Large Effect Research Articles

Abstract A040: Effects of food environment, income inequality, and racial segregation on obesity- related cancer mortality

Abstract BACKGROUND: Rural areas experience 7-12% higher risk of obesity-related cancer mortality compared to their urban counterparts. Complex interactions between social and structural factors in rural areas, combined with limited access to healthy foods and lower income, warrant further study to understand drivers of this disparity. Methods: County-level rates of age-adjusted obesity-related cancer mortality per 100,000 (2009-2020 were obtained from the Centers for Disease Control and Prevention’s Wide-Ranging ONline Data for Epidemiologic Research database. Based on data from the Food Environment Atlas, we calculated food swamp using the modified Retail Food Environment Index (mRFEI) as the ratio of fast-food restaurants and convenience stores to grocery and specialized food stores, supercenters, and farmers markets. Food swamp scores were then divided into quartiles. Next, we used Global G and local Gi statistics to identify the presence of spatial autocorrelation in food swamp and subsequently calculated a spatial moving average (SMA) across counties. Measures of economic segregation, racial segregation, and racialized economic segregation were calculated using the Index of Concentration at the Extremes (ICE) using population and demographic estimates from the 2005- 2009 American Community Survey. Larger values reflect concentrated extremes of disadvantage. Poisson regression was used to assess the impact of food swamp, urban-rural status, economic segregation, racial segregation, and racialized economic segregation on rates of obesity-related cancer mortality. Results: Among the 3014 counties included, median food swamp score was 3.6 (interquartile range=2.6-4.9), and counties in the 2nd, 3rd, and 4th quartiles for food swamp had 2%, 4%, and 6% higher rates (respectively) of obesity-related cancer mortality than those in the 1st quartile. Incidence rate ratios for the association of food swamp quartile with obesity-related cancer mortality were 1-3% smaller after control for food swamp SMA and for racialized economic Urban-rural differences in obesity-related cancer mortality varied with all ICE measures. Rural counties had 5% higher rates of obesity-related cancer mortality (IRR=1.05, 95%CI=1.04-1.06), even after controlling for food swamp and food swamp SMA, but there was no longer an association after controlling for economic segregation (IRR=0.99, 95%CI=0.98-1.00). Rural counties had 5% higher rates of obesity-related cancer mortality (IRR=1.05, 95%CI=1.04-1.07) when controlling for racial segregation and 2% higher rates when controlling for racialized economic segregation (IRR=1.02, 95%CI=1.01-1.03). Thus, we stratified our models by urban-rural status and found that each ICE measure had larger effects on obesity-related cancer mortality in rural counties than in urban. CONCLUSION: While food swamp is important, the socioeconomic environment of a county has a larger impact on obesity- related cancer mortality. Individuals may have access to healthy food stores, but whether they can afford the healthy food is more important. Citation Format: Elizabeth S. Davis, Sara Myers, Jeffrey A. Franks, Michael R. Poulson, Julie R. Palmer, Kelly M. Kenzik. Effects of food environment, income inequality, and racial segregation on obesity- related cancer mortality [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A040.

Genetic susceptibility to acute viral bronchiolitis

Abstract Background Acute viral bronchiolitis is a major cause of infant hospitalizations worldwide. Childhood bronchiolitis is considered a risk factor for asthma, suggesting shared genetic factors and biological pathways. Genetic risk loci may provide new insights into disease pathogenesis. Methods We conducted a genome-wide association study (GWAS) to examine the genetic contributions to bronchiolitis susceptibility in the FinnGen project data. We analyzed 1,465 infants hospitalized for bronchiolitis <2 years of age and 356,404 individuals without a history of acute lower respiratory infections (LRIs). Results GWAS identified associations (p<5×10-8) for variants in gasdermin B (GSDMB) and a missense variant in cadherin-related family member 3 (CDHR3). Children with bronchiolitis in infancy were more likely to develop asthma later in life compared to controls. The two associated loci were previously linked to asthma and susceptibility to wheezing illness by other causative agents than RSV. The identified loci associated with overall bronchiolitis, with larger effects in non-RSV than RSV-induced infection. Conclusion Our results suggest that genetic variants in CDHR3 and GSDMB modulate susceptibility to bronchiolitis, especially when caused by viruses other than RSV. Severe bronchiolitis in infancy may trigger the development of asthma in genetically susceptible individuals, or it could be a marker of genetic predisposition to asthma.

