Large Group Research Articles

Ultrasonographic features of thyroid carcinoma of different sizes: comparison between medullary thyroid carcinomas and papillary thyroid carcinomas

Objective: To investigate the ultrasonographic features of medullary thyroid carcinomas (MTCs) of different sizes and supply valid information for separating MTCs from papillary thyroid carcinomas (PTCs). Methods: There were 87 patients with MTC and 220 patients with PTC detected by ultrasonography and confirmed by pathology at Tianjin Medical University Cancer Institute and Hospital from June 2018 to March 2022. Nodules were divided into the large nodule group (the maximum diameter of the tumor was＞1 cm) and the small nodule group (the maximum diameter of the tumor was ≤1 cm). There were 97 cases in the small nodule group, including 28 cases of MTC and 69 cases of PTC. There were 210 cases in the large nodule group, including 59 cases of MTC and 151 cases of PTC. After stratification by thyroid nodules, ultrasonographic features of thyroid nodules and metastatic lymph nodes, preoperative serum calcitonin (CT) and carcinoembryonic antigen (CEA) levels were compared between MTC and PTC patients. Results: In the small nodule group, the proportion of MTCs exhibiting hypoecho, smooth margins, and having blood flow signals was higher than that of PTCs, with statistically significant differences (all P＜0.05). In the large nodule group, the proportion of MTCs showing cystic solidity, hypoecho, smooth margins, blood flow, and the type Ⅳvascular distribution was higher than PTCs, and the difference of calcification type between them was also statistically significant (all P＜0.05). In contrast, the differences in the number of lesions and aspect ratio between MTCs and PTCs were not statistically significant regardless of nodule size (all P＞0.05). In the small nodule group,6 metastatic lymph nodes of medullary thyroid carcinoma (LNM-MTC) and 11 metastatic lymph nodes of papillary thyroid carcinoma (LNM-PTC) were correctly diagnosed by ultrasound, respectively. The diagnostic compliance rate of ultrasound was 78.6% (22/28) and 78.3% (54/69), respectively, with no statistically significant difference (P=0.973). In the large nodule group, 28 LNM-MTC and 11 LNM-PTC were correctly diagnosed by ultrasound, respectively. The diagnostic compliance of ultrasound was 88.1% (52/59) and 73.5% (111/151), respectively, which was statistically significant (P=0.022). Among them, 82.1% of LNM-MTC and 56.6% of LNM-PTC showed abnormal blood flow signals, with a statistically significant difference (P=0.016). There were significant differences in preoperative serum CT and CEA levels of different sizes of MTCs (all P＜0.05). Conclusions: Different sizes of MTCs require diverse demonstrative criteria. Abnormal blood flow signal is of great significance in the diagnosis of LNM-MTC. Within the absence of ultrasonic characteristics, preoperative serum CT test can provide confidence for the diagnosis of MTC.

Development and validity evidence for the resident-led large group teaching assessment instrument in the United States: a methodological study.

Despite educational mandates to assess resident teaching competence, limited instruments with validity evidence exist for this purpose. Existing instruments do not allow faculty to assess resident-led teaching in a large group format or whether teaching was interactive. This study gathers validity evidence on the use of the Resident-led Large Group Teaching Assessment Instrument (Relate), an instrument used by faculty to assess resident teaching competency. Relate comprises 23 behaviors divided into six elements: learning environment, goals and objectives, content of talk, promotion of understanding and retention, session management, and closure. Messick's unified validity framework was used for this study. Investigators used video recordings of resident-led teaching from three pediatric residency programs to develop Relate and a rater guidebook. Faculty were trained on instrument use through frame-of-reference training. Resident teaching at all sites was video-recorded during 2018-2019. Two trained faculty raters assessed each video. Descriptive statistics on performance were obtained. Validity evidence sources include: rater training effect (response process), reliability and variability (internal structure), and impact on Milestones assessment (relations to other variables). Forty-eight videos, from 16 residents, were analyzed. Rater training improved inter-rater reliability from 0.04 to 0.64. The Φ-coefficient reliability was 0.50. There was a significant correlation between overall Relate performance and the pediatric teaching Milestone, r = 0.34, P = .019. Relate provides validity evidence with sufficient reliability to measure resident-led large-group teaching competence.

Modeling thermoregulatory responses during high-intensity exercise in warm environments.

