In this study, we investigated the structural, thermal, and cytotoxic properties of Mg-Al layered double hydroxides (LDHs) intercalated with quercetin. Fourier transform infrared (FTIR) and Raman spectroscopy confirmed the successful incorporation of quercetin into the LDH structure, while X-ray diffraction (XRD) showed an increased interlayer spacing due to quercetin intercalation. Thermogravimetric analysis (TGA) demonstrated greater thermal degradation in quercetin-intercalated LDHs compared to nitrate-intercalated LDHs, suggesting a higher quercetin content in the material. Atomic force microscopy (AFM) indicated morphological changes with quercetin, particularly larger surface clusters at room temperature. Cytotoxicity assays revealed that quercetin-intercalated LDHs exhibited a dose- and time-dependent reduction in cell viability, which was more pronounced at higher concentrations and longer exposure times. Quercetin alone had a stronger cytotoxic effect on NIH/3T3 cells compared with Saos-2 cells. Additionally, reactive oxygen species (ROS) assays showed distinct effects of quercetin on both cell lines. These findings highlight the potential of quercetin-LDH hybrids for biomedical applications, particularly for targeted drug delivery.

Rechargeable alkaline Zn-Ni(Co) batteries offer high output voltage and intrinsic safety; however, their practical deployment is hindered by sluggish cathodic kinetics and parasitic side reactions, which limit both energy density and power capability. Here, the design and synthesis of a crystalline-amorphous heterostructure cathode combining mixed Ni and Co sulfides (MS) with Ni-Co layered double hydroxides (LDHs) is reported. This design synergistically leverages the electrical conductivity and structural adaptability of metal sulfides with the expanded interlayer spacing and ion transport channels of LDHs. The engineered MS-LDH cathode exhibits abundant electroactive sites, enhanced hydroxide ion adsorption, and accelerated ion diffusion kinetics, delivering a high specific capacity of 773mAhg-1 at 2Ag-1. When paired with a chitosan-in-PVA gel-coated Zn anode (Zn@CP), the aqueous Zn@CP||MS-LDH battery, delivers an ultrahigh specific energy of 1309Whkg-1-among the highest reported for similar systems-and a specific power of 3.44kWkg-1, comparable to pseudocapacitors. Moreover, the battery demonstrates excellent rate capability and long-term cycling stability. These results highlight the promise of earth-abundant heterostructured materials in overcoming critical limitations of aqueous Zn-based batteries, offering a promising pathway toward sustainable, high-performance energy storage technologies.

Establishing the synergistic effect between single atoms and vacancies for the lattice oxygen mechanism (LOM) pathway of the oxygen evolution reaction (OER) is crucial for developing robust and efficient catalysts, yet remains unexplored. Herein, an ion irradiation-assisted strategy is first applied to introduce controlled oxygen vacancies into NiFe layer double hydroxides (LDH), enabling the firm anchoring of Mo single atoms with a high loading of 7.4wt.%. The precise regulation facilitates synergistic activation of lattice oxygen via Mo atoms and vacancies. Thus, the optimized SAMo-NiFe LDH/Ti delivers remarkably improved performance with a decrease of overpotential of 226mV at 10mAcm-2 and, owing to the confinement effect of vacancies, maintains 600h at 500mAcm-2. First-principles calculations reveal that Mo single atoms coupling with oxygen vacancies exhibit enhanced adsorption capability, and promote lattice oxygen activation, synergistically optimizing the electronic structure of active centers for OER. This study establishes a direct link between defect engineering, single-atom catalysis, and LOM, providing a robust strategy for rational catalyst design.

