The granulation process was examined during carbon tetrachloride (CT) biodegradation in a laboratory scale upflow anaerobic sludge blanket (UASB) reactor operated at 35 °C for 220 days. Anaerobic, unacclimated sludge and glucose were used as seed and primary substrate, respectively. CT degrading granules developed after 48 days of start-up. They grew at an accelerated pace for 6.5 months and had a maximum diameter of 2.2 mm following the pre-granulation and maturation period. Maximum specific methanogenic activity (SMA) was 1.63 g chemical oxygen demand (COD) per g total suspended solid (TSS) per day while, maximum specific organic loading rate to achieve 96% of COD removal efficiency was determined to be 12.5 g COD per l per day. About 95% CT removal efficiencies were achieved when the reactor was operating at loading rates as high as 17.5 mg CT per l per day after 220 days of continuous operation. The methane content in the total biogas collected was between 50 and 68% depending to shock organic loadings. About 96% of the total COD removed, was converted to methane, 0.024 g of TSS was yielded for each gram of COD removed at the end of 230 days of operation period. Kinetic coefficients of k (maximum specific substrate utilization rate), K s (half velocity coefficient), were determined to be 2.4×10 −3 mg CT per mg TSS per day and 1.37 mg CT per l, respectively, for CT biotransformation during granulation. Methanothrix ( Methanosaeta) sp., Methanosarecina mazei, Methanobacterium sp., Methanobrevibacter sp., Syntrophobacter sp., Methanolobus vulcani and Acetobacter woodii were identified in UASB.