Capillary Length Research Articles

Flow of viscoelastic films over grooved surfaces with partial wetting

We consider the steady flow of a viscoelastic film over an inclined plane featuring periodic trenches normal to the main flow direction. The trenches have a square cross-section and side length 5–8 times the capillary length. Owing to the orientation of the substrate, the film fails to coat the topographical feature entirely, forming a second gas–liquid interface inside the trench and two three-phase contact lines at the points where the free surface meets the wall of the trench. The volume of entrapped air depends on material and flow parameters and geometric conditions. We develop a computational model and carry out detailed numerical simulations based on the finite element method to investigate this flow. We solve the two-dimensional mass and momentum conservation equations using the exponential Phan-Thien & Tanner constitutive model to account for the rheology of the viscoelastic material. Due to the strong nonlinearity, multiple steady solutions possibly connected by turning points forming hysteresis loops, transcritical bifurcations and isolated solution branches are revealed by pseudo-arc-length continuation. We perform a thorough parametric analysis to investigate the combined effects of elasticity, inertia, capillarity and viscosity on the characteristics of each steady flow configuration. The results of our simulations indicate that fluid inertia and elasticity may or may not promote wetting, while shear thinning and hydrophilicity always promote the wetting of the substrate. Interestingly, there are conditions under which the transition to the inertial regime is not smooth, but a hysteresis loop arises, signifying an abrupt change in the film hydrodynamics. Additionally, we investigate the effect of the geometrical characteristics of the substrate, and our results indicate that there is a unique combination of the geometry and viscoelastic properties that either maximizes or minimizes the wetting lengths.

Releasing long bubbles trapped in thin capillaries via tube centrifugation and inclination

In confined systems, the entrapment of a gas volume with an equivalent spherical diameter greater than the dimension of the channel can form extended bubbles that obstruct fluid circuits and compromise performance. Notably, in sealed vertical tubes, buoyant long bubbles cannot rise if the inner tube radius is below a critical value near the capillary length. This critical threshold for steady ascent is determined by geometric constraints related to the matching of the upper cap shape with the lubricating film surrounding the elongated part of the bubble. Developing strategies to overcome this threshold and release stuck bubbles is essential for applications involving narrow liquid channels. Effective strategies involve modifying the matching conditions with an external force field to facilitate bubble ascent. However, it is unclear how changes in acceleration conditions affect the motion onset of buoyancy-driven long bubbles. This study investigates the mobility of elongated bubbles in sealed tubes with an inner radius near the critical value inhibiting bubble motion in a vertical setting. Two strategies are explored to tune bubble motion, leveraging variations in axial and transversal accelerations: tube rotation around its axis and tube inclination relative to gravity. By revising the geometrical constraints of the simple vertical setting, the study predicts new thresholds based on rotational speed and tilt angle, respectively, providing forecasts for the bubble rising velocity under modified apparent gravity. Experimental measurements of motion threshold and rising velocity compare well with theoretical developments, thus suggesting practical approaches to control and tune bubble motion in confined environments.

Impact of the Capillary Tube Length on the Refrigeration Cycle Exergy

Impact of the Capillary Tube Length on the Refrigeration Cycle Exergy

Success and failure of the spreading law for large drops of dense granular suspensions

The spreading of large viscous drops of density-matched suspensions of non-Brownian spheres on a smooth solid surface is investigated experimentally at the global drop scale. The focus is on dense suspensions with a solid volume fraction equal to or greater than $40\,\%$ , and for drops larger than the capillary length, i.e. for which the spreading is governed by the balance of gravitational and viscous forces. Our findings indicate that all liquids exhibit a power-law behaviour typical of gravity-driven dynamics, albeit with an effective suspension viscosity that is smaller than the bulk value. When the height of the drop is of the order of the particle size, the power law breaks down as the particles freeze while the contact line continues to advance.

Association of Coronary Microvascular Rarefaction and Myocardial Fibrosis With Coronary Artery Disease.