Erratum] Non-invasive brain stimulation in craving disorders: evidence-based umbrella review

INTRODUCTION: The use of brain stimulation in the control of craving disorders is controversial, mainly in relation to the best target, technique, duration, frequency and parameters. Several meta-analyses have been published, and their data should be summarized to support the best evidence-based clinical practice. OBJECTIVE: To provide the best level of evidence for the use of non-invasive brain stimulation (NIBS) in the control of craving disorders. METHODS: Umbrella review registraded on Prospero (CRD42021239577), and conducted according to PRISMA recommendations. The methodological quality and evidence level were assessed through AMSTAR, AMSTAR rank and GRADE. RESULTS: A total of 81 meta-analyses were screened and the final analysis was made on 10 studies including 224 randomized clinical trials (RCTs) enrolling 5,555 patients. The main targets of stimulation were the right, left and bi-hemispheric dorsolateral prefrontal cortices. The studies used anodal tDCS, and high-frequency rTMS. The protocols with the larger effect sizes were anodal tDCS with 2mA, for 30 minutes over the right DLPFC (g=0.45; 95%CI 0.328-0.583; p<0.001), and high-frequency rTMS (10Hz), with 100% of the resting motor threshold, over the left DLPFC (g=1.116; 95%CI 0.597-1.634; p<0.001). The quality of evidence ranged from very low to moderate because of inconsistencies mainly due to sample heterogeneity. CONCLUSION: The results of 10 meta-analyses assessing the efficacy of NIBS in the control of craving disorders are robust regarding the effect sizes and provide evidence that bi-hemispheric tDCS and high-frequency rTMS over the DLPFC are effective in the control of craving disorders. However, the evidence level is from low to moderate.

Physical and Social Servicescape: Impact on Customer Affection and Behavior at Full-Service Restaurants

ABSTRACT This study utilizes Stimulus Organism Response (SOR) theory to examine how customer, employee, and physical servicescape affect consumer behavior in full-service restaurants, as well as how customer affection mediates, and gender moderates these effects. We managed to collect 308 valid responses, which we further analyzed through structural equation modeling. The data supported the idea that customers, employees, and physical servicescape favorably affect customer affection, which in turn influences revisit intentions and WoM. Customer affection also mediates the effects of the three servicescape dimensions on WoM and revisit intentions. Males were more affected by employee servicescape and customer affection. Whereas females had a larger effect of customer servicescape on customer affection; other differences were insignificant. Within the SOR theory, we added customer affection as a mediator and gender as a moderator between servicescapes’ dimensions and behavioral outcomes (e.g. WoM and revisit intentions).

