Late Migration Research Articles

A link of the Late Miocene giraffid migration pathway from the peri-Aegean lands to the northeastern Eurasian areas

The southeastern retreat of the Paratethys Sea constrained by the Middle Sarmatian uplift of the last Eastern Carpathians nappe (Pericarpathian Nappe) caused the progressive emergence of land masses contiguous to the Dacian Basin. Diverse faunas, including large mammals, colonized these lands. However, giraffes remain poorly documented. This paper attests to the presence of giraffids documented by postcranial bones of Samotherium major and Helladotherium duvernoyi. So far, both genera have only been listed in Romania without any information about the retrieved fossil bones, description, or illustration. The fossils described herein – a metacarpal of Samotherium major and two metatarsals, and an astragalus of Helladotherium duvernoyi – were sampled from four Late Miocene outcrops of the Eastern Carpathians Foreland (Crețești 1, Văleni, Pogana and Fălciu). Two outcrops (Văleni and Fălciu) have been newly discovered. This paper also describes for the first time Samotherium major in Romania. During the Late Miocene, the giraffids were elemental components of the so-called Pikermian Biome of the Greco-Irano-Afghan Province. This biome extended from the peri-Aegean lands to Iran. However, several occurrences are known from northeastern Eurasian areas (Ukraine, Republic of Moldova, and Hungary). The new Romanian occurrences represent a link between the southern and northeastern giraffid faunas during the Late Miocene, indicating a presumed migration pathway.

The combination of sitagliptin and bee honey extract potentiates the anti-proliferative properties of 5-fluorouracil on Caco-2 cell line without detectable inflammatory events

BackgroundColon cancer originates in the colon, specifically the large intestine. It carries a poor prognosis and high mortality rate due to late diagnosis and migration. ObjectiveHere our objective was to evaluate the anticancer effects of sitagliptin (Sita) in colon cancer using Caco-2 cells. Additionally, we examined the role of bee honey extract in modulating cancer cell division and necrotic events commonly observed during drug treatments. MethodsWe monitored cell viability rate to evaluate the effect of bee honey extract compared to 5-fluorouracil (5-Fu), Sita, and their combinations. To gain further foresights into the implicated molecular interaction, we assessed the expression outline of Raf-1 and MEK, as proliferation effectors. Additionally, we examined the expression outline of p53 and Caspase 3, which are associated with programmed cell death (PCD), through western blot analysis. ResultsWe identified the Raf-1 expression pattern as a likely target for the drug combination and bee honey extract (HE), which effectively controlled colon cancer cell proliferation. Our study demonstrates that honey extract, either alone or in combination with drugs, can induce PCD by restoring the p53 and CASP-3 proteins. This was accompanied by a synergistic effect on the production of apoptotic cytokines, particularly interlukine-6 (IL-6) and IL-8, in cancer cells. Moreover, the treatment modulated the levels of pro-inflammatory cytokines, including IL-1α and IL-1β and anti-inflammatory cytokines, including IL-4 and IL-10. ConclusionOur findings shed light on honey extract and its combinations with 5-Fu and Sita in stimulating PCD and modulating cytokine production in Caco-2 cells.

Helmet of the migration period from the Yuvanayag mound cemetery

The article introduces first results of the research on an iron helmet found in 2022 at the Yuvanayag mound cemetery in the Vychegda River region, the Komi Republic. The mound cemetery belongs to the circle of the Veslyansky I type cemetery, which was left by migrants with a developed military culture. Its distinctive feature was the tradition of building mounds over graves. Those burial mounds are a reflection of the late Migration Period in the European North-East (5th–7th centuries AD). The found helmet of the Bandhelm type (after Ch. Miks’s classification) is a unique specimen for the region, which also had no analogues in the adjacent territories. Based on mineralogical and geochemical studies, the helmet is made of iron with micro-inclusions of native aluminum and lignite carbon matter. The helmet overlays are made of brass with inclusions of lead-copper-zinc alloys and copper. Its elongated shape and decoration with hemispherical brass overlays are close to the helmets of Sasanian Iran. Geographically, the closest analogy to the Yuvanayag find is the Bandhelm from the predatory excavations near the village of Tsaritsyno in Ryazan Region. Preliminary dating of the artefact from the Yuvanayag burial mound is the late 4th – 5th century AD.

