Large Amounts Of Fluid Research Articles

Liquid absorbent bamboo fiber foams: Towards 100% ligno-cellulosic menstrual absorbent pads

Traditional menstrual absorbent pads typically combine cellulose fiber fluff pulp with non-biodegradable, petroleum-based superabsorbent polymers (SAPs). To eliminate the need for SAPs, this study explores foaming as a method to create a highly porous lignocellulosic fiber network capable of storing large amounts of fluid. Bamboo fibers were chosen due to their high lignin content, which is expected to help maintain the structural integrity of the porous network during liquid absorption and preventing collapse compared to 100% cellulose fibers. The bamboo fiber foams demonstrated remarkable porosity and superior absorbency compared to commercial pads, but they exhibited lower water retention when subjected to compression. Refining the fibers and incorporating microfibrillated cellulose offer promising opportunities to enhance water retention.

A Comparative Study between Epidural Morphine Bolus and Ropivacaine-fentanyl Infusion in Gastrointestinal Oncosurgeries: A Randomised Clinical Trial (MORFIN Study)

Background and Aims: Epidural local anaesthetic infusion is the gold standard analgesia technique after abdominal surgery. However, hypotension associated with it often leads to the administration of large amounts of fluid, increased vasopressor requirement, reduction of epidural drug dose and thus increased intravenous opioid consumption. Epidural morphine can be an alternative technique. Methods: Eighty-six patients scheduled for open elective gastrointestinal (GI) oncosurgery were enroled in the study. In Group ROP, analgesia was provided with a 6 ml bolus of epidural ropivacaine (0.2%)-fentanyl (2 µg/ml) followed by an infusion at 3–10 ml/h during the perioperative period. In Group MOR, a bolus of epidural morphine 0.05 mg/kg in 10 ml bupivacaine 0.1% was administered every 8–24 h. In both groups, rescue analgesia was provided with intravenous fentanyl. The primary outcome of the study was to compare post-operative fentanyl consumption between the two groups. Results: Mean ± standard deviation (95% confidence interval) fentanyl consumption was significantly lower in Group MOR in the first 24 h (92 ± 191 [33, 151] vs. 255 ± 263 [173, 338] µg in Group ROP; P < 0.01), 24–48 h (71 ± 203 [9, 134] in Group MOR vs. 261 ± 357 [150, 372] in Group ROP; P < 0.001) and 48–72 h (51 ± 168 [0, 103] in Group MOR vs. 240 ± 319 [140, 339] in Group ROP; P < 0.001) in the post-operative period. Pain scores at rest and during movement were significantly lower in group MOR in the immediate post-operative period. The post-operative fluid requirement in the first 24 h was also significantly lower. Conclusion: Intermittent boluses of epidural morphine with low-dose bupivacaine are associated with lesser post-operative fentanyl consumption compared to epidural ropivacaine-fentanyl infusion after GI oncosurgery.

Recurrent Massive Hydrothorax in a Patient with Decompensated Liver Cirrhosis

Aim: to demonstrate the need for a detailed differential diagnosis and selection of therapy in a patient with decompensated liver cirrhosis of combined etiology (HCV infection and primary sclerosing cholangitis). Key points. The patient came to the clinic with complaints of shortness of breath with minimal physical activity, abdominal enlargement, swelling of the legs, yellowness of the skin, and severe weakness. The complaints arose two months after suffering from left-sided focal pneumonia. Laboratory tests revealed signs of systemic inflammation, liver failure, and acute kidney injury. According to the results of instrumental studies, massive hydrothorax was noted in the right pleural cavity. The patient underwent a series of thoracentesis, and a total of about four liters of non-inflammatory pleural fluid was evacuated. Differential diagnosis was based on the presence of dyspnea and respiratory failure. The patient received effective antiviral therapy with drugs using an interferon-free regimen. Subsequently, conservative therapy was carried out, against the background of which the symptoms regressed and the patient’s condition improved. Conclusions. Hepatopleural syndrome is a serious complication in patients with decompensated liver cirrhosis, although it does not always appear secondary to massive ascites. To resolve hepatic hydrothorax, it is necessary to carry out diuretic therapy, replacement transfusion therapy with albumin preparations, and if there is a large amount of fluid in the pleural cavities, therapeutic and diagnostic thoracentesis is recommended.