93 Ruminal archaea and bacteria metatranscriptomic responses to supplementation in steers fed low-quality forage

Abstract Forage comprises the majority of beef cattle diets globally, and its quality can vary. Supplementation presents a significant opportunity to improve the efficiency of production. Supplementation has been shown to increase ruminally available nitrogen, improve forage utilization, and reduce livestock methane (CH4) emissions. However, corresponding effects of supplementation on gene expression of rumen microbiota, in particular metabolic pathways involved in methanogenesis, have yet to be studied. This study aimed to evaluate the effect of supplement composition before and after feeding on rumen archaeal and bacterial gene expression in steers consuming a low-quality forage diet. Ruminal samples were collected from five ruminally cannulated Angus steers [body weight (BW) = 375 ± 45 kg] used in a 4 × 4 Latin square fed a basal diet of King Ranch Bluestem Hay (3.5% CP, 73% NDF), and one of four isonitrogenous (130 mg N/kg BW) supplements. Steers provided the two most divergent supplements (2% starch, 43% CP; 56% starch, 21% CP) were used for metatranscriptomic analysis. Rumen fluid samples were collected via rumen cannula 0 and 4 h post-feeding. Total RNA was extracted and sequenced. Differentially expressed genes (DEGs) were identified and functionally annotated. Pathway enrichment analysis was completed to determine enriched pathways (broad metabolic pathways) and modules (specific metabolic reactions). Only main effects are presented in this abstract. Archaeal hydrogenotrophic and methylotrophic methanogenesis reactions and tryptophan biosynthesis reactions were upregulated in the 2% starch supplement (P < 0.05). The 2% starch supplement resulted in fewer bacterial total upregulated carbohydrate-active enzymes compared with the 56% starch supplement (957 vs. 1,695 DEGs, respectively; P < 0.05), and an increased proportion of cellulose and hemicellulose-specific enzymes (35 vs. 29%, respectively; P < 0.05). The 56% starch supplement resulted in upregulation of the bacterial 3-Hydroxypropionate bi-cycle reaction (P < 0.05). Collection time exerted a larger effect than supplement composition on both archaeal and bacterial gene expression, with 83% and 63% of DEGs associated with time, respectively (P < 0.05). Archaeal hydrogenotrophic methanogenesis and carbon metabolism were upregulated 4 h post-feeding. In addition, 1,704 bacterial carbohydrate-active enzymes were upregulated 4 h post-feeding, as compared with 975 upregulated at 0 h (P < 0.05). However, these differences in DEGs did not correlate with significantly enriched pathways of bacterial carbohydrate metabolism. These findings demonstrate improvements to low-quality forage utilization, through CP and starch supplementation, can be correlated to relevant changes in gene expression of rumen microbiota. Furthermore, they demonstrate that supplementation influences the expression of methanogenesis reactions, suggesting an opportunity to affect CH4 production. Additional studies quantifying forage utilization, rumen microbiota gene expression and CH4 production are needed to further optimize supplementation strategies for improved efficiency of beef production whilst maintaining or reducing its carbon footprint.

Role of secondary hydrogen injection on flame stabilization of ammonia/air swirling flames

Ammonia is widely recognized as one of the most advanced hydrogen carriers and can be utilized as a fuel in gas turbines. Premixing hydrogen into the ammonia carbon free fuel system can substantially enhance stable limits, but it significantly promotes cross-reactions, leading to increased NO production. Recent findings related to other fuels suggest that the alternative approach for mitigating combustion instabilities involves introducing minimal pure hydrogen at the chamber inlet in a non-premixed mode. This may introduce a novel approach to stabilize ammonia/air swirl flames by extending the stability through a minimal hydrogen via secondary injection, with minimal impact on increasing nitrogen oxide emissions. In the present study, the flame stabilization mechanism and nitrogen oxide emission behaviors of swirl ammonia/air flames by a secondary hydrogen injection were compared with the premixed ammonia/ hydrogen/air flames. OH-/NO-PLIF and PIV techniques were applied to reveal the lean blow-off characteristics and the reacting flow features. The NOx emissions were measured by the FTIR gas analyzer. The large eddy simulation method with a developed dynamic thickened flame model was employed to further reveal the experimental findings. Experimental results show that the flame stabilization limits are largely depended on the way in which hydrogen is introduced. The secondary hydrogen injection exhibits the stronger enhancement ability for the lean/rich blow-off limits, primarily due to the local diffusion hydrogen flame at the flame root providing more active radicals and higher temperature gases. The NO emission shows an increase with the addition of premixed hydrogen, while in the secondary hydrogen injection, NO emission deteriorates due to higher temperatures, with the NO emission increasing by less than 10% compared with the ammonia flame. In the large eddy simulation analyses, the physical effects of the secondary hydrogen injection enhance the flame stability by increasing the resistance of the flame root to extinction. The heat release rate and the mass fractions of NH and H near the flame root are significantly increased by 2% secondary hydrogen injection. The enhancement of the ammonia decomposition process is stronger with secondary hydrogen injection than with fully premixed hydrogen addition. For 2% secondary hydrogen injection case, the local hydrogen injection to form a non-premixed combustion mode can provide much higher capability to increase the local heat release rate compared to the fully premixed mode.Novelty and significance statement: Introducing small amount of hydrogen to ammonia flame can effectively improving the flame stabilization in a swirl combustor. In this study, it is found that the flame stabilization limits are largely depended on the way in which hydrogen is introduced. Comparing the way of premixing hydrogen in the unburned mixture, a larger effect on blow-off limits extension was found when introducing a separate non-premixed hydrogen at the chamber inlet, which is mentioned as the secondary hydrogen injection. The lean blow-off limits can be extended from about 0.67 to 0.59 when only introducing 2% secondary hydrogen injection by heat value. The NO emission shows in the secondary hydrogen injection, NO emission deteriorates by less than 10% compared with the ammonia flame. A thickened flame model for non-premixed combustion was established and verified adequate with velocity field and flame structure. The mechanisms of enhancing flame stabilization by hydrogen introduction including physical and chemical effects for premixing and injection cases were revealed. Furthermore, the difference in the mechanisms of the two cases was emphasized.

