Large Plasma Research Articles

Characterization of sub-picosecond laser-produced fast electrons by modeling angularly resolved bremsstrahlung measurements with 3D hybrid particle-in-cell code

Hard x-rays produced by intense laser-produced fast electrons interacting with solids are a vital source for producing radiographs of high-density objects and implosion cores for inertial confinement fusion. Accurate calculation of hard x-ray sources requires a three-dimensional (3D) simulation geometry that fully models the electron transport dynamics, including electron recirculation and the generation of absolute photon yields. To date, 3D simulations of laser-produced bremsstrahlung photons over tens of picoseconds and code benchmarking have not been performed definitively. In this study, we characterize sub-picosecond laser-produced fast electrons by modeling angularly resolved bremsstrahlung measurements for refluxing and non-refluxing targets using the 3D hybrid particle-in-cell (PIC), Large Scale Plasma code. Bremsstrahlung radiation and escaped electron data were obtained by focusing a 50-TW Leopard laser (15 J, 0.35 ps, 2 × 1019 W/cm2) on a 100-μm-thick Cu foil and a Cu with a large plastic backing (Cu–CH target). Data for both the Cu and Cu–CH targets were reproduced for simulations with a given set of electron parameters. Comparison of the simulations revealed that the hard x-ray emission from the Cu target was significantly longer in duration than that from the Cu–CH target. The benchmarked hybrid PIC code could prove to be a powerful tool in the design and optimization of time- and angular-dependent bremsstrahlung sources for flash x-ray and gamma-ray radiography.

Triple-threat quantitative multiplexed plasma proteomics analysis on immune complex disease MRL-lpr mice.

Systemic lupus erythematosus is a common autoimmune inflammatory disease which is associated with increases in autoantibodies and immune complexes that deposit in the kidney. The MRL-lpr mouse is a common mouse model used for the study of lupus and immune complex glomerulonephritis but very little is known about the plasma proteome changes in this model. We performed in-depth quantitative proteome profiling on MRL-lpr and control (strain MpJ) mice to investigate the changes in the proteome, immunoglobulins and their glycoproteome as well as protein and immune complexes. Methodologies used included immunohistochemistry, immunoglobulin isotyping, multiplexed proteome profiling, immunoglobulin immunoprecipitation with glycoproteome profiling, and size exclusion chromatography (SEC) profiling to enable a comprehensive proteome profiling of proteins and protein complexes. We also used a novel native multiplexed plasma proteome profiling (NativeMP3) method that relies on native enrichment of plasma proteins enabling ultra-deep single shot profiling where we identified 922 plasma proteins at 1% false discovery rate (FDR) in a single shot mass spectrometry run. We observed many large plasma protein differences between the MRL-lpr and control strain including differences in the immunoglobulins, immunoglobulins against specific antigens, chemokines, and proteases as well as changes in protein complexes such as the immunoproteasome.

Plasma vesicular miR-155 as a biomarker of immune activation in antiretroviral treated people living with HIV.

People living with HIV (PLWH), despite suppression of viral replication with antiretroviral therapy (ART), have high morbidity and mortality due to immune activation and chronic inflammation. Discovering new biomarkers of immune activation status under ART will be pertinent to improve PLWH quality of life when the majority will be treated. We stipulate that plasma large and small extracellular vesicle (EVs) and their microRNA content could be easily measured biomarkers to monitor immune activation in PLWH. Venous blood samples from n = 128 ART-treated PLWH with suppressed viral load (≤ 20 copies/mL) and n = 60 HIV-uninfected participants were collected at five testing or treatment centers of PLWH in Burkina Faso. Large and small plasma EVs were purified, counted, and the mature miRNAs miR-29a, miR-146a, and miR-155 were quantified by RT-qPCR. Diagnostic performances of large and small EVs miRNAs level were evaluated by receiver operating characteristic (ROC) curve analysis and principal component analysis (PCA). Among the EVs microRNA measured, only large EVs miR-155 copies distinguished PLWH with immune activation, with AUC of 0.75 for CD4/CD8 < 1 (95% CI: 0.58–0.91, P = 0.0212), and 0.77 for CD8 T cells ≥ 500/µL (95% CI: 0.63–0.92, P = 0.0096). In addition, PCA results suggest that large EVs miR-155 copies may be a biomarker of immune activation. Since miR-155 may influence immune cell function, its enrichment in large EV subpopulations could be a functional biomarker of immune activation in PLWH on ART. This measure could help to monitor and diagnose the immune activation with more accuracy.

