Key Questions For Future Research Research Articles

Exploring urban novel ecosystems: Understandings, insights and recommendations for future research and practice

Novel ecosystems are those that have been altered by human activities and have afterwards experienced abandonment or human disuse, allowing for a new assemblage of species to establish. In urban areas, these ecosystems, are commonly found in post-industrial sites, vacant lots, and other unmanaged spaces. The informality of these ecosystems, assumptions of their low ecological value, and associations with negative attributes continue to prevent recognition of their social-ecological value. Although research in the last decade has started to show the potential of novel ecosystems to address several challenges such as biodiversity loss, there remains a need to understand what areas of research are needed to progress our understanding of these ecosystems in urban areas. This paper uses a modified Delphi methodology, in which a panel of knowledge-holders provided their understandings and insights of urban novel ecosystems. Through this process, we distilled key questions for future research and practice that should drive the investigation of these wild ecosystems for improved decision-making. This study sets out recommendations on how to progress the research questions as part of urban transformative agendas in which urban novel ecosystems offer new possibilities for climate experimentation, social-ecological stewardship and biodiversity conservation.

Academic Integrity and Artificial Intelligence in Higher Education (HE) Contexts: A Rapid Scoping Review

Artificial Intelligence (AI) developments challenge higher education institutions’ teaching, learning, assessment, and research practices. To contribute timely and evidence-based recommendations for upholding academic integrity, we conducted a rapid scoping review focusing on what is known about academic integrity and AI in higher education. We followed the Updated Reviewer Manual for Scoping Reviews from the Joanna Briggs Institute (JBI) and the Preferred Reporting Items for Systematic reviews Meta-Analysis for Scoping Reviews (PRISMA-ScR) reporting standards. Five databases were searched, and the eligibility criteria included higher education stakeholders of any age and gender engaged with AI in the context of academic integrity from 2007 through November 2022 and available in English. The search retrieved 2223 records, of which 14 publications with mixed methods, qualitative, quantitative, randomized controlled trials, and text and opinion studies met the inclusion criteria. The results showed bounded and unbounded ethical implications of AI. Perspectives included: AI for cheating; AI as legitimate support; an equity, diversity, and inclusion lens into AI; and emerging recommendations to tackle AI implications in higher education. The evidence from the sources provides guidance that can inform educational stakeholders in decision-making processes for AI integration, in the analysis of misconduct cases involving AI, and in the exploration of AI as legitimate assistance. Likewise, this rapid scoping review signals key questions for future research, which we explore in our discussion.

Profiling Bilateral Skills in High-Performance Male and Female Gaelic Footballers

Background: Bilateral skill in sport refers to an individual’s ability to successfully perform sporting actions with both sides of the body. Two scarcely researched areas in relation to bilateral skills are the effects of opposition proximity on skill execution and bilateral skill in high-performance female athletes. Methods: All skill executions (hand pass, kick pass, hop, solo and shot) during 121 games (76 male, 45 female) were coded using Nacsport, with the participants including male and female tier 1 (n = 181, 134) and Tier 2 (n = 238, 115) adult, high performance Gaelic football players. Irrespective of tier or gender, Gaelic football players relied upon their dominant side for the majority of skill executions. Results: No consistent differences existed between tiers and genders in relation to dominant side use, but top tier male players were generally less reliant on the dominant limb than all female players. In general, top tier male players performed more successfully than the other three tiers. Most skills were executed under low opponent proximity, limiting the requirement to use the non-dominant limb. Conclusions: These findings illustrate the demands of Gaelic football in relation to bilateral skill and identify key questions for future research.

The maternal embrace: the protection of plant embryos.

All land plants-the embryophytes-produce multicellular embryos, as do other multicellular organisms, such as brown algae and animals. A unique characteristic of plant embryos is their immobile and confined nature. Their embedding in maternal tissues may offer protection from the environment, but also physically constrains development. Across the different land plants, a huge discrepancy is present between their reproductive structures whilst leading to similarly complex embryos. Therefore, we review the roles that maternal tissues play in the control of embryogenesis across land plants. These nurturing, constraining, and protective roles include both direct and indirect effects. In this review, we explore how the maternal surroundings affect embryogenesis and which chemical and mechanical barriers are in place. We regard these questions through the lens of evolution, and identify key questions for future research.