Micelle-Containing Hydrogels and Their Applications in Biomedical Research.

Hydrogels are one of the most commonly used materials in our daily lives, which possess crosslinked three-dimensional network structures and are capable of absorbing large amounts of fluid. Due to their outstanding properties, such as flexibility, tunability, and biocompatibility, hydrogels have been widely employed in biomedical research and clinics, especially in on-demand drug release. However, traditional hydrogels face various limitations, e.g., the delivery of hydrophobic drugs due to their highly hydrophilic interior environment. Therefore, micelle-containing hydrogels have been designed and developed, which possess both hydrophilic and hydrophobic microenvironments and enable the storage of diverse cargos. Based on the functionalities of micelles, these hydrogels can be classified into micelle-doped and chemically/physically crosslinked types, which were reported to be responsive to varied stimuli, including temperature, pH, irradiation, electrical signal, magnetic field, etc. Here, we summarize the research advances of micelle-containing hydrogels and provide perspectives on their applications in the biomedical field based on the recent studies from our own lab and others.

Tracing the Scale of Fluid Flow in Subduction Zone Forearcs: Implications from Fluid-Mobile elements

Despite the importance of fluids in subduction zone processes, the extent of mass transfer and fluid circulation from the subducting plate through the forearc region remain unclear. To estimate the fluid budget and scale of fluid circulation in subducted sediments, we assess the distribution and retention of fluid-mobile elements (FME) in metamorphically equivalent metapelites from the Kodiak complex (Alaska) and the Shimanto Belt (Japan). The temperature range of interest is 230–350 °C, i.e., encompasses the base of the seismogenic zone. We examine the Li, B, Rb, Sr, Cs, and Ba concentrations in the bulk rock, as well as in fluid inclusions and individual minerals by (LA-) ICP-MS.The whole-rock composition in metapelites from Kodiak shows no significant loss of FME, which is in contrast to Shimanto where between 10% and 55% of FME (particularly Li, B and Cs) are leached out of rocks. The FME budget in Kodiak is consistent with a redistribution of elements between metamorphic illite and chlorite, whereas in Shimanto the loss of Li, B and Cs as temperature increases is the result of decreasing concentrations in illite and chlorite. The semi-quantitative analysis of fluid inclusions is consistent with a significant enrichment in all analyzed trace elements relative to seawater and interstitial pore fluids of seafloor sediments.Combining the fluid compositions with the whole-rock compositions, mass balance calculations were performed for B, Cs, and Ba. In the Kodiak complex the mass balance calculations are consistent with closed-system behavior, wherein the fluid is an insignificant reservoir for FME. Conversely, in the Shimanto Belt the mass balance calculations are consistent with open-system behavior, wherein large amounts of fluid percolated through rocks and the mass water-rock ratios correspond to 0.5–2.2. We infer that such an open system behavior was promoted by a larger amount of internal strain and the proximity to a large-scale fault zone. Moreover, fluid compositions observed in this study exhibit similarities to the composition of mud volcano fluids. This similarity is consistent with extensive, focused fluid circulation originating from depths of at least 15 km and ascending to the surface through a substantial damage zone associated with an out-of-sequence thrust.

