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Leg Strength Research Articles (Page 1)

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Overview
2290 Articles

Published in last 50 years

Related Topics

  • Lower Limb Strength
  • Lower Limb Strength
  • Leg Muscle Strength
  • Leg Muscle Strength
  • Limb Strength
  • Limb Strength

Articles published on Leg Strength

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  • New
  • Research Article
  • 10.54141/psbd.1623382
Combination of High-Intensity Interval Training and Creatine Intake Enhances Leg Strength and Anaerobic Power Without Changes in Body Composition in Physically Active Adult Men - A Randomized Controlled Study
  • Nov 4, 2025
  • Pamukkale Journal of Sport Sciences
  • Tuğçe Nur Erdoğmuş + 1 more

Various training methods and ergogenic aids have been employed to enhance athletic performance. This study aimed to understand the effect of combining six weeks of high-intensity interval training (HIIT) with creatine supplementation on body composition, leg strength, and anaerobic power in physically active male adults. In this six-week study, a total of fifteen physically active men, with a mean age of 21.13 ± 1.68 years, were divided into two groups: the Wingate-based HIIT training group (HIIT) and the Wingate-based HIIT training + creatine supplementation group (C-HIIT). Both groups performed HIIT training based on the Wingate protocol, three days a week for six weeks, with the intensity increasing during the second three-week period. In addition to the training, the C-HIIT group took a total of 10 g of creatine each training day, 5 grams 30 minutes before the exercise and 5 grams immediately after exercise. The body composition, leg strength, and anaerobic power measurements of the subjects were taken three days before the study started and three days after it ended. According to the findings, although there was no significant difference in body composition values between the two groups, it was observed that leg strength (p

  • New
  • Research Article
  • 10.25307/jssr.1632924
Investigation of Dynamometric Measurements of Leg Muscles in Vertical and Horizontal Positions in Sailing Athletes
  • Oct 31, 2025
  • Spor Bilimleri Araştırmaları Dergisi
  • Ameer Salam Sahb Alajimi + 1 more

The aim of this study is to examine the isometric strength levels of leg muscles in sailors through dynamometric measurements performed in vertical and horizontal positions, and to evaluate the effects of these positions on muscle strength and athletic performance. The study group consists of a total of 30 licensed male sailing athletes: 15 from the Marmara Sailing Club (Experimental group) and 15 from the Derince Sailing Club (Control group). Data were collected by applying specific strength training protocols whose validity and reliability had been previously established in the literature. The training program included exercises targeting the leg, shoulder, and arm muscle groups. The effects of these exercises were quantitatively evaluated through dynamometric measurements. During the statistical analysis process, the Friedman test, Wilcoxon Signed-Rank test, and Mann-Whitney U test were used. The findings revealed that the post-test body weight measurements of the participants in the experimental group showed a statistically significant decrease compared to the pre-test values (Z = -2.065, p = .039). A statistically significant increase was observed in vertical jump performance between the pre-test and post-test (Z = -4.448, p < .001). Additionally, significant improvements were recorded in vertical leg strength (Z = -3.663, p < .001) and horizontal leg strength (Z = -2.994, p = .003) measurements. Similarly, in the handgrip strength test, which evaluates upper extremity strength, significant increases were observed in both the right hand (Z = -3.266, p = .001) and the left hand (Z = -3.302, p < .001). On the other hand, no statistically significant change was found in flexibility measurements (Z = -1.648, p = .099). Based on these findings, it can be concluded that the specific strength training program had positive effects on the athletes in the experimental group, and that these effects were more pronounced compared to the control group.