To evaluate, in a cohort study, whether coronary microvasculature and myocardial structure differ between people with and without coronary artery disease (CAD). We performed histological analysis of left ventricle free wall obtained at autopsy from 25 men and 23 women with ≥1 coronary artery with ≥75% area stenosis, and 25 men and 25 women without (no or minimal) CAD, matched for sex and age, who died suddenly from noncardiac causes. Decedents with myocardial infarction or other cardiac abnormality were excluded. Decedents with and without CAD had similar height and weight. Heart weight of decedents with CAD was higher than that of decedents without CAD (mean, 391 versus 364 g; mean difference, 27 g [95% CI, 0.3-54.0], P=0.048). Decedents with CAD had lower arteriole density (mean, 1.4 per mm2 versus 1.8 per mm2; mean difference, -0.4 per mm2 [95% CI, -0.6 to -0.2], P=0.0001), lower capillary length density (mean, 3164 versus 3701 mm/mm3; mean difference, -537 [95% CI, -787 to -286], P<0.0001), and higher total myocardial fibrosis (mean, 7.5% versus 5.7%; mean difference, 1.7% [95% CI, 1.0-2.5], P<0.0001), than decedents without CAD. CAD was associated with coronary microvascular rarefaction and increased myocardial fibrosis. The association of CAD with coronary microvascular rarefaction and increased myocardial fibrosis may contribute to the increased risks of death, myocardial infarction and heart failure that accompany CAD, and may attenuate the impact of percutaneous coronary intervention on cardiovascular risk in people with stable angina.

Applying a Comprehensive Model for Single-Ring Infiltration: Assessment of Temporal Changes in Saturated Hydraulic Conductivity and Physical Soil Properties

Modeling agricultural systems, from the point of view of saving and optimizing water, is a challenging task, because it may require multiple soil physical and hydraulic measurements to investigate the entire crop cycle. The Beerkan method was proposed as a quick and easy approach to estimate the saturated soil hydraulic conductivity, Ks. In this study, a new complete three-dimensional model for Beerkan experiments recently proposed was used. It consists of thirteen different calculation approaches that differ in estimating the macroscopic capillary length, initial (θi) and saturated (θs) soil water contents, use transient or steady-state infiltration data, and different fitting methods to transient data. A steady-state version of the simplified method based on a Beerkan infiltration run (SSBI) was used as the benchmark. Measurements were carried out on five sampling dates during a single growing season (from November to June) in a long-term experiment in which two soil management systems were compared, i.e., minimum tillage (MT) and no tillage (NT). The objectives of this work were (i) to test the proposed new model and calculation approaches under real field conditions, (ii) investigate the impact of MT and NT on soil properties, and (iii) obtain information on the seasonal variability of Ks and other main soil physical properties (θi, soil bulk density, ρb, and water retention curve) under MT and NT. The results showed that the model always overestimated Ks compared to SSBI. Indeed, the estimated Ks differed by a factor of 11 when the most data demanding (A1) approach was considered by a factor of 4–8, depending on the transient or steady-state phase use, when A3 was considered and by a practically negligible factor of 1.0–1.9 with A4. A relatively higher seasonal variability was detected for θi at the MT than NT system. Under both MT and NT, ρb did not change between November and April but increased significantly until the end of the season. The selected calculation approaches provided substantially coherent information on Ks seasonal evolution. Regardless of the approach, the results showed a temporal stability of Ks at least from early April to June under NT; conversely, the MT system was, overall, more affected by temporal changes with a relative stability at the beginning and middle of the season. These findings suggest that a common sampling time for determining Ks could be set at early spring. Soil management affected the soil properties, because the NT system was significantly wetter and more compact than MT on four out of five dates. However, only NT showed a significantly increasing correlation between Ks and the modal pore diameter, suggesting the presence of a relatively smaller and better interconnected pore network in the no-tilled soil. This study confirms the need to test infiltration models under real field conditions to evaluate their pros and cons. The Beerkan method was effective for intensive soil sampling and accurate field investigations on the temporal variability of Ks.

