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- New
- Research Article
- 10.1016/j.pec.2025.109405
- Jan 1, 2026
- Patient education and counseling
- Zehra Aydin + 1 more
Education and decision support improve outcomes in urgent dialysis: A randomised trial.
- New
- Research Article
- 10.1016/j.jdiacomp.2025.109215
- Jan 1, 2026
- Journal of diabetes and its complications
- Silvia Irina Briganti + 7 more
Impact of technologies on quality of life in relation to glucose control in patients with type 1 diabetes.
- New
- Research Article
- 10.1007/978-3-032-03398-7_19
- Jan 1, 2026
- Advances in experimental medicine and biology
- Martha Mavrogiorgi + 10 more
Although menopause is a normal process, it causes a number of symptoms that affect women's health and quality of life (QoL). Furthermore, mental health problems, including depression and anxiety, in peri- and postmenopausal women are a major public health concern. The aim of this research study was to investigate menopausal symptoms and their association with mental health and quality of life. A cross-sectional study involving 78 women aged 36-58years who were in the perimenopause or menopause was conducted. The instruments used were the Greek versions of the Menopausal Rating Scale (MRS), the Depression, Stress and Anxiety Assessment Scale (DASS-21), and the World Health Organization Quality of Life Scale (WHOQoL-BREF). According to the results, menopausal symptoms were found to be of low overall severity, a small proportion (7.8%) have mild depressive symptoms and mild anxiety symptoms (9.1%), and all scales of women's quality of life show high mean values, indicating a good to fairly good quality of life. The most important findings of the study are the statistically significant negative correlations between almost all dimensions of the DASS-21 scale and the WHOQoL-BREF dimensions, and between almost all dimensions of the MRS scale and the dimensions of the WHOQOL-BREF scale. In our study, menopause was not associated with poor quality of life at a general level; however, it was confirmed to have a statistically significant negative effect on quality of life, depending on the severity of symptoms and the coexistence of other complications such as depression.
- New
- Research Article
- 10.1007/978-3-032-03398-7_42
- Jan 1, 2026
- Advances in experimental medicine and biology
- E Missouridou + 10 more
Nursing can be highly rewarding, but at the same time, overwhelmingly stressful or even traumatizing. Spirituality constitutes a central element of nurses' resilience, while personal trauma may be activated during exposure to patients' trauma. The aim of this study was to examine the impact of sociodemographic and work-related characteristics, spirituality, and personal trauma history on compassion fatigue and compassion satisfaction among Greek nurses. A cross-sectional survey study with a total of 210 nurses selected by convenience sampling and required to complete the Professional Quality of Life Scale (ProQOL V), the FACIT-Spiritual Well-Being Scale-12 nonillness scale, and the Traumatic Life Events Questionnaire (TLEQ). Thirty percent (30%) of the participants reported high compassion fatigue risk, while 76% expressed high to moderate potential for compassion satisfaction. Secondary traumatic stress (STS), as expected, was found to correlate positively with traumatic life events. Compassion satisfaction scores were found to correlate positively with spiritual well-being and the three aspects of meaning, peace, and faith. Nurses who reported good physical health, high levels of cooperation, respect for teamwork, and positive work climate also reported higher levels of Compassion Satisfaction and lower risk for compassion fatigue. The findings of this study shed light on the significant prevalence of compassion fatigue among nursing staff, highlighting the need for targeted interventions to improve the mental health of front-line healthcare professionals. Healthcare organizations must recognize the importance of fostering compassionate work environments that prioritize nurses' spiritual and psychological well-being.