Effects of the parallel flow shear on the ITG-driven turbulent transport in tokamak plasmas

The impact of the parallel flow shear on the tokamak plasma stability and turbulent transport driven by the ion temperature gradient (ITG) modes is analyzed by means of local gyrokinetic numerical analyses. It is shown that the parallel flow shear increases the ITG growth rate in the linear regime, and induces a broadening and shift of the radial spectrum. Then, the different effects of the finite parallel shear on the ITG turbulence characteristics are deeply analyzed in the nonlinear regime. These studies highlight that a reduction of the thermal-ion turbulent heat flux is induced by a complex mechanism involving the nonlinear generation of an enhanced zonal flow activity. Indeed, the turbulent sources of the zonal flows are increased by the introduction of the finite parallel flow shear in the system, beneficially acting on the saturation level of the ITG turbulence. The study has been carried out for the Waltz standard case below the critical threshold of the destabilization of the parallel velocity gradient instability, and then generalized to a selected pulse of a recent JET scenario with substantial toroidal rotation in the edge plasma region. It is, thus, suggested that the investigated complex mechanism triggered by the finite parallel flow shear reducing the ITG turbulent heat fluxes could be complementary to the well-established perpendicular flow shear in a region with sufficiently large plasma toroidal rotation.

Strong Ionospheric Spatial Gradient Events Induced by Signal Propagation Paths Aligned With Equatorial Plasma Bubbles

Low-latitude ionospheric behavior directly interferes with a wide range of applications dependent on signals and information from satellites. The most severe and variable events are plasma bubbles and ionospheric scintillation. During plasma bubble events, large and steep plasma density gradients may intersect transionospheric signal from satellites, especially around the equatorial anomaly region. Large ionospheric spatial gradients (or decorrelations) are a critical component of ionospheric threat models for global navigation satellite systems augmentation systems; however, the models cannot assimilate abrupt changes in ionospheric behavior. In this article, an investigation of the relationship between plasma depletions, the occurrence of scintillation, and strong ionospheric spatial decorrelation events was conducted. The results indicate that strong scintillations occur when large gradients are verified. Additionally, the most critical ionospheric spatial gradients were verified mostly under certain conditions: when satellite signals are aligned with the plasma bubble propagation along geomagnetic field lines. Therefore, even though amplitude scintillation may degrade communications, the critical gradient events seem to be related to a particular configuration of satellite signal across the ionosphere. Thus, it is recommended that ionospheric threat models for augmentation systems in low-latitude regions consider this alignment aspect.

High repetition rate mapping of the interaction between a laser plasma and magnetized background plasma via laser induced fluorescence

The laminar coupling of energy between a laser-produced plasma and a background magnetized plasma was investigated via planar laser induced fluorescence diagnostic and magnetic flux probes. Experiments performed on the Large Plasma Device at the University of California, Los Angeles, mapped out the two-dimensional spatiotemporal evolution of the laser-plasma (debris) ion velocity distribution function (VDF) to assess debris-background coupling in a sub-Alfvénic regime. The acquisition of these data necessitates high repetition rate (1 Hz) as each dataset is the accumulation of thousands of laser shots, which would not be feasible in single-shot experiments. Fully kinetic, three-dimensional particle-in-cell simulations are compared to the measured VDFs to provide a framework in which we can understand the coupling of a sub-Alfvénic plasma flow through a preformed, magnetized plasma. The simulations display the same departure from the expected gyromotion of the debris plasma as observed in the experimental data, and in conjunction with the measured magnetic field traces, have led to the direct observation of the collisionless coupling via laminar fields.

