Level Of Basal Metabolism Research Articles

RECENT OBSERVATIONS ON THE IODINE REACTION IN EXOPHTHALMIC GOITER*

Our observations may be summarized under three main headings: 1. The range of effective iodine dosage. 2. Refractoriness to iodine. 3. Prolonged treatment by iodine alone. 4. Myxedema during the administration of iodine. the dose of iodine While working in the thyroid clinic of the Massachusetts General Hospital in Boston, we made an attempt to determine the smallest dose of iodine that will produce any reduction in basal metabolism and the smallest amount that will produce a maximum reduction. For this purpose we observed the effect on basal metabolism of the daily administration of about 6 mgms.† of iodine (roughly, one drop of the compound solution), 3 mgms., 1.5 mgms. and 0.75 mgm. to four series of hospital patients with exophthalmic goiter and compared the effect with that of much larger doses given initially (1) (2) (3) (4). The routine was to wait until a stationary level of basal metabolism was reached. Compound solution of iodine in one of the doses mentioned was then administered and daily obse...

THE RESPIRATORY GAS PERCENTAGES DURING NITROUS OXID ANESTHESIA IN DOGS

The practical induction of nitrous oxid-oxygen anesthesia by the methods now universally practiced still leaves undetermined the question of adequacy of the supply of oxygen to the patient. The question as to availability of oxygen is rendered the more important by recent work which tends to establish the minimum requirements of oxygen in respiratory airs for efficiency in the normal individual. The experimental data of the United States Army School of Aviation Medicine prove that a normal man cannot long retain consciousness unless he breathes air of at least 6 per cent. oxygen.1In the tests, it is assumed that the individual is exerting a minimum of muscular activity. He is not far from the normal basal metabolic level. By the least additional work, as by any sudden muscular acts, he quickly consumes the oxygen below the level necessary to retain consciousness. For less resistant individuals, either normal or pathologic,