- New
- Research Article
- 10.52106/3069-9088.1004
- Dec 31, 2025
- Medical - Clinical - Research
- Garima Rajan + 1 more
The present study sought to examine the changes in executive functioning, emotion regulation, and other positive psychological outcomes among participants following their completion of a four-day online advanced yoga and meditation program conducted during the COVID-19 pandemic. The study included 32 participants (11 men and 21 women; Mage = 38.12 years; SD = 9.65) who completed the standardized Stroop test and Go/No-go task for executive functioning assessment. Participants also responded to Emotion Regulation Questionnaire and Cognitive Emotion Regulation Questionnaire- Short Version, Multidimensional Flourishing Scale, Peace of Mind Scale, and Harmony in Life Scale through the Android smartphone app, PsyEx, in a pre–post-test design. The results of pre–post test scores using paired t-test on Stroop task showed statistically significant improvement for inhibitory control or response inhibition, cognitive flexibility, and selective attention from the online advanced yoga and meditation program. The results also revealed that the participants made significantly greater use of cognitive reappraisal strategy for emotion regulation and reported significantly lower use of expressive suppression emotion regulation strategy after the advanced yoga and meditation program. The study findings also revealed a significant improvement in overall flourishing, harmony in life, and peace of mind among participants following the short, intensive online advanced yoga and meditation program. The present study demonstrates the effectiveness of short, online yoga- and meditation-based programs in improving emotional regulation, executive functioning, and overall well-being. Furthermore, the study provides robust evidence supporting the integration of yoga- and meditation-based programs as effective psychological interventions for diverse populations.
- New
- Research Article
- 10.1080/07853890.2025.2561793
- Dec 31, 2025
- Annals of Medicine
- Yu-Feng Li + 6 more
Objective This study evaluated the impact of a timeline-based management protocol on treatment efficiency and short-term outcomes in acute ischemic stroke (AIS) patients. Methods A quasi-experimental study compared two cohorts treated at a single emergency department: a control group (n = 138) receiving conventional care (January–June 2022) and an intervention group (n = 125) managed with a timeline-based protocol (August–December 2022). Key metrics included door-to-needle time (DTN), admission-to-puncture time, order-to-CT time, and order-to-platelet-result time. Thrombolysis rates, Glasgow Outcome Scale (GOS), Fugl-Meyer scores, and stroke-specific quality of life were also analyzed. Results The intervention group showed significantly shorter DTN, puncture, CT, and platelet result times (p < 0.05), along with a higher thrombolysis rate. Significant improvements were also observed in GOS, motor function, and quality of life scores (p < 0.05). Conclusion The timeline-based protocol, featuring parallel coordination and a rapid-response stroke team, reduced treatment delays and improved clinical outcomes in AIS patients. These results support the adoption of time-sensitive protocols to enhance stroke care efficiency and prognosis.
- New
- Research Article
- 10.30569/adiyamansaglik.1689616
- Dec 31, 2025
- Adıyaman Üniversitesi Sağlık Bilimleri Dergisi
- Sevil Şahin + 6 more
Aim: This study aimed to determine the prevalence of smoking among women aged 18–49, assess nicotine dependence levels, and evaluate the relationship between smoking and sexual quality of life. Materials and Methods: A cross-sectional study was conducted between June 12, 2023, and January 21, 2024, with a sample of 845 women. Data were collected using a literature-based questionnaire, the Fagerström Test for Nicotine Dependence, and the Quality of Sexual Life Scale. Results: The prevalence of smoking was found to be 48.2%. Smoking was significantly more common among unmarried women (p=0.001). There was no statistically significant difference in sexual quality of life between smokers and non-smokers (p=0.828). Conclusion: The findings of this study suggest that smoking duration and dependence level have no significant impact on sexual quality of life. Further rigorous and multidimensional research is warranted to elucidate this relationship.
- New
- Research Article
- 10.47191/rajar/v11i12.16
- Dec 31, 2025
- RA JOURNAL OF APPLIED RESEARCH
- Daniela Tavera- Garcia + 1 more
Objective: To examine the quality of life of patients with gonarthrosis who underwent conservative treatment. Methods: A descriptive, prospective, observational, and cross-sectional study was conducted with a sample of 114 patients registered at Family Medicine Unit 35, calculated using the formula for finite populations. A non-probability sampling method was used. The Oxford Knee Quality of Life Scale was administered. Statistical analysis included chi-square tests. Results: A significant difference (p < 0.001, chi-square) was found in quality of life. Those receiving conservative treatment (weight control), those receiving conservative treatment (physical exercise), and those without pharmacological treatment were more frequently associated with excellent and good quality of life. Conclusion: This study demonstrated that conservative treatment (weight control and physical exercise), as well as those without pharmacological treatment, is associated with a better perception of quality of life in this study group, particularly through weight control and physical exercise.