Establishment and evaluation of a rabbit model of frozen shoulder induced by persistent strain injuries and ice compression

To evaluate the rabbit modle of frozen shoulder induced by persistent strain injuries and ice compression. Twelve clean, healthy male New Zealand rabbits with a mass of (2 500±500) g were selected and randomly divided into a blank group and a control group with 6 rabbits in each group. In the control group, the rabbits were modeled with persistent strain injuries and ice compression, the general conditions of the rabbits and the active and passive activities of the shoulder joint were observed and their body weights were recorded. MRI was performed on the affected shoulder joints at 6 d and 29 d after modelling to observe the fluid and soft tissue;HE staining was used to observe the morphology of the rabbit biceps longus tendon and the synovial membrane of the joint capsule;Masson staining was used to observe the fibrous deposits of the rabbit biceps longus tendon and the synovial membrane of the joint capsule, and the fibrous deposits were analysed semi-quantitatively by Image J software. Six days after the end of modeling, the active movement of the shoulder joints in the control group was limited, the passive movement was not significantly limited, and they walked with a limp;29 days after the end of the modeling, the active and passive movements of the shoulder joints in the model group were severely limited. Compared with the blank group (2.50±0.14) kg, the body weight of the model group (2.20±0.17) kg was significantly reduced(P<0.01). MRI showed that 6 days after modelling, the muscles around the shoulder joint were not smooth in shape, the joint capsule structure was narrowed and a large amount of fluid was seen in the joint cavity;29 days after modelling, the muscles around the shoulder joint were rough in shape, structure of the joint capsule was unclear and the fluid in the joint cavity was reduced compared with 6 days after modelling. Pathological staining showed that the long-headed biceps tendon fibres in the control group were disorganised, curled or even broken, and the synovial tissue of the joint capsule was heavily vascularised, with collagen fibre deposits and severe inflammatory cell infiltration. The fiber deposition of the long head of biceps brachii in the model group [(23.58±3.41)%, (27.56±3.70)%] and synovial tissue [(41.78±5.59)%, (62.19±7.54)%] were significantly higher than those in the blank group [(1.79±1.03) %, (1.29±0.63) %] at 7 and 30 days after modeling and synovial tissue fiber deposition [(8.15±3.61) %, (11.29±7.10) %], as shown by the semi-quantitative analysis of Masson staining results by Image J software. And the longer the time, the more severe the fibrosis (P<0.01). The behavioral, imaging and pathological findings showed that the rabbit frozen shoulder model with persistent strain injuries and ice compression is consistent with the clinical manifestations and pathogenesis of periarthritis, making it an ideal method for periarthritis research.

Three-dimensional VP, VS, and VP/VS imaging based on AI microseismic detection reveals the mechanism of induced earthquakes in the Xiluodu Reservoir Area, China

The Xiluodu Reservoir (XLD), the third hydropower station developed downstream of the Jinsha River, is currently the fourth largest hydropower station worldwide. The reservoir has been impounded for 10 years, and numerous earthquakes have occurred, thus indicating an increased seismic risk. In existing studies, the deep tectonics and fine-scale structure in the reservoir area have not been sufficiently explained. Thus, the mechanism underlying reservoir-induced seismicity in this area remains unclear. In this study, we utilized a microseismic catalogue compiled based on the LOC-FLOW workflow (Li et al., 2023), alongside long-term observation data from a dense seismic array in the Jinsha River downstream, to obtain high-precision 3D VP, VS and VP/VS structures, as well as refined seismic relocations in the XLD Reservoir area. Additionally, we incorporated petrological, geomagnetic, gravity, crustal density, geodetic observation and numerical simulation data, which demonstrate that seismicity in the reservoir head area and near the Manao Fault is influenced by fluids. Moreover, the two M4 earthquakes that occurred east of the Lianfeng Fault are indicative of tectonic activity. Of these earthquakes, the Tianba earthquake cluster in the reservoir head area is located in a high-VP/VS zone, while a low-VS anomaly channel is observed here, which suggests that large amounts of fluid infiltrated along the fault, increasing the pore pressure and reducing the effective stress on the fault. The Wuji earthquake cluster in the head area is also located in a low-VP/VS zone, which indicates a low porosity and possibly undrained conditions. Thus, the earthquakes in this area are the result of coupled elastic stress-pore water pressure interactions.