Microglial Regulation of Sleep and Wakefulness.

Sleep serves a multitude of roles in brain maturation and function. Although the neural networks involved in sleep regulation have been extensively characterized, it is increasingly recognized that neurons are not the sole conductor orchestrating the rhythmic cycle of sleep and wakefulness. In the central nervous system, microglia have emerged as an important player in sleep regulation. Within the last two decades, microglia have gained substantial attention for carrying out numerous nonimmune tasks that are crucial for brain development and function by co-opting similar mechanisms used in their conventional immune functions. Here, we highlight the importance of microglia in sleep regulation with recent findings reporting an arrhythmic sleep/wake cycle in the absence of microglia. Although the underlying mechanisms for such regulation are still being uncovered, it is likely that microglial contributions to the rhythmic control of the sleep/wake cycle come from their influence on synaptic strength and neuronal activity. We review the current literature to provide speculative signaling pathways and suggest key questions for future research. Advancing our knowledge of the mechanistic contribution of microglia to sleep regulation will not only further our insight into this critical biological process but also be instrumental in providing novel therapeutic strategies for sleep disorders.

Hitting the Target: Developing High-quality Evidence for Proton Beam Therapy Through Randomised Controlled Trials

The National Health Service strategy for the delivery of proton beam therapy (PBT) in the UK provides a unique opportunity to deliver high-quality evidence for PBT through randomised controlled trials (RCTs). We present a summary of three UK PBT RCTs in progress, including consideration of their key design characteristics and outcome assessments, to inform and support future PBT trial development. The first three UK multicentre phase III PBT RCTs (TORPEdO, PARABLE and APPROACH), will compare PBT with photon radiotherapy for oropharyngeal squamous cell carcinoma, breast cancer and oligodendroglioma, respectively. All three studies were designed by multidisciplinary teams, which combined expertise from clinicians, clinical trialists and scientists with strong patient advocacy and guidance from national radiotherapy research networks and international collaborators. Consistent across all three studies is a focus on the reduction of long-term radiotherapy-related toxicities and an evaluation of patient-reported outcomes and health-related quality of life, which will address key uncertainties regarding the clinical benefits of PBT. Innovative translational components will provide insights into mechanisms of toxicity and help to frame the key future research questions regarding PBT. The UK radiotherapy research community is developing and delivering an internationally impactful PBT research portfolio. The combination of data from RCTs with prospectively collected data from a national PBT outcomes registry will provide an innovative, high-quality repository for PBT research and the platform to design and deliver future trials of PBT.

The Role of Hedonic Goal Pursuit in Self-Control and Self-Regulation: Is Pleasure the Problem or Part of the Solution?

This paper examines the role of hedonic goal pursuit in self-control and self-regulation. We argue that not all pursuit of immediate pleasure is problematic and that successful hedonic goal pursuit can be beneficial for long-term goal pursuit and for achieving positive self-regulatory outcomes, such as health and well-being. The following two key questions for future research are discussed: How can people's positive affective experiences during hedonic goal pursuit be enhanced, and how exactly do those affective experiences contribute to self-regulatory outcomes? We also call for an intercultural perspective linking hedonic goal pursuit to self-regulatory outcomes at different levels. We suggest that understanding the cognitive, motivational, and affective mechanisms at play can help individuals reap the benefits of successful hedonic goal pursuit. Considering those potential benefits, hedonic goal pursuit should be studied more systematically. To achieve this, we argue for a stronger integration of affective science and self-control research.