- New
- Research Article
- 10.55737/rl.2025.44135
- Dec 30, 2025
- Regional Lens
- Maryam Khurshid + 3 more
When parents learn they are pregnant, they typically envision a healthy, fully grown child with a promising future. However, all the joy and satisfaction of having a kid turns into despair and sorrow when the parents are informed later in the pregnancy that the child is abnormal. The birth of a child with physical and mental disabilities is extremely difficult and interferes with the family's regular activities. Boys who are physically disabled from birth or due to a family injury face significant obstacles for their parents and siblings. The primary goal of the study was to examine the connection between life satisfaction and anxiety among parents of boys with physical disabilities. Sixty parents of male children with physical disabilities from the Nishtar Hospital in Multan made up the sample. Data was gathered using the snowball sampling approach. Mothers and dads of children with physical disabilities were also compared. Study factors are measured using the Anxiety and Satisfaction with Life Scale. The results of the study show that anxiety and life satisfaction are significantly correlated negatively. Furthermore, among parents of boys with physical disabilities, there is a notable gender difference in worry and life satisfaction.
- New
- Research Article
- 10.3390/children13010053
- Dec 30, 2025
- Children
- Dimitrios Papadopoulos + 1 more
Background/Objectives: Caring for a child with Autism Spectrum Disorder (ASD) is often associated with elevated psychological distress and reduced life satisfaction. Mindfulness-based interventions may offer substantial benefits by enhancing emotion regulation, reducing maladaptive cognitive patterns, and strengthening mindful parenting. This randomized controlled trial (RCT) examined the effectiveness of an eight-week Mindfulness-Based Cognitive Therapy (MBCT) program, enriched with mindful parenting practices, delivered to parents of children with ASD. The primary aim was to improve parental mental health, while secondary analyses explored potential indirect, parent-perceived changes in child behavior outcomes. Methods: Fifty-six parents of children with ASD were randomly assigned to an MBCT intervention group (n = 30) or a waitlist control group (n = 26). Parents completed assessments at baseline (T0), post-intervention (T1), and at one-month follow-up (T2), including the Depression Anxiety Stress Scales–21 (DASS-21), the Positive and Negative Affect Schedule (PANAS), and the Satisfaction With Life Scale (SWLS). They also rated the overall severity of their child’s behavior problems to explore indirect treatment effects. Results: All parents receiving MBCT (100%) completed the program successfully and reported high acceptability. At baseline, no significant differences were observed between groups. At T1, the MBCT group demonstrated significant reductions in depression, anxiety, and stress, alongside increases in positive affect and life satisfaction. These improvements were maintained or strengthened at T2. However, the control group showed no significant changes over time. Additionally, parents in the MBCT group reported indirect improvements in their children’s behavioral adjustment at T1 and T2. Conclusions: Findings demonstrate that MBCT constitutes an effective intervention for reducing parental psychopathology and indirectly supporting parent-perceived improvements in child behavior, emphasizing the importance of incorporating mindfulness and mindful parenting components into family-centered interventions for parents of children with ASD.
- New
- Research Article
- 10.1007/s40520-025-03244-9
- Dec 29, 2025
- Aging clinical and experimental research
- Li Yan + 3 more
This paper aims to assess the clinical effectiveness of an Enhanced Recovery After Surgery (ERAS)-based care bundle in facilitating early rehabilitation in patients with acute ischemic stroke (AIS). A total of 120 AIS patients were randomly assigned to either a control group (n = 60), receiving routine nursing care, or an experimental group (n = 60), which received additional ERAS-guided bundled care. Outcome measures included neurological function [NIH Stroke Scale (NIHSS), modified Rankin Scale (mRS)], limb strength (Lovett scale), language ability [Boston Diagnostic Aphasia Examination (BDAE)], swallowing function [Water Swallow Test (WST)], psychological status [Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA)], and quality of life [Stroke-Specific Quality of Life Scale (SS-QOL)]. Incidence of adverse events was also recorded. Post-intervention, NIHSS and mRS scores declined more markedly in the experimental group than in the control group (P < 0.05). The experimental group had a higher number of patients with Lovett muscle strength grade 4, BDAE grades 4 and 5, and WST grade 1 compared to the control group (P < 0.05). The HAMD and HAMA scores in the experimental group were lower than those in the control group (P < 0.05). The experimental group also had lower adverse event rate compared to the control group (P < 0.05). An ERAS-based care bundle can significantly enhance early functional recovery, mitigate psychological distress, and reduce complications in AIS patients, supporting its clinical applicability in stroke rehabilitation.
