Juvenile Psammomatoid Ossifying Fibroma Research Articles

Psammomatoid juvenile ossifying fibroma of maxilla: An uncommon neoplasm

Juvenile ossifying fibroma (JOF) is a rare variant of ossifying fibroma. JOF is classified into two distinct clinicopathological variants: Trabecular and psammomatoid JOF. Based on the age group involved, most common site of occurrence and clinical behavior, JOF differs from the larger group of ossifying fibromas. We report a case of psammomatoid JOF of maxilla in a 10-year-old female who presented with a swelling over the right side of the face.

PSAMMOMATOID JUVENILE OSSIFYING FIBROMA CAUSING EXUBERANT ORBITAL DYSTOPIA

Psammomatoid juvenile ossifying fibroma (PJOF) is an aggressive fibro-osseous neoplasm that mainly occurs in the periorbital, frontal and ethmoid bones of young individuals. We present a case of PJOF in the frontal bone causing exuberant orbital dystopia.

Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Proximal Radius: A Rare Entity.

Background:Juvenile psammomatoid ossifying fibroma (JPOF) is a rare fibro-osseous lesion that usually occurs in the facial bones. The pathognomonic histopathologic feature is the presence of spherical ossicles, which are similar to psammoma bodies. It is considered to be a unique lesion because of its reported tendency to occur in children and adolescents and its tendency for locally aggressive growth. Because this lesion is aggressive in nature with high recurrence rate, early detection and complete surgical excision are essential.Case Report:Herein, we present a case of 11 year old girl, who presented to our clinic with history of gradual onset pain around right elbow associated with limitation of right forearm rotation for 3 months. After getting informed consent, we performed needle biopsy and histopathologically it was diagnosed as Psammomatoid type juvenile ossifying fibroma (JPOF) of proximal radius. We performed extensive debridement, curettage of entire cystic lesion involving the proximal radius and filled the cavity with allograft bone granules and intramedullary titanium elastic nail through fibular strut graft, bridging the cystic lesion.Conclusion:As far as our knowledge there is no reported case of psammomatoid type of juvenile ossifying fibroma of proximal radius. We believe that such tumors in long bones are aggressive and have tendency for recurrence. Definitive diagnosis is utmost important for proper planning, surgical excision and reconstruction of long bones and need regular follow up to look for any recurrence or malignant transformation.

Juvenile ossifying fibroma: an analysis of clinico-pathological features in a case series with a literature review

Juvenile Aggressive Ossifying Fibroma (JAOF) is divided into two entities namely Juvenile Psammomatoid Ossifying Fibroma (JPOF) and Juvenile Trabecular Ossifying Fibroma (JTOF). JAOFs are aggressive but benign tumours that require clinico-pathological correlation to arrive at the definitive diagnosis. We report nine new cases of JPOF and 6 cases of JTOF with a brief review of the literature to aid correct diagnosis of these two different entities. According to the clinico-pathological analysis both JPOF and JTOF had occurred in children and adults, with a mean age of 28.6 years and 21 years at presentation respectively. JPOF showed a male predilection while equal gender distribution was observed in JTOF. Both tumours occurred most often in the mandible. Regarding the histopathological features all tumours were unencapsulated. All cases of JPOF showed presence of psammoma bodies which can be considered as a main diagnostic feature. JTOF showed osteoid and immature woven bone trabeculae. Osteoblastic rimming was commonly observed among JTOF but absent in JPOF. Other histopathological features did not show any striking difference between the two lesions. In conclusion, the term “Juvenile aggressive ossifying fibroma” is a misnomer as it can occur in adults as well. Therefore, the word “Juvenile” should be excluded when renaming the tumour which is a “need of the hour”. Further, the study demonstrates the use of demographic, radiological and histopathological features with clinico-pathological correlation to diagnose and exclude mimics of JPOF and JTOF.

