In this paper, SiO2-P2O5-Ca(Sr/Zn)O-Na2O-F system glasses with varying CaO:SrO and CaO:ZnO ratios were prepared by traditional melting method, which combined the remineralization properties of bioglass with the special functions of Zn2+ and Sr2+. The evolution of glass composition and its thermal properties, network structure, and biological properties was investigated by DSC, FTIR, and biological experiment. The results showed that all the extracts of glass powder could promote the osteogenic differentiation of human periodontal ligament cells (HPDLCs). Among them, the two kinds of glass containing 6 wt% SrO and only 2 wt% ZnO had the greatest potential to accelerate the bone tissue reconstruction. Hematoxylin-eosin (HE) staining histological results showed that 3 months after the two kinds of glass were implanted in the animal model of periapical inflammation, the bone matrix formed a good seal in the apical foramen, and new bone and capillaries were formed in the apical area, which has a clinical application and transformation prospect.
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