ISEE-784 Objective: Although it is clear that Latino children bear an additional burden of exposure to lead due to cultural factors (contaminated pottery and food products), the importance of this contribution is unknown. This study attempts to quantify the level of such cultural exposures, juxtaposed with the usual environmental factors (contaminated soil, paint, house dust, and drinking water). A combination of epidemiologic (multivariate regression) and toxicological (pharmacokinetic modeling) approaches will be used to estimate and model exposure. Materials and Methods: Households in 12 City of San Diego zip codes with high levels of Latino residents, speaking Spanish at home and have elevated blood lead levels were selected via simple random sampling of a commercial address list. Data were collected via questionnaires; dust, soil, and water samples taken in and around the residence; and culturally-appropriate in-home phlebotomy offered at no cost. Results: A total of 128 households containing 166 Latino children aged 12 to 71 months in innercity San Diego were enrolled into the study. Extensive data were collected on participants, including sociologic data related to Latino identity and degree of acculturation; household activities implicated in lead exposure; consumption of Mexican candies and food prepared in Mexican pottery; child behaviors implicated in lead exposure; and health care access and utilization. Blood lead testing was offered to all children; 89% accepted and an additional 4% provided recent test results. Preliminary results are presented, including descriptive statistics and univariate associations between blood lead level and the principal exposure factors. Conclusions: Further analysis will use the Integrated Exposure Uptake Biokinetic Model for Lead in Children (IEUBK) to estimate the relative contributions of all exposure factors for all individual participants. This information is necessary to design appropriate interventions for this group of children with extraordinary exposures to lead.