Event Abstract Back to Event Protein synthesis dependent synaptic plasticity is competitive and dendritically compartmentalized Inbal Israely1*, Arvind Govindarajan1, Shu-Ying Huang1 and Susumu Tonegawa1 1 Massachusetts Institute of Technology, The Picower Institute for Learning and Memory, RIKEN-MIT-Picower Center for Neural Circuit Genetics, Department of Biology and Department of Brain and Cognitive Sciences, United States Long-term memory (LTM) and a cellular correlate of LTM, the late-phase of long-term potentiation (L-LTP) require protein synthesis at the time of training and stimulation, respectively. While it is known that L-LTP induced at some synapses can facilitate L-LTP expression at other synapses, it is not know what the spatial and temporal limits are over which this process can occur at the single spine level, a fact that is crucial in determining if stable memory engrams are stored at synapses spatially clustered within a dendritic branch or dispersed throughout the dendritic arbor of a neuron. Here, using glutamate uncaging and two-photon imaging, we found that L-LTP at one spine facilitated L-LTP at neighboring spines; furthermore, this facilitative effect decreases with increasing time between stimulations, increasing distance between stimulated spines and with the spines being on different dendritic branches. Paradoxically, stimulated spines can also compete for L-LTP expression if stimulated too closely together in time. These local characteristics of L-LTP bias neurons towards the formation of memories in a clustered fashion. Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Poster Presentation Topic: Neuronal Communication Citation: Israely I, Govindarajan A, Huang S and Tonegawa S (2009). Protein synthesis dependent synaptic plasticity is competitive and dendritically compartmentalized. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.158 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Aug 2009; Published Online: 12 Aug 2009. * Correspondence: Inbal Israely, Massachusetts Institute of Technology, The Picower Institute for Learning and Memory, RIKEN-MIT-Picower Center for Neural Circuit Genetics, Department of Biology and Department of Brain and Cognitive Sciences, Cambridge, MA, United States, inbal@mit.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Inbal Israely Arvind Govindarajan Shu-Ying Huang Susumu Tonegawa Google Inbal Israely Arvind Govindarajan Shu-Ying Huang Susumu Tonegawa Google Scholar Inbal Israely Arvind Govindarajan Shu-Ying Huang Susumu Tonegawa PubMed Inbal Israely Arvind Govindarajan Shu-Ying Huang Susumu Tonegawa Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.