Carcinoma of the colon in youth is a rare condition. On the basis of the cases reported, the prognosis appears practically hopeless. If, however, the fact that cancer in youth can and does occur were to be stressed through the recording of all such cases, it is believed that earlier diagnosis might be established, which should in turn improve the outlook. About 45 per cent of all the various types of cancer occur in the gastro-intestinal tract (1). Of this number, approximately 11 per cent are in the large intestine (2). Malignant tumors in youth have been variously estimated as accounting for 1 to 4 per cent of all malignant neoplastic diseases (3, 4). Thirty-two cases of carcinoma of the large intestine in patients fifteen years of age or under were reported up to 1941 (5–18). In that year Pennell (19) reviewed the literature and added another case to the list. Laird (20), also in 1941, listed 3 cases (21, 22, 23) not quoted by Pennell and added a case of his own. The case presented here is thus the 38th to be reported. Case Report J. D. A., a white boy aged 15 years, was brought to Harper Hospital (Detroit) on March 8, 1945, by ambulance, the chief complaint being “stomach cramps” of three weeks' duration. He had previously had a number of similar attacks of abdominal cramps, the first occurring in 1943, two years before admission, at which time the pains lasted about one to two minutes and recurred every fifteen to twenty minutes over a period of twenty-four hours. There had been no nausea, vomiting, diarrhea, constipation, bloody or tarry stools, associated with the pain. Beginning in August 1944, the cramps became more frequent and more severe until the middle of February 1945, when the pain was intense and the patient vomited about once every twenty-four hours. During the three weeks prior to admission to the hospital, he had lost 15 pounds in weight, his appetite was poor, and he had a moderate degree of constipation. Bright red blood was noted in the stool on a single occasion, following an enema. The earlier history and family history were non-contributory. The only positive physical findings were in the abdomen, where there was exquisite tenderness to light palpation over the course of the transverse and descending colon. There was no rigidity, no masses were palpable, and the liver, spleen, and kidneys could not be felt. Examination of the blood on admission revealed a slight leukocytosis, with a white blood count of 11,400 (stab cells 33 per cent; segmented cells 41 per cent; lymphocytes 16 per cent; monocytes 8 per cent; eosinophils 1 per cent). The red blood cell count was 4,680,000, and hemoglobin 93 per cent. A roentgenographic gastro-intestinal study done previous to hospital admission showed “deformity of the second and third parts of the duodenum and the mid portion of the transverse colon, with complete obstruction in the mid transverse colon and retrograde filling of the bowel with barium.