  • New
  • Research Article
  • 10.33899/rjss.v28i88.53610
Effect of special exercises using a ball-throwing machine with light stimuli on several physical variables among advanced table tennis players of Al-Futowa Sports Club
  • Oct 24, 2025
  • Al-Rafidain Journal For Sport Sciences
  • يونس طلال شريف النعيمي + 1 more

This study aimed to examine the impact of specialized exercises using a ball-throwing machine with light stimuli on certain physical variables among advanced table tennis players at Al-Futowa Sports Club. The researcher used the experimental method because it was well-suited to the study's purpose. The sample was intentionally selected from eight advanced players at Al-Futowa Sports Club in Nineveh Governorate. The participants were randomly divided into two groups: experimental and control. The researcher used a two-group experimental design (experimental and control) with pre- and post-tests for both groups. The procedures involved creating a training program with a light-stimulus device designed with the help of a specialized engineer. This device was connected to the ball-throwing machine to function as a single system, emitting light stimuli in five specific areas on the table surface. The light stimulus area changed simultaneously with the ball's release from the throwing machine. The researcher designed skill-based exercises by analyzing the best matches of the world’s top three players, based on the International Table Tennis Federation (ITTF) rankings. The training program was implemented by the experimental group using the light-stimulus device, the ball-throwing machine, and the specially designed exercises derived from the match analysis. In contrast, the control group followed the training program prepared by the team coach. The training program lasted for eight weeks, consisting of two medium training cycles and eight microcycles, with three training sessions per week. The results revealed that the training program had a positive effect on the physical variables—namely, eye–arm coordination, reaction speed, explosive arm strength, explosive leg strength, trunk flexibility, and shoulder flexibility—in favor of the experimental group in the post-tests.

  • New
  • Research Article
  • 10.1093/gerona/glaf222
The Predictive Power of Brain-Predicted Age and Leg Strength on Mobility Decline in Aging: Findings from the Baltimore Longitudinal Study of Aging.
  • Oct 23, 2025
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • Brooke A Vaughan + 10 more

Muscle weakness and poor brain health both contribute to mobility limitations in older adults, but their respective contributions and interaction are not well-understood. This study examines the relationship between MRI-estimated brain-predicted age difference (brain-predicted age-chronological age), leg strength, and their interaction on mobility decline using Baltimore Longitudinal Study of Aging data (N = 645, 78.1 ± 7.54 years, 56% women). Partial Spearman correlations evaluated the relationships between leg strength, brain-predicted age difference (BPAD), gait speed, and time to complete 5 chair stands (5CS). Mixed-effects linear regression models examined associations of baseline BPAD, leg strength, and lifestyle factors with mobility change over time (5.74 ± 2.87 years). Logistic regression modeled predictors of success in a narrow course walking task. Leg strength significantly correlated with gait speed (r = 0.26, p < 0.001) and 5CS (r=-0.27, p < 0.001). BPAD was associated with decreased gait speed (β=-0.022, p = 0.011) and slower 5CS (β = 0.331, p = 0.012). Greater leg strength was associated with preserved gait speed (β = 0.023, p = 0.022) and faster 5CS (β=-0.552, p < 0.001). BPAD (OR = 0.712, 95% CI: 0.687, 0.940) and leg strength (OR = 0.805, 95% CI: 0.696, 0.964) predicted lower likelihood of narrow walk success. Interactions between BPAD and leg strength were not significant for any measure. These findings suggest accelerated brain aging and leg weakness independently contribute to mobility decline, highlighting the need for interventions targeting brain health and muscle strength to preserve mobility in aging populations.

  • New
  • Research Article
  • 10.1111/jgs.70166
Effectiveness of Exercise in Older Adults Discharged From the ER After Minor Injuries: The CEDeComS Stepped-Wedge Trial.
  • Oct 20, 2025
  • Journal of the American Geriatrics Society
  • Marie-Josée Sirois + 11 more

Older adults consulting Emergency Departments (EDs) for minor injuries are at risk for new functional impairments in the 6 months following their injuries. To compare the effects of exercise programs versus usual ED practices on functional status and physical performance at 3-6 months in at-risk older adults with minor injuries. Stepped-wedge randomized trial in six Canadian EDs from 2017 to 2020. Participants aged ≥ 65 years were screened for low, moderate, or high risk of functional decline and assessed three times: baseline at ED, 3 and 6 months. Multicomponent (flexibility, balance, strengthening, aerobic) and risk-level adapted exercise programs targeting moderate- and high-risk patients, 3×/week for 12 weeks, at home or in community groups. Usual ED care. Functional decline was defined as a 2/28-point loss from baseline on the Older Americans Resources and Services (OARS) scale. Basic physical performance (leg strength, balance, walking speed) was measured using the Short Physical Performance Battery (SPPB) test. Generalized linear mixed log-binomial regressions were used to examine the effects of the intervention on outcomes compared to usual ED care, stratified by risk level. The intervention and control phases included 277 and 205 moderate-risk individuals, and 249 and 128 high-risk individuals, respectively. Among moderate-risk individuals, functional loss in intervention participants at 3 months was half that of controls: 12% [95% CI: 8%-17%] vs. 25% [95% CI: 18%-34%], RR: 0.48 [0.26, 0.90]. 12-week multicomponent exercises implemented early after minor injuries are associated with lower proportions of functional decline at 3 months in moderate-risk seniors and may help those at high risk recover some physical performance. ClinicalTrials.gov, ID Cedecoms NCT03991598.