A rare cause of maxillary mass: juvenile ossifying fibroma

<p class="abstract">Juvenile ossifying fibroma (JOF) is a unique fibro-osseous neoplasm. It has 2 histopathological variants. Psammomatoid juvenile ossifying fibroma (PsJOF) and Trabecular juvenile ossifying fibroma (TrJOF) affecting the jaws of children. Only 20% of the patients are over 15 years of age. JOF is more common in maxilla than mandible. It presents as an asymptomatic progressive, rapid expansion of jaws. It has a recurrence rate of 30-58%. Surgery is the only cure for this kind of lesion and total excision should be the goal of the treatment. We present a case report of 12 year-old female patient with clinical, radiographic and histopathological features of Psammomatoid JOF which clinically admitted to our clinic as maxillary sinus mass.</p>

Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases

The management of patients with juvenile ossifying fibroma (JOF) remains controversial. To explore the correlations between different treatments and the patient prognosis, 15 cases of JOF of the jaw were reviewed. Five patients were male and 10 were female. Patient age at the time of disease onset ranged from 7 to 18 years (mean 10.9 years). Nine tumours were located in mandible and six in the maxilla. These cases typically manifested clinically as painless swelling of the jaw (9/15, 60%); 40% (6/15) of the cases were associated with pain, diplopia, stuffy nose, and/or rapid growth. Images of JOF can show a radiolucent, mixed, or ground glass-like appearance. Pathological examinations revealed 10 cases of juvenile trabecular ossifying fibroma (JTOF) and five cases of juvenile psammomatoid ossifying fibroma (JPOF). In terms of the treatment plan, six patients initially received radical surgery; nine patients underwent conservative treatment, among whom six (6/9, 66.7%) had one or more recurrence. At the end of the follow-up period, 12 patients had no evidence of tumour recurrence and three cases were alive with a tumour. In summary, surgeons should develop the surgical plan according to the extent of the lesion, relapse status, growth rate, and family choice, and these patients should be followed up closely.

Extragnathic psammous desmo-osteoblastoma of maxilla - A unique entity

Juvenile psammomatoid ossifying fibroma (JPOF) is a rare fibro-osseous neoplasm in young children which is locally aggressive, spreads quickly and has a very high recurrence rate. Early detection and complete excision are essential. It generally occurs in extragnathic craniofacial bones such as periorbital, frontal, and ethmoid bones. Jaw bones are rarely involved. Here, we report a case of JPOF of the maxilla in a 16-year-old female patient. Complete surgical excision along with removal of the first premolar was done. It was initially thought to be Fibro-osseous lesions which were provisionally diagnosed as juvenile ossifying fibroma clinically and radiographically but confirmed histopathologically as JPOF. Definitive diagnosis and treatment of such lesions depend on the collective correlation of clinical, radiographic, and histopathological features.

篩骨洞に発生したjuvenile psammomatoid ossifying fibroma例

線維性骨病変は，骨形成性線維腫，線維性異形成症，セメント質骨異形成症に分類される。骨形成性線維腫はさらにjuvenile psammomatoid ossifying fibroma（JPOF）やjuvenile trabecular ossifying fibroma（JTOF）に分類され，JPOFは組織学的に良性の腫瘤であるが，局所侵襲性のある非常に稀な疾患である。今回我々は左篩骨洞に発生した腫瘤を内視鏡下に摘出術を施行しJPOFと診断した稀な症例を経験したので報告する。症例は7歳5か月の男児。2か月前より出現した左眼球突出のため当院眼科を紹介された。眼窩MRI撮影したところ左篩骨洞に充実性腫瘤を認めたため当科を紹介受診となった。腫瘤は38×24mmでMRI所見はT2強調画像で高信号，T1強調画像で軽度高信号であった。単純CTでは腫瘤内部は比較的高吸収値で周囲骨の膨隆性変化と左眼窩内側壁の圧排と一部壁の消失を認めた。視野欠損や視力障害などは認めなかったが，診断と治療目的で全身麻酔下に内視鏡下鼻内副鼻腔手術を施行した。腫瘤は弾性硬で周囲に骨性隔壁構造を有しており，内部は易出血性であった。眼窩内側壁が一部欠損し，出血も多かったため手術は診断目的を優先し眼窩側の骨性隔壁物は残して総中鼻道側の隔壁を除去し手術を終了とした。病理組織学検査でJPOFと診断した。

The modified hemi-Lothrop procedure: A variation of the endoscopic endonasal approach for resection of a supraorbital psammomatoid ossifying fibroma