Transverse arch stenting and its effect on systemic hypertension.

This study aimed to investigate the safety and efficacy of transverse aortic arch stenting and evaluate the course of hypertension and the act of arch stenting on systemic hypertension. The transverse aortic arch stenting procedures between January 2007 and May 2023 were retrospectively analyzed. Detailed procedure information, technical aspects, pressure measurements, angiographic data, balloons and stents used, complications, and immediate results were examined. Early and mid-term results were assessed. Eighteen patients (10 males and 8 females; mean age: 14.5±5.3 years; range, 4 to 23 years) were included in the study, all of whom were hypertensive before the procedure. The mean weight was 56.8±19.6 kg. In seven patients, the stent struts had to be dilated due to the stent causing jailing at the entrance of nearby arch vessels. After stenting, there was a significant increase in arch diameter and a decrease in ascending aorta pressure and the pressure gradient across the aorta. There were no early mortality or major complications. Late migration of the stent was observed in one patient. Three patients became normotensive immediately after the intervention, and five became drug-free during the follow-up. The requirement for dual antihypertensive therapy was significantly reduced. Residual transverse arch lesions may contribute to the persistence of systemic hypertension after coarctation treatment. Transverse arch stent implantation can be performed safely with favorable outcomes, facilitating better blood pressure control. However, it should be noted that these patients remain at risk for lifelong hypertension and should be closely monitored in this regard.

Consistent delay in recent timing of passerine autumn migration

Climate change affects important biological processes, bird migration phenology being a particular well-documented one. While spring migration have been found to advance by numerous studies, autumn migration is less studied and show more variable change in timing. Few studies of autumn migration are based on data from after 2000, leaving the last two decades to be relatively less studied. Here, we investigate recent change in autumn migration phenology of European passerines. The most recent available bird ringing data from Denmark is used to analyse phenological change of median and late migration of 14 passerine migrants between 2003–2021. We find an overall delay of autumn migration, mainly driven by short-distance migrants. All short-distance migrants, one out of five medium-distance and three out of five long-distance migrants delay autumn migration. None of the included species advance autumn migration significantly. As climate change has continuously resulted in milder conditions in north-western Europe, we expect this to cause further effects on migration phenology also in recent decades. Our results provide novel insight into recent migration phenology trends, and the observed delay in long-distance migrants may illustrate a changed response to climate change.

An RNAi screen for ribosome biogenesis genes required for Drosophila border cell collective migration.

Ribosome biogenesis is critical for the proper production of proteins in cells and has emerged as a regulator of cell invasion and migration in development and in cancer. The Drosophila border cells form a collective that invades and migrates through the surrounding tissue during oogenesis. We previously found that a significant number of ribosome biogenesis genes are differentially expressed from early to late migration stages. Here, we performed a small-scale RNAi screen of a subset of these ribosome genes. Knockdown of seven genes disrupted border cell migration, thus revealing a role for ribosome biogenesis genes in regulating collective cell migration.

Human diet in Lithuania during the Late Roman and Migration periods ( ca. 200–700 AD) based on stable carbon and nitrogen isotope data

In this study, 71 human individuals were subjected to stable carbon (δ13C) and nitrogen (δ15N) isotope analysis of bone collagen samples for the purpose of determining human dietary patterns in Lithuania during the Late Roman and Migration periods. More specifically, based on the isotopic data, the aim was to determine and evaluate any potential dietary differences between individuals on the basis of their sex, age, social status and place of residence during the periods in question. The results of this study suggest that there were isotopically clearly distinguishable dietary differences between individuals from different parts/regions of Lithuania. Also, statistically significant dietary differences (on the basis of δ15N values) between males and females were observed (although, when making the same sex-based isotopic comparisons at an individual site level, the same result was observed only among those from Marvelė cemetery). However, no statistically significant isotopic differences were detected between different social or age groups. Overall, these results give us one of the first glimpses into the types of dietary habits practiced by people in various parts of Lithuania during the Roman and Migration periods, which could also serve as a good starting point for future investigations into other dietary aspects in the territories and periods in question that still remain unknown.