A Slow-Exchange Interstitial Fluid Compartment in Volunteers and Anesthetized Patients: Kinetic Analysis and Physiology.

Physiological studies suggest that the interstitial space contains 2 fluid compartments, but no analysis has been performed to quantify their sizes and turnover rates. Retrospective data were retrieved from 270 experiments where Ringer's solution of between 238 and 2750 mL (mean, 1487 mL) had been administered by intravenous infusion to awake and anesthetized humans (mean age 39 years, 47% females). Urinary excretion and hemoglobin-derived plasma dilution served as input variables in a volume kinetic analysis using mixed-models software. The kinetic analysis successfully separated 2 interstitial fluid compartments. One equilibrated rapidly with the plasma and the other equilibrated slowly. General anesthesia doubled the rate constants for fluid entering these 2 compartments (from 0.072 to 0.155 and from 0.026 to 0.080 min -1 , respectively). The return flows to the plasma were impeded by intensive fluid therapy; the rate constant for the fast-exchange compartment decreased from 0.251 to 0.050 when the infusion time increased from 15 to 60 minutes, and the rate constant for the slow-exchange compartment decreased from 0.019 to 0.005 when the infused volume increased from 500 to 1500 mL. The slow-exchange compartment became disproportionately expanded when larger fluid volumes were infused and even attained an unphysiologically large size when general anesthesia was added, suggesting that the flow of fluid was restrained and not solely determined by hydrostatic and oncotic forces. The dependence of the slow-exchange compartment on general anesthesia, crystalloid infusion rate, and infusion volume all suggest a causal physiological process. Kinetic analysis supported that Ringer's solution distributes in 2 interstitial compartments with different turnover times. The slow compartment became dominant when large amounts of fluid were infused and during general anesthesia. These findings may explain why fluid accumulates in peripheral tissues during surgery and why infused fluid can remain in the body for several days after general anesthesia.

Role of CFTR in diabetes-induced pancreatic ductal fluid and HCO3 - secretion.

Type 1 diabetes is a disease of the endocrine pancreas; however, it also affects exocrine function. Although most studies have examined the effects of diabetes on acinar cells, much less is known regarding ductal cells, despite their important protective function in the pancreas. Therefore, we investigated the effect of diabetes on ductal function. Diabetes was induced in wild-type and cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice following an i.p. administration of streptozotocin. Pancreatic ductal fluid and HCO3 - secretion were determined using fluid secretion measurements and fluorescence microscopy, respectively. The expression of ion transporters was measured by real-time PCR and immunohistochemistry. Transmission electron microscopy was used for the morphological characterization of the pancreas. Serum secretin and cholecystokinin levels were measured by an enzyme-linked immunosorbent assay. Ductal fluid and HCO3 - secretion, CFTR activity, and the expression of CFTR, Na+ /H+ exchanger-1, anoctamine-1 and aquaporin-1 were significantly elevated in diabetic mice. Acute or chronic glucose treatment did not affect HCO3 - secretion, but increased alkalizing transporter activity. Inhibition of CFTR significantly reduced HCO3 - secretion in both normal and diabetic mice. Serum levels of secretin and cholecystokinin were unchanged, but the expression of secretin receptors significantly increased in diabetic mice. Diabetes increases fluid and HCO3 - secretion in pancreatic ductal cells, which is associated with the increased function of ion and water transporters, particularly CFTR. KEY POINTS: There is a lively interaction between the exocrine and endocrine pancreas not only under physiological conditions, but also under pathophysiological conditions The most common disease affecting the endocrine part is type-1 diabetes mellitus (T1DM), which is often associated with pancreatic exocrine insufficiency Compared with acinar cells, there is considerably less information regarding the effect of diabetes on pancreatic ductal epithelial cells, despite the fact that the large amount of fluid and HCO3 - produced by ductal cells is essential for maintaining normal pancreatic functions Ductal fluid and HCO3 - secretion increase in T1DM, in which increased cystic fibrosis transmembrane conductance regulator activation plays a central role. We have identified a novel interaction between T1DM and ductal cells. Presumably, the increased ductal secretion represents a defence mechanism in the prevention of diabetes, but further studies are needed to clarify this issue.