Non-sputum-based diagnostic tests for tuberculosis (TB) are critical to global TB control. Herein, we developed an electrochemical aptasensor for detecting the ESAT-6 antigen of Mycobacterium tuberculosis (MTB) in human serum, using NiMn-layered double hydroxides@palladium nanoparticles (NiMn-LDHs@PdNPs) as a high-performance signal enhancer. NiMn-LDHs@PdNPs were synthesized via spontaneous in situ reduction, which requires no toxic reagents or complex equipment. This design not only addresses the limitations of insufficient active sites and slow electron transfer in layered double hydroxides (LDHs) but also mitigates the agglomeration tendency of palladium (Pd) nanoparticles, thereby enabling synergistic peroxidase-like activity and, importantly, relative spatial decoupling of recognition sites from catalytic sites. Functionalization with aptamers targeting the MTB ESAT-6 antigen did not significantly impair its catalytic activity. Employing a classic sandwich configuration, the aptasensor exhibited a wide linear detection range of 75pg/mL to 10ng/mL with a low limit of detection (LOD) of 0.629pg/mL, alongside excellent specificity, stability, and reproducibility. In clinical validation, it successfully distinguished 14TB patients from 14 healthy donors with 100% accuracy and outperformed enzyme-linked immunosorbent assay (ELISA). This work provides a high-performance non-sputum-based tool for TB diagnosis and advances the design of nanozyme-based biosensors.

One stone two birds: Fe3+ ions as corrosion agent and catalyst for one-step synthesis of nickel‑iron layered double hydroxide @polypyrrole composite for water splitting.

Advancement of LDH-carbonaceous coupled structure towards promising water splitting and supercapacitor applications.

Topology-engineered radio-theranostic layered double hydroxide nanocarrier via surface modification with spacer-linked cancer targeting ligand and lattice-integrated radioisotope.

Efficient electrocatalytic reduction of nitrate in a three-dimensional system via zirconium-based metal-organic framework-modified Zn-Fe layered double hydroxide.

Optimising Mg–La- layered double hydroxide (LDH) molar ratio for maximum phosphate adsorption

Unlocking the potential of photocatalysts: Recent advances in layered double hydroxide and future outlook.

Enhanced overall water splitting performance in alkaline solutions using hollow nanocage nickel‑cobalt‑iron layered double hydroxide derived from zeolitic imidazolate framework-67: The synergy of fast etching and metallic ions.

Advancing lithium-sulfur batteries using layered double hydroxide (LDH) -based nanocomposites: Progress, performance, challenges, and future prospects for energy storage

Structural and catalytic properties analysis of Ni-Ca-Al bi-functional materials derived from layered double hydroxide (LDH) precursors: Influence of Ca sources on performance of sorption enhanced steam methane reforming

3D-architected nickel-cobalt (NiCo) layered double hydroxide (LDH) for bifunctional supercapacitor and oxygen evolution reaction (OER) applications

Ternary layered double hydroxide-derived sulfides for oxygen evolution reaction.

Interlayer-engineered MXene Nanosheets confining CoGa-LDH enable ultrafast charge transfer kinetics for high-energy potassium-ion supercapacitors.

Synergistic heterojunctions of CoSe2 and NiFe layed double hydroxide: bridging in situ phase evolution and charge redistribution as bifunctional catalysts for water splitting.

Engineering 3D Delhi flower-like ZIF-67 derived NiCo layer double hydroxide electrodes with vertically aligned channels for high performance supercapacitor

The electrochemical restructuring of nickel-iron layered double hydroxide (NiFe LDH) into high-oxidation-state Ni/Fe oxyhydroxide is crucial for the alkaline oxygen evolution reaction (OER). Nevertheless, the sluggish self-reconstruction kinetics including high energy barriers and complex phase-transition dynamics of NiFe LDH significantly restrict its electrocatalytic performances. Herein, an oxygen vacancy-rich NiFe LDH decorated on iron foam (FF) is synthesized through a corrosion strategy. The corrosion process provides undercoordinated active sites in NiFe LDH/FF for OER. In alkaline electrolytes, NiFe LDH/FF displays an exceptional OER activity (a mere 254mV overpotential with a Tafel slope of 51.7mVdec-1) and a remarkable stability over 100h at 500mAcm-2. Comprehensive experimental and theoretical calculations further reveal that NiFe LDH/FF with undercoordinated active sites facilitates electrochemical reconstruction into highly active NiOOH and FeOOH phases against NiFe LDH/nickel foam. The Fe active sites in NiFe LDH/FF can effectively reduce the adsorption strength of oxygen intermediates, thereby altering the rate-determining step from (O* → OOH*) to (OH*→ O*) and lowering its reaction energy barrier during the OER process. This work presents an innovative strategy for designing low-energy-consumption OER electrocatalysts through a corrosion strategy and defect engineering.

Experimental study on the suppression effect of composite ultrafine dry powder fire extinguishing agents containing ternary layered double hydroxides on hydrogen deflagration