  • New
  • Research Article
  • 10.32996/jspes.2025.5.3.2
Acute Effects of Dynamic and Plyometric Warm-Up Protocols on Speed Strength Flexibility and Jump Performance in Taekwondo Athletes
  • Oct 19, 2025
  • Journal of Sports and Physical Education Studies
  • Serkan Kızılca + 1 more

This study investigates the acute effects of dynamic warm-up (DWU) and plyometric warm-up (PWU) protocols on sprint, strength, flexibility, and jump performance in young taekwondo athletes. A total of 17 participants (9 females, 8 males; mean age = 13.06 ± 0.97 years) completed two warm-up sessions in randomized order, separated by a 48-hour interval. Performance outcomes included 10 m and 20 m sprint times, leg strength, sit-and-reach flexibility, and countermovement jump (CMJ). Data collection was conducted under standardized conditions in a school gymnasium to minimize external variability. Results showed no significant differences between protocols for 10 m and 20 m sprint tests (p &gt; 0.05). However, PWU produced significantly greater improvements in leg strength, flexibility, and CMJ performance compared to DWU (p &lt; 0.05), with large effect sizes observed. These findings highlight that PWU strategies may offer superior acute benefits for enhancing explosive strength and flexibility in taekwondo athletes. This study contributes novel evidence to combat sports literature, emphasizing the importance of tailored warm-up protocols for optimizing athletic performance.

  • Research Article
  • 10.1093/cercor/bhaf277
Working memory improvements following supramaximal high-intensity interval training predicted by increased prefrontal cortex activation and leg strength gains
  • Oct 14, 2025
  • Cerebral Cortex (New York, NY)
  • Sofi Sandström + 4 more

Physical exercise shows positive effects on cognitive functions such as working memory (WM) for older adults; however, large individual differences in response exist and the underlying mechanisms are not well understood. We tested the hypothesis that exercise-induced changes in cardiorespiratory fitness and leg strength would improve WM-related brain activity, which subsequently would improve WM performance. This study was based on the Umeå HIT study, a randomized controlled trial assessing the effects of watt-controlled supramaximal high-intensity interval training (HIT) versus moderate-intensity training for nonexercising older adults (N = 68). A subsample (n = 43, 66 to 79 years, 56% females) underwent task-based functional magnetic resonance imaging, testing WM. The outcomes of interest were change in WM performance, WM task activation, cardiorespiratory fitness, and leg strength. For WM performance, we found no significant between-group difference in change; however, there was a significant within-group increase for HIT in WM composites. For HIT, changes in leg strength significantly predicted increased right dorsolateral prefrontal cortex activation, which in turn predicted improved in-scanner WM task performance. Cardiorespiratory fitness did not predict WM-related functional change. These results indicate a specific physiological ingredient, namely leg strength gains, that is a potential mechanism in exercise-induced prefrontal activation and WM performance increases.

  • Research Article
  • 10.1016/j.physbeh.2025.115039
Characterizing link among phase angle, muscle strength, body composition variables, and urine metabolites in Japanese females with or without dysmenorrhea: A pilot study.
  • Oct 1, 2025
  • Physiology & behavior
  • Suraiya Khatun + 11 more

Characterizing link among phase angle, muscle strength, body composition variables, and urine metabolites in Japanese females with or without dysmenorrhea: A pilot study.