Genetic variation associated with adult migration timing in lineages of Steelhead and Chinook Salmon in the Columbia River.

With the discovery of a major effect region (GREB1L, ROCK1) for adult migration timing in genomes of both Chinook Salmon and Steelhead, several subsequent studies have investigated the effect size and distribution of early and late migration alleles among populations in the Columbia River. Here, we synthesize the results of these studies for the major lineages of Chinook Salmon and Steelhead that include highly distinct groups in the interior Columbia River that exhibit atypical life histories from most coastal lineage populations of these two species. Whole-genome studies with high marker density have provided extensive insight into SNPs most associated with adult migration timing, and suites of markers for each species have been genotyped in large numbers of individuals to further validate phenotypic effects. For Steelhead, the largest phenotypic effect sizes have been observed in the coastal lineage (36% of variation for passage timing at Bonneville Dam; 43% of variation for tributary arrival timing) compared to the inland lineage (7.5% of variation for passage timing at Bonneville Dam; 8.4% of variation for tributary arrival timing) that overwinter in freshwater prior to spawning. For Chinook Salmon, large effect sizes have been observed in all three lineages for multiple adult migration phenotypes (Coastal lineage: percentage of variation of 27.9% for passage timing at Bonneville Dam, 28.7% for arrival timing for spawning; Interior ocean type: percentage of variation of 47.6% for passage timing at Bonneville Dam, 39.6% for tributary arrival timing, 77.9% for arrival timing for spawning; Interior stream type: percentage of variation of 35.3% for passage at Bonneville Dam, 9.8% for tributary arrival timing, 4.7% for arrival timing for spawning). Together, these results have extended our understanding of genetic variation associated with life history diversity in distinct populations of the Columbia River, however, much research remains necessary to determine the causal mechanism for this major effect region on migration timing in these species.

New data on Neanderthal behavior in the Altai region, Russia

Until recently, only two sites yielding Micoquian/Keilmessergruppen (KGM) lithic assemblages were known in the Russian Altai Region, which are the result of Late European Neanderthal migrations from Eastern Europe. European Micoquian/KMG sites, often located in close proximity to one another, vary functionally, reflecting complex behavioral patterns of Neanderthal populations. Conversely, two sites in the Altai Region are identified as base camps only, suggesting that sites with other functions either have yet been undiscovered or destroyed by post-depositional processes. Here, we present new data from Verkhnyaya Sibiryachikha Cave, located close to Okladnikov Cave in southern Siberia. A stone tool typical of the Micoquian/KMG was recovered from Verkhnyaya Sibiryachikha Layers 3, chronologically overlapping Neanderthal cultural strata uncovered in Okladnikov Cave. The tool's typology and chronology suggest that it belonged to a Neanderthal from Okladnikov Cave. Verkhnyaya Sibiryachikha Cave may have been used as a game observation point for hunters pursuing prey in the river valley below. Like their European cousins, late Neanderthals in the Altai Region explored areas near their habitations, which suggests no significant changes in the behavior of the Neanderthal population that migrated eastward into Siberia.

Detection of regularities in auditory sequences before and at term-age in human neonates