Impact of the electron density and temperature gradient on drift-wave turbulence in the Large Plasma Device

In this paper we present an experimental study of edge turbulence in the Large Plasma Device at UCLA. We utilize a scan of discharge power and prefill pressure (neutral density) to show experimentally that turbulent density fluctuations decrease with decreasing density gradient, as predicted for resistive drift-wave turbulence (RDWT). As expected for RDWT, we observe that the cross-phase between the density and potential fluctuations is close to 0. Moreover, the addition of an electron temperature gradient leads to a reduction in the amplitude of the density fluctuations, as expected for RDWT. However, counter to theoretical expectations, we find that the potential fluctuations do not follow the same trends as the density fluctuations for changes either in density gradients or the addition of a temperature gradient. The disconnect between the density and potential fluctuations is connected to changes in the parallel flows as a result of differences in the prefill pressure, i.e. neutral density. Further analysis of the density and potential fluctuation spectra show that the electron temperature gradient reduces the low frequency fluctuations up to $10 \,{\rm kHz}$ and the introduction of a temperature gradient leads to an unexpected ${\sim }{\rm \pi}$ shift of the density–potential cross-phase at ${\sim }10\,{\rm kHz}$ , while maintaining the typical resistive drift-wave cross-phase at lower frequencies. These experiments partly confirm existing knowledge on resistive drift-wave turbulence, but also introduce new observations that indicate a need for dedicated nonlinear three-dimensional turbulence simulations that include neutrals.

Thomson scattering on the large plasma device.

We have developed a non-collective Thomson scattering diagnostic for measurements of electron density and temperature on the Large Plasma Device. A triple grating spectrometer with a tunable notch filter is used to discriminate the faint scattering signal from the stray light. In this paper, we describe the diagnostic and its calibration via Raman scattering and present the first measurements performed with the fully commissioned system. Depending on the discharge conditions, the measured densities and temperatures range from 4.0 × 1012 to 2.8 × 1013 cm-3 and from 1.2 to 6.8eV, respectively. The variation of the measurement error with plasma parameters and discharges averaged is also discussed.

Modeling study of divertor particle and heat flux asymmetries for EAST H-mode discharges

The BOUT++ transport code is run to study the effects of plasma drifts on the divertor out-in asymmetries (DOIAs) of particle and heat fluxes and their decay widths for EAST lower single null H-mode discharges. The diamagnetic drift seems to have no effects on the DOIAs of total particle and heat fluxes due to its divergence-free nature. However, it could significantly increase the DOIAs of peak particle and heat fluxes and the flux decay widths. The E × B drift is found to induce a large plasma flow to the divertor region, enhancing the DOIAs of both total and peak particle and heat fluxes and the flux decay widths. Both the radial and poloidal components of the E × B drift are necessary in increasing the DOIAs, however, the radial E × B drift seems to play a more important role. The effects on the DOIAs caused by both diamagnetic and E × B drifts are reversed with the reverse of toroidal magnetic field. The heat flux decay width λq and spreading width Sq are important physical and engineering parameters for the divertors and could be obtained by fitting the heat flux profiles at divertor targets. The λq at the outer target from the simulation case with all drifts could well match with the multi-machine scaling proposed by Eich and the DOIA of λq is in reasonable agreement with the scaling proposed by Goldston.

Plasma Formation And Its Sustainment In Time And Space In Microwave Enhanced Laser Induced Breakdown Spectroscopy

The transient and unstable plasma generation in the laser-induced breakdown is potentially resolved by the addition of microwaves. The laser and microwave technology combination extends the plasma lifetime and enhanced its emission intensity and volume. The expansion of the plasma started a few seconds after the initial formation of the plasma seed and the absorption of the microwave by the plasma also started to take effect. Large dome-shaped plasma is then briefly sustained until the end of the microwave duration. As the plasma expands, the plasma drifts away from the sample surface which is a good indication of the non-ablation effect of the microwave energy. The expansion of the plasma by microwaves enhances the breakdown of the plasma but potentially regulates the formation of toxic ablation fumes.