  • Research Article
  • 10.1152/ajpregu.00072.2025
Integrated muscle protein synthesis during disuse and rehabilitation in late-midlife adults.
  • Oct 1, 2025
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • Sean P Kilroe + 10 more

The purpose of this study was to investigate the sex-specific differences in how late-midlife adults respond to short-term disuse and rehabilitation. Sixteen late-midlife adults, who were free of overt disease (8 males: 58 ± 2 yr, BMI 29.4 ± 0.8 kg·m-2; 8 postmenopausal females: 56 ± 2 yr, BMI 29.1 ± 1.1 kg·m-2) underwent 7 days of unilateral lower limb suspension (ULLS), followed by 7 days of rehabilitation. Vastus lateralis muscle biopsies were collected before and following ULLS [in both control (CON) and immobilized (IMM) legs] and in the IMM leg post-rehabilitation. We applied deuterium oxide to measure muscle protein synthesis (MPS), immunoblotting to assess mTORC1 signaling, and assessed changes in muscle fiber cross-sectional area (CSA) and leg strength. MPS was 17.8 ± 14.6 and 32.7 ± 10.9% lower in the IMM compared with the CON leg in males (P = 0.32) and females (P < 0.05), respectively, during immobilization. MPS was 27.5 ± 24.5 and 9.7 ± 38.9% higher in the IMM leg during the rehab compared with during the IMM phase in the males and females, respectively (P > 0.05). Leg extension one repetition maximum declined by 24.2 ± 2.4 and 17.1 ± 2.1% in males and females, respectively, after IMM (both P < 0.01), in the IMM leg with no change in the CON leg (P > 0.05). Our data show that late-midlife males and females experience similar reductions in MPS and muscle fiber CSA. Seven days of resistance exercise rehabilitation partially reverses the decline in muscle strength, CSA, and MPS, but longer rehabilitation periods are required for full recovery in late-midlife adults.NEW & NOTEWORTHY This study provides novel data on the average rate of muscle protein synthesis during 7 days of disuse and 7 days of rehabilitation in late-midlife adults. Both sexes experienced a similar reduction in muscle protein synthesis, strength, and fiber cross-sectional area during disuse. Seven days of resistance exercise rehabilitation partially reverses the disuse-induced decline in muscle protein synthesis, strength, and fiber size; however, longer periods of rehabilitation are required for full recovery.

  • Research Article
  • 10.26773/smj.251009
Physical and Physiological Responses to Training and Their Association with Performance Outcomes in Young Sub-Elite Sprinters
  • Oct 1, 2025
  • Sport Mont
  • Soumyadip Ghosh + 6 more

Sprinting requires great physical fitness and physiological qualities. This study aims to assess the impact of structured training on body composition, physical fitness, and physiological variables, as well as their correla- tions with performance outcomes in sub-elite sprinters. One hundred thirty boys (aged 18-20 years) were re- cruited and separated into two groups: control group (CG, n=65) and short-distance runner (SDR, n=65). The SDR group received supervised training (4 hours/day, 5 days/week, for 12 weeks), but the CG group did not receive any. Body composition, physical fitness, and physiological markers were measured at the beginning (0 weeks), middle (8 weeks), and end (12 weeks) of the intervention. After the intervention, the SDR group displayed significant gains in hand grip strength, back and leg strength, standing broad jump, vertical leap, push-up and sit-up scores, flexibility, speed, anaerobic power, fatigue index, VO2max, FEV1, and FEV1/FVC ratio. Compared to baseline, there were substantial (p&lt;0.05) reductions in body fat percentage, BMI, body mass, 30 m and 100 m sprint times, response time, resting and exercise heart rate, blood pressure, and peak blood lactate levels. These findings highlight the practical importance of establishing comprehensive sprint training programs to improve performance-related qualities in young athletes. Coaches and practitioners are advised to incorporate strength, conditioning, and recovery measures into training programs in order to maximize sprint- ing performance. Future research should look into the long-term effects of training at various levels and devel- opmental phases, as well as individual responses and recovery dynamics.

  • Research Article
  • 10.1016/j.rehab.2025.102008
Effects of mindfulness and exercise on cognition and emotion in adults with mild deficits in the chronic post-stroke phase: A randomized controlled trial.
  • Oct 1, 2025
  • Annals of physical and rehabilitation medicine
  • Adrià Bermudo-Gallaguet + 16 more

Effects of mindfulness and exercise on cognition and emotion in adults with mild deficits in the chronic post-stroke phase: A randomized controlled trial.