During the last trimester of gestation, fetuses and preterm neonates begin to respond to sensory stimulation and to discover the structure of their environment. Yet, neuronal migration is still ongoing. This late migration notably concerns the supra-granular layers neurons, which are believed to play a critical role in encoding predictions and detecting regularities. In order to gain a deeper understanding of how the brain processes and perceives regularities during this stage of development, we conducted a study in which we recorded event-related potentials (ERP) in 31-wGA preterm and full-term neonates exposed to alternating auditory sequences (e.g. “ba ga ba ga ba”), when the regularity of these sequences was violated by a repetition (e.g., ``ba ga ba ga ga''). We compared the ERPs in this case to those obtained when violating a simple repetition pattern (“ga ga ga ga ga” vs. “ga ga ga ga ba”). Our results indicated that both preterm and full-term neonates were able to detect violations of regularity in both types of sequences, indicating that as early as 31 weeks gestational age, human neonates are sensitive to the conditional statistics between successive auditory elements. Full-term neonates showed an early and similar mismatch response (MMR) in the repetition and alternating sequences. In contrast, 31-wGA neonates exhibited a two-component MMR. The first component which was only observed for simple sequences with repetition, corresponded to sensory adaptation. It was followed much later by a deviance-detection component that was observed for both alternation and repetition sequences. This pattern confirms that MMRs detected at the scalp may correspond to a dual cortical process and shows that deviance detection computed by higher-level regions accelerates dramatically with brain maturation during the last weeks of gestation to become indistinguishable from bottom-up sensory adaptation at term.

Cave funeral practices during the Roman and Migration Periods in the Cracow Upland, southern Poland

Although caves have been used for funerary purposes almost since the dawn of time, there is very little evidence of such use in Central European Barbaricum. This paper presents newly obtained results from the Cracow Upland (southern Poland) concerning multiple skeletal remains that apparently share a similar third–fifth centuries AD chronology, corresponding to the Late Roman and Early Migration Periods. Multiple analyses have been performed to supplement archaeological data, including radiocarbon dating, osteoarchaeological analysis, ancient DNA research and isotopic analysis. The complex picture points towards unusual burial practices, which generally spanned from the third to the fifth centuries AD and involved a broad demographic, with no indication of selection based on an individual's biological profile. Isotopic analysis has also indicated the individuals’ heterogeneity with regard to diet and local versus nonlocal origin. The results point towards the previously unrecognized unique role of caves in the Przeworsk culture, then present in southern Poland.

Serengeti–Masai Mara ecosystem dynamics inferred from rainfall extremes

The Serengeti–Masai Mara Ecosystem (SMME) is an iconic ecological and biodiversity resource in East Africa with a spectacular great animal migration feature. Environmental shocks like droughts, floods, and land degradation threaten the SMME’s ecological functioning. However, the spatiotemporal ecosystem dynamics during climate extremes are inadequately examined. Here we quantified water availability and vegetation changes during extreme wet (EWE) and dry (EDE) events over the SMME for wet and dry seasons in 1982–2020. We derived extreme events from seasonal mean precipitation anomaly exceeding standard deviation and applied composite and correlation techniques to assess their dynamics with animal populations and migration prospects. Wet season EWE increases vegetative and moist conditions over southern SMME, suggesting elongating migrants’ occupancy compared to normal periods and delayed northward migration. Wet season EDE significantly suppresses these features, heightening ecosystem competition and survival threats, proposing an earlier northward migration. Dry season EWE increases vegetation and water availability over northern SMME, prompting the late southward migration. Dry season EDE significantly reduces vegetation and water availability over northern SMME, suggesting an early southward migration towards regions with more vegetation and increased water availability. The SMME also experiences multiple EDE occurring in consecutive seasons, prolonging dry conditions that aggregate wildlife survival threats. Notably, two EDE prevailed consecutively from the 1993 dry season to the 1994 wet season, coupled with a population decline of wildebeest (1.2–0.9 million), buffalo (40–20 thousand), and lion (1.3–0.9 thousand). We also note a reversal from more EDE to EWE during the study period. Prevalent EWE can lessen wet and vegetative conditions distribution gradient, which is imperative for the functioning of the SMME migratory ecosystem. Our study unveiled hotspot areas of extremes-driven ecosystem changes for the sustainable SMME migratory functioning essential for framing meaningful conservation management policies under climate change.

