The Pathophysiological Mechanism of Beni-koji Choleste-Help or Puberulic Acid-Induced Kidney Injury.

Tubular STING drives renal fibrosis via extracellular vesicle-mediated activation of the SMO/GLI-1 pathway.

A severe case of rhabdomyolysis, acute kidney injury, cardiogenic shock, and chronic complications caused by an excessively large dose of Tripterygium glycoside.

Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most frequent and severe complications after cardiac surgery. The association between acute kidney injury and the mismatch between oxygen consumption and delivery has been well established during cardiopulmonary bypass (CPB). In this study, we aim to explore the prognostic value of the central venous-to-arterial pCO2 gap during CPB to predict CSA-AKI. Bicentric retrospective study conducted in two teaching hospitals. All patients who underwent cardiac surgery requiring CPB in two periods between 2019 and 2023 were screened for inclusion. Patients were divided into 2 groups according to the presence or absence of an elevated pCO2 gap during CPB, which was defined as greater than 6 mmHg. The primary outcome was the occurrence of CSA-AKI. Among 318 patients included, 213 were in the low pCO2 gap group and 105 in the elevated pCO2 gap group. No significant difference in CSA-AKI occurrence was found between groups (32.4% vs. 23.8%; p = 0.14). pCO2 gap was not a good predictor of CSA-AKI, with an area under the curve for the ROC curve of 0.63 (p = 0.87). Except for SVO2 during CPB, we did not find any correlation between pCO2 gap and other tissue perfusion parameters during or after CPB. We did not find any association between the presence of an elevated pCO2 gap during CPB and the occurrence of CSA-AKI. This may suggest that a single intraoperative measurement of pCO2 gap is not a reliable marker of persistent tissue hypoperfusion in this context.

Imeglimin is a first-in-class oral antidiabetic that enhances glucose-induced insulin secretion and improves insulin resistance. Although imeglimin has been shown to exert protective effects on β-cells and hepatocytes partly by reducing the production of reactive oxygen species, its renoprotective effects remain largely unknown. In this study, we evaluated the effects of imeglimin on the kidneys using a mouse model of acute kidney injury induced by ischemia-reperfusion injury. Imeglimin significantly attenuated the increase in serum creatinine and blood urea nitrogen levels, as well as histological kidney injury. Gene ontology analysis of differentially expressed genes identified by RNA-sequencing of kidney tissues revealed that pathways related to inflammation were enriched in genes downregulated by imeglimin, whereas lipid metabolism and regulation of sodium ion transport were among the top enriched categories for genes upregulated by imeglimin. Moreover, ischemia-induced increase in the number of γH2AX-positive nuclei in proximal tubules was significantly suppressed by imeglimin. In addition, imeglimin inhibited increase in reactive oxygen species levels in human proximal tubule cells induced by transient hypoxia. These results indicate that imeglimin protects the kidney from ischemia-reperfusion injury by attenuating inflammatory responses and DNA damage, thereby maintaining gene expression associated with renal function. This protective effect may be partly mediated by a reduction in reactive oxygen species production. The potential of imeglimin to provide clinically meaningful protection against kidney complications warrants further investigation, considering the protective effects observed in ischemia-reperfusion injury.

Fuzheng pill (FZP) is a traditional Chinese medicine formula with anti-hepatocellular carcinoma (HCC) effect in clinical practice, but its therapeutic mechanism is still unclear. In this study, ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry method was used to analyze the chemical composition of FZP, and combined with invivo and invitro experiments, to explore its potential mechanism of action in the treatment of liver cancer. A total of 236 components were identified in FZP. Invivo experiments revealed that FZP suppressed tumor growth, improved immune function, and reversed liver and kidney injury caused by tumors, as shown by significant increases in the immune organ index, and that the levels of IFN-γ, IL-2, and TNF-α significantly increased after its administration. Serum biochemical indicators of liver and kidney function decreased. FZP inhibited the proliferation of HepG2 cells. Flow cytometry and Western blot results revealed that FZP modulated the expression levels of Bcl-2, Bax, Caspase-3, and cleaved Caspase-3, and promoted cell apoptosis. FZP may promote the apoptosis of tumor cells by activating the endogenous Bax/Bcl-2/cleaved Caspase-3 apoptosis pathway, which is mediated by mitochondria. These findings revealed the potential of FZP in the treatment of HCC and provided more treatment options for patients.