  • Research Article
  • 10.26773/smj.251019
Effects of Different Walking Models on the Health-Related Fitness Parameters of Elderly Persons: A Systematic Review
  • Oct 1, 2025
  • Sport Mont
  • Andrea Marković + 5 more

Exercise and physical activity are widely promoted as an effective means of improving the health and physical functioning of older adults. Walking as a recreational activity is one of the safest and most appropriate forms of physical activity for older adults. The aim of the study was to explain, by searching the available literature, how different walking models affect the health-related fitness parameters of the elderly. The search and anal- ysis of the studies were done in accordance with the PRISMA guidelines, and the study protocol was registered with PROSPERO, number CRD42023461140. An electronic databases search (Google Scholar, PubMed, Mendeley, Science Direct, and Scopus) yielded 225 relevant studies conducted in the last 15 years. A total of 15 studies were included in the qualitative synthesis, which analyzed the effects of different types of walking, such as Nordic walking, normal walking, and other unconventional walking programs, such as dog walking, ecological walk- ing, walking with ankle weights, and continuous stair walking, on various health fitness variables in the older population. Nordic walking has been shown to be an effective exercise for improving body composition, cardio- vascular fitness, motor abilities, and balance in the elderly individuals. Normal walking has also been found to positively influence body composition and muscle strength, while improving VO2max, balance, and flexibility. Unconventional walking programs such as dog walking, ecological walking, walking with ankle weights, and continuous stair walking have also shown positive results in improving aerobic endurance, leg strength, upper limb strength, and functionality of heart capacity. However, it is important to ensure proper intensity and volume of training to avoid potential negative outcomes, such as an increase in subcutaneous fat or overtraining. Overall, walking programs can be an effective and accessible way for elderly individuals to improve their physical fitness and overall health. The obtained results indicate the necessity of physical activity in old age in order to lead a quality and healthy life.

  • Research Article
  • 10.56639/jsar.1698583
Acute Effects of Dynamic Stretching and Foam Rolling Warm-Up Protocols on Certain Performance Parameters in Canoeists
  • Sep 30, 2025
  • Herkes için Spor ve Rekreasyon Dergisi
  • Gaye Kanik + 4 more

This study aimed to investigate the acute effects of warm-up protocols involving dynamic stretching (DS) and foam rolling (FR) on specific performance parameters in canoe athletes. By examining the individual and combined effects of these two warm-up methods on performance, the study sought to provide a scientific basis for identifying the most effective warm-up strate-gy. A total of 13 volunteer flatwater canoe athletes (age: 13.07±1.32 years; training age: 3.07±1.32 years; height: 1.60±0.11 cm; body weight: 51.07±11.96 kg; body mass index: 19.61±2.79 kg/m²) participated in the study. The research employed a randomized, crossover, counterbalanced ex-perimental design and was conducted over three test days with 48-hour intervals. On each test day, participants were randomly assigned to one of three warm-up protocols: FR only, DS only, or a combination of FR+DS. Following each warm-up protocol, performance tests including ver-tical jump, visual reaction time, flexibility, back and leg strength, and balance were conducted. Additionally, the Borg Scale (RPE) was used to assess perceived exertion, and the Visual Analog Scale (VAS) was administered to rate delayed onset muscle soreness (DOMS). Differences be-tween variables were analyzed using repeated-measures ANOVA. The results revealed no statis-tically significant differences among the groups in terms of vertical jump, anaerobic power, back and leg strength, balance, RPE, VAS, or visual reaction time values (p&gt;0.05). However, a statisti-cally significant difference was observed in flexibility values between the FR and FR+DS groups (p

  • Research Article
  • 10.31435/ijitss.3(47).2025.3827
THE ROLE OF COLLAGEN SUPPLEMENTATION IN KNEE JOINT DISORDERS: A SYSTEMATIC REVIEW OF CLINICAL STUDIES
  • Sep 30, 2025
  • International Journal of Innovative Technologies in Social Science
  • Bartłomiej Zarębski + 9 more

