including monoclonal antibodies and immune modulators, have shown exceptional efficacy in managing these conditions, providing long-lasting relief and reducing disease burden for patients. Additionally, advancements in molecular research and genetic profiling have paved the way for personalized medicine in dermatology, allowing for tailored treatment plans based on an individual's unique genetic makeup and characteristics.
 Furthermore, technological innovations have brought forth significant advancements in dermatological therapies. Laser and light-based treatments have revolutionized the management of various skin conditions, including acne scars, vascular lesions, and unwanted pigmentation. These non-invasive procedures offer precise targeting and minimal downtime, delivering remarkable results with reduced risks. Moreover, the integration of artificial intelligence and digital health technologies has enhanced diagnostic accuracy and improved treatment outcomes. From teledermatology to image analysis algorithms, these technologies streamline patient care, facilitate remote consultations, and enable efficient data-driven decision-making.
 Collaborative efforts between dermatologists and pharmaceutical companies have also led to the development of novel therapeutic agents. New drug discoveries, formulations, and delivery systems have expanded treatment options for conditions such as skin cancer, fungal infections, and chronic inflammatory disorders. Researchers continue to explore innovative pathways, including immunotherapies and microbiome-targeted therapies, opening doors to further advancements in the field. Advancements in dermatological therapies have ushered in a new era of precision and effectiveness in the management of various skin conditions. From targeted biologics to technological innovations, these breakthroughs have transformed the way dermatologists approach patient care. Embracing these advancements and staying abreast of the latest developments is essential for dermatologists to provide the best possible care and improve patient outcomes. As the field continues to evolve, ongoing research, collaboration, and technological integration will shape the future of dermatological therapies, empowering both clinicians and patients in their pursuit of optimal skin health

Cobalt ferrite nanoparticle for the elimination of CD133+CD44+ and CD44+CD24−, in breast and skin cancer stem cells, using non-ionizing treatments

BackgroundCancer stem cells (CSCs) are the most challenging issue in cancer treatment, because of their high resistance mechanisms, that can cause tumor recurrence after common cancer treatments such as drug and radiation based therapies, and the insufficient efficiency of common treatments in CSCs removal and the recurrence of tumors after these treatments, it is essential to consider other methods, including non-ionizing treatments likes light-based treatments and magnetic hyperthermia (MHT). Method and materialAfter synthesis, characterization and investigation, the toxicity of novel on A375 and MAD-MB-231 cell lines, magnetic hyperthermia and light-based treatments were applied. MTT assay and flow cytometry was employed to determine cell survival. the influence of combination therapy on CD44 + CD24−and CD133 + CD44+ cell population, Comparison and evaluation of combination treatments was done respectively using Combination Indices (CIs). ResultThe final nanoparticle has a high efficiency in producing hydroxyl radicals and generating heat in MHT. According to CIs, we can conclude that combined using of light-based treatment and MHT in the presence of final synthesized nanoparticle have synergistic effect and a high ability to reduce the population of stem cells in both cell lines compared to single treatments. ConclusionIn this study a novel multi-functional nanoplatform acted well in dual and triple combined treatments, and showed a good performance in the eradication of CSCs, in A375 and MAD-MB-231 cell lines.

Decentralized approach toward organic pollutants removal using UV radiation in combination with H2O2-based electrochemical water technologies

The current literature lacks a comprehensive discussion on the trade-off between pollutant degradation/mineralization and treatment time costs in utilizing UV light in combination with H2O2-based electrochemical advanced oxidation processes (EAOPs). The present study sheds light on the benefits of using the photoelectro-Fenton (PEF) process with UVA or UVC for methylparaben (MetP) degradation in real drinking water. Although light boosts the photodegradation of refractory Fe(III) complexes and the photolysis of H2O2 (with UVC only), the energy-intensive nature of light-based treatments is acknowledged. To help tackle the high energy consumption issue, a novel approach was employed: partial application of UVA or UVC light after a predetermined electro-Fenton electrolysis time. The proposed treatment approach yielded satisfactory comparable results to those obtained from the application of PEF/UVA or PEF/UVC in terms of total organic carbon removal (ca. 100%), with notably lower energy consumption (ca. 50%). The study delves into the combined method's feasibility, analyzing pollutant degradation/mineralization process and overall energy consumption. The research identifies possible degradation routes based on intermediate detection and radical quenching experiments. Finally, toxicological assessments evaluate the toxicity levels of MetP and its intermediates. The findings of this study bring meaningful contributions to the fore and point to the highly promising potential of the proposed approach, in terms of sustainability and cost-effectiveness, when applied for decentralized water treatment.