The effects of foreign direct investment on human capital accumulation—Evidence from China

AbstractThis paper examines the effect of foreign direct investment (FDI) on human capital accumulation in China. The identification strategy exploits variations in FDI inflows across manufacturing sub‐sectors caused by China's FDI liberalisation and initial sectoral composition patterns across cities. Using a panel of city‐level data from 1990 to 2005, the paper shows that FDI liberalisation accelerated human capital accumulation. Cities with higher exposure to FDI liberalisation experienced higher growth in high school and college enrollment. FDI incentivizes individuals' investment in their human capital by paying a higher wage premium for skilled workers, pushing up the skill premium in the local labor market, and raising household income. Compared to export‐oriented FDI and FDI in less‐skilled industries, market‐seeking FDI and skill‐intensive FDI have a much larger effect on college enrollment.

Family Death During Upbringing and Maladaptive Personality Traits

Major depression and other serious mental health concerns appear to follow parental or sibling death for many child and adolescent survivors. While grief and depression remain a central focus in bereavement research, the impact of sibling and parental death on personality development remains incompletely understood. This study focused on coarser personality adaptations that may occur in response to childhood or adolescent grief. Analysis was conducted on a crowdsourced survey sample (N = 2,398) which included respondents with parent (n = 143) or sibling (n = 102) death prior to age of 17. Parental death was associated with Callousness and Hostility as personality dimensions. Sibling death was linked to higher Callousness, Hostility, Physical Aggression, Depressivity, and Hypomanic trait scores. Callousness elevations (>1 SD) were more common among respondents classified in the sibling and parental bereavement groups (ORs of 3.02 & 2.17, respectively). Significant differences were found after control of variance associated with respondent age and childhood adversity exposure count. Parent and sibling suicide exclusions reduced trait differences between the bereaved and nonbereaved respondents. Sibling death was associated with more trait differences and larger effect sizes than parental loss. Questions remain regarding the nature of the psychological conditions that differentiate normative, resilient, and callous personality adaptations in the aftermath of early family tragedy. The prognostic value of the DSM-5-TR traumatic bereavement specifier was discussed.

Community representation and policing: Effects on Black civilians

AbstractDoes increased representation of Black individuals in the police force lead to less aggressive policing of Black individuals? The current study uses a Chicago panel data set with monthly police unit observations between 2013 and 2015 to understand 1) how police units’ representation of Black individuals affects the number of stops of Black residents and 2) how individual police officers patrol differently depending on the racial/ethnic background of co‐working officers. Using fixed‐effects negative binomial regression, we found that increasing racial congruence between police officers and the community being patrolled was associated over time with fewer stops of Black residents. Individual analyses showed that Black (vs. White) officers stopped fewer Black civilians, with larger effects in police units with higher percentages of Black officers, indicating a unit group effect. Furthermore, as the number of Black officer co‐workers in a shift increased, Black civilian stops declined for all officers, including White officers, which is consistent with active representation. These findings indicate that a more diverse and representative police force can reduce aggressive policing of minority communities by mitigating group threat and cultivating positive cross‐racial exchanges within police organizations and smaller peer groups.