The 2024 Mj 7.6 Noto Peninsula, Japan earthquake caused by the fluid flow in the crust

On January 1, 2024 ​at 16:10:09 JST, an Mj 7.6 earthquake struck the Noto Peninsula in the southern part of the Sea of Japan. This location has been experiencing an earthquake swarm for more than three years. Here, we provide an overview of this earthquake, focusing on the slip distribution of the mainshock and its relationship with the preceding swarm. We also reexamined the source areas of other large earthquakes that occurred around the Sea of Japan in the past and compared them with the Matsushiro earthquake swarm in central Japan from 1964 to 1968. The difference between the Matsushiro earthquake swarm and the Noto earthquake swarm is the surrounding stress field. The Matsushiro earthquake swarm was a strike-slip stress field, so the cracks in the crust were oriented vertically. This allowed fluids seeped from the depths to rise and flow out to the surface. On the other hand, the Noto area was a reverse fault stress field. Therefore, the cracks in the earth's crust were oriented horizontally. Fluids flowing underground in deep areas could not rise and spread over a wide area in the horizontal plane. This may have caused a large amount of fluid to accumulate underground, triggering a large earthquake. Although our proposed mechanism does not take into account other complex geological conditions into consideration, it may provide a simple way to explain why the Noto swarm is followed by a large earthquake while other swarms are not.

A Comparison of Pumping Infusion-Induced Contamination With Different Syringe Types.

Health care providers use several types of syringes in their daily routine to provide or safely deliver therapeutic agents to patients. Pump infusion with a syringe (PIS) are used for the rapid delivery of large amounts of fluid or blood to patients in critical conditions, such as hypovolemic shock. Patients often experience bacterial infections, such as catheter-related bloodstream infections, specifically when they are in critical condition in the intensive care unit (ICU) after surgery or undergoing resuscitation in an emergency department. A previous study has shown that PIS may cause intraluminal contamination. This study compared PIS-induced contamination among different types of available syringes, including disposable plastic syringes produced by several companies, glass syringes, and syringes with plastic covers. The authors found that plastic syringes caused approximately equivalent PIS-induced contamination and that glass syringes caused substantially more contamination than plastic syringes. However, syringes equipped with a plastic cover exhibited no contamination. Furthermore, disinfection with ethanol completely prevented PIS-induced contamination. This study supports the evidence that PIS may cause bacterial contamination and that a thorough aseptic technique is needed, especially when using glass syringes. These findings highlight the need to develop alternative devices for rapid infusion.

Understanding and addressing the cholera outbreak in Zambian communities

Cholera is a bacterial infection caused by the Vibrio cholera bacterium, primarily transmitted through contaminated water and food. The effects of cholera on health can be severe and potentially life-threatening. The hallmark symptom of cholera is acute watery diarrhea, which can lead to rapid dehydration and electrolyte imbalance. As the body loses large amounts of fluid and essential salts, individuals with cholera often experience intense thirst, dry mucous membranes, sunken eyes, and lethargy. If left untreated, the dehydration can progress rapidly, causing a dangerous condition known as choleric dehydration and in most cases death. Hence, the study was conducted to analyze the effects of cholera on health in selected communities of Lusaka district in Zambia. The study employed both qualitative and quantitative methods and a descriptive survey design that sampled 42 participants purposively and conveniently. Data was obtained from the respondents by means of questionnaires and record reading. The data was analyzed by the use of software; Statistical Package for Social Sciences (version 26) and Microsoft Excel (version 16). Frequency tables, graphs, figures, and pie charts were also used to analyze the data. The findings revealed that the effect of cholera on health extends beyond dehydration, affecting various organ systems. Severe cases may lead to hypovolemic shock, characterized by a significant drop in blood pressure and inadequate perfusion of organs. The study also found that Cholera outbreaks pose significant public health challenges, particularly in areas with inadequate sanitation and limited access to clean water. The study therefore recommended that since cholera is highly contagious, primarily through contaminated water and food, those affected should be isolated to prevent the spread of the bacteria. Additionally, Proper hygiene, such as regular handwashing, is essential to reduce the risk of transmission.