Treatment of mild to severe acne with 1726 nm laser: A safe alternative to traditional acne therapies.

Acne is the most common reason for dermatology consultation in adolescents and young adults. Consultation is often delayed despite unsuccessful self-treatment. Postponing effective treatment places acne sufferers at higher risk for permanent acne scars and post-inflammatory pigment changes. This review discusses clinical challenges with present therapeutic options for acne treatment and the role of a 1726 nm laser for acne. Current acne treatment guidelines were reviewed. A literature review was conducted for trials of light-based acne therapy. The selectivity of previous light-based therapies was reviewed. Available acne therapy is effective, but treatment-related side effects are common. Acne treatment guidelines do not include recommendations for light-based treatments. Different types of light-based treatments have been tried but until now no wavelength specifically targeted sebaceous glands. The 1726 nm laser is safe and effective for treating mild to severe acne in all Fitzpatrick skin types. Acne resolution is apparent within the first month and improves for up to 2 years beyond treatment.

Assessing the role of combination of stem cell and light-based treatments on skin wound repair: A meta-analysis.

The meta-analysis aims to evaluate and compare the impact of the combination of stem cells (SCs) and light-based treatments (LBTs) on skin wound (SW) repair. Examinations comparing SCs to LBT with SCs for SW repair was among the meta-analysis from various languages that met the inclusion criteria. Using continuous random-effect models, the results of these investigations were examined, and the mean difference (MD) with 95% confidence intervals was computed (CIs). Seven examinations from 2012 to 2022 were recruited for the current analysis including 106 animals with SWs. Photobiomodulation therapy (PBT) plus SCs had a significantly higher wound closure rate (WCR) (MD, 9.08; 95% CI, 5.55-12.61, p < 0.001) compared to SCs in animals with SWs. However, no significant difference was found between PBT plus SCs and SCs on wound tensile strength (WTS) (MD, 2.01; 95% CI, -0.42 to 4.44, p = 0.10) in animals with SWs. The examined data revealed that PBT plus SCs had a significantly higher WCR, however, no significant difference was found in WTS compared to SCs in animals with SWs. Nevertheless, caution should be exercised while interacting with its values since all the chosen examinations were found with a low sample size and a low number of examinations were found for the comparisons studied for the meta-analysis.

Effect of tunable femtosecond laser pulses on the sporulation of Eimeria species oocysts of chickens: An in vitro study

Parasitic Eimeria species infection is a severe disease in the poultry industry and a major cause of coccidiosis and disease-engendered financial losses. Increasing resistance to drug-based treatment presents a significant problem, as does the use of disinfectants to sanitize poultry farms, because of increasing oocyst resistance to chemical interventions and contamination of poultry products. Reducing the rate of sporulation of Eimeria species oocysts can minimize the spread of the disease. Therefore, we studied the effect of femtosecond laser pulses on oocysts sporulation rate with the goal of developing an effective light-based treatment for coccidiosis, as an alternative to pharmaceutical intervention. Eimeria species oocysts were harvested from the intestines of infected broiler chickens. Unsporulated oocysts obtained were distributed over 96 well plates and irradiated with pulsed femtosecond laser at various wavelengths and exposure times. Irradiation of the oocysts with pulsed 360 to 390 nm femtosecond laser significantly reduced their sporulation rate and altered their morphology compared to untreated controls. Compared to other wavelengths within the 360 to 390 nm spectra, treatment with pulsed 370 nm wavelength was most effective in decreasing oocyst sporulation rate, reducing sporulation to 17%, 15%, and 11%, after 5-, 10-, and 15-min exposure times, respectively. In contrast, irradiation with infrared 720 nm and 800 nm wavelengths had no significant effect on oocysts sporulation rate. These findings clearly show that irradiation with a pulsed 370 nm femtosecond laser effectively reduces Eimeria species oocyst sporulation and that it is possible to develop an effective light-based treatment for coccidiosis.