The six cylinder thermoregulatory model (SCTM) has been validated thoroughly for resting humans. This type of modeling is helpful to predict and develop guidance for safe performance of work and recreational activities. In the context of a warming global climate, updating the accuracy of the model for intense exercise in warm environments will help a wide range of individuals in athletic, recreational, and military settings. Three sets of previously collected data were used to determine SCTM accuracy. Dataset 1: two groups [large (LG) 91.5 kg and small (SM) 67.7 kg] of individuals performed 60 min of semirecumbent cycling in temperate conditions (25.1°C) at metabolic rates of 570-700 W. Dataset 2: two LG (100 kg) and SM (65.8 kg) groups performed 60 min of semirecumbent cycling in warm/hot environmental conditions (36.2°C) at metabolic rates of 590-680 W. Dataset 3: seven volunteers completed 8-km track trials (∼30 min) in cool (17°C) and warm (30°C) environments. The volunteers' metabolic rates were estimated to be 1,268 W and 1,166 W, respectively. For all datasets, SCTM-predicted core temperatures were found to be similar to the observed core temperatures. The root mean square deviations (RMSDs) ranged from 0.06 to 0.46°C with an average of 0.2°C deviation, which is less than the acceptance threshold of 0.5°C. Thus, the present validation shows that SCTM predicts core temperatures with acceptable accuracy during intense exercise in warm environments and successfully captures core temperature differences between large and small individuals.NEW & NOTEWORTHY The SCTM has been validated thoroughly for resting humans in warm and cold environments and during water immersion. The present study further demonstrated that SCTM predicts core temperatures with acceptable accuracy during intense exercise up to 1,300 W in temperate and warm environments and captures core temperature differences between large and small individuals. SCTM is potentially useful to develop guidance for safe operation in athletic, military, and occupational settings during exposure to warm or hot environments.

Identifying the Risk Factors of Allergic Rhinitis Based on Zhihu Comment Data Using a Topic-Enhanced Word-Embedding Model: Mixed Method Study and Cluster Analysis.

Allergic rhinitis (AR) is a chronic disease, and several risk factors predispose individuals to the condition in their daily lives, including exposure to allergens and inhalation irritants. Analyzing the potential risk factors that can trigger AR can provide reference material for individuals to use to reduce its occurrence in their daily lives. Nowadays, social media is a part of daily life, with an increasing number of people using at least 1 platform regularly. Social media enables users to share experiences among large groups of people who share the same interests and experience the same afflictions. Notably, these channels promote the ability to share health information. This study aims to construct an intelligent method (TopicS-ClusterREV) for identifying the risk factors of AR based on these social media comments. The main questions were as follows: How many comments contained AR risk factor information? How many categories can these risk factors be summarized into? How do these risk factors trigger AR? This study crawled all the data from May 2012 to May 2022 under the topic of allergic rhinitis on Zhihu, obtaining a total of 9628 posts and 33,747 comments. We improved the Skip-gram model to train topic-enhanced word vector representations (TopicS) and then vectorized annotated text items for training the risk factor classifier. Furthermore, cluster analysis enabled a closer look into the opinions expressed in the category, namely gaining insight into how risk factors trigger AR. Our classifier identified more comments containing risk factors than the other classification models, with an accuracy rate of 96.1% and a recall rate of 96.3%. In general, we clustered texts containing risk factors into 28 categories, with season, region, and mites being the most common risk factors. We gained insight into the risk factors expressed in each category; for example, seasonal changes and increased temperature differences between day and night can disrupt the body's immune system and lead to the development of allergies. Our approach can handle the amount of data and extract risk factors effectively. Moreover, the summary of risk factors can serve as a reference for individuals to reduce AR in their daily lives. The experimental data also provide a potential pathway that triggers AR. This finding can guide the development of management plans and interventions for AR.

Application effect of a dual release system of androgen and its antagonist in the repair of full-thickness burn wounds in mice

Application effect of a dual release system of androgen and its antagonist in the repair of full-thickness burn wounds in mice

A Preliminary Exploratory Factor Analysis of the BDSM Counselor Competency Scale.

