Background & AimTo compare the efficacy of Levosimendan with Nitrogycerin in patients with isolated diastolic dysfunction undergoing corornary artery bypass grafting (CABG)Methods30 patients with isolated diastolic dysfunction undergoing on pump CABG were randomized into two groups receiving Levosimendan or Nitroglycerin infusion. The infusion was started prior to sternotomy and continued in the postoperative period. Perioperatively, diastolic function was serially evaluated at three different time points using echocardiography. N-terminal fragment of pro- B-natriuretic peptide (NT pro BNP) levels were measured in both the groups.ResultsThere was a significant improvement in diastolic function as measured by isovolumic relaxation time (p=0.0001, p=0.001) and deceleration time (p=0.0001, p=0.0001) in the Levosimendan group from the baseline in patients with impaired relaxation, Similarly, tissue Doppler imaging also revealed an improvement from the baseline in patients with a pseudonormal pattern (p=0.018, p=0.001). Further there was a significant improvement in the above parameters when compared to the Nitroglycerin group. The NT pro BNP levels also demonstrated a similar pattern between the two groups (p=0.03, p=0.02) when Levosimendan was compared with nitroglycerin in patients with a pseudonormal pattern on echocardiography.ConclusionLevosimendan is superior to Nitroglycerin in improving the diastolic function irrespective of coronary revascularizationReference1. Tritapeppe L, De Santis V, Vitale D, Guarracino F, Pellegrini F, Pietropaoli P et al. Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery. Br J Anesth 2009;102(2):198-204. Background & AimTo compare the efficacy of Levosimendan with Nitrogycerin in patients with isolated diastolic dysfunction undergoing corornary artery bypass grafting (CABG) To compare the efficacy of Levosimendan with Nitrogycerin in patients with isolated diastolic dysfunction undergoing corornary artery bypass grafting (CABG) Methods30 patients with isolated diastolic dysfunction undergoing on pump CABG were randomized into two groups receiving Levosimendan or Nitroglycerin infusion. The infusion was started prior to sternotomy and continued in the postoperative period. Perioperatively, diastolic function was serially evaluated at three different time points using echocardiography. N-terminal fragment of pro- B-natriuretic peptide (NT pro BNP) levels were measured in both the groups. 30 patients with isolated diastolic dysfunction undergoing on pump CABG were randomized into two groups receiving Levosimendan or Nitroglycerin infusion. The infusion was started prior to sternotomy and continued in the postoperative period. Perioperatively, diastolic function was serially evaluated at three different time points using echocardiography. N-terminal fragment of pro- B-natriuretic peptide (NT pro BNP) levels were measured in both the groups. ResultsThere was a significant improvement in diastolic function as measured by isovolumic relaxation time (p=0.0001, p=0.001) and deceleration time (p=0.0001, p=0.0001) in the Levosimendan group from the baseline in patients with impaired relaxation, Similarly, tissue Doppler imaging also revealed an improvement from the baseline in patients with a pseudonormal pattern (p=0.018, p=0.001). Further there was a significant improvement in the above parameters when compared to the Nitroglycerin group. The NT pro BNP levels also demonstrated a similar pattern between the two groups (p=0.03, p=0.02) when Levosimendan was compared with nitroglycerin in patients with a pseudonormal pattern on echocardiography. There was a significant improvement in diastolic function as measured by isovolumic relaxation time (p=0.0001, p=0.001) and deceleration time (p=0.0001, p=0.0001) in the Levosimendan group from the baseline in patients with impaired relaxation, Similarly, tissue Doppler imaging also revealed an improvement from the baseline in patients with a pseudonormal pattern (p=0.018, p=0.001). Further there was a significant improvement in the above parameters when compared to the Nitroglycerin group. The NT pro BNP levels also demonstrated a similar pattern between the two groups (p=0.03, p=0.02) when Levosimendan was compared with nitroglycerin in patients with a pseudonormal pattern on echocardiography. ConclusionLevosimendan is superior to Nitroglycerin in improving the diastolic function irrespective of coronary revascularization Levosimendan is superior to Nitroglycerin in improving the diastolic function irrespective of coronary revascularization