Effect of photothermal and photodynamic therapy with cobalt ferrite superparamagnetic nanoparticles loaded with ICG and PpIX on cancer stem cells in MDA-MB-231 and A375 cell lines

BackgroundCancer cells are resistant to treatments such as chemotherapy and radiotherapy due to their characteristics such as self-renewal, high proliferation and other resistance mechanisms. To overcome this resistance, we combined a light-based treatment with nanoparticles to get advantage of both PDT and PTT in order to increase efficiency and beater outcome. Methods and materialAfter synthesis and characterization of CoFe2O4@citric@PEG@ICG@ PpIX NPs, their dark cytotoxicity concentration was determined with MTT assay. Then light-base treatments were performed by two different light source for MDA-MB-231 and A375 cell lines. After treatment, the results were evaluated 48 h and 24 h after treatment by MTT assay and flow cytometry. Among CSCs defined markers, CD44, CD24 and CD133 are the most widely-used markers in CSC research and are also therapeutic targets in cancers. So we used proper antibodies to detect CSCs. Then indexes like ED50, synergism defined to evaluated the treatment. ResultsROS production and temperature increase have a direct relationship with exposure time. In both cell lines, the death rate in combinational treatment (PDT/PTT) is higher than single treatment and the amount of cells with CD44+CD24- and CD133+CD44+ markers has decreased. According to the synergism index, conjugated NPs show a high efficiency in use in light-based treatments. This index was higher in cell line MDA-MB-231 than A375. And the ED50 is proof of the high sensitivity of A375 cell line compared to MDA-MB-231 in PDT and PTT. ConclusionConjugated NPs along with combined photothermal and photodynamic therapies may play an important role in eradication CSCs.

Enhanced photocatalytic degradation of organic contaminants in water by highly tunable surface microlenses

Photocatalysis is one of the dominant technologies used to enhance the efficiency of water decontamination with light-based treatments. However, the effectiveness of photocatalysts is usually limited by the irradiation conditions and the properties of the water matrix. In this work, we have demonstrated the capability of surface microlenses (MLs) as a clean technology for more efficient photocatalytic water decontamination. Random or ordered surface MLs were fabricated from simple polymerization of nanodroplets produced in a solvent exchange process. Both random microlenses (MLR) and microlenses array (MLA) could enhance the photocatalytic degradation efficiency (η) of four representative organic pollutants, including methyl orange (MO), norfloxacin (NFX), sulfadiazine (SFD), sulfamethoxazole (SMX), spiked in ultra-pure water, synthetic natural water, or real river water. By controlling the conditions of light treatment, η could be enhanced by up to 402%. The effectiveness of surface MLs was validated under both visible LED light and simulated solar light and for two photocatalysts zinc oxide (ZnO) and titanium dioxide (TiO2). By reducing the concentration of the photocatalysts from 100 to 5 mg/L and the intensity of irradiation intensity from 1 Sun to 0.3 Sun, our findings suggest that the enhancement factor by MLs was higher at lower catalyst concentration, or at lower light intensity. Based on optical simulations and experimental results, we demonstrated that surface MLs optimize the light distribution and promote the formation of active species, which results in the enhancement of η. The use of MLs may serve as a novel strategy to improve the photocatalytic degradation of micropollutants, especially in places where the available light source is weak, such as indoors or in cloudy regions.Synopsis: MLs-enhanced photocatalysis degradation of organic contaminants in different water matrices.

Prospective study of efficacy and safety of non-ablative 1927 nm fractional thulium fiber laser in Asian skin photoaging.