BDSM practitioners represent a large sexual minority group often overlooked, misunderstood, and unnecessarily pathologized by mental health clinicians. Although developing cultural competence for diverse and marginalized populations is widely understood to be a core component of delivering efficacious therapeutic services that can counteract these stigmatizing mental healthcare experiences, no measures currently exist that assess clinicians' self-reported competence to work with BDSM practitioners. Previous measurement work has been done to establish self-report competency scales for clinicians working with other sexual and gender minority groups, but no such scales exist for working with BDSM practitioners. In the current study, we adapted a version of the Sexual Orientation Counselor Competency Scale (SOCCS) to measure clinicians' self-reported competence to work with BDSM practitioners and did a preliminary exploratory factor analysis of the new scale (n = 124). After an initial 24-item administration, principal axis factoring of our final 17-item solution revealed two latent factors (attitudes and skills/knowledge) consistent with the 2013 SOCCS and the theoretical constructs of cultural competency. The BDSM Counselor Competency Scale (BDSM-CCS) can help clinicians, practices, agencies, and training programs track self-reported cultural competence with the BDSM population. Future research directions for scale development and clinical and training applications are discussed.

Continuously tunable silicon optical true-time delay lines with a large delay tuning range and a low delay fluctuation.

On-chip switchable optical true-time delay lines (OTTDLs) feature a large group delay tuning range but suffer from a discrete tuning step. OTTDLs with a large delay tuning range and a continuous tuning capability are highly desired. In this paper, we propose and experimentally demonstrate a silicon-based broadband continuously tunable OTTDL comprising a 7-bit delay line and a switch-based continuously tunable delay line. The group delay of the entire OTTDL can be continuously tuned from 0 to 1020.16 ps. A delay error within -1.27 ps to 1.75 ps, and a delay fluctuation of less than 2.69 ps in the frequency range of 2∼25 GHz are obtained. We analyze the causes of the delay fluctuation and its influence on beamforming. Moreover, we also propose a simplified non-invasive calibration method that can significantly reduce the complexity of the delay state calibration and can be easily extended to delay lines with more stages of optical switches. The high performance of our OTTDL chip and the calibration method drive practical applications of integrated OTTDLs.

Characterization of two CYP80 enzymes provides insights into aporphine alkaloid skeleton formation in Aristolochia contorta.

Aporphine alkaloids are a large group of natural compounds with extensive pharmaceutical application prospects. The biosynthesis of aporphine alkaloids has been paid attentions in the past decades. Here, we determined the contents of four 1-benzylisoquinoline alkaloids and five aporphine alkaloids in root, stem, leaf, and flower of Aristolochia contorta Bunge, which belongs to magnoliids. Two CYP80 enzymes were identified and characterized from A. contorta. Both of them catalyze the unusual C-C phenol coupling reactions and directly form the aporphine alkaloid skeleton. AcCYP80G7 catalyzed the formation of hexacyclic aporphine corytuberine. AcCYP80Q8 catalyzed the formation of pentacyclic proaporphine glaziovine. Kingdom-wide phylogenetic analysis of the CYP80 family suggested that CYP80 first appeared in Nymphaeales. The functional divergence of hydroxylation and C-C (or C-O) phenol coupling preceded the divergence of magnoliids and eudicots. Probable crucial residues of AcCYP80Q8 were selected through sequence alignment and molecular docking. Site-directed mutagenesis revealed two crucial residues E284 and Y106 for the catalytic reaction. Identification and characterization of two aporphine skeleton-forming enzymes provide insights into the biosynthesis of aporphine alkaloids.

Sensory Function of Children With Strabismus After Epiblepharon Surgery.

To investigate the effect of epiblepharon surgery on motor and sensory function in children with epiblepharon and concomitant strabismus. Among 564 patients who underwent epiblepharon correction surgery from May 2016 to April 2023, 45 children who were examined for strabismus were included in the study. Preoperative and postoperative visual acuity, refraction, and angle of deviation were analyzed. For those with significant angle of deviation, additional stereopsis, sensory fusion, and returning time were retrospectively investigated. The angle of deviation was examined by one examiner at distance and near. The mean age of 45 children (18 boys and 27 girls) was 6.8 ± 2.9 years. Fifteen had significant strabismus at the time of epiblepharon surgery. Visual acuity improved in both the total and strabismus groups. Improvement in stereopsis and fusion was also observed in the strabismus group. The angle of deviation showed no difference in both groups. Epiblepharon could affect ocular manifestations of strabismus as shown in this study. The authors suggest strabismus treatment be continued after epiblepharon surgery, with improved sensory function. Further evaluation with larger groups is needed in the future. [J Pediatr Ophthalmol Strabismus. 2024;61(4):257-261.].

Superb Microvascular Imaging in Pediatric Focal Nodular Hyperplasia.