Revealing the influence of ring-shaped beam profiles in high-speed laser beam microwelding by synchrotron x-ray imaging

Laser beam microwelding is a precise technique for joining miniature metal components with high feed rates, which is crucial for productivity. However, high feed rates provoke humping formation—periodic beadlike protuberances along the weld seam—that compromise weld integrity. While humping has been associated with the keyhole transition from a narrow to an elongated shape using standard laser intensity distributions (e.g., Gaussian, top-hat), the impact of complex beam profiles, like ring-shaped intensity distributions, remains less understood. In this work, the influence of core-only, ring-only, and superimposed core-ring intensity distributions on humping formation during laser beam microwelding is investigated by means of synchrotron x-ray imaging. Single-track experiments on stainless steel (1.4404) at 1000 mm/s reveal that the keyhole geometry shifts from deep and narrow with core-only power input to shallow and elongated with ring-only power input. Using a superimposed core-ring intensity distribution (Pc = 300 W, Pr = 600 W) results in a U-shaped capillary and the reduction of the humping amplitude by nearly 80% (from 45.61 μm with core-only to 10.29 μm). The additional laser power comes with the tripling of the melt pool width (from 81 μm with core-only to 263 μm) likely decreasing the melt flow velocity. The reduced variability of the capillary length present for the superimposed intensity distribution further indicates a stabilized evaporation behavior. This work provides valuable insights into mitigating humping formation during laser beam microwelding of stainless steel at elevated feed rates using core-ring intensity distributions.

Enhancing pipe chilldown with axial grooves filled with silicone sealant

This study proposes a method to accelerate the chilldown process in pipes using liquid nitrogen flow. Axial grooves were machined along the inner surface of the pipe and then filled with silicone sealant. This approach achieves a shorter chilldown time compared to previously proposed methods. Initial experiments involving pool boiling in liquid nitrogen were conducted to determine the optimal groove width and the ratio of groove-to-sealant area. The shortest chilldown time in pool boiling was achieved when the groove pitch was close to the capillary length. The effect of the copper-to-silicone sealant area ratio on the chilldown process was minimal. The shortest chilldown time was achieved with a surface that had a 2 mm pitch and a copper-to-silicone sealant area ratio of 0.25. The chilldown time was 1/4.4 of that of the bare surface. Pipes with different pitch and groove widths were tested in a flow chilldown experiment. Using the surface texture, the chilldown time of a stainless-steel pipe with an outer diameter of 1/2″ and a length of 120 mm from room temperature to the saturation temperature was reduced to a maximum of 1/3.6. The shortest cooling time is obtained at a groove pitch of 2 mm. In addition to the shorter cooling time, the amount of liquid nitrogen required for chilldown was also reduced.

Experimental study on grid-patterned low thermal conductivity coatings for fast chill-down of flat plate in liquid nitrogen pool

This study investigates a fast chill-down technology utilizing grid-patterned low-thermal-conductivity (low-k) coatings. Experiments were conducted on the transient pool boiling of liquid nitrogen on stainless steel plates under various conditions: bare, partially coated, and fully coated surfaces with coating thicknesses ranging from 50 to 200 μm. Fully coated surfaces exhibited a 52–58 % shorter chill-down time owing to the rapid transition from film to transition boiling. However, these surfaces reduced thermal performance in the nucleate boiling regime owing to the added thermal resistance of the low-k coating. To address this, a partially coated surface with a grid-patterned design was proposed and examined for various pattern sizes of d = 2.5, 5, and 10 mm. The rapid regime transition was most effectively facilitated when the pattern size was comparable to the wavelength determined by the Taylor instability. In the nucleate boiling regime, thermal performance improved as the pattern size approached the capillary length. Consequently, the chill-down time for the partially coated surface with d = 2.5 mm was reduced by 79 %, owing to both the rapid regime transition and improved performance throughout the entire process. Finally, the grid-patterned coatings showed a twofold increase in coating effectiveness (∼4.8) compared to the fully coated surfaces (∼2.4). This study establishes a new design guideline for low-k coatings, optimizing cooling performance across all boiling regimes.