Photoaging manifests as deeper wrinkles and larger pores. It has been tried to rejuvenate photoaging skin using a variety of lasers, including fractionated lasers, which are a popular photorejuvenation treatment. A new breakthrough for skin rejuvenation is the 1927 nm fractional thulium fiber laser (FTL), a laser and light-based treatment option. Clinical data regarding the FTL for treating photoaging are limited despite its effectiveness and safety. This study is aim to evaluate FTL' clinical effectiveness and safety. Fitzpatrick skin types II-IV subjects with mild to moderate photoaging signs were enrolled in this prospective study. At intervals of one month, patients received three full face treatments. Wrinkles, spots, texture, pores, melanin index, erythema index (MI and EI), skin elasticity and hydration were measured with non-invasive tool. The epidermal thickness and dermal density on ultrasonography were compared between baseline and one month after all treatment sessions. The Global Score for Photoaging scale (GSP) was rated by two independent evaluators at the baseline and final follow-up visit. Secondary outcomes included patient-rated pain on a 10-point visual analog scale (VAS), as well as overall satisfaction. Following each treatment, adverse events were noted. Totally 27 subjects (24 females and 3 males) with Fitzpatrick skin types II to IV and a mean age of 44.41 (range33-64) were enrolled. Results suggests that the epidermal thickness has significantly improved after treatment. Statistically significant improvements in melanin index, skin elasticity and wrinkles were noted. An analysis of 12 subjects' reports (44%) suggested their skin felt brighter. No post-inflammatory hyperpigmentation changes or adverse events were observed. 70% patients reporting "satisfied" or "extremely satisfied". In this study, FTL was found to be a safe and effective treatment option for treating photoaging.

Photodynamic Priming Overcomes Per- and Polyfluoroalkyl Substance (PFAS)-Induced Platinum Resistance in Ovarian Cancer†.

Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants linked to adverse outcomes, including for female reproductive biology and related cancers. We recently reported, for the first time, that PFAS induce platinum resistance in ovarian cancer, potentially through altered mitochondrial function. Platinum resistance is a major barrier in the management of ovarian cancer, necessitating complementary therapeutic approaches. Photodynamic therapy (PDT) is a light-based treatment modality that reverses platinum resistance and synergizes with platinum-based chemotherapy. The present study is the first to demonstrate the ability of photodynamic priming (PDP), a low-dose, sub-cytotoxic variant of PDT, to overcome PFAS-induced platinum resistance. Comparative studies of PDP efficacy using either benzoporphyrin derivative (BPD) or 5-aminolevulinic acid-induced protoporphyrin IX (PpIX) were conducted in two human ovarian cancer cell lines (NIH:OVCAR-3 and Caov-3). BPD and PpIX are clinically approved photosensitizers that preferentially localize to, or are partly synthesized in, mitochondria. PDP overcomes carboplatin resistance in PFAS-exposed ovarian cancer cells, demonstrating the feasibility of this approach to target the deleterious effects of environmental contaminants. Decreased survival fraction in PDP + carboplatin treated cells was accompanied by decreased mitochondrial membrane potential, suggesting that PDP modulates the mitochondrial membrane, reducing membrane potential and re-sensitizing ovarian cancer cells to carboplatin.

Efficacy and hazards of 425 nm oral cavity light dosing to inactivate SARS-CoV-2

ObjectiveUsing a battery of preclinical tests to support development of a light-based treatment for COVID-19, establish a range of 425 nm light doses that are non-hazardous to the tissues of the oral cavity and assess whether a 425 nm light dose in this non-hazardous range can inactivate SARS-CoV-2 in artificial saliva. MethodsThe potential hazards to oral tissues associated with a range of acute 425 nm light doses were assessed using a battery of four preclinical tests: (1) cytotoxicity, using well-differentiated human large airway and buccal epithelial models; (2) toxicity to commensal oral bacteria, using a panel of model organisms; (3) light-induced histopathological changes, using ex vivo porcine esophageal tissue, and (4) thermal damage, by dosing the oropharynx of intact porcine head specimens. Then, 425 nm light doses established as non-hazardous using these tests were evaluated for their potential to inactivate SARS-CoV-2 in artificial saliva. ResultsA dose range was established at which 425 nm light is not cytotoxic in well-differentiated human large airway or buccal epithelial models, is not cytotoxic to a panel of commensal oral bacteria, does not induce histopathological damage in ex vivo porcine esophageal tissue, and does not induce thermal damage to the oropharynx of intact porcine head specimens. Using these tests, no hazards were observed for 425 nm light doses less than 63 J/cm2 delivered at irradiance less than 200 mW/cm2. A non-hazardous 425 nm light dose in this range (30 J/cm2 at 50 mW/cm2) was shown to inactivate SARS-CoV-2 in vitro in artificial saliva. ConclusionPreclinical hazard assessments and SARS-CoV-2 inactivation efficacy testing were combined to guide the development of a 425 nm light-based treatment for COVID-19. Clinical significanceThe process used here to evaluate the potential hazards associated with 425 nm acute light dosing of the oral cavity to treat COVID-19 can be extended to other wavelengths, anatomical targets, and therapeutic applications to accelerate the development of novel photomedicine treatments.