A systematic review and Bayesian meta-analysis of 30 years of stress generation research: Clinical, psychological, and sociodemographic risk and protective factors for prospective negative life events.

Stress generation posits that (a) individuals at-risk for psychopathology may inadvertently experience higher rates of prospective dependent stress (i.e., stressors that are in part influenced by their thoughts and behaviors) but not independent stress (i.e., stressors occurring outside their influence), and (b) this elevated dependent stress, in some measure, is what places these individuals at-risk for future psychopathology. In recognition of 30 years of stress generation research, we conducted a systematic review and meta-analysis using frequentist and Bayesian approaches (102 articles with 104 eligible studies, N = 31,541). Generally strong support was found for psychopathology predicting dependent stress (e.g., dsOverall psychopathology = 0.36-0.52, BF₁₀ = 946.00 to 4.65 × 10¹⁸). Moderator analyses for dependent stress revealed larger effects for briefer assessments periods, shorter follow-ups, and self-report measures than for interviews. Among risk factors, depressogenic cognitive styles (ds = .26-.50, BF₁₀ = 47.50 to 1.00 × 10⁵) and general interpersonal vulnerability (ds = .26-.44, BF₁₀ = 2.72 to 2708.00) received the strongest support as stress generation mechanisms, and current evidence is modest for protective factors predicting dependent stress. Overall, larger effects were generally found for prospective prediction of dependent stress than independent stress. Evaluations of mediation in the research literature were relatively few, limiting the current review to qualitative analysis of the mediation component of stress generation. General support was found, however, for dependent stress as a mediator for psychopathology and associated risk factors in relation to subsequent psychopathology. The current review ends with recommendations for future research and integration of stress generation within minority stress frameworks. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring

BackgroundPrevious work indicates that polygenic risk scores (PRS) for bipolar disorder (BD) are elevated in adults and youth with BD, but whether BD-PRS can inform person-level diagnostic prediction is unknown. Here, we test whether BD-PRS improves performance of a previously published risk calculator (RC) for BD. Methods156 parents with BD-I/II and their offspring ages 6–18 were recruited and evaluated with standardized diagnostic assessments every two years for >12 years. DNA was extracted from saliva samples, genotyping performed, and BD-PRS calculated based on a 2021 meta-analysis. Using a bootstrapped and cross-validated penalized Cox regression, we assessed whether BD-PRS (alone and interacting with clinical variables) improved RC performance. ResultsOf 227 offspring, 38 developed BD during follow-up. The penalized regression selected BD-PRS and interactions between BD-PRS and parental age at mood disorder onset (AAO), depression, and anxiety. The resulting RC discriminated offspring who developed BD (vs. those that did not) with good accuracy (AUC = 0.81); removing BD-PRS and its interaction terms was associated with a significant decrement to the AUC (decrement = 0.07, p = 0.039). Further exploration of selected interaction terms indicated that all were significant (p-values<0.02), indicating that BD-PRS has a larger effect on the outcome in offspring with depression and anxiety, whose affected parent had a younger AAO. ConclusionsThe addition of BD-PRS to clinical/demographic predictors in the RC significantly improved its accuracy. BD-PRS predicted BD on the person-level, particularly in offspring of parents with earlier AAO who already had symptoms of anxiety and depression at intake.

α-Synuclein strain propagation is independent of cellular prion protein expression in a transgenic synucleinopathy mouse model.