New Developments and Emergent Challenges in International Inclusive Education—A Response to Growing Family Needs and the Pandemic

Home education is a phenomenon that has been increasing globally over the past decade, particularly for families of children with special educational needs or disabilities. The impact of the COVID-19 pandemic has exacerbated this phenomenon with many families continuing to home educate even after their children can officially return to school. This paper reports on a small-scale design-based research project that explored the needs of families who are home educating children with autistic spectrum disorder (ASD). Working in partnership with educational settings, practitioners, and families during the second year of the pandemic, academic researchers in Malaysia and England designed, implemented and evaluated a home learning pack for children with ASD aged 6–12 years old. The findings emphasised the role of economic, social and cultural capital for the families involved and how this impacted their ability to work and educate their children successfully. This raises crucial questions in relation to the place of home education within the wider international inclusive education debate and matters of social equality whilst also highlighting key questions for future research in this field on how policy and provision might develop to meet a growing diversity of need.

Microplastics as an emerging menace to environment: Insights into their uptake, prevalence, fate, and sustainable solutions

The inflated demand for plastic products has led to tremendous rise in plastic debris in different environmental matrices, thereby resulting in plastic pollution. This affects plants, animals, and even humans, as microplastics can enter the food chain and cause several health implications. Microplastics are the small plastic particles (size below 5 mm) that are largely debated nowadays owing to their environmental risk assessment. Their potential to interact with other toxic contaminants, their tendency to be ingested or taken up by living organisms and their longevity is a serious threat to our environment. However, despite wealth of recent information, still there is a gap, particularly in eco-toxicology studies, fate, prevalence and feasible solutions to cope up with the menace of microplastics pollution. This review unravels the environmental fate and behaviour of microplastics as well as their global distribution in the marine and terrestrial environment. Furthermore, we aim to contribute to the international debate on the microplastics global paradigm. We briefly suggest sustainable solutions and recommendations to achieve future research goals on microplastics. Our review reveals some of the newest biological (green algae and modified sponges) and physical (nano-particles and membrane treatment) remediation solutions to eradicate microplastics from different types of environment. This review presents a critical evaluation of the state of knowledge of micro-plastics and suggested some recommendations which can help in identifying some important key questions for future research.

Integrated analysis of potential microbial consortia, soil nutritional status, and agro-climatic datasets to modulate P nutrient uptake and yield effectiveness of wheat under climate change resilience.

Climate change has a devastating effect on wheat production; therefore, crop production might decline by 2030. Phosphorus (P) nutrient deficiency is another main limiting factor of reduced yield. Hence, there is a dire need to judiciously consider wheat yield, so that human requirements and nutrition balance can be sustained efficiently. Despite the great significance of biostimulants in sustainable agriculture, there is still a lack of integrated technology encompassing the successful competitiveness of inoculated phosphate-solubilizing bacteria (PSB) in agricultural systems in the context of climatic conditions/meteorological factors and soil nutritional status. Therefore, the present study reveals the modulation of an integrated P nutrient management approach to develop potential PSB consortia for recommended wheat varieties by considering the respective soil health and agro-climatic conditions. The designed consortia were found to maintain adequate viability for up to 9 months, verified through field emission scanning electron microscopy and viable count. Furthermore, a significant increase in grain yield (5%-8%) and seed P (4%) content was observed in consortia-inoculated wheat plants with 20% reduced Diammonium phosphate (DAP) application under net house conditions. Fluorescence in situ hybridization analysis of roots and amplification of the gcd gene of Ochrobactrum sp. SSR indicated the survival and rhizosphere competency of the inoculated PSB. Categorical principal component analysis (CAT-PCA) showed a positive correlation of inoculated field-grown wheat varieties in native soils to grain yield, soil P content, and precipitation for sites belonging to irrigated plains and seed P content, soil organic matter, and number of tillers for sites belonging to Northern dry mountains. However, the impact of inoculation at sites belonging to the Indus delta was found significantly correlated to soil potassium (K) content, electrical conductivity (EC), and temperature. Additionally, a significant increase in grain yield (15%) and seed P (14%) content was observed in inoculated wheat plants. Thus, the present study demonstrates for the first time the need to integrate soil biological health and agro-climatic conditions for consistent performance of augmented PSB and enhanced P nutrient uptake to curtail soil pollution caused by the extensive use of agrochemicals. This study provides innovative insights and identifies key questions for future research on PSB to promote its successful implementation in agriculture.

