Isoquinolinium Iodide Research Articles

Screening of cesticidal compounds on a tapeworm Hymenolepis nana in vitro.

A simple and convenient in vitro technique is described for the screening of compounds for action against Hymenolepis nana and probably many other intestinal worms. The results obtained from this test are in broad agreement with the findings of clinical experience and of a small series of in vivo tests. Among the substances tested, the most active ones were oil of chenopodium, dichlorophen, extract of cashew nut (Anacardium occidentale), antimony potassium tartrate, and BIQ 20 [eicosamethylenebis(isoquinolinium iodide)].

Chemotherapeutic Properties of Some New Quaternary Ammonium Salts

Abstract Several new quaternary ammonium salts have been tested for antifilarial activity against Litomosoides carinii, filarial parasite of the cotton rat. Many of these compounds are active in killing L. carinii; the most promising (BIQ 20) eicosane 1:20-bis(isoquinolinium iodide) and (BAC 20) eicosane 1:20-bis(4-aminocinnolinium iodide) possess an index (LD50 mice/minimum effective dose cotton rats) of 19 and 39 respectively. The compounds have a direct filaricidal action on the adult worms while the microfilariae are comparatively unaffected.