- New
- Research Article
- 10.1186/s12883-025-04588-5
- Dec 28, 2025
- BMC neurology
- Athira George + 3 more
Virtual reality (VR) has emerged as a promising tool in neurorehabilitation to improve motor function in individuals with hemiplegia. VR applications are typically categorized into immersive and non-immersive types, both of which have demonstrated efficacy in enhancing upper limb function. This study aimed to compare the effectiveness of immersive virtual reality (IMVR) and non-immersive virtual reality (NIVR) therapies in improving upper limb motor function in individuals with subacute hemiplegia. This single-blinded randomized controlled trial included 30 participants (aged 25-40 years, both male and female) with subacute hemiplegia. Individuals with pre-existing musculoskeletal or neurological conditions affecting the upper limb, severe motion sickness, photosensitivity, or perceptual deficits were excluded. Participants were randomly allocated into two groups: Both groups initially received conventional physiotherapy, following which the immersive VR and non-immersive VR interventions were administered to the respective group. Each session lasted 60min, with three sessions per week for six weeks. Assessments were conducted at baseline, post-intervention (6 weeks), and follow-up (6 months) using the Fugl-Meyer Assessment (FMA), Wolf Motor Function Test (WMFT), and Stroke-Specific Quality of Life Scale (SS-QOL). The System Usability Scale (SUS) and User Experience Questionnaire (UEQ) were used to evaluate the safety and usability of both VR methods. No statistically significant differences were observed in baseline characteristics between the groups. SUS and UEQ scores also showed no significant differences in user experience. However, IMVR demonstrated statistically significant improvements in FMA, WMFT, and SS-QOL scores compared to NIVR at both post-test and follow-up (p < 0.05). Both immersive and non-immersive VR therapies were effective in enhancing upper limb motor function and quality of life among individuals with subacute hemiplegia. However, IMVR showed greater clinical significance in improving motor function and quality of life. Future research should explore the integration of VR across different stroke stages and focus on developing simple, task-specific games to further support rehabilitation. This clinical trial was registered in clinicaltrials.gov under the trial ID NCT06615141 on September 26, 2024.
- New
- Abstract
- 10.1002/alz70859_106890
- Dec 25, 2025
- Alzheimer's & Dementia
- James E Galvin + 4 more
BackgroundZervimesine (CT1812) is an experimental oral, small‐molecule drug candidate in development for Alzheimer’s disease and dementia with Lewy bodies (DLB). Zervimesine is designed to protect neurons by preventing the binding of oligomers of pathogenic proteins including β‐amyloid and ɑ‐synuclein.MethodThe COG1201 ‘SHIMMER’ study is the first study to measure tolerability and clinical effects of zervimesine in adults with DLB. The study enrolled 130 individuals with a clinical diagnosis of DLB and MMSE of 18‐27 who were randomized 1:1:1 to receive once‐daily oral doses of zervimesine (100 or 300 mg) or placebo for 26 weeks. Among clinical assessments tools, SHIMMER employed the Neuropsychiatric Inventory (NPI), Alzheimer's Disease Cooperative Study‐Activities of Daily Living (ADCS‐ADL) scale and the Unified Parkinson's Disease Rating Scale (UPDRS) Part III.ResultZervimesine‐treated participants experience strong therapeutic responses across behavioral, functional, cognitive, and movement measures in SHIMMER. At the end of the study period, zervimesine‐treated DLB (n=88) patients progressed 86% slower than placebo‐treated patients (n=42) on the NPI, 52% slower on the ADCS‐ADL and 62% slower on the UPDRS Part III. We intend to present for the first time a detailed characterization of the baseline participant characteristics including demographics, baseline scores on outcome measures, concomitant medications, comorbidities and baseline biomarker levels.ConclusionThese data will allow comparison of the SHIMMER population to prior DLB study populations. SHIMMER results support the potential for zervimesine to slow clinical progression in patients with mild‐to‐moderate DLB. The robust therapeutic response observed across neuropsychiatric, cognitive, motor and functional measures is particularly encouraging. An analysis of participant characteristics will help guide recruitment in future clinical studies of zervimesine and its potential use to treat people with DLB.Cognition Therapeutics conducted COG1201 with University of Miami Miller School of Medicine and the Lewy Body Dementia Association under a grant from the National Institute of Aging (R01AG071643).