To investigate superb microvascular imaging (SMI), a novel Doppler ultrasound technique that can visualize low-velocity microvascular flow, for assessing pediatric focal nodular hyperplasia (FNH). Nine FNH lesions in 6 patients were enrolled. On SMI and color Doppler imaging (CDI), intralesional vascularity was assessed visually and categorized as typical spoke-wheel pattern (central vessel radiating from the center to the periphery), multifocal spoke-wheel pattern, and nonspecific pattern. We compared the vascular features of the lesions between SMI and CDI and evaluated vascular patterns according to lesion size. In terms of vascularity pattern, the typical spoke-wheel pattern of FNH was noted more frequently on SMI (67%) than on CDI (11%; P < 0.05). In addition, a multifocal spoke-wheel pattern was noted in all remaining lesions (33%) on SMI. On the contrary, a nonspecific vascular pattern was detected in the majority (78%) of CDI. Regarding the lesion size and vascularity on SMI, the typical spoke-wheel pattern was seen more frequently in the small FNH group than in the large FNH group. The intralesional vascular signal was detected more frequently on SMI (100%) than on CDI (89%). SMI is feasible in evaluating FNH in children and has a greater ability to demonstrate the spoke-wheel pattern than CDI.

Foraging plasticity in Chilean flamingos: influence of water depth, food abundance and intra-flock distances

In a natural context, many avian species exhibit the ability to assess and balance factors such as food availability, food quality, and energy expenditure when making foraging decisions. However, avian behaviours can also diverge from the predictions, influenced by a range of variables, including social behaviours, predation pressures, and individual personalities. Chilean flamingos, popular social birds native to South America, remain relatively underexplored in terms of their foraging ecology and the interplay between environmental conditions and foraging behaviours, especially within the context of conservation. To address this knowledge gap, we conducted a comprehensive study, collecting monthly physical and biological data from foraging flocks of Chilean flamingos at Lagoa do Peixe National Park, a vital contra-nuptial site located in southern Brazil, spanning from October 2021 to September 2022. We employed Generalized Linear Mixed Models to establish correlations between this dataset and the relative frequency and duration of four identified foraging behaviours: Pecking up, Head-dipping, Feet-trembling, and Dredging. Our findings substantiate that the foraging patterns exhibited by Chilean flamingos in this region are intricately linked to the trade-off between energy expenditure and the rewards obtained, primarily influenced by factors such as lagoon depth and the availability of food resources. Moreover, our results unveil a parabolic pattern in the distances maintained between individual flamingos in the flock, potentially attributed to facilitate foraging dynamics within larger groups, despite the concurrent increase in aggressive interactions. In summary, our study underscores the multifaceted variables that influence the foraging strategies of Chilean flamingos in a significant contra-nuptial area in southern Brazil. It sheds light on the behavioural adaptability of these birds and underscores the potential repercussions of this dynamic on individual and population performance and fitness.

Metabolic engineering of Synechocystis sp. PCC 6803 for the improved production of phenylpropanoids

BackgroundPhenylpropanoids are a large group of plant secondary metabolites with various biological functions, derived from aromatic amino acids. Cyanobacteria are promising host organisms for sustainable production of plant phenylpropanoids. We have previously engineered Synechocystis sp. PCC 6803 to produce trans-cinnamic acid (tCA) and p-coumaric acid (pCou), the first intermediates of phenylpropanoid pathway, by overexpression of phenylalanine- and tyrosine ammonia lyases. In this study, we aimed to enhance the production of the target compounds tCA and pCou in Synechocystis.ResultsWe eliminated the 4-hydroxyphenylpyruvate dioxygenase (HPPD) activity, which is a competing pathway consuming tyrosine and, possibly, phenylalanine for tocopherol synthesis. Moreover, several genes of the terminal steps of the shikimate pathway were overexpressed alone or in operons, such as aromatic transaminases, feedback insensitive cyclohexadienyl dehydrogenase (TyrC) from Zymomonas mobilis and the chorismate mutase (CM) domain of the fused chorismate mutase/prephenate dehydratase enzyme from Escherichia coli. The obtained engineered strains demonstrated nearly 1.5 times enhanced tCA and pCou production when HPPD was knocked out compared to the parental production strains, accumulating 138 ± 3.5 mg L−1 of tCA and 72.3 ± 10.3 mg L−1 of pCou after seven days of photoautotrophic growth. However, there was no further improvement when any of the pathway genes were overexpressed. Finally, we used previously obtained AtPRM8 and TsPRM8 Synechocystis strains with deregulated shikimate pathway as a background for the overexpression of synthetic constructs with ppd knockout.ConclusionsHPPD elimination enhances the tCA and pCou productivity to a similar extent. The use of PRM8 based strains as a background for overexpression of synthetic constructs, however, did not promote tCA and pCou titers, which indicates a tight regulation of the terminal steps of phenylalanine and tyrosine synthesis. This work contributes to establishing cyanobacteria as hosts for phenylpropanoid production.