Introduction and Purpose: Collagen is essential for maintaining the structure and function of the knee joint, making it a promising option for managing joint-related conditions. This review explores current clinical research on the impact of collagen supplements on knee pain, mobility, and overall joint health in individuals with osteoarthritis, early arthritis, meniscal injuries, and functional joint discomfort. Materials and Methods: A literature search was conducted using PubMed and Google Scholar, focusing on studies from 2016 onward. Keywords included "collagen," "knee joint," "supplementation," and "osteoarthritis" to identify relevant clinical trials and studies. Main Findings: The review indicates that collagen supplementation, particularly types I, II, and III, offers notable benefits for knee joint health. In patients with osteoarthritis and early joint degeneration, undenatured type II collagen and collagen peptides significantly reduced pain, stiffness, and improved mobility, as measured by standardized tools like WOMAC, KOOS, and VAS. Similar improvements were noted in athletes and active individuals experiencing activity-related knee discomfort, with reported reductions in joint pain and decreased reliance on additional treatment. Certain collagen formulations also improved range of motion and flexibility in both healthy subjects and those with minor joint issues. Additionally, recent studies show that collagen can help those with meniscal injuries by reducing pain, boosting leg strength, and enhancing quality of life. Conclusion: Collagen supplements appear to be a safe and effective option for improving knee joint health, particularly in cases of osteoarthritis and functional joint discomfort. While outcomes vary depending on the collagen type and dosage, overall evidence supports their potential in reducing pain and enhancing joint function across a range of populations.

  • Research Article
  • 10.3390/jcm14186652
The VincerEmo Pilot Study: Prospective Analysis of Controlled Physical Activity in People with severe Hemophilia
  • Sep 21, 2025
  • Journal of Clinical Medicine
  • Federica Valeri + 13 more

Background/Objectives: The approach to physical activity in people with hemophilia (PwH) is still conditioned by many difficulties. Thus, a prospective observational pilot study has been carried out aiming to evaluate how an adequate and controlled training program can slow down the onset or evolution of arthropathy and improve musculoskeletal health and quality of life. Methods: Performed from April 2022 to April 2023, this study involved nine severe hemophilic A and B patients, aged > 18 years old, on regular prophylaxis with replacement products. Participants, without changing the usual prophylaxis schedule and maintaining a trough level of at least 20% FVIII/FIX before training, were involved in physical activity twice a week. Results: After 12 months, no increase in annual bleeding ratio (ABR) was observed, and baseline joint status (as assessable by HEAD US score, HJHS, and NRS) was maintained. Even if not statistically significant, a trend toward improvement in mean HEAD US score (15.55 vs. 13.11) and HJHS (14.4 vs. 11) from baseline was observed. Some of the physical tests performed showed a significant improvement at 6 months and 12 months from baseline (5 Rep Sit to Stand, Sit and Reach, and 6-minute Walking Test), meaning an improvement in leg strength, dorsal flexibility, and aerobic resistance. Conclusions: This is the first pilot study evaluating at 360 degrees the safety and impact of a controlled physical activity in PwH. No participant experienced bleedings or a worsening in joint status, but they experienced an improvement in articular functionality. Without changing the usual prophylaxis, scheduling training sessions according to individual pharmacokinetics turned out to be a safe and a cost-effective approach.

  • Research Article
  • 10.1177/13872877251378670
The feasibility, acceptability, and effects of the adapted 6-month Otago exercise program on cognitive, physical, and psychological function in people living with dementia in residential care facilities: The ENABLED randomized controlled trial.
  • Sep 17, 2025
  • Journal of Alzheimer's disease : JAD
  • Deborah A Jehu + 14 more