Energy-selective confinement of fusion-born alpha particles during internal relaxations in a tokamak plasma

Long-pulse operation of a self-sustained fusion reactor using toroidal magnetic containment requires control over the content of alpha particles produced by D-T fusion reactions. On the one hand, MeV-class alpha particles must stay confined to heat the plasma. On the other hand, decelerated helium ash must be expelled before diluting the fusion fuel. Here, we report results of kinetic-magnetohydrodynamic hybrid simulations of a large tokamak plasma that confirm the existence of a parameter window where such energy-selective confinement can be accomplished by exploiting internal relaxation events known as sawtooth crashes. The physical picture — a synergy between magnetic geometry, optimal crash duration and rapid particle motion — is completed by clarifying the role of magnetic drifts. Besides causing asymmetry between co- and counter-going particle populations, magnetic drifts determine the size of the confinement window by dictating where and how much reconnection occurs in particle orbit topology.

Reduction in RF sheath rectification with insulating antenna enclosure walls

Radiofrequency (RF) sheath rectification is one of the most prominent deleterious effects associated with ion cyclotron range of frequencies (ICRF) heating in fusion plasmas. RF sheaths and associated effects, such as impurity generation and convective cell generation, need to be mitigated to ensure that ICRF is a viable option for heating in future fusion devices. Experiments were performed on the Large Plasma Device (LAPD) at UCLA to explore the effects of using electrically-insulating antenna enclosures on RF rectified sheaths. Three different enclosure side-wall materials were used, including copper, MACOR (electrically insulating), and MACOR over copper. In the case of the MACOR–copper side walls, the non-conductive MACOR material was exposed to the bulk plasma but a layer of copper was added below to allow for image currents to flow. All three of the experiments had similar plasma density, temperature, and background magnetic field. In the case of the copper enclosure, RF rectified potentials, many times the local electron temperature, and associated formation of convective cells were observed and reported Martin M. et al (2017 Phys. Rev. Lett. 119 205002). In the experiments with MACOR and MACOR–copper enclosures, RF rectification was significantly reduced. Additionally, these latter two experiments showed no evidence of convective cell formation. Although the results from the MACOR experiment are reminiscent of the results obtained in ASDEX-U with a three-strap antenna optimized to reduce image currents on the antenna limiters Bobkov V. et al (2016 Nucl. Fusion 56 084001), the MACOR–copper experiment seems to suggest that insulating plasma facing materials have at least an equally strong impact on reducing potential rectification.

Three-dimensional reconstruction of large non-uniform surface wave plasma using multi-lens array attached to a single viewing port

A new passive monitoring system applied to large surface wave plasmas (SWP) is experimentally tested. In the first experiment, spatial distributions of the electron density and temperature are measured using double probes. Subsequently, integral photography with deconvolution techniques is applied to identify the three-dimensional emissivity distribution of SWP. The result obtained from the first experiment seems to identify the localization of SWP around the antenna launching an 860 MHz microwave.

Ceramic membrane for water filtration: Addressing the various concerns at once

The scarcity of fresh water is a pressing issue due to the rapid growth of the population, industrialization, pollution, etc. Therefore, a membrane dealing with various major issues simultaneously could help for application even the pathway of commercialization and fulfil the fresh water scarcity. These issues are as following (i) One step and industrial friendly membrane fabrication technique (ii) high water flux at low transmembrane pressure (TMP) (iii) higher contamination rejection rate (iv) low fouling and (v) mechanically robust. Herein, we demonstrated an impressive approach to fabricate ceramic membranes using a large throughput atmospheric plasma spraying (APS) technique for water filtration. Plasma sprayed YSZ membranes were fabricated with three different thicknesses, viz., 100, 200, and 300 µm containing ∼ 30% porosity. Among the pores, 80% of the pores were in the range of 0.3–1.2 µm. The plasma sprayed YSZ membranes unveiled pure water flux, contamination rejection rate, and permeability for various feed water (waste, salt water) up to 370 Lm−2h−1, >95% and 380 Lm−2h−1bar−1 respectively. The membranes also showed excellent fouling resistance, a superhydrophilic nature (Contact Angle < 10°), and outstanding reusability with the added advantage of intact mechanical properties. Their mechanical properties, viz. hardness, elastic modulus, and fracture toughness, range from 5 to 7 GPa, 120–145 GPa, and 2.3–2.5 MPam−1 respectively. Our plasma sprayed YSZ membranes are cheaper and can be utilized in various sectors such as urban water filtration, industrial waste water filtration, food and pharmaceutical industries, etc.