- New
- Research Article
- 10.35460/2546-1621.2025-0200
- Dec 24, 2025
- Journal of Medicine, University of Santo Tomas
- Gio Miguel D Manipula + 6 more
Background: There has been little research done on the prevalence of compassion fatigue (CF) among obstetricians–gynecologists (OBGYNs), despite research suggesting that traumatic childbirth experiences can negatively impact physicians’ well-being and consequently, patient care. Objectives: This study aims to determine the prevalence of CF and compassion satisfaction (CS) among OBGYN resident physicians in selected hospitals in Manila and identify the associated contributory factors. Materials and Methods:A cross-sectional study was conducted among 105 OBGYN residents using the Professional Quality of Life Scale Version 5 (ProQOL 5), which measures CS and CF—further divided into burnout (BO) and secondary traumatic stress (STS). Data were collected through an online survey and analyzed using Jamovi software. Descriptive statistics were reported as frequencies, percentages, means, standard deviations and 95% confidence intervals. Associations between variables were determined using independent t-tests and Kruskal-Wallis tests, with a significance level set at p<0.05. Results:Most residents scored moderate levels in CS (68.6%), BO (72.4%) and STS (73.3%). Significant associations were found between all three subscales and most work-related factors such as hours of sleep per day, working hours per week and frequency of being called in during off-duty hours. Marital status and parity were also significantly associated with higher BO and STS scores. Conclusion:The study highlights the presence of CF among OBGYN residents with reported associations with work and personal factors. These findings emphasize the need for institutional interventions to support the well-being of resident physicians, especially in demanding clinical environments. Keywords: Compassion fatigue, Compassion satisfaction, Obstetrics and Gynecology residents
- New
- Research Article
- 10.53016/jerp.v6i2.321
- Dec 24, 2025
- Journal of Education and Recreation Patterns
- Büşra Özdek + 3 more
The aim of this study was to examine the relationships among weight status, physical activity, nutritional habits, and life satisfaction in middle school students. The study was conducted with a sample of 216 students (96 male and 120 female) attending public middle schools. Data was collected using a personal information form, the Physical Activity Questionnaire for Older Children (PAQ-C), the Nutritional Behavior Scale, and the Satisfaction with Life Scale for Children. In addition, objective physical activity data were obtained using Polar Ignite® smartwatches, which participants wore continuously for only a 48-hour monitoring period. Statistical analyses included independent samples t-tests, one-way analysis of variance (ANOVA), chi-square tests, and Pearson correlation analyses. The results indicated that 61.1% of the participants were classified as normal weight, while 23.1% were overweight and 11.1% were obese. Male participants exhibited significantly higher Body Mass Index (BMI) values than female participants (p0.05). No significant gender differences were observed in physical activity levels, life satisfaction, or nutritional habits (p0.05). However, 11-year-old students demonstrated significantly higher physical activity levels and healthier nutritional habits than students aged 12 and 13 years. Correlation analyses revealed positive and significant associations between physical activity and life satisfaction, as well as between physical activity and nutritional habits (p0.01). No significant association was found between life satisfaction and nutritional habits (p0.05). In conclusion, promoting sustained physical activity and healthy nutrition during early adolescence may support both physical health and psychosocial well-being among middle school students overall effectively.Keywords: Nutrional Behaviors, Obesity, Physical Activity.
