Purpose. Work out ways to realize the genetic potential of breeds and crosses of poultry of meat and egg directions of productivity based on the use of new types of feed products, taking into account the analysis of the dynamics of the microbiome at the level of taxonomic types of microorganisms. Materials and Methods. Studies on the inclusion of prebiotic feed additive "Laktuvet" and mineral feed additive "Saponit" were conducted in the conditions of the SS "Svetly" of the CJSC "Agrofirma "Vostok" of the Volgograd Region on "Hysex Brown" cross laying hens. Scientific experiment on the effect of the additive "Quercetinolact" on the growth and development of meat chickens was conducted on broilers of "Ross-308" cross in the vivarium of VRIMMP. Zootechnical, clinical and biochemical research methods were used in the research work. Hematological studies were carried out in certified laboratory on automatic biochemical analyzers using an appropriate set of biochemical reagents. The obtained results were processed using software, calculating the mean value (M), standard errors of the mean (±SEM) and determining the reliability criterion of difference according to Student-Fisher. Results. Adding the prebiotic feed additive "Laktuvet" to the feed of laying hens in an amount of 0.5% in the diet structure contributed to an increase in the gross collection of eggs and the intensity of egg laying by 1.84 (85 eggs) and 1.74%, egg weight – by 1.17 g (1.86%; P≤0.001) due to an increase in the number of microorganisms by 22.9%. Among them, the number of bacteria of Actinobacteria, Lactobacillales and Ruminococcaceae groups increased by 9.0; 1.8 and 1.4 times compared to the control, respectively. Taking into account the data obtained, new feed additive “Quercetinolact” was tested in feeding broiler chickens of Ross-308 cross. Chickens that received Quercetinolact additive exceeded their counterparts in control group in live weight by 4.13 (P≤0.001); 5.19 (P≤0.001) and 5.48% (P≤0.001), which in absolute terms amounted to 108.1; 136.1 and 142.8 g. In terms of meat yield in live weight, the superiority amounted to 3.07; 3.65 and 3.82%, respectively, feed savings per 1 kg of gain 3.66; 6.10 and 6.71%. Mineral feed additive "Saponit" in feeding laying hens in the amount of 1 and 3 kg per ton of feed contributed to an increase in egg productivity by 1.58 and 2.37%, respectively, egg laying intensity – by 1.20 and 2.01%, and gross yield eggs – 90 (1.18%) and 150 pcs. (1.97%), egg weight – by 1.16 and 1.49%. Conclusion. The use of natural mineral complexes and prebiotic feed additives in the diets of chickens of egg and meat breeds and crosses in order to realize the genetic potential and taking into account the analysis of microbiome dynamics at the level of taxonomic types of microorganisms is advisable.