The cellular prion protein, PrPC, has been postulated to function as a receptor for α-synuclein, potentially facilitating cell-to-cell spreading and/or toxicity of α-synuclein aggregates in neurodegenerative disorders such as Parkinson's disease. Previously, we generated the "Salt (S)" and "No Salt (NS)" strains of α-synuclein aggregates that cause distinct pathological phenotypes in M83 transgenic mice overexpressing A53T-mutant human α-synuclein. To test the hypothesis that PrPC facilitates the propagation of α-synuclein aggregates, we produced M83 mice that either express or do not express PrPC. Following intracerebral inoculation with the S or NS strain, the absence of PrPC in M83 mice did not prevent disease development and had minimal influence on α-synuclein strain-specified attributes such as the extent of cerebral α-synuclein deposition, selective targeting of specific brain regions and cell types, the morphology of induced α-synuclein deposits, and the structural fingerprints of protease-resistant α-synuclein aggregates. Likewise, there were no appreciable differences in disease manifestation between PrPC-expressing and PrPC-lacking M83 mice following intraperitoneal inoculation of the S strain. Interestingly, intraperitoneal inoculation with the NS strain resulted in two distinct disease phenotypes, indicative of α-synuclein strain evolution, but this was also independent of PrPC expression. Overall, these results suggest that PrPC plays at most a minor role in the propagation, neuroinvasion, and evolution of α-synuclein strains in mice that express A53T-mutant human α-synuclein. Thus, other putative receptors or cell-to-cell propagation mechanisms may have a larger effect on the spread of α-synuclein aggregates during disease.

Team-based Learning (TBL) in Medical Education: Fostering Collaboration and Enhancing Learning Outcomes

ABSTRACT Background and Aim: Team-based learning (TBL) is an instructional strategy that has gained popularity in various educational settings, including anatomy courses. It is an active learning approach that encourages students to work collaboratively in small teams to solve problems, discuss concepts, and apply their knowledge. Therefore, the purpose of this study was to assess how well students engaged with and learned about anatomy through the medium of TBL. Materials and Methods: The current study was carried out for phase I MBBS students in the Department of Anatomy at KAHER’s J N Medical College, Belagavi. TBL sessions included 65 students. One week prior, students were provided pertinent reading materials for the gross anatomy topics that were chosen. The Pre-TBL test, which was composed of five MCQs based on case scenarios, was administered before the start of the session. Students completed the Individual Readiness Assurance Test (IRAT), which had ten multiple-choice questions (MCQs) at the start of the class. The students were then put into groups where they collaborated on the same MCQs, talked about the topics, and provided identical answers. This is called the Group Readiness Assurance Test (GRAT). A post-TBL test was given after the case scenario discussion to wrap up the session. This test’s questions were the same as those on the Pre-TBL. Results: The effect sizes provide insights into the magnitude of change observed between pre-TBL and post-TBL test scores. In this study, significant statistical differences were found between pre and post-TBL tests across all sessions [Table 1, P &lt; 0.001], indicating larger effect sizes associated with more significant improvements in learning outcomes attributed to TBL. This aids in interpreting the statistical significance of the results. Conclusion: TBL can help students achieve academic success through teamwork. Study revealed that TBL is one of the most effective ways to teach anatomy and can complement traditional didactic lectures.

Intraocular Lens Power and Corneal Topographic Change After Pterygium Surgery: Pterygium Effects on IOL Power Calculation

PurposeTo investigate the impact of pterygium excision on intraocular lens (IOL) power calculation and corneal astigmatism. DesignsProspective cohort study MethodsWe enrolled 30 eyes with primary pterygium that underwent pterygium excision with a conjunctival autograft. IOL power calculation and keratometry using the IOL Master 700, along with topographic parameters using the Pentacam Scheimpflug topography system, were performed preoperatively and at 1, 3, 6, and 12 months postoperatively. We analyzed correlations between pterygium length/area and IOL power, as well as corneal topographic changes. ResultsThe mean pterygium length was 2.08 ± 0.58 mm, and the mean area was 6.05 ± 2.41 mm2. One year after pterygium surgery, the calculated IOL power values using all formulas were lower than the preoperative values. Pterygia with a horizontal length of 1.73 mm and an area of 4.45 mm2, and those with a horizontal length of 2.25 mm and an area of 6.95 mm2 created 0.5 D and 1.0 D errors in calculated IOL power, respectively (p<0.001). The calculated IOL power values changed significantly from preoperative to six months postoperatively but did not change significantly from six to 12 months postoperatively. Pterygia with a horizontal length greater than 1.83 mm (p<0.001) and an area greater than 5.1 mm2 (p < 0.001) created a 2.0 D error in anterior corneal astigmatism. ConclusionsPterygium causes errors in IOL power calculation, with greater pterygium length/area exerting a larger effect. Cataract surgery with IOL implantation is recommended at least six months after pterygium surgery. In combined case, calculated IOL power should be decreased by 0.5-1.5 D based on the pterygium length/area.