Radiation and Scattering of EM Waves in Large Plasmas Around Objects in Hypersonic Flight

The hypersonic flight regime is conventionally defined for Mach > 5; in these conditions, the flying object becomes enveloped in a plasma. This plasma is densest in thin surface layers, but, in typical situations of interest, it impacts electromagnetic wave propagation in an electrically large volume. We address this problem with a hybrid approach. We employ the equivalence theorem to separate the inhomogeneous plasma region from the surrounding free space via an equivalent (Huygens) surface and the Eikonal approximation to Maxwell equations in the large inhomogeneous region for obtaining equivalent currents on the separating surface. Then, we obtain the scattered field via (exact) free-space radiation of these surface equivalent currents. The method is extensively tested against reference results and then applied to a real-life reentry vehicle with full 3-D plasma computed via computational fluid dynamic (CFD) simulations. We address both scattering [radar cross section (RCS)] from the entire vehicle and radiation from the onboard antennas. From our results, significant radio link path losses can be associated with plasma spatial variations (gradients) and collisional losses to an extent that matches well the usually perceived blackout in crossing layers in the cutoff. Furthermore, we find good agreement with existing literature concerning significant alterations of the radar response (RCS) due to the plasma envelope.

Efficient and Sustainable Platform for Preparation of a High-Quality Immunoglobulin G as an Urgent Treatment Option During Emerging Virus Outbreaks.

During the pre-vaccine era of the COVID-19 pandemic convalescent plasma has once again emerged as a major potential therapeutic form of passive immunization that in specific cases still represents irreplaceable treatment option. There is a growing concern that variable concentration of neutralizing antibodies, present in convalescent plasma which originates from different donors, apparently affects its effectiveness. The drawback can be overcome through the downstream process of immunoglobulin fraction purification into a standardized product of improved safety and efficacy. All modern procedures are quite lengthy processes. They are also based on fractionation of large plasma quantities whose collection is not attainable during an epidemic. When outbreaks of infectious diseases are occurring more frequently, there is a great need for a more sustainable production approach that would be goal-oriented towards assuring easily and readily available immunoglobulin of therapeutic relevance. We propose a refinement strategy for the IgG preparation achieved through simplification and reduction of the processing steps. It was designed as a small but scalable process to offer an immediately available treatment option that would simultaneously be harmonized with an increased availability of convalescent plasma over the viral outbreak time-course. Concerning the ongoing pandemic status of the COVID-19, the proof of concept was demonstrated on anti-SARS-CoV-2 convalescent plasma but is likely applicable to any other type depending on the current needs. It was guided by the idea of persistent keeping of IgG molecules in the solution, so that protection of their native structure could be assured. Our manufacturing procedure provided a high-quality IgG product of above the average recovery whose composition profile was analyzed by mass spectrometry as quality control check. It was proved free from IgA and IgM as mediators of adverse transfusion reactions, as well as of any other residual impurities, since only IgG fragments were identified. The proportion of S protein-specific IgGs remained unchanged relative to the convalescent plasma. Undisturbed IgG subclass composition was accomplished as well. However, the fractionation principle affected the final product’s capacity to neutralize wild-type SARS-CoV-2 infectivity, reducing it by half. Decrease in neutralization potency significantly correlated with the amount of IgM in the starting material.

Generalized plasma waves in layered superconductors: A unified approach

In a layered and strongly anisotropic superconductor, the hybrid modes provided by the propagation of electromagnetic waves in the matter identify two well-separated energy scales connected to the large in-plane plasma frequency and to the soft out-of-plane Josephson plasmon. Despite wide interest in their detection and manipulation by means of different experimental protocols, the physical ingredients underlying a unified description of plasma waves valid at arbitrary energy and momentum are still poorly understood. Here we provide a complete description of generalized plasma waves in layered superconductors in terms of the gauge-invariant superconducting phase by including both the Coulomb interaction and the relativistic effects. We show that the anisotropy of the superfluid response leads to two intertwined hybrid light-matter modes with mixed longitudinal and transverse character, while a purely longitudinal plasmon is only recovered for wave vectors larger than the crossover scale set in by the plasma-frequency anisotropy. Interestingly, below such scale both modes appear with equal weight in the physical density response. Our results open a promising perspective for plasmonic applications made possible by next-generation spectroscopic techniques able to combine submicron momentum resolution with THz energy resolution.