Genetic Landscape of Factor VII Deficiency: Insights from a Comprehensive Analysis of Pathogenic Variants and Their Impact on Coagulation Activity.

Congenital factor VII (FVII) deficiency is a rare genetic bleeding disorder characterized by deficient or reduced activity of coagulation FVII. It is caused by genetic variants in the F7 gene. We aimed to evaluate the rate of detection of pathogenic variants in the F7 gene in a large group of patients with FVII deficiency and investigate the correlations between the F7 genotype and FVII activity (FVII:C). Moreover, the influence of the common genetic variant rs6046: c.1238G>A; p.(Arg413Gln), designated as the M2 allele, on FVII:C was investigated. Genetic analysis of the F7 gene was performed on 704 index patients (IPs) using either direct Sanger- or next-generation sequencing. Genetic variants were detected in 390 IPs, yielding a variant detection rate (VDR) of 55%. Notably, the VDR exhibited a linear decline with increasing FVII:C levels. We identified 124 genetic variants, of which 48 were not previously reported. Overall, the frequency of the M2 allele was considerably higher in patients with mild deficiency (FVII:C > 20 IU/dl). Furthermore, IPs lacking an identified pathogenic variant exhibited a significantly higher prevalence of the M2 allele (69%) compared to IPs with a disease-causing variant (47%). These results strongly support the association of the M2 allele with decreased FVII:C levels. This study shows the utility of FVII:C as a predictive marker for identifying pathogenic variants in patients with FVII deficiency. The M2 allele contributes to the reduction of FVII:C levels, particularly in cases of mild deficiency.

Supernumerary presence of the oribatid mite Archegozetes sp. Grandjean, 1931 in stomach contents of the túngara frog Engystomops pustulosus (Cope, 1864) encourages validation of interaction pathways: phoretic, parasitic, or prey?

ABSTRACT The trhypochthoniid mite Archegozetes sp. was identified at high abundances (N = 126 and 46) in the stomach contents of the túngara frog Engystomops pustulosus. This is the second report of the genus Archegozetes for Colombia. This species has been reported in Central and South America attached to the skin of some anurans, and these observations were assumed as either phoretic or parasitic interactions between both groups. However, based on our data and the fact that Archegozetes forms large aggregations, we hypothesize that 1) E. pustulosus exploits this ecological behaviour through a predator-prey interaction, and that 2) external presence previously reported in the frogs may have been accidental while the frog fed on these large groups of oribatid mites.

Large litters have a detrimental impact on litter performance and postpartum maternal behaviour in primiparous sows

BackgroundOur previous study confirmed that large litter size adversely affects prepartum maternal hormones and behaviour, concurrently with heightened oxidative stress in primiparous sows. The purpose of this study was to examine the effect of large litter size on litter performance, postpartum maternal behaviour, salivary cortisol levels, and colostral immunoglobulin levels in sows, as well as investigate their correlations with the levels of oxidative stress parameters.ResultsA total of 24 primiparous sows (Landrace\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \ imes $$\\end{document}Large white) and their offspring were categorised into two groups based on litter size: NORMAL (n = 8) with litter size ranging from 7 to 14 (mean 11.5\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \\pm $$\\end{document}2.7), and LARGE (n=16) with litter size ranging from 15 to 20 (mean 15.9\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \\pm $$\\end{document}1.4). All sows were housed in a group housing system during gestation and transitioned to an adaptable loose housing system (2.4\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \ imes $$\\end{document}2.3 m) during the farrowing and lactation periods. The nursing and carefulness behaviour of the sows was monitored over a 24-h period between 72 and 96 h after parturition. Saliva samples were collected for cortisol assay on 35, 21, and 7 days before parturition (D-35, D-21, and D-7, respectively), as well as on days 1, 7, and 28 after parturition (D1, D7, and D28, respectively). On D1, higher piglet mortality rates were observed among the LARGE group compared to the NORMAL group (p<0.01). The total and successful nursing behaviours of the sows were less frequent in the LARGE group than in the NORMAL group (p<0.05, for both), and the carefulness score of the LARGE group was also lower than that of the NORMAL group (p< 0.01). On D1, cortisol levels in LARGE sows were higher than those in NORMAL sows (p< 0.05), and for other time points (D-21, D-7, D7, and D28), cortisol levels in LARGE sows tended to be higher than those in NORMAL sows (p < 0.10, for all). Successful nursing behaviour displayed negative correlations with levels of salivary cortisol and certain oxidative stress parameters measured on D1.ConclusionsThese findings suggest that the strategy for alleviating physiological and oxidative stress during the peripartum periods could benefit potential postpartum maternal behaviour and litter performance in the sows with large litters.