Introduction: Journaling and Mental Health during COVID-19: Insights from the Pandemic Journaling Project

In this article, we introduce the SSM-MH Special Issue “Journaling and Mental Health during COVID-19: Insights from the Pandemic Journaling Project,” which presents findings from the Pandemic Journaling Project (PJP). PJP is an online journaling platform and mixed-methods research study created in May 2020 to provide ordinary people around the world an opportunity to chronicle the impact of the COVID-19 pandemic in their lives—for themselves and for posterity. The essays in this collection demonstrate how journaling via an online platform can help illuminate experiences of mental wellbeing and distress, with important implications for both research and clinical practice. We begin by introducing the Pandemic Journaling Project and describing our procedures for generating the data subsets analyzed in the papers collected here. We then outline the principal interventions of the special issue as a whole, introduce the papers, and identify a number of cross-cutting themes and broader contributions. Finally, we point toward key questions for future research and therapeutic practice by highlighting the three-fold value of online journaling as a research method, a therapeutic strategy, and a tool for advancing social justice. We focus in particular on how this innovative methodological approach holds promise as both a modality for psychotherapeutic intervention and a form of grassroots collaborative ethnography. We suggest that our methods create new opportunities for confronting the impact of pandemics and other large-scale events that generate radical social change and affect population-level mental health.

The ecology and evolution of human‐wildlife cooperation

AbstractHuman‐wildlife cooperation is a type of mutualism in which a human and a wild, free‐living animal actively coordinate their behaviour to achieve a common beneficial outcome.While other cooperative human‐animal interactions involving captive coercion or artificial selection (including domestication) have received extensive attention, we lack integrated insights into the ecology and evolution of human‐wildlife cooperative interactions.Here, we review and synthesise the function, mechanism, development, and evolution of human‐wildlife cooperation.Active cases involve people cooperating with greater honeyguide birds and with two dolphin species, while historical cases involve wolves and orcas.In all cases, a food source located by the animal is made available to both species by a tool‐using human, coordinated with cues or signals.The mechanisms mediating the animal behaviours involved are unclear, but they may resemble those underlying intraspecific cooperation and reduced neophobia.The skills required appear to develop at least partially by social learning in both humans and the animal partners. As a result, distinct behavioural variants have emerged in each type of human‐wildlife cooperative interaction in both species, and human‐wildlife cooperation is embedded within local human cultures.We propose multiple potential origins for these unique cooperative interactions, and highlight how shifts to other interaction types threaten their persistence.Finally, we identify key questions for future research. We advocate an approach that integrates ecological, evolutionary and anthropological perspectives to advance our understanding of human‐wildlife cooperation. In doing so, we will gain new insights into the diversity of our ancestral, current and future interactions with the natural world.Read the freePlain Language Summaryfor this article on the Journal blog.

Can cell-free DNA (cfDNA) testing alleviate psychological distress in early miscarriage? A commentary.

Psychological, emotional, and mental distress affects many patients who experience early pregnancy loss (EPL). A common concern is that the patient's actions or choices caused the loss. Understanding the cause of EPL may improve the distress of EPL patients and their partners. Chromosomal abnormalities leading to a significant portion of EPL. Cell-free DNA (cfDNA) testing, a non-invasive test providing high quality information about the chromosomal makeup of a fetus, may offer assurance that a fetal abnormality caused the loss, and provide more certainty or closure in processing EPL. CfDNA may be a useful adjunct to patient-centered care in the setting of EPL. This commentary explores the possibility of cfDNA testing in lessening the emotional distress that often accompanies EPL. The peer reviewed literature was explored for manuscripts addressing (1) the potential for cfDNA serum testing for patients experiencing EPL and screening products of conception to determine the cause of EPL; and/or (2) the impact that information might have on the psychological morbidity of EPL for patients and their partners. Themes generated from extracted data were used to generate key questions for future research. Preliminary findings suggest fetal fraction values are instrumental in the success of cfDNA testing, and a successful cfDNA testing experience can have a positive impact on patients. Ultimately, we conclude cfDNA testing could have a positive impact in patient care and improve the well-being of patients undergoing the emotional toll of EPL by reducing feelings of guilt and providing closure to those who learn the loss was associated with chromosomal abnormality. Further trials and studies that explore the intersection of mental health of EPL on patients should explore the efficacy of cfDNA testing as an adjunct to patient-centered care in these cases.