S2130 30 Years Later – Late Surgical Clip Migration After Laparoscopic Cholecystectomy

S2130 30 Years Later – Late Surgical Clip Migration After Laparoscopic Cholecystectomy

Filler Migration after Facial Injection—A Narrative Review

Background: The injection of dermal fillers for facial esthetics has become a very popular procedure. Although usually safe in the hands of the experienced user, filler injections may bear a risk of unwanted side effects. Material and Methods: This is a narrative review of dermal filler migration after facial injections. We performed research on the literature on Pubmed and Google Scholar. Inclusion criteria were observational studies, case reports, and clinical trials which investigated the association of facial filler injections to filler migration. Animal studies have not been considered. Intravascular injections were excluded. Results: We identified 28 reports that met the inclusion criteria. The age range of affected patients was 21 to 86 years (mean ± standard deviation: 47 ± 14.8 years). Women were 25 times more reported than males. Hyaluronic acid and polyalkylimide were the most commonly encountered filler substances. Injections into the nose, lips, nasolabial folds, and forehead (including glabella) are more often reported for filler migration than injections into the cheeks. Tear-trough correction bears a risk for orbital migration. The delay from injection to presentation of filler migration was highly variable. Very late filler migration was more commonly seen with permanent fillers than non-permanent products. Conclusions: Filler migration distant from the injection site can occur even several years after the primary treatment. All filler types can be involved. Permanent fillers bear a higher risk of very late filler migration. Migration of permanent fillers needs surgical treatment, while HA fillers respond to hyaluronidase injections. Detailed knowledge of facial anatomy, safer injection techniques, and filler qualities are preventive measures.

Genetic monitoring of steelhead in the Klickitat River to estimate productivity, straying, and migration timing

AbstractObjectiveSalmonids with a complex life history variation present challenges for conservation management, but genetic approaches alongside fisheries monitoring can address questions regarding the viability of the natural populations.MethodsWe genotyped adult (n = 3108) and juvenile (n = 2624) samples of steelhead Oncorhynchus mykiss that were collected in the Klickitat River, Washington, USA at traps in the lower drainage to examine tributary level productivity, straying from outside sources, and variation in adult migration timing.ResultGenetic assignment of steelhead from this system indicated that the majority were produced within or near tributaries of the middle Klickitat River (juvenile mean = 72.8%; adult mean = 87.3%). Analyses with parentage‐based tagging identified that most hatchery‐origin adults were assigned to the Skamania Hatchery (80.8%), as expected, since this has been the release stock for decades within the Klickitat River drainage. Hatchery‐origin adults were also identified from programs operating outside the Klickitat River, which were primarily strays from Snake River hatcheries. Most natural‐origin steelhead were assigned to the Klickitat River, but there were also natural‐origin fish identified as strays from other regions of the Columbia River (22.3% of natural returns). We also examined genes known to be associated with migration timing in adult steelhead observed at the trap and observed a strong relationship between migration date and alleles for early and late migration, but individual outliers were detected across seasons.ConclusionOur results indicate that genetic variation of steelhead in the Klickitat River has been influenced by hatchery programs as well as natural‐origin straying from other subbasins, but genetic diversity remains high throughout the subbasin, and both early and late migration alleles are maintained. The genetic diversity present in Klickitat River steelhead may enable this Endangered Species Act listed (threatened) species to better adapt to stochastic environmental conditions compared to less diverse populations.

From the Sundarban delta to Deccan ‘Aurangabad’: climatic refugees’ resilience for livelihood

ABSTRACT Climatic disasters and ecological threats lead to migrations of people with transitions in livelihood as displaced communities. Climatic changes and demographic pressures are harshly hampering the ecological balance of the Sundarbans delta region. Western Indian Ocean region's industrial spaces and town economies are alternatives of livelihood for migrants from Sundarbans delta. Historically, the two littorals and hinterland of Arabian Sea and Bay of Bengal of the Indian Ocean remain connected through trade networks. The Colonial State connected these two hinterlands of South Asia through railway networks. Since the late nineteenth century migrations within the regions for livelihood increased. With the twenty-first century the severity of the migration increased because of climatic change. In this research, I investigated the patterns of migration from the Sundarbans delta to the Western Indian Ocean region hinterland city of `Aurangabad.' This empirical study situates the transitions and impacts on livelihood fragility of the communities displaced.

Subgroups and differences of fixation in 3-part proximal humerus fractures.