- New
- Research Article
- 10.35460/2546-1621.2025-0094
- Dec 24, 2025
- Journal of Medicine, University of Santo Tomas
- Angelica Marie V Mandario + 10 more
Introduction: Stroke is a significant public health burden in the Philippines, ranking among the leading causes of death and disability, yet a specific health-related quality of life (HRQOL) assessment tool tailored for Filipino stroke survivors is lacking. This study aimed to address this gap by translating the Stroke-Specific Quality of Life (SS-QOL) questionnaire into Filipino and subsequently validating this new version to provide a culturally relevant and reliable outcome measure for stroke patients in the country. Methodology: A descriptive, cross-sectional design was utilized, involving the translation of the SS-QOL from English to Filipino through Collaborative Translation Protocols, which centered on group consensus. Three Filipino language experts rigorously evaluated the initial translation for linguistic and cultural appropriateness. To assess content and face validity, an expert committee of three neurology consultants provided ratings, which were analyzed using the item-level content validity index (i-CVI). Subsequently, a pilot testing phase was conducted with 10 stroke survivors recruited via purposeful sampling in Metro Manila to evaluate the SS-QOL-Filipino's clarity, layout, understandability and answerability, while also measuring the intraclass correlation coefficient (ICC) to assess consistency and agreement among items. Results: The SS-QOL was successfully forward translated and refined through focused group discussions (FGD) with language experts. The translated questionnaire demonstrated high content validity, with all items achieving an i-CVI of 1.0 as rated by neurology experts. Face validity was also established, incorporating minor revisions based on expert feedback. Pilot testing yielded an average measures ICC of 0.761, indicating strong agreement, and responses on a 5-point Likert scale showed the questionnaire was easy-to-very-easy to understand and answer (mode ranging from 3-5). Discussion: This study successfully developed a stroke-specific HRQOL tool for the Philippines, addressing a critical need for objective measures in patient-centered care. The use of Collaborative Translation Protocols ensured the questionnaire's conceptual, linguistic and cultural equivalence, incorporating nuances specific to the Filipino context in areas like eating habits, emotional expressions and technological terms. The high face and content validity, coupled with strong consistency and high understandability observed during pilot testing underscore the SS-QOL-Filipino's suitability for the target population, positioning it as a valuable instrument for both clinical practice and research. Conclusion: The SS-QOL scale was successfully translated into Filipino using Collaborative Translation Protocols and rigorously validated. The SS-QOL-Filipino version demonstrates high content and face validity, strong consistency and excellent understandability and answerability, affirming its status as a reliable and appropriate outcome measure for assessing the QOL among stroke patients in Metro Manila. Keywords: Stroke, collaborative translation protocols, quality of life, stroke specific quality of life scale, Filipino.
- New
- Research Article
- 10.29329/jsomer.74
- Dec 23, 2025
- Journal of Social Media Research
- Nail Değirmenci + 7 more
Social media envy is a complex social emotion that involves a mix of unpleasant, often painful feelings that occur when someone perceives a lack of a superior quality, achievement, or possession that another person has (based on positively distorted content on social media). This study aims to adapt the Social Media Envy Scale (SMES), developed by Tandoc et al. (2015), to Turkish culture and examine its psychometric properties. To assess the scale's structural validity, criterion validity, and reliability, a cross-sectional study was conducted with 410 participants (57.3% female). Confirmatory Factor Analysis (CFA) was used to assess whether the original seven-item, single-factor structure of the scale held in the Turkish sample. One item was removed due to low factor loading. The fit indices from the final model indicated that the single-factor structure was acceptably confirmed in the Turkish context. The internal consistency coefficients also showed that the scale has adequate reliability. To evaluate its criterion validity, Pearson correlation analyses were performed using the Satisfaction with Life Scale (SWLS) and the DASS-21 subscales (Depression, Anxiety, and Stress) as external measures. The results showed that the SMES had a significant moderate negative correlation with the SWLS, and moderate positive correlations with depressive, anxious, and stress symptoms, supporting the scale’s criterion validity by reflecting relationships in expected directions. This study added value to the current literature by providing a valid scale to measure envy arising from social media in Turkish culture. Within only six items, the one-dimensional structure of Turkish SMES still demonstrates acceptable psychometric properties, including internal consistency and criterion validity. Its robustness supported the future use in a larger-scale study focusing on psychological mechanisms among Turkish social media users.