Changing the Trajectory of Heart Failure and Kidney Disease: A Call for Action.

Changing the Trajectory of Heart Failure and Kidney Disease: A Call for Action.

An Overview of the Electron-Transfer Proteins That Activate Alkane Monooxygenase (AlkB).

Alkane-oxidizing enzymes play an important role in the global carbon cycle. Alkane monooxygenase (AlkB) oxidizes most of the medium-chain length alkanes in the environment. The first AlkB identified was from P. putida GPo1 (initially known as P. oleovorans) in the early 1970s, and it continues to be the family member about which the most is known. This AlkB is found as part of the OCT operon, in which all of the key proteins required for growth on alkanes are present. The AlkB catalytic cycle requires that the diiron active site be reduced. In P. putida GPo1, electrons originate from NADH and arrive at AlkB via the intermediacy of a flavin reductase and an iron–sulfur protein (a rubredoxin). In this Mini Review, we will review what is known about the canonical arrangement of electron-transfer proteins that activate AlkB and, more importantly, point to several other arrangements that are possible. These other arrangements include the presence of a simpler rubredoxin than what is found in the canonical arrangement, as well as two other classes of AlkBs with fused electron-transfer partners. In one class, a rubredoxin is fused to the hydroxylase and in another less well-explored class, a ferredoxin reductase and a ferredoxin are fused to the hydroxylase. We review what is known about the biochemistry of these electron-transfer proteins, speculate on the biological significance of this diversity, and point to key questions for future research.

Personality dynamics

Traditionally, personality psychology has been understood as the study of stability in people’s dispositions. However, a different strand of personality research has highlighted the importance of acknowledging and explaining the meaningful intraindividual variation in human thoughts, feelings, and behavior across different contexts and time. The goal of this paper is to review this strand, highlight current research, and outline key questions for future research. We summarize historical perspectives on the dynamic processes underlying the emergence of personality within and across individuals (e.g. the pioneering theorizing of Allport; the person-situation debate), recent theoretical and empirical advances in incorporating dynamic processes into the definition and assessment of personality (e.g., the study of personality states; dynamic approaches to personality including Cognitive Affective Personality System [CAPS], Whole Trait Theory, the Knowledge-and-Appraisal Personality Architecture [KAPA] framework, and Nonlinear Interaction of Person and Situation [NIPS]), and new directions in current research (e.g. idiographic approaches; understanding variability in narrative identity). We end with suggestions for future research.

Underappreciated features of cultural evolution.

Cultural evolution theory has long been inspired by evolutionary biology. Conceptual analogies between biological and cultural evolution have led to the adoption of a range of formal theoretical approaches from population dynamics and genetics. However, this has resulted in a research programme with a strong focus on cultural transmission. Here, we contrast biological with cultural evolution, and highlight aspects of cultural evolution that have not received sufficient attention previously. We outline possible implications for evolutionary dynamics and argue that not taking them into account will limit our understanding of cultural systems. We propose 12 key questions for future research, among which are calls to improve our understanding of the combinatorial properties of cultural innovation, and the role of development and life history in cultural dynamics. Finally, we discuss how this vibrant research field can make progress by embracing its multidisciplinary nature. This article is part of the theme issue 'Foundations of cultural evolution'.