Intense pulsed light-based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

BackgroundOcular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40% to 59% of these patients worldwide. The current study was aimed at evaluating the potential clinical benefit of an intense pulsed light (IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments. To our knowledge, this is the first series analyzing the therapeutic effect of this treatment option in this type of patients.MethodsThis non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye symptomatology. All patients received four sessions of IPL treatment using the Optima IPL system (Lumenis, Yokneam, Israel) adjusted to the official optimized Lumenis setting. Changes in symptomatology, corneal staining, conjunctival hyperemia, non-invasive break-up time (NIBUT), tear osmolarity, tear meniscus height (TMH), meiboscore and meibomian gland expressibility was analyzed after treatment.ResultsStatistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires [ocular surface disease index (OSDI), standard patient evaluation of eye dryness (SPEED) and symptom assessment questionnaire in dry eye (SANDE)] as well as with the visual analogue scale (P < 0.001). Mean change in OSDI was − 15.0 ± 11.3. A significant reduction was found after treatment in the corneal staining score (P < 0.001). A significant reduction was found in tear film meniscus height (P = 0.012), as well as in tear film osmolarity (P = 0.001). A significant reduction was also found in meibomian gland expressibility (P = 0.003), changing the percentage of grade 3 eyes from 44.4% before IPL to 17.2% after treatment.ConclusionsIPL therapy combined with meibomian gland expression (MGX) seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments, with an additional improvement in clinical signs, such as tear osmolarity and corneal staining.

Getting to the Core of Contemporary Therapies for Post-Inflammatory Hyperpigmentation.

Post-inflammatory hyperpigmentation (PIH) is a typical complication of inflammatory dermatoses that more frequently and severely affects people with darker skin. External insults to the skin, such as burn injuries, dermatologic treatments, and intrinsic skin disorders (eg, eczema and acne), are common causes of PIH. Individuals with darker skin are prone to develop PIH, which can cause substantial psychological suffering. PIH can be prevented or alleviated. When this happens, it is essential to point out what is causing it and treat it as soon as possible to prevent inflammation and PIH from progressing. If the inflammatory symptoms go away or there is no evidence of inflammation at the time of diagnosis, PIH treatments should be evaluated. To hasten the resolution of PIH, treatment should begin as soon as possible. Treatment begins with the care of the initial inflammatory condition. Topical medications, chemical peels, laser and light-based treatment, phototherapy, and other therapeutic modalities are offered to treat PIH. Understanding the therapy options available helps the physician in choosing the best treatment for each patient. With these backgrounds, the current review aimed to discuss the epidemiology, pathogenesis, clinical presentation, and available treatment options for the PIH. J Drugs Dermatol. 2022;21(3):276-283. doi:10.36849/JDD.6485.

Skin, Light and their Interactions, an In-Depth Review for Modern Light-Based Skin Therapies

Light-based therapies, including laser, have evolved over the last decades in the dermatology and cosmetic fields. Practitioners should have a deep understanding of the mechanism of action and the effect of different laser parameters on treatments outcomes and safety profiles. Moreover, practitioners would not be able to improve the existing laser treatment protocols or develop new ones without understanding the light fundamentals and different laser-skin interactions. This review article attempts to bridge the theoretical concepts of laser and skin anatomy with the practical applications of light-based treatments.

Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review.

The current knowledge about the mechanisms of action of light-based treatments (chiefly photodynamic therapy and phototherapy) in skin diseases leans to the possible involvement of epigenetic and oxidative stress mechanisms. To better understand and exploit, to the fullest, these relatively safe and reproducible treatments, several studies have focused on miRNAs, small non-encoding RNAs (22–24 nucleotides), after light-based treatments. The current narrative review focused on 25 articles. A meta-analysis was not deemed appropriate. The results gather the most recurrent skin-related miRNAs up- or downregulated after light treatment. Five of these, miR-21, -29, -125, -145 and -155, are either the most consistently related to efficacy/resistance to treatment or identified as helpful diagnostic tools. A specific class of miRNAs (angioMIRs) requires further studies. Future treatments and imaging techniques could benefit greatly from the use of antagomirs as a possible co-adjuvant therapy along with light-based treatments.