- New
- Research Article
- 10.64514/vmsjournal.2025.11
- Dec 23, 2025
- Dogu Akdeniz Aile Hekimleri Dernegi (DAAHED)
- Esra Saatci + 1 more
Abstract Objective and Aim Aims: Diabetes mellitus negatively affects the quality of life, work life, interpersonal relationships, social activities and health of patients. The aim of this study is to investigate the relationship between treatment compliance and diabetes-related quality of life in patients with type 2 diabetes. Material and Methods This cross-sectional study was conducted at Çukurova University Training Family Health Center between 01 January 2024 and 29 February 2024. Patients who had given informed consent completed the Sociodemographic Data Collection Questionnaire, the Diabetes Specific Quality of Life Scale (DQOL), and the Modified Morisky Scale. Data was analyzed using SPSS (Statistical Package for the Social Sciences) 23.0 package program. Results The participants’ mean DQOL score was 3.92±0.7 showing a moderate-good quality of life. The participants' mean medication adherence motivation level score was 1.53±0.7 and the mean medication adherence knowledge level score was 1.88±0.7 showing a high level of medication adherence. A weak positive (linear) correlation was found between the medication adherence motivation level scores and DQOL anxiety/worry about diabetes scores (r= 0.168) (p=0.031). A weak positive (linear) correlation was found between low treatment adherence and the anxiety/worry about diabetes (r= 0.180) (p=0.021). It was found that the DQOL scale scores of patients with normal body weight were significantly higher than those of the obese patients (p=0.042). DQOL scale scores were significantly lower in patients with diabetes-related complications compared to those without diabetes-related complications (p=0,002). Conclusion As the motivation level for medication adherence increased, anxiety about diabetes decreased. Participant’s medication adherence, motivation and knowledge levels were high. Follow-ups of diabetic patients in primary care will help to improve their medication adherence and the quality of life. Keywords: Diabetes mellitus, Quality of life, Medication adherence, Family medicine
- New
- Research Article
- 10.25259/jish_15_2025
- Dec 23, 2025
- Journal of Integrated Standardized Homoeopathy
- Nishi Agarwal + 3 more
Objectives: Melasma is a common acquired hyperpigmentation disorder. It is characterised by symmetrical, dark brown macules with irregular contours but clear limits, on photoexposed sites. It commonly occurs among Indians with a greater incidence in women. Sun exposure, pregnancy, use of oral contraceptive pills, certain medications and family history are among the factors responsible for the development of melasma. The primary objective of this study was to determine the usefulness of homoeopathic treatment in melasma using the modified melasma area and severity index (mMASI). The secondary objective was to assess the quality of life in melasma after homoeopathic treatment using the melasma quality of life scale (MELASQOL). Material and Methods: This was a prospective study conducted on patients who attended the peripheral outpatient department of Bakson Homoeopathic Medical College and Hospital, Greater Noida, Uttar Pradesh. A total of 35 women aged 18–59 years who were clinically diagnosed were included. The mMASI and MELASQOL scores were statistically analysed using a paired “ t ” test at baseline and 6 months. Results: There was a mean reduction of 0.75 ± 0.77 and 6.05 ± 6.30 in mMASI and MELASQOL scores at the end of the 6 th month ( P < 0.0001). Conclusion: The study demonstrated a statistically significant improvement in the mMASI and MELASQOL scores before and after treatment with homoeopathic remedies. Further evaluation involving larger sample sizes and longer study duration is necessary.
- New
- Research Article
- 10.1371/journal.pone.0338646
- Dec 22, 2025
- PLOS One
- Jarosław Fugiel + 5 more
ObjectivesThis study aimed to explore the relationship between selected motor performance tests and indicators of cognitive impairment in older adults. Specifically, it examined associations with the Mini-Mental State Examination (MMSE) and the Lawton Instrumental Activities of Daily Living (IADL) scale. A secondary aim was to assess whether these motor tests correlate more strongly with cognitive and functional status than with chronological age.MethodsSixty-two institutionalized adults aged 60 years and older were evaluated. Motor performance was measured using tasks from the Vienna Test System (MLS), including pin insertion, tapping, targeting, tremor control, and line tracking. Handgrip strength was also assessed as a reference. Pearson’s correlation coefficients were calculated to examine relationships among motor test scores, MMSE, IADL, and age.ResultsMost fine motor tests showed moderate to strong correlations with MMSE and IADL scores, but not with chronological age. Pin insertion, tracking, and tremor control were especially indicative of cognitive and functional status. Handgrip strength, by contrast, was significantly associated with age but not with MMSE or IADL.ConclusionFine motor tasks, particularly pin insertion and tracking, show significant associations with cognitive and functional performance in older adults. These findings suggest that such tasks may hold potential as practical indicators for identifying individuals at risk of decline; however, longitudinal studies are needed to confirm their predictive value and causal relationships.