BHMT Prevents renal ischemia/reperfusion injury via suppressing ROS-induced apoptosis by targeting NOX4.

Contrast-associated acute kidney injury (CA-AKI) is a frequent complication after mechanical thrombectomy (MT). Cerebral small vessel disease (CSVD) reflects cerebral microvascular dysfunction driven by systemic vascular risk factors that also affect renal integrity, and may therefore serve as a surrogate marker of renal vulnerability. We prospectively included 351 patients with anterior circulation large-vessel occlusion who underwent MT. Baseline non-contrast CT was used to derive the modified small vessel disease (mSVD) score and the Brain Frailty Score (BFS). CA-AKI was defined as ≥ 0.5 mg/dL or ≥ 25 % increase in serum creatinine within 48-72 h after MT. Multivariable logistic regression, Firth penalized models, and XGBoost machine learning identified independent predictors. CA-AKI occurred in 42 patients (12.0 %). Affected patients were older (68 vs. 62 years), had higher glucose (143 vs. 118 mg/dL), elevated systolic pressure, and more pronounced CSVD features. Severe BFS (score=3) independently predicted CA-AKI (OR=5.13; 95 % CI 1.46-91.28; p = 0.039) after adjustment for age, glucose, and recanalization, whereas mSVD and individual imaging markers were not significant. The final model showed good discrimination and calibration (AUC=0.73; Brier=0.08) and remained stable in sensitivity analyses. In Firth regression, BFS remained significant (OR=4.26; 95 % CI 1.23-22.54). XGBoost achieved an AUC= 0.84, confirming the consistent predictive relevance of vascular, metabolic, and imaging factors across models. BFS predicts CA-AKI after thrombectomy, outperforming both conventional CSVD scoring and individual imaging markers. These findings support the concept of Systemic Microvasculature Frailty, in which cerebral microangiopathy reflects global endothelial vulnerability with acute renal implications.

Renogrit protects against folic acid-induced kidney damage in rat model of acute renal failure by regulating serum creatinine and urea levels.

Retrospective Cohort Study: Supraceliac Cross Clamping Does Not Affect Early Outcomes After Juxtarenal Aneurysm Repair.

Fish oil supplementation and clinical outcomes in patients with sepsis-associated acute kidney injury: A retrospective cohort study from the MIMIC-IV database.

Machine learning survival analysis for predicting kidney disease progression in patients with acute kidney injury undergoing continuous kidney replacement therapy: An analysis of the LINKA database.

Dietary methylglyoxal induces renal lipotoxicity primarily through adipose tissue dysfunction in mice fed normal or obesogenic high-fat diets.

Impact of hypotension prediction index-guided management on intraoperative hypotension and postoperative outcomes in abdominal surgery: A meta-analysis of randomized controlled trials.

Renal-targeted tFNA-TPP nanoagonist treats acute kidney injury by amplifying mitophagy.

A novel serum phosphorus to chloride and bicarbonate ratio predicts severe acute kidney injury in critically ill patients: a multicenter cohort study.

TRIM7 negatively regulates CMPK2 suppressing inflammation and apoptosis in renal ischemia-reperfusion injury.

Apolipoprotein J-mediated hepato-renal crosstalk drives renal injury in chronic kidney disease.

Selenium regulates pyroptosis through the ROS-mtDNA-cGAS-STING axis to alleviate trimethyltin chloride-induced inflammation in chicken kidneys.

From Equipoise to Evidence: Pre-Trial Setup of the European Uncomplicated Type B Aortic Repair Clinical Trial.