BackgroundPeople living with dementia (PWD) have poor executive function, which impacts their independence and fall risk. Exercise is a promising strategy but needs to be adapted for PWD in residential care settings. Thus, the feasibility, acceptability, and efficacy of adapted exercise on executive function need to be established.ObjectiveThe purpose of the 6-month assessor-blinded strENgth And BaLance exercise on Executive function in people living with Dementia (ENABLED) randomized controlled trial was to determine 1) the feasibility and acceptability, and 2) if the adapted physical therapist-led Otago Exercise Program (OEP) plus usual care would improve executive function (primary) and secondary cognitive, physical, and psychological function measures as well as falls compared to usual care only in PWD in residential care facilities.MethodsWe randomized PWD to the exercise (n = 21) or usual care group (n = 21) at two residential care facilities in our parallel, assessor-blinded RCT (1:1) [NCT05488951]. A physical therapist delivered our adapted OEP 3x/week over 6 months. We examined feasibility and acceptability. Participants completed a battery of assessments, with the Color-Word Stroop as our primary outcome.ResultsAttrition (19.0%), exercise adherence (60.2 ± 34.5%; 47/78 sessions), and satisfaction were acceptable (4.2/5 points). We found no differences in the Color-Word Stroop, but better working memory, leg strength, and quality of life following exercise relative to usual care (p < 0.05). No differences in falls emerged.ConclusionsThis feasible and acceptable RCT indicates that exercise improves working memory, leg strength, and quality of life and has implications for the design of therapeutic intervention in PWD.

  • Research Article
  • 10.3390/jcm14186370
Associations Between Pulmonary Function and Muscle Strength in Turkish National Karate Athletes
  • Sep 10, 2025
  • Journal of Clinical Medicine
  • Gurkan Tokgoz + 9 more

Background: Respiratory efficiency is considered important in karate due to its role in sustaining muscular performance during high-intensity actions. This study examined the association between pulmonary function and isometric muscle strength in national-level karate athletes. Methods: A total of 23 elite karate athletes (mean age: 23.0 ± 2.3 (mean ± SD) years) participated in the study. Pulmonary function was assessed using a digital spirometer, while isometric handgrip, lower back, and leg strength were measured using a dynamometer. The correlation between pulmonary function and isometric strength was analyzed, and linear regression was employed to examine the predictive capacity of pulmonary parameters for muscle strength. Results: The results revealed significant correlations, ranging from large to very large, between pulmonary function and isometric muscle strength, with correlation coefficients from 0.639 to 0.812 (p < 0.01). Pulmonary function was strongly associated with isometric strength, accounting for 27% to 67% of the variance (p < 0.05). Multiple regression analysis revealed that pulmonary function parameters accounted for 71% of the variance in handgrip strength, 47% in leg strength, and 71% in back strength (p < 0.05). Conclusions: These findings highlight the strong associations between pulmonary function and isometric muscle strength in elite karate athletes. The results emphasize the importance of pulmonary health and respiratory muscle function in athletic performance, particularly for sports requiring high-intensity, dynamic movements like karate. Future longitudinal studies are needed to explore the mechanisms underlying the association and potential implications, and for training and performance optimization.

  • Research Article
  • 10.1007/s11357-025-01857-6
The association of thigh myosteatosis with lower cognitive function in older cancer survivors.
  • Sep 5, 2025
  • GeroScience
  • Brendan L Mcneish + 3 more

Cancer is associated with accelerated aging, including changes in muscle composition and cognition. However, the relationship between myosteatosis and cognitive function has not been investigated in older cancer survivors. This study evaluated the association between myosteatosis and cognitive function in this population. The sample included 75 cancer survivors (age 76-85; 65% men; 31% Black; 41% prostate cancer; 21% breast cancer) from the Health ABC study who developed cancer within the first five years, completed CT imaging at Year 6, and cognitive testing at Year 10. Thigh intermuscular fat area (myosteatosis) was measured by CT at Year 6. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST) and Modified Mini-Mental Status Exam (3MS) at Years 5 and 10. Multivariable models adjusted for demographics, education, cognitive function, and thigh muscle area at Year 5. Sensitivity analyses adjusted for leg strength, race, dementia risk factors, BMI, abdominal visceral fat, and thigh subcutaneous fat. LASSO regression identified key predictors of DSST and 3MS scores. Greater thigh myosteatosis at Year 6 was associated with lower DSST (B = - 0.212, p < 0.05) and 3MS (B = - 0.145, p < 0.05) scores at Year 10. Associations remained significant after adjustment for strength, dementia risk, and adiposity. LASSO identified race, education, Year 5 cognition, and myosteatosis as key predictors for DSST as well as thigh muscle area and physical activity for 3MS. Thigh myosteatosis is independently associated with lower cognitive performance in older cancer survivors and may represent a rehabilitation target to improve cognitive outcomes.