Quantification choices for individual differences: An example of mapping self-report to psychophysiological responses

A popular focus in affective neuroscience research has been to map the relationships between individual differences (e.g. personality and environmental experiences) and psychophysiological responses, in order to further understand the effect of individual differences upon neurobehavioral systems that support affect and arousal. Despite this trend, there have been a lack of practical examples demonstrating how the quantification of individual differences (e.g. categorical or continuous) impacts the observed relationships between different units of analysis (e.g. self-report > psychophysiological responses). To address this gap, we conducted a two-stage aggregated meta-analysis of self-reported intolerance of uncertainty (IU) and skin conductance responses during threat extinction (k = 18, n = 1006) using different quantification choices for individual differences in self-reported intolerance of uncertainty (continuous, categorical via median split, and categorical via extremes – one standard deviation above/below). Results from the meta-analyses revealed that the different quantification techniques produced some consistent (e.g. higher IU was significantly associated with skin conductance responding during late extinction training) and inconsistent IU-related effects. Furthermore, the number of statistically significant effects and effect sizes varied based on the quantification of individual differences in IU (e.g. categorical, compared to continuous was associated with more statistically significant effects, and larger effect sizes). The current study highlights how conducting different quantification methods for individual differences may help researchers understand the individual difference construct of interest (e.g. characterisation, measurement), as well as examine the stability and reliability of individual difference-based effects and correspondence between various units of analysis.

Impact of trade on industry-level output

This study examines whether a country's trade significantly increases industry-level output and whether this impact is greater for industries with higher levels of differentiation. To empirically answer these questions, the Frankel and Romer [(1999). “Does Trade Cause Growth?” American Economic Review 89 (3): 379–399] method, which uses the geographical component of trade as an instrument, is extended in two ways. First, the study examines the impacts on industry-level output instead of country-level output. Second, an index of industry differentiation based on Rauch [(1999). Networks Versus Markets in International Trade.” Journal of International Economics 48 (1): 7–35] is introduced. Using a two-stage least squares estimation and data for 20 manufacturing industries and 99 countries in 2015, it is found that the impact of a country’s trade on industry-level output and output per worker is heterogeneous across industries. A one-percentage-point increase in the trade/GDP ratio results in a larger effect for industries with higher degrees of differentiation, ranging from 0.340% to 1.736% for industrial output and from 0.754% to 1.566% for industrial output per worker. This heterogeneity with respect to industry differentiation is robust even when controlling for latitude and institutional variables. These results suggest that a country’s trade affects industry-level output differently depending on the industry’s level of differentiation.

Exercise and Acute Cognitive Enhancement.

Substantial research has explored the effects of a single session of exercise on cognitive performance. Meta-analytic reviews provide summary statistics relative to these effects when the cognitive task is performed while exercising and when performed after exercise. When performed concomitantly the effects of exercise are typically small or negative with the exception of moderate effects for speed of cognitive performance during moderate intensity exercise. When cognitive performance is assessed following the cessation of exercise, the effects are typically positive. When considering the effects following exercise, most studies have focused on executive function and episodic memory as the cognitive outcomes of interest with meta-analyses supporting small-to-moderate benefits. When potential moderators related to exercise parameters or participants characteristics are examined, results suggest that 20 minutes of moderate to vigorous intensity exercise consistently benefits performance with larger effects evident for executive function tasks with higher cognitive demands, for long-term memory tasks when exercise is performed prior to information encoding, and when considering individuals with lower initial cognitive performance levels. These observed benefits are likely due to the impacts acute exercise can have on physiological arousal, brain function, and brain neurotrophic factors. Advancements in our understanding of the potential of a single session of exercise to benefit cognitive performance are important for exercise prescription and to inform chronic exercise programs designed to benefit cognition.