Recent advances and future research in ecological stoichiometry

Studies on ecological stoichiometry (ES) have increased rapidly in number in recent years. Continuous exploration of classical concepts such as the growth-rate hypothesis (GRH),), which is based on the relationship between the nitrogen:phosphorus (N:P) ratio of organisms and their growth-rate capacity, has identified new patterns and uncertainties, particularly with regard to terrestrial plants and microbial systems. Another concept that has proven to be helpful is the Redfield ratio, which postulates a consistent carbon:nitrogen:phosphorus (C:N:P) molar ratio of 100:16:1 in marine phytoplankton and open oceanic waters, and this ratio is related to the protein:rRNA ratio associated with protein synthesis. ES studies in all types of ecosystems have demonstrated that shifts in the elemental composition of water, soil, organisms, and communities are linked to the spatiotemporal structure and function of the ecosystem communities. The recent trend of also considering additional bio-elements such as potassium (K), magnesium (Mg) and calcium (Ca), has improved our understanding of how resource availability in complex ecosystems affects basic organism functions such as growth, stress responses, and defensive mechanisms. The biogeochemical or bio-elemental niche hypothesis is a novel tool that uses the concentrations and ratios of several bio-elements to define species niches and to scale up processes at the community and ecosystem levels. Global environmental changes, such as an increase in atmospheric CO2, drought, N deposition, and species invasion, change the elemental composition of the growth media (soil and water), organisms, and ecosystems. For example, the growing imbalance between N and P that results from very large anthropogenic inputs of reactive N and smaller inputs of P into the biosphere is increasingly affecting the health of both ecosystems and humans. In this review, we summarise recent advances in ecological stoichiometry and identify key questions for future research on the impacts of ES on ecosystem function and structure due to global environmental change.

Assessing Policy Issue Interdependencies in Environmental Governance

The ability to effectively resolve complex environmental problems hinges upon the capacity to address several different challenges in concert. These challenges, what we refer to as policy issues, often relate to one another – they interdepend. Policy issue interdependency has been extensively theorised in the literature, yet few methodological approaches and little empirical evidence exist to translate the concept of policy issue interdependency to the on-the-ground realities facing policy actors in specific cases and contexts. We build from previous studies to develop a methodological procedure that investigates policy issue interdependencies in ways that take into account what measures and possible solutions policy actors have at their disposal in specific cases for specific environmental problems. By applying our methodological procedure to a case of water governance in Sweden, four insights emerged. First, validation by stakeholders confirms that our procedure produces reliable results. Second, we find that many, but certainly not all, policy issues are interdependent. More specifically, different patterns of policy issue interdependencies are associated with the biophysical and the governance spheres, respectively. Third, our results suggest that policy issue interdependencies are most important to consider when the overall level of interdependency is moderate. Last, our study raises new questions about policy actors’ perception of policy issue interdependencies. In particular, a key question for future research would be if reinforcing (win-win) or counteracting (trade-off) interdependencies are easier to comprehend and act on for policy actors.

The Phenomenon of Exquisite Motor Control in Tic Disorders and its Pathophysiological Implications.

The unifying characteristic of movement disorders is the phenotypic presentation of abnormal motor outputs, either as isolated phenomena or in association with further clinical, often neuropsychiatric, features. However, the possibility of a movement disorder also characterized by supranormal or enhanced volitional motor control has not received attention. Based on clinical observations and cases collected over a number of years, we here describe the intriguing clinical phenomenon that people with tic disorders are often able to control specific muscle contractions as part of their tic behaviors to a degree that most humans typically cannot. Examples are given in accompanying video documentation. We explore medical literature on this topic and draw analogies with early research of fine motor control physiology in healthy humans. By systematically analyzing the probable sources of this unusual capacity, and focusing on neuroscientific accounts of voluntary motor control, sensory feedback, and the role of motor learning in tic disorders, we provide a novel pathophysiological account explaining both the presence of exquisite control over motor output and that of overall tic behaviors. We finally comment on key questions for future research on the topic and provide concluding remarks on the complex movement disorder of tic behaviors. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.