Demystifying Renal Tubular Disorders in children : A simplified approach

Renal tubular disorders essentially include all disorders of the highly specialized channels of the renal tubular system, from the proximal convoluted tubule to the cortical and medullary collecting ducts. This tubular system is responsible for reabsorption of 99% of glomerular ultrafiltrate, which contains a large amount of fluid (approximately 180 L/day) as well as most electrolytes and many metabolites such as glucose (G), amino acids, bicarbonate (HCO3-), phosphate (PO4 3-), and low-molecular-weight proteins and is essential for maintaining fluid, electrolyte, and acid–base balance. In this review, we will briefly discuss when to suspect a renal tubular disorder, a simplified algorithm for evaluation, and specific mutations of a few common disorders.

Morphology of the epididymal duct of the domestic pig (Sus scrofa domesticus).

The study provides a general overview of the morphology of the epididymal duct in pigs. Four epididymides from two sexually mature boars were dissected into 32 segments and examined histologically. Duct lumen and wall thickness were measured and relative surface area of different components was assessed by Chalkley's random hit method. The epithelial lining was characterized at X1000. Lumen diameter and wall thickness of efferent ductules averaged 177 and 30 µm, respectively. Of the epididymal duct from caput to distal corpus the luminal diameter was 332 µm, with a narrower section in the proximal corpus. Wall thickness averaged 70 µm. In the cauda, luminal diameter and wall thickness increased to 717and 751 µm, respectively. The epithelial lining of the efferent ductules consists of a single layer of columnar cells with average height 21 µm. The lining of the epididymal duct consists of ciliated, pseudo-stratified columnar epithelium composed of "basal cells" and "principal cells." Particularly tall principal cells (96 µm) were found in the proximal caput. Height decreased to 40 µm at the distal cauda. Microvilli from principal cells were 14-17 µm long in the distal caput but decreased to 5 µm in the distal cauda. The epithelial lining was folded in the proximal caput and more so in the distal cauda. Secretory granules (epididymosomes) were present in small amounts in efferent ductules and epididymal duct; the largest quantities occurred in the distal cauda. Leukocytes were present throughout the duct, albeit in insignificant numbers. Chalkley's random hit method showed rapid spermatozoan transport through efferent ductules and proximal caput in large amounts of fluid. Sperm concentration increased due to fluid resorption in the proximal caput, was highest from caput flexure to proximal cauda and decreased at the caudal flexure, indicating secretory activity.

Knowledge Regarding Intravenous Therapy among Health Workers of a Teaching Hospital Birgunj, Parsa, Nepal

INTRODUCTION: Intravenous fluid is a continuous process of administration of large amount of fluid into the vein by a drip apparatus. The main purpose of intravenous therapy is to supply fluid and electrolyte to prevent or treat fluid and electrolyte imbalance in the body. The intravenous drug injected through vein into the body for quick action. At the time of infusion the nurse check or observe the flow rate of fluid for any adverse affect and also for others complication. Globally more than 330 million people receive invasive procedure of intravenous catheter placement annually. 60% to 90% patients require an intravenous catheter during hospitalization in US and studies said that 35%-50% patient is in fail intravenous catheters in hospitalization and arise complication. The objective of the study was to find out the knowledge regarding intravenous therapy among health workers of Teaching Hospital Birgunj, Parsa. MATERIALS AND METHODS: A descriptive cross sectional study design was adopted for the study. This carried out in national medical college teaching hospital is a tertiary level Hospital, Birgunj, Nepal, with the sample size of 139. The instruments used for the study was a structured knowledge questionnaire was used in the study, after reviewing related literatures, which consists of 28 items and data were collected within 2 weeks. RESULTS: Among 139 health workers, 43.2% had moderate level of knowledge, 33.1% had low level of knowledge and 23.7% had adequate level of knowledge. CONCLUSION: From the study finding it can be concluded that knowledge regarding intravenous therapy among respondents had moderate level of knowledge. Hence, various educational programmes for health workers should be focused on enhancing their knowledge regarding intravenous therapy which enables them to provide quality care for patients.