On the formation of quasi-parallel shocks, magnetic and electric field turbulence, and the ion energization mechanism

ABSTRACT The analysis of four-point measurements by the NASA Magnetospheric Multiscalespacecraft reveals that the formation of quasi-parallel shocks is consistent with the counter-streaming ion–ion resonant right-handed instability. The counter-streaming occurs between the incoming solar wind and a diffuse hot ion population moving upstream. It is found that the onset of the instability is initiated by 30 s period oscillations, which steepen to shorter wavelengths and higher frequencies. The turbulent cascade in the electric field ranges from 0.01 Hz to a few kHz. The dominant frequency of the instability in the magnetic field is observed around the proton cyclotron frequency, consistent with the theoretical predictions. The instability produces large amplitude magnetic field and plasma density shocklets with the perpendicular scale length of 300 km (3 proton gyroradii) and the parallel scale length three times larger. The active acceleration regions are characterized by non-gyrotropic ion populations in the velocity space, in addition to the solar wind beam and a diffuse hot beam propagating upstream. We show that non-gyrotropic ion populations are consistent with the $ExB$ wave energization mechanism that can both heat bulk plasma and accelerate some ions to the observed energies of 200 keV.

Dual Sounding Rocket and C/NOFS Satellite Observations of DC Electric Fields and Plasma Density in the Equatorial E- and F-Region Ionosphere at Sunset.

E × B plasma drifts and plasma number density were measured on two NASA rockets launched simultaneously at sunset from Kwajalein Atoll with apogees of 182 and 331 km, with similar, coincident measurements gathered on the Communications/Navigation Outage Forecasting System (C/NOFS) satellite at 390 km. The combined measurements portray a highly dynamic ionosphere in a narrow range of local time and altitude, providing evidence of vortex‐like motions. Although the vertical plasma drift was upwards, its magnitude was not constant, increasing between ∼150 and 250 km altitude where the plasma density was reduced. The zonal plasma drifts displayed a shear with altitude, changing from eastward to westward flow below 270 km, coincident with the larger upward drifts and consistent with the maintenance of the vortex flow. The plasma density on the western flank was highly structured compared to the eastern flank, despite the fact that the western region corresponded to slightly earlier local times. These observations illustrate that the low latitude ionosphere at sunset must be considered as an ensemble of interconnected flows encompassing an evolving “theater,” as opposed to a background that simply unfolds linearly with respect to local time. The observations also underscore how satellites at high altitudes do not capture the highly dynamic ionosphere and thermosphere at the lower altitudes which are critical for understanding the electrodynamics system. Such motions set the stage for large scale plasma instabilities to form later in the evening, as observed by radars at Kwajalein and subsequent passes of the C/NOFS satellite.

Observation of low temperature VUV tungsten emission in JET divertor plasmas

The properties of tungsten make it ideal for use as a plasma facing surface in the divertor of large plasma machines such as JET and ITER. However, the intense heat and particle fluxes that fall on the divertor surfaces lead to its release from these surfaces into the plasma and it is necessary to model its transport from the divertor and plasma edge into the plasma core. This requires measurement of spectral features over a wide temperature range. In large machines the W influx is often determined from W I line intensities, there being few measurements of discrete W lines from other low ionization stages. Their observation is highly desirable because the transport of neutral W differs markedly from that of the W ions. A change in the line-of-sight of a VUV survey spectrometer on JET to view directly into the divertor has led to the observation of numerous discrete low temperature W lines in the VUV spectral region. The spectrum of an intense influx in which W IV to W VIII features are observed has been analysed in order to provide spectral classifications so that these lines can be used for diagnostic purposes. The first observation of a VUV low temperature W magnetic dipole (M1) transition is reported for the W VIII ionization stage. The analysis shows where further line identifications are needed and that the provision of the highest quality atomic data for these ionization stages is desirable. W VI and W VII line intensity measurements are used to illustrate their use in determining the electron temperature of the emitting plasma region and the W concentration. Dependences of the W line intensities on plasma parameters shows the optimal conditions for the W release and suggests the site of its release.