Experimental optimization and evaluation of an R600a/R1150 auto-cascade refrigeration systems for ultra-low temperature applications

Auto-cascade refrigeration systems are the most employed systems for ultra-low temperature applications, especially for small capacity systems. Recent investigations have allowed to analyze them energetically and thermodynamically, starting a research line focused on enhancing their energy performance from experimental approaches. This work focuses on the energy optimization of a real auto-cascade system working with the mixture R600a/R1150 [70/30 %], which has been evaluated using two compressor models for R404A and R290 as well as the optimization of the two capillary tubes used in the system. Results indicate that overall efficiency of the R290 compressor is up to 21 % higher than with R404A, leading to COP increments between 35 and 81 %. Optimum capillary lengths have been determined in terms of COP and energy consumption, reaching similar values, however, the inner parameters of the system change as function of these lengths, which needs to be considered in prototypes design.

Fiber-type composition and 3D capillary analysis of the human splenius capitis muscle.

Despite the significance of neck muscles in musculoskeletal disorders, their microscopic anatomy remains poorly characterized. This study examined the splenius capitis muscle, focusing on its fiber-type composition, fiber size, and capillary network characteristics. For comparison and validation, the vastus lateralis muscle was also analyzed. Muscle samples from 13 young male subjects (mean age ± SD: 35.7 ± 8.6 years) were collected within 24-h post-mortem during autopsy. Myosin heavy chain (MyHC) isoform expression was characterized immunohistochemically in 10 μm sections, while the capillary network architecture was assessed in 100 μm sections. Immunofluorescence staining, confocal microscopy, and 3D image analysis were employed to quantify capillary tortuosity, anisotropy, branch density (Br dens), and the length of capillaries per muscle volume (LV), per muscle fiber length (LL), per fiber surface area (LS), and per fiber volume (LVf). Compared to the vastus lateralis muscle, the splenius capitis muscle had a higher percentage of type 1 fibers (51.2% vs 39.7%), fewer type 2a fibers (16.2% vs 31.4%), and smaller fiber diameters (35.5-40.9 μm vs 47-56.1 μm). It also displayed lower Br dens (P = 0.0069), higher anisotropy (P = 0.0004), and lower LL (P < 0.0001) but higher LVf (P = 0.0486). In the splenius capitis muscle, body mass index (BMI) negatively correlated with LV (P = 0.0155), LS (P = 0.0091), LVf (P = 0.0137), and anisotropy (P = 0.0425), and positively correlated with tortuosity (P = 0.0473), indicating a reduction in the capillary network. In the vastus lateralis muscle, only LV (P = 0.0161) decreased with high BMI. This study characterized the fiber-type composition, fiber size, and 3D capillary network of the splenius capitis muscle, establishing a baseline for investigations into pathological muscle alterations.

Getting the Best out of Capillary Electrophoresis and Capillary Electrophoresis-Mass Spectrometry by Quantifying Sources of Peak Broadening for Proteins Using Polyelectrolyte Multilayer Coated Fused Silica Capillaries.

Capillary electrophoresis (CE) has emerged as a relevant technique for protein and biopharmaceutical analysis, as it combines high separation efficiency, sensitivity, and versatility. The use of capillary coatings, including successive multiple ionic-polymer layers (SMILs), reduces interactions between analytes and the capillary, further improving the CE performance. Nevertheless, separations done on SMIL coatings rarely surpass 500 × 103 plates/m. To obtain the best out of the CE, it is interesting to have a detailed look at the sources of peak dispersion. Separations of a mix of model proteins were performed on (poly(diallyldimethylammonium chloride)/poly(styrenesulfonate))2.5-coated capillaries at different electrical field strengths, leading to plate height H against migration velocity u plots that enabled a quantitative analysis of each contribution. Using this model, capillary lengths and injected volumes were systematically varied. For the first time, the contribution of sample electrophoretic heterogeneity to the total peak dispersion was deciphered for model proteins and a monoclonal antibody. Dispersion due to electromigration was seen to have an impact on plate heights in the case of triangular peaks of small molecules but not for proteins under the present conditions. UV and mass spectrometry detections were compared on the same capillary, providing valuable information on the impact of the detection type on separation efficiency. Close to 1 million plates/m were reached in the best conditions.

Randomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia.

This study aimed to assess the impact of a combination of probiotic strains of Lactiplantibacillus on the treatment of androgenic alopecia (AGA). To this end, 136 individuals with AGA (62 men and 74 women) aged 18-65 years were enrolled in a double-blind, parallel-group clinical trial. A total of 115 individuals (57 in the probiotic group and 58 in the placebo group) completed this study within a 16-week intervention period. Capillary density, thickness, and length of hair were analyzed before and after the intervention using FotoFinder Trichoscale Pro. In addition, the gut microbiota was assessed by paired-end sequencing on the Illumina MiSeq platform (2 × 300 bp). At the conclusion of the treatment period, a notable decline (p < 0.05) in the number of telogen hairs was evident in the probiotic group while hair thickness decreased in the placebo group (p < 0.05). However, the remaining variables did not exhibit any statistically significant changes. In the probiotic-treated group, individuals aged less than 37.5 years exhibited a reduction in the number and density of telogen hair (p = 0.0693 and p = 0.0669, respectively) and an increase in hair length (p = 0.0871). Furthermore, a notable decline in the number and density of vellus hair (p < 0.05) was observed, and this was accompanied by no change in the hair thickness. The probiotic-treated group exhibited a significantly higher abundance of Lactobacillus (p-adjusted < 0.05, DEseq2 test) and demonstrated a notable reduction in the number and density of telogen hair, and this was accompanied by an increase in the percentage of anagen hair. The probiotic mixture was well tolerated by the participants, with a treatment adherence rate of 90%. In light of this study's limitations, it can be concluded that a mixture of three strains of Lactiplantibacillus promotes the presence of terminal follicles, preventing their gradual miniaturization, which is a characteristic of AGA.

Flow Patterns of Tetraflouroethane Refrigerant in Different Small Diameter Tubes Used for Vaccine Delivery Boxes

This study aims to determine the flow patterns of tetrafluorethane refrigerant in different small diameter tubes. It attempts to establish a relationship among the temperature, pressure drop, volumetric flow of tetraflouroethane refrigerant in a 900 mm long small diameter tube. Tests are conducted to determine the effect of varying hydraulic tube diameter to the temperature and pressure drop of tetraflouroethane refrigerant in different flow rate. A copper tube with hydraulic diameter of 0.20 mm, 0.25 mm, 0.30 mm, 0.35 mm, 0.40 mm and 0.45 mm were used in this study. For every known hydraulic diameter, there are six (6) test points located in every 150 mm interval. The experimental rig is composed of six (6) pieces of 900 mm long copper tubes for the given hydraulic diameters. Each tube is marked with 150 mm, 300 mm, 450 mm, 600 mm, 750 mm and 900 mm. The markings represent the length of capillary tubes in millimeters where test points are located. A pressure transducer is attached to every test point and is used to measure the pressure drop at every length of the small diameter capillary tube. The result shows that pressure drop increases as the tube hydraulic diameter decreases and attained an evaporator temperature as low as -5 oC. The smaller the diameter of the tube, the more it is effective to give pressure drop for the design of a handy vaccine delivery box refrigeration system.

YOLOv8-Based System for Nail Capillary Detection on a Single-Board Computer.