Risk Factors for Pulmonary Complications After Major Oral and Maxillofacial Surgery With Free Flap Reconstruction.

Background Postoperative pulmonary complications (PPCs) are common and result in increased morbidity and mortality. A variable incidence of PPCs has been reported in patients who have undergone major oral and maxillofacial surgery with free flap reconstruction, which is one of the most extensive forms of head and neck cancer surgery, and perioperative risk factors for PPCs in these patients have not been fully elucidated. Furthermore, the ARISCAT (Assess Respiratory Risk in Surgical Patients in Catalonia) score and Gupta risk index have not been investigated in patients undergoing head and neck cancer surgery. This study aimed to identify perioperative risk factors for PPCs after major oral and maxillofacial surgery with free flap reconstruction. Methodology This was a single-center, retrospective cohort study of 118 patients who had undergone major oral and maxillofacial surgery with free flap reconstruction between 2009 and 2020. PPCs were defined as pneumonia, hypoxemia caused by atelectasis, pleural effusion, pulmonary embolism, pulmonary edema, bronchospasm, pneumothorax, and acute respiratory failure. Predictors of PPCs were identified in univariate and multiple Poisson regression analyses. Results The incidence of PPCs was 18.6% (22/118 patients). The most frequent PPC was pneumonia. No preoperative patient-related parameter was identified to predict PPCs. In univariate analysis, the only predictor was anesthesia time ≥1,140 minutes (odds ratio = 3.0, p = 0.036). Multivariable Poisson regression identified two independent predictors of PPCs, namely, anesthesia time ≥1,140 minutes (incidence rate ratio (IRR) = 2.18, 95% confidence interval (CI) = 1.1-4.3, p = 0.024) and a large amount of intraoperative fluid (IRR = 1.00018, 95% CI = 1.000018-1.000587, p = 0.037). Conclusions Patients undergoing major oral and maxillofacial surgery with free flap reconstruction are at high risk of PPCs. Longer anesthesia time and administering a large amount of fluid during surgery were significantly correlated with the risk of PPCs.

DESIGN OF HYDRAULIC FRACTURING CARBONATE RESERVOIR USING A SIMULATOR IN THE IQ FIELD X WELL

The inability of a reservoir to pass large amounts of fluid can be caused by very low permeability. Objective: This research aims to increase well productivity in wells that have low permeability. Based on reservoir data, the permeability in the IQ well is tight permeability, namely 0.153 mD, so that fluid in the reservoir cannot flow into the well due to the low permeability of the formation. The low permeability of the formation resulted in a low production rate of 39 BLPD. Methodology and results: in this research a stimulation acidizing method was used but this method was less than optimal (seen from the absence of a pressure drop after acid was injected at a high flow rate), so a hydraulic fracturing method was carried out on the IQ well to increase well productivity. The results of this research use the PKN (Perkins, Kern &amp; Nordgren) fracturing model to obtain a fracture length greater than the fracture height. The fracturing fluid used as pad and slurry is YF120.HTD and the flush fracturing fluid used is 4% KCL Water. The proppant used is Carbolite 20/40. The resulting fracture geometry was 111 ft, fracture height 55 ft and fracture width 0.375 in. The conductivity value of the fracture formed was 18.1 mD with a fracture permeability of 320,177.383 mD/ft. The productivity index increased by 2,945 with a production rate of 440.14 BFPD. The total cash flow obtained was $4,858,624.11 and NVP $2,413,572.70. The capital issued will be returned within 21 days. Conclusion: based on the results above, the IQ well is suitable for hydraulic fracturing