Heart Rate Variability Biofeedback as a Treatment for Military PTSD: A Meta-Analysis.

Emerging research has provided tentative support for the use of heart rate variability biofeedback (HRVB) as a treatment for several psychological disorders, with meta-analyses providing compelling evidence for HRVB as a promising treatment for anxiety, depression, and PTSD. Given the prevalence of PTSD in military veterans and the comparatively lower benefit and higher attrition rate of traditional psychological treatment for PTSD relative to civilian counterparts, it is important to examine complementary and alternative treatment approaches such as HRVB in this population. Although studies of HRVB for PTSD have been conducted with military veterans, they have involved relatively small sample sizes, limiting interpretation. To address this, the current article presents a comprehensive meta-analysis, consolidating existing literature to more accurately evaluate the efficacy of HRVB in reducing PTSD symptoms within military populations. This meta-analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and our protocol was registered with PROSPERO to increase review transparency. A literature search of HRVB interventions was conducted using PubMed, PsycINFO, Military Database, PTSDPubs, and EBSCO's Psychological and Behavioral Sciences Collection. Five studies met eligibility criteria, providing a combined sample size of 95 military services members. For all studies, effect sizes were negative, indicating a reduction in PTSD symptoms. Effect sizes ranged from -1.614 to -0.414, resulting in an overall moderate to large mean effect for HRVB (Hedges's g = -0.557; 95% confidence interval = -0.818 to -0.296; P < .001). Additionally, cumulative attrition was 5.8%, significantly lower than commonly reported rates for evidence-based treatments (16%-36%). The present study is the first meta-analysis to examine HRVB as a treatment for military service members with PTSD. Results indicate that HRVB may be a viable treatment approach to reduce PTSD symptomatology. Low attrition rates, ease of accessibility, and favorable participant outlook serve as additional benefits for the use of HRVB.

Immorality backward, morality forward? Metaphorical morality in Chinese-English bilinguals.

This study explored whether instructing participants to make forward or backward joystick movements in response to morality words is consistent with the conceptual metaphor MORAL IS MOVING FORWARD/IMMORAL IS MOVING BACKWARD in Chinese-English bilinguals' first and second languages. Chinese-English bilinguals were instructed to categorize words as moral or immoral while moving a joystick in a compatible block (moral-forward, immoral-backward) and an incompatible block (moral-backward, immoral-forward). The results revealed three main conclusions: First, participants showed faster categorization of immoral words when their responses involved backward joystick movements compared to forward joystick movements. Second, participants also demonstrated a slightly faster categorization of moral words when their responses involved backward joystick movements compared to forward joystick movements. Third, Chinese morality words were categorized faster overall than English morality words. However, despite a slightly larger effect size observed in L1, the action compatibility effects for morality words exhibited a similar pattern across both languages. In sum, bilinguals showed shared access to the IMMORAL IS MOVING BACKWARD conceptual metaphor across both L1 and L2, but they did not access the MORAL IS MOVING FORWARD conceptual metaphor in either L1 or L2. This study provides new evidence supporting the conceptual metaphor theory.

Field-induced slow magnetic relaxation in a mononuclear Dy(III) complex with octahedral geometry

We have synthesized a mononuclear Dy(III)-based complex, [Dy(CyPh2PO)3Cl3)] (1) (CyPh2PO = cyclohexylbisphenylphosphine oxide), constructed from a phosphine oxide ligand and a light halogen Cl donor. The Dy(III) ion presents an octahedral geometry where two O atoms from two phosphine ligands locate at two vertexes, while the equatorial positions are completed by three Cl anions and a O atom from another phosphine ligand. Magnetism results reveal that slow relaxation of the magnetizations exists in 1 under an extra dc field because of the significant quantum tunnelling of magnetization (QTM) at 0 Oe dc field. The lighter Cl ions in equatorial plane result in a larger effect to QTM, and thus smaller contribution to slow magnetic relaxation.