This study aimed to determine the morphological differences of three-part proximal humerus fractures, the group in which plate screw fixation is most frequently used, and to evaluate the functional and radiological results of the methods applied for different subgroups. Twenty-nine patients (6 males and 23 females) with three-part proximal humerus fractures were in the study, with an average age of 64. The patients were in three groups according to their fracture types. Group 1 included eight patients with valgus impaction fracture. Group 2 included eleven patients with easily achieved stability after reduction. Group 3 consisted of ten patients with procurvatum varus angulation, a significant displacement between fragments, and in whom medial cortical continuity was not maintained without fixation. All patients underwent surgery with a minimally invasive deltoid split approach method and locked ana-tomic plate screw osteosynthesis. In group 1 patients, the space in the area where valgization is present in the head was filled with cortico-cancellous allografts. No grafting or metaphyseal compression took place in Group 2 patients. In group 3 patients, the metaphyseal compression technique was applied to the bone defect area. Cephalodiaphyseal angles (CDA) were measured at the postoperative and final follow-up. The constant Murley score made the functional evaluation. The patients were followed for an average of 27.6 months, and the union was present in all patients for an average of 3.6 months. Early screw migration was present in three patients, and late screw migration was in one patient. There were twenty-four excellent and 5 good results. CDA decreased from 139.42° to 136.13°. A statistically significant difference was present between the values of Groups 2 and 3 in the final control CDA of the groups. In this study, the functional scores of grafting stable valgus-impacted fractures and metaphyseal compression of unstable fractures with insufficient medial support were as good as stable 3-part fractures. Considering neer type 3 fractures should be evaluated with their subgroups, and fixation and stability-enhancing solutions specific to the groups are essential.

30 years later—a case report of late surgical clip migration after laparoscopic cholecystectomy

30 years later—a case report of late surgical clip migration after laparoscopic cholecystectomy

DREAM

The distribution of close-in exoplanets is shaped by a complex interplay between atmospheric and dynamical processes. The Desert-Rim Exoplanets Atmosphere and Migration (DREAM) program aims at disentangling those processes through the study of the hot Neptune desert, whose rim hosts planets that are undergoing, or survived, atmospheric evaporation and orbital migration. In this first paper, we use the Rossiter-McLaughlin revolutions (RMR) technique to investigate the orbital architecture of 14 close-in planets ranging from mini-Neptune to Jupiter-size and covering a broad range of orbital distances. While no signal is detected for the two smallest planets, we were able to constrain the sky-projected spin-orbit angle of six planets for the first time, to revise its value for six others, and, thanks to constraints on the stellar inclination, to derive the 3D orbital architecture in seven systems. These results reveal a striking three-quarters of polar orbits in our sample, all being systems with a single close-in planet but of various stellar and planetary types. High-eccentricity migration is favored to explain such orbits for several evaporating warm Neptunes, supporting the role of late migration in shaping the desert and populating its rim. Putting our measurements in the wider context of the close-in planet population will be useful to investigate the various processes shaping their architectures.

Mirusiųjų deginimo papročio plitimas rytų Lietuvoje: naujas chronologinis modelis, paremtas radiokarboninio datavimo duomenimis

The article discusses the model of the spread of cremation in the East Lithuanian barrow culture based on the data of radiocarbon dating. It proposes a review of the model established in literature that a wave of cremation spread from the south of the region to the north between the late 4th century AD and of the early 6th century AD. The stage of the earliest cremations can be dated to 248–335 cal AD, and the stage of the latest inhumations to 420–556 cal AD. This suggests that both inhumation and cremation were practised in Eastern Lithuania for about two centuries from the Late Roman period to the Late Migration period. The hypothesis that the practice of cremation spread from south to north is being corrected rather than refuted. While this process was quite sudden, it was due to the spread of a new tradition alongside the old rather than a wave of change regarding burial rites. Cremation spread early (c. 250–400 cal AD) in the northern part of the region and was an established practice alongside inhumation. The practice of cremation probably became prevalent earlier in Southeastern Lithuania. These processes are synchronous with the emergence of the horizon of the burials of chieftains and warriors in Eastern Lithuania, but the determination of an earlier date for this horizon provides grounds for new discussions about its historical, cultural, and social background.