Nail capillaroscopic examination is an inexpensive and easily applicable method to identify capillary morphological changes in patients with conditions such as systemic sclerosis and Raynaud's. The detection of changes in capillaries makes an important contribution to diagnosing these diseases. Capillary morphology is important in the symptoms of these diseases, and capillary diameter, visibility, distribution, length, microbleeds, blood flow, and density are important indicators in capillaroscopic evaluation. Manual examination to determine these parameters is subjective, causes inconsistent results, and is labor-intensive and time-consuming. To overcome these problems, a YOLOv8s-based system was proposed in this paper to detect the number, thickness, and density of capillaries in the nail bed. The system's components include database systems that store the analysis results, artificial intelligence-based software that runs on the SBC (Single-Board Computer), and recorded microscope images. mAP and F1_score parameters were used to evaluate the system's performance, and values of 0.882 and 0.83 were obtained. The proposed system is promising in improving the diagnosis process of diseases such as systemic sclerosis and Raynaud's by providing objective measurements and the early diagnosis and monitoring of diseases.

Exergetic analysis of a domestic refrigerator with an innovative mini-channel flat tube condenser

In this study, the energetic and exergetic performance of a household refrigerator with a unique compact heat exchanger composed of a mini-channel flat tube condenser and offset strip fins (OSF) is investigated experimentally by considering varying amounts of R600a (48–64 g) and capillary tube lengths (2800, 3300, and 3800 mm). The experiments have been performed for two refrigerators involving two different innovative condensers composed of mini-channel flat tube and offset strip fins which have varying orientations instead of conventional wire-on-tube condensers. The experiments were conducted in a climatic chamber at a temperature of 25 ± 0.5°C. According to the standard of IEC 62552:2015, the target temperatures of the fresh food and freezer compartments are set at 4°C and −18°C, respectively. Specific and relative exergy destructions of each component, total exergy destruction, the coefficient of performance, and second-law efficiency of the overall system with two different mini-channel condensers are reported for varying amounts of refrigerant and capillary tube lengths. The major concern of the investigation is to reveal the key components contributing to the degradation of the overall performance of the unique design. It is observed that the evaporator, which has a ratio of 52–69% in total exergy destruction within all investigated cases, is the most exergy destructive component and the exergy destruction of the evaporator decreases when the amount of R600a increases. The mini-channel condensers are the second exergy destructive components with a ratio of 19–22%. As an important outcome of this unique design’s investigation, exergy destruction of the condenser and compressor does not show a monotonic change with respect to the refrigerant amount and capillary length. Besides, the highest coefficient of performance and second-law efficiency are obtained when the amount of R600a is 48–50 g in all three capillary tube lengths.

Identifying effective parameters on capillary tube performance with HCFCs, HFCs blends, and hydrocarbon refrigerants: Numerical assessment

This work offers a comprehensive numerical evaluation of the performance of capillary tube utilizing different refrigerants, including HCFCs, HFCs blends (Zeotropic, Azeotropic), and hydrocarbon, such as such as R22, R404A, R407C, R410A, R507A, and R290 refrigerants to predict the critical length of the adiabatic capillary tube. Utilizing a comprehensive thermodynamic model is applied to simulate the behavior of different refrigerants. Moreover, the effective design parameters based on the internal diameter for the adiabatic capillary tube (ACT), inside surface tube roughness, degree of subcooled, metastable region, condenser diameter, design of evaporator pressure (at critical length), condenser operating pressure, and refrigeration capacity are considered. The numerical model is developed based on the governing equations for mass, momentum, and energy, while a specified empirical equations are employed to represent each of the friction factor for single-and-two phase flow and metastable region. The results showed that the longest length of the ACT of 10.5 m revealed with R410A at mass flow rate of 8 g/s compared with 0.25 m at mass flow rate of 16 g/s for R290. Also, the results showed that the minimum value of friction factor of 0.0189 for R410A compared with maximum value of 0.0208 for R407C. The developed model is validated with available experimental results and models under different operation conditions and is found expectable with a good agreement. Where the standard error for different refrigerant with range value between (2.774% to 3.677%). However, the model represents accurate prediction the flow behavior and the thermal performance of the ACT.

Relationship between Capillaroscopic Architectural Patterns and Different Variant Subgroups in Fabry Disease: Analysis of Cases from a Multidisciplinary Center.