Intersectional analysis of social disparities in type 2 diabetes risk among adults in Germany: results from a nationwide population-based survey

BackgroundDifferences in type 2 diabetes risk have been reported for several sociodemographic determinants including sex/gender or socioeconomic status. From an intersectional perspective, it is important to not only consider the role of social dimensions individually, but also their intersections. This allows for a deeper understanding of diabetes risk and preventive needs among diverse population groups.MethodsAs an intersectionality-informed approach, multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) was used in a population-based sample of adults without known diabetes in Germany from the cross-sectional survey “Disease knowledge and information needs– Diabetes mellitus (2017)”. Diabetes risk was assessed by the German Diabetes Risk Score (GDRS, range 0-122 points), estimating the individual risk of developing type 2 diabetes within the next 5 years based on established self-reported risk factors. Nesting individuals in 12 intersectional strata defined by combining sex/gender, educational level, and history of migration, we calculated measures to quantify the extent to which individual differences in diabetes risk were explained at strata level, and how much this was due to additive or multiplicative intersectional effects of social determinants.ResultsDrawing on data of 2,253 participants, we found good discriminatory accuracy of intersectional strata (variance partition coefficient = 14.00% in the simple intersectional model). Model-predicted GDRS means varied between 29.97 (corresponding to a “low risk” of < 2%) in women with high educational level and a history of migration, and 52.73 (“still low risk” of 2–5%) in men with low educational level without a history of migration. Variance in GDRS between strata was mainly explained by additive effects of social determinants (proportional change in variance to intersectional interaction model = 77.95%) with being male and having low educational level being associated with higher GDRS. There was no evidence of multiplicative effects in individual strata.ConclusionsType 2 diabetes risk differed between intersectional strata and can to some extent be explained at strata level. The role of intersectional effects was minor and needs to be further investigated. Findings suggest a need for specific preventive measures targeted at large groups with increased diabetes risk, such as men and persons with low educational level.

Computational Intelligence Supporting the Safe Control of Autonomous Multi-Objects

The essence of this work, which is an extension of the author’s previous research, is an analysis of computational intelligence algorithms that the support safe control of an autonomous object moving in a large group of other autonomous objects. Linear and dynamic programming methods with neural constraints on the process state, as well as positional and matrix game methods, were used to synthesize computational algorithms for the safe trajectory of one’s own object. The aim of the comparative analysis of intelligent computational methods for the safe trajectory of an object was to show, through their use, the possibility of taking into account the risk of collision resulting from both the degree of cooperation of objects while observing traffic laws and the impact of the environment in the form of visibility and the complexity of the situation. Simulation tests of the algorithms were carried out on the example of a real navigation situation of several dozen objects passing each other at sea.

