The paper’s primary goal is to investigate mass and heat transfer processes in reactive nanofluid particles. Within Buongiorno’s model, three chemical reactions are discussed. The main subject is on the nanoparticle fractions at the boundary. The characteristics of [Formula: see text] and [Formula: see text] with regard to the nanoparticle fraction have been found to be passively rather than actively controlled at the boundary. To put it another way, these qualities naturally develop and are controlled by the circumstances at the boundary or interface where the nanoparticles interact with the surrounding medium. They are not the result of active manipulation or outside forces. The system of partial differential equations was converted into ordinary differential equations using similarity transformations. To solve the system of ODEs, they combined the shooting method with a numerical technique known as RK-Fehlberg. The study examines various physical parameters and their effects using graphs. The paper also contains a table showing how different parameters affect the regional Nusselt and Sherwood numbers. This enables a deeper comprehension of the impact that these variables have on the heat and mass transfer within the reactive nanofluid particles. Core findings: Examining three chemical reactions involving nanofluids has led to the study’s key discoveries. Additionally, it looks into how specific physical variables may affect the Nusselt and Sherwood numbers.