Anderson-Fabry disease (AFD) is a genetic lysosomal storage disorder caused by mutations in the α-galactosidase A gene, leading to impaired lysosomal function and resulting in both macrovascular and microvascular alterations. AFD patients often exhibit increased intima-media thickness (IMT) and reduced flow-mediated dilation (FMD), indicating non-atherosclerotic arterial thickening and the potential for cardiovascular events. Nailfold capillaroscopy, a non-invasive diagnostic tool, has shown potential in diagnosing and monitoring microcirculatory disorders in AFD, despite limited research. This study evaluates nailfold capillaroscopy findings in AFD patients, exploring correlations with GLA gene variant subgroups (associated with classical or late-onset phenotypes and variants of uncertain significance (VUSs)), and assessing morpho-functional differences between sexes. It aims to determine whether capillaroscopy can assist in the early identification of individuals with multiorgan vascular involvement. A retrospective observational study was conducted with 25 AFD patients from AOUP "G. Rodolico-San Marco" in Catania (2020-2023). Patients underwent genetic testing, enzyme activity evaluation, and nailfold capillaroscopy using Horus basic HS 200 videodermatoscopy. Parameters like angiotectonic disorder, vascular areas, capillary density, and intimal thickening were assessed. The study identified significant differences in capillaroscopy findings among patients with different GLA gene variant subgroups. Classic AFD variant patients showed reduced capillary length and signs of erythrocyte aggregation and dilated subpapillary plexus. No correlation was found between enzymatic activity and capillaroscopy parameters. However, Lyso-Gb3 levels were positively correlated with average capillary length (ῤ = 0.453; p = 0.059). Sex-specific differences in capillaroscopy findings were observed in neoangiogenesis and average capillary length, with distinct implications for men and women. This study highlights the potential of nailfold capillaroscopy in the diagnostic process and clinical management of AFD, particularly in relation to specific GLA gene mutations, as a valuable tool for the early diagnosis and monitoring of AFD.

Universal Correlation for Droplet Fragmentation in a Microfluidic T-Junction.

Despite extensive research on droplet dynamics at microfluidic T-junction, for different droplet lengths and Capillary numbers, there remains limited understanding of their dynamics at different viscosity ratio. In this study, we adopt a modeling framework in a three-dimensional (3D) configuration to numerically investigate the droplet dynamics as it passes through a symmetric T-junction with varying Capillary numbers, droplet lengths, and viscosity ratios. We present a 3D regime map for the first time to demarcate the droplet breakup and no breakup regimes. Herein, we propose a simple surface equation accounting for the critical Capillary number for breakup, in terms of viscosity ratio and dimensionless droplet length. The proposed universal relationship aligns well with experimental and computational findings from the existing literature. Furthermore, we reveal a new droplet breakup characteristic at high viscosity ratio and high Capillary number where the droplet spreads almost twice its initial value before splitting. Overall, this research provides comprehensive understanding of droplet dynamics at the T-junction and has significant implications for several related applications, including the large-scale synthesis of microdroplets using microchannel networks.

A novel micro-capillary discharge plasma jet triggered gas switch.

To reduce the working coefficient and jitter of the three-electrode gas switch used in linear transformer drivers, a novel trigger method that uses a nanosecond pulse in cooperation with the microplasma jet generated by capillary discharge was developed. A microplasma jet was generated by the nanosecond trigger pulse and injected into the follow-up breakdown gap of the gas switch to decrease the working coefficient. The influence of capillary parameters on the development of the microplasma jet was simulated. The results showed that the microplasma jet significantly reduced the breakdown delay time, jitter, and working coefficient. Increasing the capillary length and decreasing the diameter results in better triggered breakdown performance. Furthermore, the gas switch triggered by a positive pulse exhibits a lower breakdown delay and jitter. Combined with the intensified charge coupled device's shooting results, it can be concluded that the microplasma jet has a distinct influence on streamer formation, which is important for improving the working performance of the gas switch.