The morphological mix of dwarf galaxies in the nearby Universe

ABSTRACT We use a complete, unbiased sample of 257 dwarf (10$^{8}\, {\rm M}_{\odot } \lt M_{\rm {\star }} \lt 10^{9.5}\, {\rm M}_{\odot }$) galaxies at z &amp;lt; 0.08, in the COSMOS field, to study the morphological mix of the dwarf population in low-density environments. Visual inspection of extremely deep optical images and their unsharp-masked counterparts reveals three principal dwarf morphological classes. 43 per cent and 45 per cent of dwarfs exhibit the traditional ‘early-type’ (elliptical/S0) and ‘late-type’ (spiral) morphologies, respectively. However, 10 per cent populate a ‘featureless’ class, that lacks both the central light concentration seen in early-types and any spiral structure – this class is missing in the massive-galaxy regime. 14 per cent, 27 per cent, and 19 per cent of early-type, late-type, and featureless dwarfs respectively show evidence for interactions, which drive around 20 per cent of the overall star formation activity in the dwarf population. Compared to their massive counterparts, dwarf early-types show a much lower incidence of interactions, are significantly less concentrated and share similar rest-frame colours as dwarf late-types. This suggests that the formation histories of dwarf and massive early-types are different, with dwarf early-types being shaped less by interactions and more by secular processes. The lack of large groups or clusters in COSMOS at z &amp;lt; 0.08, and the fact that our dwarf morphological classes show similar local density, suggests that featureless dwarfs in low-density environments are created via internal baryonic feedback, rather than by environmental processes. Finally, while interacting dwarfs can be identified using the asymmetry parameter, it is challenging to cleanly separate early and late-type dwarfs using traditional morphological parameters, such as ‘CAS’, M20, and the Gini coefficient (unlike in the massive-galaxy regime).

In which rounds were the most rotations of key players made, and how did this affect physical activity? Analysis of the eight best teams of the 2018 FIFA world cup Russia

BackgroundTeam management, especially player selection, rotation, and availability, are critical issues when dealing with the high demands of modern training and gameplay. As such, research continuously seeks ways to improve these actions or implement new ideas to gain a competitive advantage through the rotation of players in the starting line-up. The current study aimed to examine the rounds of the 2018 FIFA World Cup Russia in which the most rotations of key players were made and how this affected physical activity.MethodsThe sample consisted of 110 players from the top eight teams in the 2018 World Cup Russia who played entire matches for up to 90 min in seven consecutive games. All players were divided into key players (KPs, n = 58) and non-key players (NKPs, n = 52). The analysis used data collected by an advanced motion analysis system known as STATS®, with physical activity variables analyzed, including total distance covered (TDC), distance covered with high intensity over 20 km/h (HIR), and the number of sprints undertaken. In statistical analysis, differences between categories and consecutive matches were calculated using the Kruskal-Wallis H test, and if a significant effect size was found, a multiple comparisons p values test was performed.ResultsThe best teams at the 2018 FIFA World Cup Russia used the most KP rotations with NKPs in the third match of the group stage. In addition, this was even more visible among more successful teams than less successful teams. The rotation strategy among the best eight teams allowed them to maintain the physical activity of KPs and NKPs in all rounds of the tournament.ConclusionsCoaches and coaching staff should incorporate squad rotation that includes a large group of players in their team management to improve their success. Team management expertise in player rotation during matches played over congested schedules at top tournaments maintains high levels of physical activity indicators (TDC, HIR, and sprints).

Efficient secure channel free identity-based searchable encryption schemes with privacy preserving for cloud storage service

Cloud storage is a basic service model of the cloud computing. Since the cloud data is stored in the ciphertext for the data confidentiality, how to search the cloud data again in ciphertext state for users is a natural requirement. The searchable encryption (SE) gives an efficient solution to achieve both the data confidentiality and the searchable requirement simultaneously. In SE schemes, the user can transfer a search trapdoor to the cloud server from a secure channel and the cloud server can use the received trapdoor to search the corresponding keyword ciphertext. Since the keywords are with low entropy, the traditional SE is vulnerable to keyword guessing attack. In order to remove the need of the secure channel and also to achieve the security against the keyword guessing attack, we build a single-user identity-based secure channel free SE scheme in the random oracle model by using lattice-based tools. Only the designated cloud server can finish the ciphertext search which means the secure channel between the user and the cloud server is not needed in the proposed scheme. Under the hardness of the learning with errors problem, we prove that the proposed scheme is ciphertext indistinguishable under the selective identity and chosen keyword attacks. Moreover, the proposed scheme also satisfies the trapdoor indistinguishability which directly leads to the security against the outside offline keyword guessing attack. Furthermore, we extend the proposed single-user scheme into the multi-user scenario. The proposed multi-user scheme inherits all functions achieved in the single-user scheme, such as secure channel free. Meanwhile, ciphertext length is fixed with the number of users increasing, which is more suitable for the large group users. In addition, we analyze the theoretical evaluation and experimental evaluation between the proposed schemes and some known literatures respectively. The results demonstrate that our proposed algorithms have several advantages in the both single-user and multi-user schemes, for example, the ciphertext lengths in the single/multi-user schemes are only 5.632KB and 6.016KB respectively and the running time of Test algorithm for any user groups is fixed to be 0.65ms in our simulated experiments.