Tumors in the supraorbital region are most commonly accessed through transcranial approaches, including fronto-orbital, orbitozygomatic, and eyebrow supraorbital keyhole approaches. Purely endoscopic endonasal approaches (EEA) are more challenging to perform because of limitations in access and visualization for lateral extension beyond the midline corridor. The modified hemi-Lothrop procedure, a variation of an extended EEA, allows for binostril access and visualization of the lateral supraorbital region while preserving the contralateral frontal sinus drainage pathway. The operative technique and nuances are illustrated in a rare case of a supraorbital juvenile psammomatoid ossifying fibroma (JPOF) causing symptomatic orbital compression. The key components of the approach consisted of an endoscopic Draf IIB (left frontal sinusotomy) ipsilateral to the tumor, and a superior septectomy for binostril bimanual instrumentation. Excellent visualization, access, and tumor removal of the supraorbital region was achieved with angled endoscopy and curved instrumentation from the contralateral nasal cavity and through the septectomy window (“cross-court” trajectory). The modified hemi-Lothrop procedure with angled endoscopy is a safe and effective alternative route to traditional transcranial approaches to access the supraorbital region. To our knowledge, this is the first case of a supraorbital JPOF that was successfully resected via a purely EEA.

A Novel Treatment of Aggressive Psammomatoid Juvenile Ossifying Fibroma: A Case Report

Introduction: Juvenile ossifying fibroma is a benign, bone-forming neoplasm with aggressive local growth that is distinguished from other fibro-osseous lesions primarily by its age of onset, clinical presentation and aggressive behavior. Although a benign entity, juvenile ossifying fibroma is known to be locally aggressive and has a high tendency to recur. Two distinctive microscopic patterns have been described: a trabecular variant and a psammomatoid variant. This latter variant is predominantly a craniofacial lesion and occurs rarely in the jaws. Treatment plans include a range of enucleation to total resection. Case Presentation: Reported here is a case of a huge psammomatoid juvenile ossifying fibroma of the maxilla in a 19-year-old man. Right maxillectomy was done while brain exposure in sphenoid and ethmoidal region was covered with fat and bone graft. After 1 year follow up, an endosseous dental implant was inserted in right lateral pterygoid plate. Conclusions: Six months later an obturator was made over that osseointegrated implant to reconstruct the anatomic defect, achieving functional rehabilitation and satisfactory facial appearance.

Juvenile psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of mandible

Juvenile psammomatoid ossifying fibroma (JPOF) is a rare, slowly progressive tumor of the extragnathic craniofacial bones, with a tendency towards locally aggressive behavior and recurrence. The pathognomonic histopathologic feature is the presence of spherical ossicles, which are similar to psammoma bodies. Very few cases in association with the secondary aneurysmal bone cyst (ABC) formation have been reported in the literature. Treatment consists of complete surgical removal; the incomplete excision has been associated with a high local recurrence rate. The prognosis is good because malignant change and metastasis have not been reported. We report a case of JPOF of the mandible with secondary ABC in an 18-year-old male patient.

Correction: Psammomatoid Juvenile Ossifying Fibroma of the Maxilla: Radical Surgery with Maxillary Resection in a 7-year-old Girl

Correction: Psammomatoid Juvenile Ossifying Fibroma of the Maxilla: Radical Surgery with Maxillary Resection in a 7-year-old Girl

Psammomatoid Juvenile Ossifying Fibroma of the Maxilla: Radical Surgery with Maxillary Resection in a 7-year-old Girl

Corrected by: Correction: Psammomatoid Juvenile Ossifying Fibroma of the Maxilla: Radical Surgery with Maxillary Resection in a 7-year-old GirlKlin Padiatr 2013; 225(07): e2-e2DOI: 10.1055/s-0033-1363986

Subacute cystic expansion of intracranial juvenile psammomatoid ossifying fibroma

Juvenile psammomatoid ossifying fibroma (JPOF) is a benign fibro-osseous lesion typically associated with the jaw, paranasal region, or orbit. However, JPOF may also originate from the skull base and locally invade the cranium. In published reports, intracranial JPOFs constitute only a small percentage of cases, and therefore it is not known whether more aggressive behavior typifies this distinct population of JPOFs compared with those in other locations. Nevertheless, JPOF histopathology is characterized by a number of active processes, including cystic transformation, that may precipitate violation of skull base boundaries. In the following article, the authors present a case of skull base JPOF that underwent cystic expansion in a young girl, produced a focal neurological deficit, and was resolved using a staged surgical approach.