  • Research Article
  • 10.3389/fnut.2025.1670641
Eight weeks of creatine monohydrate supplementation is associated with increased muscle strength and size in Alzheimer’s disease: data from a single-arm pilot study
  • Sep 4, 2025
  • Frontiers in Nutrition
  • Aaron N Smith + 5 more

ObjectiveTo investigate the potential muscular benefits of an eight-week creatine monohydrate (CrM) supplementation in patients with Alzheimer’s disease (AD).MethodsThis single-arm pilot trial, conducted at the University of Kansas Medical Center in Kansas City, examined the intervention-associated changes in muscle strength, muscle size, and neuromuscular junction (NMJ) integrity following 8 weeks of CrM supplementation (20 g/day) in 20 participants with AD. All participants completed handgrip-strength measurements on the dominant hand (highest of three trials in kg of force). Ten participants completed lower body strength assessment via leg dynamometry at three velocities (1.05 rad∙s−1, 2.10 rad∙s−1, 3.14 rad∙s−1), with peak torque (in Newton-meters) recorded over five repetitions. Eighteen participants completed muscle size assessment by ultrasound measurement of cross-sectional area (mCSA, cm2) in the rectus femoris and vastus medialis, as well as muscle thickness (cm) in the rectus femoris, vastus medialis, and vastus lateralis. NMJ integrity was assessed in 19 participants by measuring plasma C-terminal agrin fragment (CAF) levels. All assessments were measured at baseline and 8 weeks.ResultsFollowing 8 weeks of CrM, mean hand-grip strength increased by 1.9 kg from baseline (p = 0.02). Lower leg strength did not change for any velocity among the ten participants who completed leg dynamometry. mCSA (n = 18) increased from baseline in the rectus femoris (p = 0.03) and vastus medialis (p = 0.01), but muscle thickness (n = 18) did not change in the rectus femoris (p = 0.41), vastus medialis (p = 0.37), nor vastus lateralis (p = 0.17). Subcutaneous fat (n = 18) decreased in the rectus femoris region (p = 0.006) and vastus lateralis region (p = 0.003), with no change in the vastus medialis region (p = 0.52). Mean CAF (n = 19) values did not change (p = 0.46).ConclusionThis eight-week pilot trial suggests that 20 g/day of CrM may provide modest skeletal muscle benefits in patients with AD. These data provide preliminary evidence to warrant further investigation of the potential for CrM to prevent AD-related decline in muscle function.Clinical trial registrationClinicalTrials.gov, identifier NCT05383833.

  • Research Article
  • 10.1055/a-2675-1198
The Role of Growth and Maturation in the Physical Development of Youth Male Soccer Players.
  • Sep 2, 2025
  • International journal of sports medicine
  • Hilde Gundersen + 8 more

Biological maturation and growth influence youth athletes' physical performance during adolescence. However, how this association develops over time remains unclear. Thus, this study examined associations between biological maturity and sprint speed, vertical jumping ability, leg strength, and aerobic capacity between ages 14.1 and 17.4 in youth male soccer players. A total of 103 players were followed. Performance in 40-m sprint, countermovement jump (CMJ), leg press, and maximal oxygen consumption (V̇O2max) was tested biannually at seven time points. Maturity was estimated using bone age from hand-wrist X-rays. Latent growth modelling examined changes in maturity-performance associations over time. Maturity was significantly (p < 0.05) associated with sprint, CMJ, leg strength (force and power), and V̇O2 max at ages 14.1, 14.7, and 15.3 years. The associations were, however, less significant over time. Specifically, maturity was no longer statistically associated with sprint and CMJ performance at 15.7 years, force and V̇O2 max at 16.4 years, and power at 16.8 years. There were no significant associations at 17.4 years. Biological maturity influences physical capacities during early adolescence, but its impact diminishes as players age. The timing of this decline appears to vary between physical performance domains, with sprint and jump performance stabilizing earlier than muscular strength and aerobic capacity.

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