Comparison of hydraulic, pneumatic and electric linear actuation systems

Different applications or industries use different systems for linear actuation, such as hydraulic, pneumatic or electric. Electric systems are becoming increasingly popular and are already replacing hydraulic systems in various applications. These are known to be potentially harmful to the environment, as large amounts of fluid can be released into the environment in the event of a pipe burst or other accident. This paper presents the results of a comparison between hydraulic, pneumatic and electric systems under variable conditions but with similar loads in all three systems. The common feature of all three systems is the input power, which was limited to 1.1 kW. There was no hydraulic accumulator in the hydraulic system and no pressure vessel in the pneumatic system, so no stored energy could influence the system behaviour or results. The main difference between the systems studied was the profile of displacement and power consumption. The most consistent response and lowest power consumption were obtained with the electric system, although both hydraulic and pneumatic systems can achieve consistent response with some modifications.

Disorders of aqueous humor flow in the posterior part of the eye in the mechanisms of optic nerve damage development (literature review)

The study based on the literature search revealed that the peculiarities of fluid circulation in the posterior part of the eye have been studied insufficiently compared to the anterior part. It is suggested that the retina and optic nerve have their own cleansing system, which functions independently or in interaction with the brain's cleansing system. Of interest is the theory of the glymphatic system of the eye, which probably functions similarly to the glymphatic system of the brain, has four segments and ensures the exchange between intraocular, intracranial and interstitial fluids and the removal of metabolic waste products in the posterior part of the eye. Purpose. To determine the disorders of fluid circulation in the posterior part of the eye in the mechanisms of optic nerve damage development according to the literature. Methods: literature search of 48 sources. It is important to understand that the optic nerve under normal conditions passes a large amount of fluid from the eye to the brain and vice versa. The balance of perfusion (and, presumably, reperfusion in case of pathology) is ensured by the lamina cribrosa, the location of subarachnoid spaces in different parts of the nerve, and the AQP4 channels that support them. The question is whether the optic nerve has its own separate glymphatic system, or whether it interacts with the glymphatic system of the brain. It also remains unclear how the circulation of intraocular fluid, interstitial fluid of the retina and brain, and cerebrospinal fluid in the optic nerve is coordinated with blood, as well as with fluctuations in atmospheric pressure. Although this theory has not yet been recognized, it nevertheless has many supporters who explain optic nerve damage as a result of fluid circulation disturbances. The slowing of fluid flow, as well as the slowing of axonal transport, can be considered as the moment when neuropathy transforms into optic atrophy. That is why the study of the peculiarities of fluid flow and exchange in the posterior part of the eye is important when studying diseases of the optic nerve, whereas the correction of such circulation disorders could be used for therapeutic purposes. Conclusion. Impaired fluid circulation in the posterior part of the eye can occur in mechanisms of optic nerve damage. Improved diagnostics with the ability to assess hydrodynamics will help to understand the role of individual components, while their correction will likely contribute to the optic nerve recovery.

Ferulated Poly(vinyl alcohol) based hydrogels

New graft copolymers were prepared by reaction of poly (vinyl alcohol) (PVA) with mono-imidazolide or bis-imidazolide derivatives of ferulic acid (FA) with the formation of ester bonds. The obtained graft copolymers, thanks to the crosslinking capability of FA, formed in water strong gels as verified by rheological analyses. The resulting hydrogels were characterized to evaluate their applicability as wound dressing. In this perspective, their capability to absorb and retain a large amount of fluid without dissolving was verified by swelling kinetics and Moisture Vapour Transmission Rate measurements. Their stability towards mechanical solicitations was assessed by quantifying elasticity, compliance, stress-relaxation, and adhesivity properties. The analyses pointed out that hydrogel PVA-FA2-3 obtained by feruloylation of PVA with bis-imidazole derivative of ferulic acid using an acylation agent/polymer molar ratio 0.03/1 resulted the best candidate for the foreseen application.