Juvenile psammomatoid ossifying fibroma of maxillary sinus: case report with review of literature.

Juvenile psammomatoid ossifying fibroma is a rare benign fibro-osseous tumor of the gnathic and extragnathic craniofacial bones, particularly the periorbital, frontal and ethmoid bones. It is slowly progressive with aggressive local growth, invasion and destruction of the surrounding tissue, bone erosion and recurrence after surgical excision. It is distinguished from the other fibro-osseous lesions by its age of onset, clinical presentation and aggressive behavior.

Juvenile psammomatoid ossifying fibroma: An unusual case report

Ossifying fibromas are well-demarcated benign fibro-osseous tumors of craniofacial skeleton most often in the jaws. It has two types, conventional and juvenile ossifying fibroma (JOF). JOF is considered a separate entity from ossifying fibroma due to its locally aggressive behavior and tendency to occur at a young age. Two subtypes of JOF, i.e., juvenile psammomatoid ossifying fibroma (JPOF) and juvenile trabecular ossifying fibroma have been identified on the basis of histology 70% of the JPOF occur in the paranasal sinuses, 20% in the maxilla and only 10% in the mandible. Here, we report a case of JPOF in a 14-year-old girl causing an asymptomatic expansile swelling in the right mandibular posterior region, which is a rare site for this tumor.

A massive sinonasal psammomatoid variant of juvenile ossifying fibroma: Report of a rare entity

Juvenile ossifying fibroma (JOF) is an uncommon, benign, bone-forming neoplasm with an aggressive local growth that is distinguished from other fibro-osseous lesions primarily by its age of onset, clinical presentation and aggressive behaviour. JOF is considered as a variant of the ossifying fibroma (OF) and the former includes psammomatoid JOF (PsJOF) and Trabecular JOF (TrJOF). Both variants involve the craniofacial bones with the trabecular variant being more common in the jaws and the psammomatoid variant being more common in the craniofacial skeleton. PsJOF is an unique variant of JOF that has a predilection for the sinonasal tract and the orbit particularly centered on the periorbital, frontal, and ethmoid bones. We report a rare case of massive PsJOF involving the maxillary sinus in a 20-year-old female.

CT and Magnetic Resonance Imaging Findings of Psammomatoid Juvenile Ossifying Fibroma of the Middle Turbinate: A Case Report

Ossifying fibroma of the middle turbinate is extremely rare. We report a case of psammomatoid juvenile ossifying fibroma (PsJOF) of the middle turbinate in an 18-year-old adolescent female along with its CT, MRI and pathologic features. PsJOF of the middle turbinate may present a well-demarcated, expansile, solidly enhancing mass with focal bony destruction, which may mimic various benign and malignant neoplasms of the sinonasal area. A combination of clinical, imaging and pathologic findings is prerequisite for establishing an accurate diagnosis. Index terms

Juvenile Psammomatoid Ossifying Fibroma of the Forehead, Radical Resection, and Defect Coverage with a Hydroxyl-Apatite Composite—A Case Report

Juvenile Psammomatoid Ossifying Fibroma of the Forehead, Radical Resection, and Defect Coverage with a Hydroxyl-Apatite Composite—A Case Report

Juvenile psammomatoid ossifying fibroma of the orbit and paranasal sinuses. A case report

Juvenile psammomatoid ossifying fibroma (JPOF) is an uncommon benign fibro-osseous lesion predominantly arising in the paranasal sinuses and orbits of children and young adults. We report a case of JPOF involving the paranasal sinuses and orbit in a 15-year-old boy that presented due to progressive proptosis and downward displacement of the left eye. The lesion, first described as fibrous dysplasia (FD), was totally removed surgically, and then proved to be a JPOF, by histopathology. We discuss its differential diagnosis with other fibro-osseous lesions, histopathological features, and treatment options.